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2000
Volume 23, Issue 10
  • ISSN: 1570-159X
  • E-ISSN: 1875-6190

Abstract

The interaction in a drug combination can be assessed using either the Chou's or Jin’s method. The combination index in the former (., CI-C) is calculated based on doses, while the latter (., CI-J) is based on effects. This perspective demonstrates a consistency between 1/CI-C and CI-J when applied to both released and simulated data. Thus, 1/CI-C and CI-J are functionally equivalent for evaluating the drug interaction. Combining these two indices is preferred: a consistency shows a reliable verdict, and an inconsistency indicates a requirement for further analyses. However, it has been observed that evaluating released data raises certain concerns.

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2025-02-06
2025-09-04
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