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2000
Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Background

Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting inflammatory condition of unknown etiology that is characterized by fever and painful lymphadenopathy. KFD commonly involves the posterior cervical region and very rarely occurs in the axilla.

Case Presentation

We report on a case of KFD that presented 3 weeks after receiving the messenger ribonucleic acid-based coronavirus disease 2019 (COVID-19) vaccine. In this case, we suspected the lesions as COVID-19 vaccination-related lymphadenopathy on the initial ultrasonographic examination.

Conclusion

Through this case report, we highlight that KFD should be considered in the differential diagnosis of patients with axillary lymphadenopathy who have undergone COVID-19 vaccination, as unusual side effects of COVID-19 vaccination have been increasingly reported in the literature owing to the rapid development of various COVID-19 vaccines during the pandemic period. In addition, we emphasize the importance of clinical suspicion in diagnosing KFD due to the fact that axillary involvement of KFD is extremely rare.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2024-01-01
2025-09-11

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References

  1. CocciaM. Optimal levels of vaccination to reduce COVID-19 infected individuals and deaths: A global analysis.Environ. Res.202220411231410.1016/j.envres.2021.11231434736923
     [Google Scholar]
  2. BardaN. DaganN. Ben-ShlomoY. KeptenE. WaxmanJ. OhanaR. HernánM.A. LipsitchM. KohaneI. NetzerD. ReisB.Y. BalicerR.D. Safety of the BNT162b2 mRNA covid-19 vaccine in a nationwide setting.N. Engl. J. Med.2021385121078109010.1056/NEJMoa211047534432976
     [Google Scholar]
  3. RobinsonK.A. MaimoneS. Gococo-BenoreD.A. LiZ. AdvaniP.P. ChumsriS. Incidence of axillary adenopathy in breast imaging after COVID-19 vaccination.JAMA Oncol.2021791395139710.1001/jamaoncol.2021.312734292295
     [Google Scholar]
  4. Fernández-PradaM. Rivero-CalleI. Calvache-GonzálezA. Martinón-TorresF. Acute onset supraclavicular lymphadenopathy coinciding with intramuscular mRNA vaccination against COVID-19 may be related to vaccine injection technique, Spain, January and February 2021.Euro Surveill.20212610210019310.2807/1560‑7917.ES.2021.26.10.210019333706861
     [Google Scholar]
  5. KeshavarzP. YazdanpanahF. RafieeF. MizandariM. Lymphadenopathy following COVID-19 vaccination: Imaging findings review.Acad. Radiol.20212881058107110.1016/j.acra.2021.04.00733985872
     [Google Scholar]
  6. WolfsonS. KimE. PlaunovaA. BukhmanR. SarmientoR.D. SamreenN. AwalD. ShethM.M. TothH.B. MoyL. ReigB. Axillary adenopathy after COVID-19 vaccine: No reason to delay screening mammogram.Radiology2022303229729910.1148/radiol.21322735133198
     [Google Scholar]
  7. PerryA.M. ChoiS.M. Kikuchi-Fujimoto disease: A review.Arch. Pathol. Lab. Med.2018142111341134610.5858/arpa.2018‑0219‑RA30407860
     [Google Scholar]
  8. UngerP.D. RappaportK.M. StrauchenJ.A. Necrotizing lymphadenitis (Kikuchi’s disease). Report of four cases of an unusual pseudolymphomatous lesion and immunologic marker studies.Arch. Pathol. Lab. Med.198711111103110343499129
     [Google Scholar]
  9. YoukJ.H. KimE-K. KoK.H. KimM.J. Sonographic features of axillary lymphadenopathy caused by kikuchi Disease.J Ultrasound Med2008276847853
     [Google Scholar]
  10. DaghriS. BelmoufidN. RamiA. Al BouzidiA. BouananiN. Kikuchi-fujimoto’s disease or histiocytic necrotizing lymphadenitis following mRNA COVID-19 vaccination: A rare case.Cureus2022144e2415510.7759/cureus.2415535592214
     [Google Scholar]
  11. GuanY XiaX LuH Kikuchi-Fujimoto disease following vaccination against COVID-19.J hematopathol20221512123
     [Google Scholar]
  12. TanH.M. HueS.S.S. WeeA. SeeK.C. Kikuchi–fujimoto disease post COVID-19 vaccination: Case report and review of literature.Vaccines2021911125110.3390/vaccines911125134835182
     [Google Scholar]
  13. SoubH.A. IbrahimW. MaslamaniM.A. A AliG. UmmerW. Abu-DayehA. Kikuchi-Fujimoto disease following SARS CoV2 vaccination: Case report.IDCases202125e0125310.1016/j.idcr.2021.e0125334395192
     [Google Scholar]
  14. CaocciG. FanniD. PorruM. GrecoM. NemolatoS. FirinuD. FaaG. ScuteriA. La NasaG. Kikuchi-Fujimoto disease associated with hemophagocytic lymphohistiocytosis following the BNT162b2 mRNA COVID-19 vaccination.Haematologica202110751222122510.3324/haematol.2021.28023934965702
     [Google Scholar]
  15. KashiwadaT. SaitoY. TerasakiY. ShirakuraY. ShinbuK. TanakaT. TanakaY. SeikeM. GemmaA. Kikuchi-Fujimoto disease can present as delayed lymphadenopathy after COVID-19 vaccination.Hum. Vaccin. Immunother.2022185207108010.1080/21645515.2022.207108035583472
     [Google Scholar]
  16. de JuanM.G. PérezD.B.A. HerreraR.E.G. GonzálezR.M. MontesM.S. Kikuchi–Fujimoto disease type lymph node reaction with increased plasmacytoid dendritic cells may appear as a side effect following COVID-19 vaccination: Report of a case and literature review.Rev. Esp. Patol.202310.1016/j.patol.2023.01.002
     [Google Scholar]
  17. KikuchiM. Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytes: A clinicopathological study.Acta Haematol Jpn197235379380
     [Google Scholar]
  18. FujimotoY. Cervical subacute necrotizing lymphadenitis. A new clinicopathological entity.Intern. Med.197220920927
     [Google Scholar]
  19. WatanabeT. HashidateH. HirayamaY. IinumaY. Kikuchi–Fujimoto disease following vaccination against human papilloma virus infection and Japanese encephalitis.Eur. J. Pediatr.201217191409141110.1007/s00431‑012‑1729‑122476507
     [Google Scholar]
  20. PoduguA. KobeM. Kikuchi-Fujimoto Disease (KFD): A rare cause of fever and lymphadenopathy following influenza vaccination.Chest20131444230A10.1378/chest.1703273
     [Google Scholar]
  21. KimJ.Y. LeeH. YunB.L. Ultrasonographic findings of Kikuchi cervical lymphadenopathy in children.Ultrasonography2017361667010.14366/usg.1604727998053
     [Google Scholar]
  22. ChangJ.M. HaS.M. Regional lymphadenopathy following COVID-19 vaccination in patients with or suspicious of breast cancer: A quick summary of current key facts and recommendations.Korean J. Radiol.202223769169510.3348/kjr.2022.029235695320
     [Google Scholar]
  23. HaS.M. ChuA.J. LeeJ. KimS.Y. LeeS.H. YoenH. ChoN. MoonW.K. ChangJ.M. US evaluation of axillary lymphadenopathy following covid-19 vaccination: A prospective longitudinal study.Radiology20223051465310.1148/radiol.22054335471107
     [Google Scholar]
  24. HlC. GjW. JwtL. JS. LpM. HtL.P. Ultrasound features to differentiate COVID-19 vaccine-induced benign adenopathy from breast cancer related malignant adenopathy.Acad. Radiol.20222971004101210.1016/j.acra.2022.02.01535296413
     [Google Scholar]
  25. ParkJ.Y. LeeJ.Y. YiS.Y. Axillary lymphadenopathy on ultrasound after COVID-19 vaccination and its influencing factors: A single-center study.J. Clin. Med.202211123810.3390/jcm1101023835011979
     [Google Scholar]
  26. RomeoV. StanzioneA. D’AuriaD. FulgioneL. GiustoF. MaureaS. BrunettiA. COVID-19 vaccine-induced lymphadenopathies: Incidence, course and imaging features from an ultrasound prospective study.J. Ultrasound202225496597110.1007/s40477‑022‑00674‑335507248
     [Google Scholar]
  27. VassalloP. WerneckeK. RoosN. PetersP.E. Differentiation of benign from malignant superficial lymphadenopathy: The role of high-resolution US.Radiology1992183121522010.1148/radiology.183.1.15496751549675
     [Google Scholar]
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Kikuchi-fujimoto Disease in the Axilla after COVID-19 Vaccination: A Case Report
Curr. Med. Imaging 20, e200623218120 (2024); https://doi.org/10.2174/1573405620666230620115956
/content/journals/cmir/10.2174/1573405620666230620115956
/content/journals/cmir/10.2174/1573405620666230620115956
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  • Article Type:     Case Report
Keyword(s): Axilla; COVID-19 vaccines; Histiocytic necrotizing lymphadenitis; Kikuchi-Fujimoto’s disease; Lymphadenopathy; Ultrasonography

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