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Volume 23, Issue 7
  • ISSN: 1570-159X
  • E-ISSN: 1875-6190

Abstract

Background

The incidence of Major Depressive Disorder (MDD) is high among adolescent females, and MDD is often accompanied by suicide attempts (SAs), which have a serious negative impact on health. However, changes in lipids, thyroid hormone, and brain metabolism among female adolescents with MDD and the relationships between these three markers and MDD with SA have yet to be elucidated.

Methods

This study enrolled 71 MDD patients with SA (MDD+SA), 66 MDD patients without SA (MDD-SA), and 47 healthy controls (HCs). We analysed the lipid and thyroid hormone levels and magnetic resonance spectroscopy results of the subjects.

Results

Low levels of social support, high levels of life stress, and high levels of suicidal ideation (SI) were risk factors for SA. In MDD patients, 1) thyroid stimulating hormone was positively correlated with triglyceride (TG) and N-acetyl aspartic acid (NAA)/creatinine in the prefrontal cortex (PFC) and negatively correlated with high-density lipoprotein and the choline/creatinine in the thalamus; 2) free thyroxine was negatively correlated with the choline/creatinine in the thalamus; 3) total cholesterol, TG, low-density lipoprotein, and choline/NAA in the PFC were positively correlated with the severity of SI and suicide risk; and 4) NAA/creatinine in the thalamus was negatively correlated with the severity of SI and suicide risk.

Conclusion

In female adolescents with MDD, there are significant synergistic changes in lipids, thyroid hormones, and brain metabolism-related factors, and the changes in these indicators may be related to the pathological mechanism of SA.

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References

  1. KnightM.J. BauneB.T. Cognitive dysfunction in major depressive disorder.Curr. Opin. Psychiatry2018311263110.1097/YCO.0000000000000378 29076892
     [Google Scholar]
  2. MollerC.I. BadcockP.B. HetrickS.E. RiceS. BerkM. WittK. ChanenA.M. DeanO.M. GaoC. CottonS.M. DaveyC.G. Predictors of suicidal ideation severity among treatment-seeking young people with major depressive disorder: The role of state and trait anxiety.Aust. N. Z. J. Psychiatry20235781150116210.1177/00048674221144262 36629043
     [Google Scholar]
  3. ShoreyS. NgE.D. WongC.H.J. Global prevalence of depression and elevated depressive symptoms among adolescents: A systematic review and meta‐analysis.Br. J. Clin. Psychol.202261228730510.1111/bjc.12333 34569066
     [Google Scholar]
  4. AvenevoliS. SwendsenJ. HeJ.P. BursteinM. MerikangasK.R. Major depression in the national comorbidity survey-adolescent supplement: Prevalence, correlates, and treatment.J. Am. Acad. Child Adolesc. Psychiatry20155413744.e210.1016/j.jaac.2014.10.010 25524788
     [Google Scholar]
  5. PompiliM. InnamoratiM. ErbutoD. LucianoM. SampognaG. Abbate-DagaG. BarlatiS. CarmassiC. CastelliniG. De FazioP. Di LorenzoG. Di NicolaM. FerrariS. GoracciA. GramagliaC. MartinottiG. NanniM.G. PasquiniM. PinnaF. PoloniN. SerafiniG. SignorelliM. TortorellaA. VentriglioA. VolpeU. FiorilloA. High depression symptomatology and mental pain characterize suicidal psychiatric patients.Eur. Psychiatry2022651e5410.1192/j.eurpsy.2022.2312 36041998
     [Google Scholar]
  6. RocaM. del AmoA.R.L. Riera-SerraP. Pérez-AraM.A. CastroA. Roman JuanJ. García-ToroM. García-PazoP. GiliM. Suicidal risk and executive functions in major depressive disorder: A study protocol.BMC Psychiatry201919125310.1186/s12888‑019‑2233‑1 31420027
     [Google Scholar]
  7. WalshE.H. McMahonJ. HerringM.P. Research Review: The effect of school‐based suicide prevention on suicidal ideation and suicide attempts and the role of intervention and contextual factors among adolescents: A meta‐analysis and meta‐regression.J. Child Psychol. Psychiatry202263883684510.1111/jcpp.13598 35289410
     [Google Scholar]
  8. TangJ.J. YuY. WilcoxH.C. KangC. WangK. WangC. WuY. ChenR. Global risks of suicidal behaviours and being bullied and their association in adolescents: School-based health survey in 83 countries.EClinicalMedicine20201910025310.1016/j.eclinm.2019.100253 32140671
     [Google Scholar]
  9. Miranda-MendizabalA. CastellvíP. Parés-BadellO. AlayoI. AlmenaraJ. AlonsoI. BlascoM.J. CebriàA. GabilondoA. GiliM. LagaresC. PiquerasJ.A. Rodríguez-JiménezT. Rodríguez-MarínJ. RocaM. Soto-SanzV. VilagutG. AlonsoJ. Gender differences in suicidal behavior in adolescents and young adults: Systematic review and meta-analysis of longitudinal studies.Int. J. Public Health201964226528310.1007/s00038‑018‑1196‑1 30635683
     [Google Scholar]
  10. HoT.C. GifuniA.J. GotlibI.H. Psychobiological risk factors for suicidal thoughts and behaviors in adolescence: A consideration of the role of puberty.Mol. Psychiatry202227160662310.1038/s41380‑021‑01171‑5 34117365
     [Google Scholar]
  11. WeiS. WomerF.Y. EdmistonE.K. ZhangR. JiangX. WuF. KongL. ZhouY. TangY. WangF. Structural alterations associated with suicide attempts in major depressive disorder and bipolar disorder: A diffusion tensor imaging study.Prog. Neuropsychopharmacol. Biol. Psychiatry20209810982710.1016/j.pnpbp.2019.109827 31778758
     [Google Scholar]
  12. RuchD. SheftallA.H. HeckK. McBee-StrayerS.M. TissueJ. ReynoldsB. AckermanJ. BrentD.A. CampoJ.V. BridgeJ.A. Neurocognitive vulnerability to youth suicidal behavior.J. Psychiatr. Res.202013111912610.1016/j.jpsychires.2020.08.032 32961501
     [Google Scholar]
  13. ZhangJ. MckeownR.E. HusseyJ.R. ThompsonS.J. WoodsJ.R. Gender differences in risk factors for attempted suicide among young adults: Findings from the third national health and nutrition examination survey.Ann. Epidemiol.200515216717410.1016/j.annepidem.2004.07.095 15652723
     [Google Scholar]
  14. DekkerM.C. FerdinandR.F. Van LangN.D.J. BongersI.L. Van Der EndeJ. VerhulstF.C. Developmental trajectories of depressive symptoms from early childhood to late adolescence: Gender differences and adult outcome.J. Child Psychol. Psychiatry200748765766610.1111/j.1469‑7610.2007.01742.x 17593146
     [Google Scholar]
  15. WuS. DingY. WuF. XieG. HouJ. MaoP. Serum lipid levels and suicidality: A meta-analysis of 65 epidemiological studies.J. Psychiatry Neurosci.2016411566910.1503/jpn.150079 26505144
     [Google Scholar]
  16. PengR. DaiW. LiY. Low serum free thyroxine level is correlated with lipid profile in depressive patients with suicide attempt.Psychiatry Res.201826611111510.1016/j.psychres.2018.05.059 29859497
     [Google Scholar]
  17. LiuJ.J. HezghiaA. ShaikhS.R. CenidoJ.F. StarkR.E. MannJ.J. SubletteM.E. Regulation of monoamine transporters and receptors by lipid microdomains: Implications for depression.Neuropsychopharmacology201843112165217910.1038/s41386‑018‑0133‑6 30022062
     [Google Scholar]
  18. ZhangC. YangY. ZhuD. ZhaoW. ZhangY. ZhangB. WangY. ZhuJ. YuY. Neural correlates of the association between depression and high density lipoprotein cholesterol change.J. Psychiatr. Res.202013091810.1016/j.jpsychires.2020.07.012 32768711
     [Google Scholar]
  19. PompiliM. GibiinoS. InnamoratiM. SerafiniG. Del CasaleA. De RisioL. PalermoM. MonteboviF. CampiS. De LucaV. SherL. TatarelliR. BiondiM. DuvalF. SerrettiA. GirardiP. Prolactin and thyroid hormone levels are associated with suicide attempts in psychiatric patients.Psychiatry Res.20122002-338939410.1016/j.psychres.2012.05.010 22748186
     [Google Scholar]
  20. KarakatsoulisG.N. TsapakisE.M. MitkaniC. FountoulakisK.N. Subclinical thyroid dysfunction and major depressive disorder.Hormones (Athens)202120461362110.1007/s42000‑021‑00312‑3 34427900
     [Google Scholar]
  21. KotkowskaZ. StrzeleckiD. Depression and autoimmune hypothyroidism-their relationship and the effects of treating psychiatric and thyroid disorders on changes in clinical and biochemical parameters including BDNF and other cytokines-A systematic review.Pharmaceuticals (Basel)202215439110.3390/ph15040391 35455388
     [Google Scholar]
  22. FengX.Z. WangK. LiZ. WangF. LiZ.Y. TanX. ZhuW.L. ZhangX.Y. LiS.X. Association between thyroid autoimmunity and clinical characteristics in first-episode and drug-naive depressed patients with suicide attempts.Gen. Hosp. Psychiatry20238315616310.1016/j.genhosppsych.2023.05.008 37201445
     [Google Scholar]
  23. LindbergL. HagmanE. DanielssonP. MarcusC. PerssonM. Anxiety and depression in children and adolescents with obesity: A nationwide study in Sweden.BMC Med.20201813010.1186/s12916‑020‑1498‑z 32079538
     [Google Scholar]
  24. BaekJ.H. KangE.S. FavaM. MischoulonD. NierenbergA.A. YuB.H. LeeD. JeonH.J. Serum lipids, recent suicide attempt and recent suicide status in patients with major depressive disorder.Prog. Neuropsychopharmacol. Biol. Psychiatry20145111311810.1016/j.pnpbp.2014.01.018 24495778
     [Google Scholar]
  25. DarayF.M. MannJ.J. SubletteM.E. How lipids may affect risk for suicidal behavior.J. Psychiatr. Res.2018104162310.1016/j.jpsychires.2018.06.007 29920417
     [Google Scholar]
  26. KaradenizS. YamanH. BilginerÇ. Hızarcı BulutS. YamanS.Ö. Serum nesfatin-1, ghrelin, and lipid levels in adolescents with first episode drug naïve unipolar depression.Nord. J. Psychiatry202074861361910.1080/08039488.2020.1772363 32496844
     [Google Scholar]
  27. ZhaoK. ZhouS. ShiX. ChenJ. ZhangY. FanK. ZhangX. WangW. TangW. Potential metabolic monitoring indicators of suicide attempts in first episode and drug naive young patients with major depressive disorder: A cross-sectional study.BMC Psychiatry202020138710.1186/s12888‑020‑02791‑x 32723375
     [Google Scholar]
  28. LiuZ. SunL. ZhangY. WangJ. SunF. ZhangZ. SunG. SunL. YangR. The prevalence of underweight and obesity in chinese children and adolescents with major depressive disorder and relationship with suicidal ideation and attempted suicide.Front. Psychiatry202314113043710.3389/fpsyt.2023.1130437 37215666
     [Google Scholar]
  29. LiC. LiX. LiY. NiuX. The nonlinear relationship between body mass index (BMI) and perceived depression in the chinese population.Psychol. Res. Behav. Manag.2023162103212410.2147/PRBM.S411112 37325255
     [Google Scholar]
  30. ZhangY. LaiS. WuW. WangY. zhaoH. heJ. ZhuY. ChenG. QiZ. ChenP. lvS. songZ. huY. MiaoH. YanS. luoY. RanH. huangX. LuX. ZhongS. JiaY. Associations between executive function impairment and biochemical abnormalities in depressed adolescents with non-suicidal self-injury.J. Affect. Disord.2022298Pt A49249910.1016/j.jad.2021.10.13234737017
     [Google Scholar]
  31. ZhongS. WangY. ZhaoG. XiangQ. LingX. LiuS. HuangL. JiaY. Similarities of biochemical abnormalities between major depressive disorder and bipolar depression: A proton magnetic resonance spectroscopy study.J. Affect. Disord.201416838038610.1016/j.jad.2014.07.024 25106035
     [Google Scholar]
  32. ShanY. JiaY. ZhongS. LiX. ZhaoH. ChenJ. LuQ. ZhangL. LiZ. LaiS. WangY. Correlations between working memory impairment and neurometabolites of prefrontal cortex and lenticular nucleus in patients with major depressive disorder.J. Affect. Disord.201822723624210.1016/j.jad.2017.10.030 29102838
     [Google Scholar]
  33. LiuX. ZhongS. LiZ. ChenJ. WangY. LaiS. MiaoH. JiaY. Serum copper and zinc levels correlate with biochemical metabolite ratios in the prefrontal cortex and lentiform nucleus of patients with major depressive disorder.Prog. Neuropsychopharmacol. Biol. Psychiatry20209910982810.1016/j.pnpbp.2019.109828 31778759
     [Google Scholar]
  34. ZavorotnyyM. ZöllnerR. RekateH. DietscheP. BoppM. SommerJ. MellerT. KrugA. NenadićI. Intermittent theta-burst stimulation moderates interaction between increment of N-Acetyl-Aspartate in anterior cingulate and improvement of unipolar depression.Brain Stimul.202013494395210.1016/j.brs.2020.03.015 32380445
     [Google Scholar]
  35. PosnerK. OquendoM.A. GouldM. StanleyB. DaviesM. Columbia classification algorithm of suicide assessment (C-CASA): Classification of suicidal events in the FDA’s pediatric suicidal risk analysis of antidepressants.Am. J. Psychiatry200716471035104310.1176/ajp.2007.164.7.1035 17606655
     [Google Scholar]
  36. ParkS. Hatim SulaimanA. SrisurapanontM. ChangS. LiuC.Y. BautistaD. GeL. Choon ChuaH. Pyo HongJ. The association of suicide risk with negative life events and social support according to gender in Asian patients with major depressive disorder.Psychiatry Res.2015228327728210.1016/j.psychres.2015.06.032 26160206
     [Google Scholar]
  37. LiuR.T. MillerI. Life events and suicidal ideation and behavior: A systematic review.Clin. Psychol. Rev.201434318119210.1016/j.cpr.2014.01.006 24534642
     [Google Scholar]
  38. SteeleK.R. TownsendM.L. GrenyerB.F.S. Parenting and personality disorder: An overview and meta-synthesis of systematic reviews.PLoS One20191410e022303810.1371/journal.pone.0223038 31574104
     [Google Scholar]
  39. PompiliM. ErbutoD. InnamoratiM. LucianoM. SampognaG. Abbate-DagaG. BarlatiS. CarmassiC. CastelliniG. FazioP.D. LorenzoG.D. NicolaM.D. FerrariS. GramagliaC. NanniM.G. PasquiniM. PinnaF. PoloniN. SerafiniG. SignorelliM. VentriglioA. VolpeU. FiorilloA. The relationship between mental pain, suicide risk, and childhood traumatic experiences.J. Clin. Psychiatry202283421m1417610.4088/JCP.21m1417635704708
     [Google Scholar]
  40. TureckiG. BrentD.A. GunnellD. O’ConnorR.C. OquendoM.A. PirkisJ. StanleyB.H. Suicide and suicide risk.Nat. Rev. Dis. Primers2019517410.1038/s41572‑019‑0121‑0 31649257
     [Google Scholar]
  41. SousaG.S. SantosM.S.P. SilvaA.T.P. PerrelliJ.G.A. SougeyE.B. Revisão de literatura sobre suicídio na infância.Cien. Saude Colet.20172293099311010.1590/1413‑81232017229.14582017 28954160
     [Google Scholar]
  42. JiangS. RenQ. JiangC. WangL. Academic stress and depression of chinese adolescents in junior high schools: Moderated mediation model of school burnout and self-esteem.J. Affect. Disord.202129538438910.1016/j.jad.2021.08.085 34492431
     [Google Scholar]
  43. CastellvíP. Lucas-RomeroE. Miranda-MendizábalA. Parés-BadellO. AlmenaraJ. AlonsoI. BlascoM.J. CebriàA. GabilondoA. GiliM. LagaresC. PiquerasJ.A. RocaM. Rodríguez-MarínJ. Rodríguez-JimenezT. Soto-SanzV. AlonsoJ. Longitudinal association between self-injurious thoughts and behaviors and suicidal behavior in adolescents and young adults: A systematic review with meta-analysis.J. Affect. Disord.2017215374810.1016/j.jad.2017.03.035 28315579
     [Google Scholar]
  44. DuarteT.A. PaulinoS. AlmeidaC. GomesH.S. SantosN. Gouveia-PereiraM. Self-harm as a predisposition for suicide attempts: A study of adolescents’ deliberate self-harm, suicidal ideation, and suicide attempts.Psychiatry Res.202028711255310.1016/j.psychres.2019.112553 31526562
     [Google Scholar]
  45. BrittonR.H. FockerM. LibudaL. AntelJ. OzturkD. KiewertC. MunteanuM. PetersT. FuhrerD. ZwanzigerD. ThammM. HebebrandJ. GrasemannC. Increased prevalence of subclinical hypothyroidism and thyroid autoimmunity in depressed adolescents.J. Clin. Psychiatry20218222797310.4088/JCP.20m13511 33988923
     [Google Scholar]
  46. LohH.H. LimL.L. YeeA. LohH.S. Association between subclinical hypothyroidism and depression: An updated systematic review and meta-analysis.BMC Psychiatry20191911210.1186/s12888‑018‑2006‑2 30621645
     [Google Scholar]
  47. FuX.L. LiX. JiJ.M. WuH. ChenH.L. Blood hormones and suicidal behaviour: A systematic review and meta-analysis.Neurosci. Biobehav. Rev.202213910472510.1016/j.neubiorev.2022.104725 35690122
     [Google Scholar]
  48. Makarow-GronertA. MargulskaA. StrzeleckiD. KrajewskaK. GmitrowiczA. Gawlik-KotelnickaO. Comparison of thyroid-stimulating hormone levels in adolescents with schizophrenia, bipolar disorder, unipolar depression, conduct disorders, and hyperkinetic disorders.Medicine (Baltimore)202110049e2816010.1097/MD.0000000000028160 34889284
     [Google Scholar]
  49. KimB. KangE.S. FavaM. MischoulonD. SoskinD. YuB.H. LeeD. LeeD.Y. ParkH.D. JeonH.J. Follicle-stimulating hormone (FSH), current suicidal ideation and attempt in female patients with major depressive disorder.Psychiatry Res.2013210395195610.1016/j.psychres.2013.08.057 24080256
     [Google Scholar]
  50. BaekJ.H. KangE.S. FavaM. MischoulonD. NierenbergA.A. LeeD. HeoJ.Y. JeonH.J. Thyroid stimulating hormone and serum, plasma, and platelet brain-derived neurotrophic factor during a 3-month follow-up in patients with major depressive disorder.J. Affect. Disord.201416911211710.1016/j.jad.2014.08.009 25189990
     [Google Scholar]
  51. HirtzR. LibudaL. HinneyA. FöckerM. BühlmeierJ. AntelJ. HolterhusP.M. KulleA. KiewertC. HebebrandJ. GrasemannC. Lack of evidence for a relationship between the hypothalamus-pituitary-adrenal and the hypothalamus-pituitary-thyroid axis in adolescent depression.Front. Endocrinol. (Lausanne)20211266224310.3389/fendo.2021.662243 34108936
     [Google Scholar]
  52. ShangguanF. ChenZ. FengL. LuJ. ZhangX.Y. The prevalence and clinical correlates of suicide attempts in comorbid subclinical hypothyroidism in patients with never-treated major depressive disorder in China.J. Affect. Disord.2022312546010.1016/j.jad.2022.06.020 35728676
     [Google Scholar]
  53. PompiliM. SerafiniG. InnamoratiM. Möller-LeimkühlerA.M. GiupponiG. GirardiP. TatarelliR. LesterD. The hypothalamic-pituitary-adrenal axis and serotonin abnormalities: A selective overview for the implications of suicide prevention.Eur. Arch. Psychiatry Clin. Neurosci.2010260858360010.1007/s00406‑010‑0108‑z 20174927
     [Google Scholar]
  54. ZhuQ. JiangG. LangX. ZhangJ. FuZ. ZhangP. ZhengY. ZhangX.Y. Prevalence and clinical correlates of thyroid dysfunction in first-episode and drug-naïve major depressive disorder patients with metabolic syndrome.J. Affect. Disord.2023341354110.1016/j.jad.2023.08.103 37633524
     [Google Scholar]
  55. TolozaF.J.K. MaoY. MenonL. GeorgeG. BorikarM. ThummaS. MotahariH. ErwinP. OwenR. MarakaS. Association of thyroid function with suicidal behavior: A systematic review and meta-analysis.Medicina (Kaunas)202157771410.3390/medicina57070714 34356995
     [Google Scholar]
  56. YongC.E. KimY.B. LyuJ. Body mass index, subjective body shape, and suicidal ideation among community-dwelling Korean adults.Arch. Public Health20217919610.1186/s13690‑021‑00627‑y 34103086
     [Google Scholar]
  57. KlinitzkeG. SteinigJ. BlüherM. KerstingA. WagnerB. Obesity and suicide risk in adults-A systematic review.J. Affect. Disord.2013145327728410.1016/j.jad.2012.07.010 22871535
     [Google Scholar]
  58. PereraS. EisenR.B. DennisB.B. BaworM. BhattM. BhatnagarN. ThabaneL. de SouzaR. SamaanZ. Body mass index is an important predictor for suicide: Results from a systematic review and meta‐analysis.Suicide Life Threat. Behav.201646669773610.1111/sltb.12244 27094229
     [Google Scholar]
  59. KrausC. KautzkyA. WatzalV. GramserA. KadriuB. DengZ.D. BartovaL. ZarateC.A.Jr LanzenbergerR. SoueryD. MontgomeryS. MendlewiczJ. ZoharJ. FanelliG. SerrettiA. KasperS. Body mass index and clinical outcomes in individuals with major depressive disorder: Findings from the gsrd european multicenter database.J. Affect. Disord.202333534935710.1016/j.jad.2023.05.042 37196934
     [Google Scholar]
  60. ZhouS. ZhaoK. ShiX. SunH. DuS. MiaoX. ChenJ. YangF. XingM. RanW. LaoJ. ZhangX. WangW. TangW. Serum lipid levels and suicide attempts within 2 weeks in patients with major depressive disorder: Is there a relationship?Front. Psychiatry20211267604010.3389/fpsyt.2021.676040 34163387
     [Google Scholar]
  61. LewisC.P. PortJ.D. BlackerC.J. SonmezA.I. SeewooB.J. LefflerJ.M. FryeM.A. CroarkinP.E. Altered anterior cingulate glutamatergic metabolism in depressed adolescents with current suicidal ideation.Transl. Psychiatry202010111910.1038/s41398‑020‑0792‑z 32327639
     [Google Scholar]
  62. Scotti-MuzziE. Umla-RungeK. Soeiro-de-SouzaM.G. Anterior cingulate cortex neurometabolites in bipolar disorder are influenced by mood state and medication: A meta-analysis of 1H-MRS studies.Eur. Neuropsychopharmacol.202147627310.1016/j.euroneuro.2021.01.096 33581932
     [Google Scholar]
  63. ChenJ. ZhangX. QuY. PengY. SongY. ZhuoC. ZouS. TianH. Exploring neurometabolic alterations in bipolar disorder with suicidal ideation based on proton magnetic resonance spectroscopy and machine learning technology.Front. Neurosci.20221694458510.3389/fnins.2022.944585 36161155
     [Google Scholar]
  64. GabbayV. HessD.A. LiuS. BabbJ.S. KleinR.G. GonenO. Lateralized caudate metabolic abnormalities in adolescent major depressive disorder: A proton MR spectroscopy study.Am. J. Psychiatry2007164121881188910.1176/appi.ajp.2007.06122032 18056244
     [Google Scholar]
  65. WangR. ShenY. LiG. DuR. PengA. Quantitative magnetic resonance spectroscopy of depression: The value of short-term metabolite changes in predicting treatment response.Front. Neurosci.202216102588210.3389/fnins.2022.1025882 36523438
     [Google Scholar]
  66. LvS. ZhongS. ZhangS. LaiS. WangY. ZhaoH. ZhangY. LuoY. YanS. RanH. ChenP. ChenG. JiaY. Correlations between facial emotion processing and biochemical abnormalities in untreated adolescent patients with major depressive disorder: A proton magnetic resonance spectroscopy study.J. Affect. Disord.202229640841710.1016/j.jad.2021.08.129 34638025
     [Google Scholar]
  67. VarmaG. Kalkan-OğuzhanogluN. EfeM. KırogluY. DumanT. Neurochemical metabolites in prefrontal cortex in patients with mild/moderate levels in first-episode depression.Neuropsychiatr. Dis. Treat.201391053105910.2147/NDT.S42627 23976854
     [Google Scholar]
  68. WangY. JiaY. XuG. LingX. LiuS. HuangL. Frontal white matter biochemical abnormalities in first-episode, treatment-naive patients with major depressive disorder: A proton magnetic resonance spectroscopy study.J. Affect. Disord.2012136362062610.1016/j.jad.2011.10.020 22129769
     [Google Scholar]
  69. BrambillaP. StanleyJ.A. NicolettiM.A. SassiR.B. MallingerA.G. FrankE. KupferD.J. KeshavanM.S. SoaresJ.C. 1H Magnetic resonance spectroscopy study of dorsolateral prefrontal cortex in unipolar mood disorder patients.Psychiatry Res. Neuroimaging2005138213113910.1016/j.pscychresns.2004.12.001 15766636
     [Google Scholar]
  70. GalvánA. Adolescent brain development and contextual influences: A decade in review.J. Res. Adolesc.202131484386910.1111/jora.12687 34820955
     [Google Scholar]
  71. PatelP.K. LeathemL.D. CurrinD.L. KarlsgodtK.H. Adolescent neurodevelopment and vulnerability to psychosis.Biol. Psychiatry202189218419310.1016/j.biopsych.2020.06.028 32896384
     [Google Scholar]
  72. FitzgeraldJ.M. KlumppH. LangeneckerS. PhanK.L. Transdiagnostic neural correlates of volitional emotion regulation in anxiety and depression.Depress. Anxiety201936545346410.1002/da.22859 30408261
     [Google Scholar]
  73. ChabertJ. AllauzeE. PereiraB. ChassainC. De ChazeronI. RotgéJ.Y. FossatiP. LlorcaP.M. SamalinL. Glutamatergic and n-acetylaspartate metabolites in bipolar disorder: A systematic review and meta-analysis of proton magnetic resonance spectroscopy studies.Int. J. Mol. Sci.20222316897410.3390/ijms23168974 36012234
     [Google Scholar]
  74. ZhangY. LaiS. ZhangJ. WangY. ZhaoH. HeJ. HuangD. ChenG. QiZ. ChenP. YanS. HuangX. LuX. ZhongS. JiaY. The effectiveness of vortioxetine on neurobiochemical metabolites and cognitive of major depressive disorders patients: A 8-week follow-up study.J. Affect. Disord.202435179980710.1016/j.jad.2024.01.272 38311073
     [Google Scholar]
  75. SuL. BlamireA.M. WatsonR. HeJ. HayesL. O’BrienJ.T. Whole-brain patterns of 1H-magnetic resonance spectroscopy imaging in Alzheimer’s disease and dementia with Lewy bodies.Transl. Psychiatry201668e877e87710.1038/tp.2016.140 27576166
     [Google Scholar]
  76. SaccaroL.F. TassoneM. TozziF. RutiglianoG. Proton magnetic resonance spectroscopy of N-acetyl aspartate in first depressive episode and chronic major depressive disorder: A systematic review and meta-analysis.J. Affect. Disord.202435526528210.1016/j.jad.2024.03.150 38554884
     [Google Scholar]
  77. ZhouL. DingS. LiY. WangL. ChenW. BoT. WuK. LiC. LiuX. ZhaoJ. XuC. GaoL. Endoplasmic reticulum stress may play a pivotal role in lipid metabolic disorders in a novel mouse model of subclinical hypothyroidism.Sci. Rep.2016613138110.1038/srep31381 27539723
     [Google Scholar]
  78. HuJ. JiY. LangX. ZhangX.Y. Association of thyroid function with abnormal lipid metabolism in young patients with first-episode and drug naïve major depressive disorder.Front. Psychiatry202314108510510.3389/fpsyt.2023.1085105 36865071
     [Google Scholar]
  79. JiaY. ZhongS. WangY. LiuT. LiaoX. HuangL. The correlation between biochemical abnormalities in frontal white matter, hippocampus and serum thyroid hormone levels in first-episode patients with major depressive disorder.J. Affect. Disord.201518016216910.1016/j.jad.2015.04.005 25913802
     [Google Scholar]
  80. JollantF. NearJ. TureckiG. Richard-DevantoyS. Spectroscopy markers of suicidal risk and mental pain in depressed patients.Prog. Neuropsychopharmacol. Biol. Psychiatry201773647110.1016/j.pnpbp.2016.10.005 27984159
     [Google Scholar]
  81. LaiS. ZhongS. ZhangY. WangY. ZhaoH. ChenG. ChenF. ShenS. HuangH. JiaY. Association of altered thyroid hormones and neurometabolism to cognitive dysfunction in unmedicated bipolar II depression.Prog. Neuropsychopharmacol. Biol. Psychiatry202110511002710.1016/j.pnpbp.2020.110027 32791168
     [Google Scholar]
  82. PompiliM. On mental pain and suicide risk in modern psychiatry.Ann. Gen. Psychiatry2024231610.1186/s12991‑024‑00490‑5 38229110
     [Google Scholar]
/content/journals/cn/10.2174/1570159X23666250122093451
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Metabolomic Changes in Major Depressive Disorder Adolescent Females with or without Suicide Attempts
Curr. Neuropharmacol. 23, 787 (2025); https://doi.org/10.2174/1570159X23666250122093451
/content/journals/cn/10.2174/1570159X23666250122093451
/content/journals/cn/10.2174/1570159X23666250122093451
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  • Article Type:     Research Article
Keyword(s): brain metabolism-related factors; lipid metabolism; magnetic resonance spectroscopy; Major depressive disorder; suicidal ideation; thyroid hormones

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