Radiation Dosimetric Determination from Animal to Human

It is important to assess the deleterious effects of newly developed radiopharmaceutical in humans. These effects arise from the absorption of energy in tissues and depend on a number of factors such as organ size or location. Because of the variations of the factors from one individual to another, the effects of the radiopharmaceutical were evaluated on “reference” man. The radiation absorbed dose can be calculated semi-automatically by computer software “OLINDA”. From temporal sampling study or quantitative dynamic imaging study, area under the curve of percent injection dose in each organ can be calculated, and converted to the residence time of each organ. With the information of radionuclide, phantom model used as “reference” man, and the residence time of each organ, the OLINDA gives the absorbed dose of each organ and effective dose of the radiopharmaceutical.