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Volume 23, Issue 7
  • ISSN: 1570-159X
  • E-ISSN: 1875-6190

Abstract

Post-Traumatic Stress Disorder (PTSD) is mainly characterized by dysregulated fear responses, including hyperarousal and intrusive re-experiencing of traumatic memories. This work delves into the intricate interplay between abnormal fear responses, cortisol dysregulation, and the Hypothalamic-Pituitary-Adrenal (HPA) axis, elucidating their role in the manifestation of PTSD. Given the persistent nature of PTSD symptoms and the limitations of conventional therapies, innovative interventions are urgently needed. One promising avenue of research revolves around the modulation of cortisol through targeting receptors, with dexamethasone emerging as a critical agent capable of reducing cortisol levels, thus potentially aiding in the extinction of fear. In this study, we emphasize the need for innovative interventions in the neuropharmacological treatment of PTSD, focusing on cortisol modulation and its impact on fear regulation mechanisms. The complex interplay between the HPA axis, cortisol modulation, and fear dysregulation not only broadens our comprehension but also reveals promising paths to enhance therapeutic outcomes for individuals struggling with PTSD, underscoring a crucial need for more effective treatment strategies.

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2025-05-18

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/content/journals/cn/10.2174/1570159X23666250123142526
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Cortisol Imbalance and Fear Learning in PTSD: Therapeutic Approaches to Control Abnormal Fear Responses
Curr. Neuropharmacol. 23, 835 (2025); https://doi.org/10.2174/1570159X23666250123142526
/content/journals/cn/10.2174/1570159X23666250123142526
/content/journals/cn/10.2174/1570159X23666250123142526
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  • Article Type:     Review Article
Keyword(s): cortisol dysregulation; dexamethasone; fear extinction; fear learning; hypothalamic-pituitary-adrenal (HPA) axis; Post-traumatic stress disorder (PTSD)

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