Skip to content
2000
Volume 21, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
file format text download EPUB
file format pdf download PDF
side by side viewer icon HTML

Abstract

Background

Phlebosclerotic colitis is a rare type of chronic ischemic colitis, with most documented cases occurring in Asians. Plain-film and computed tomography findings of pericolonic vascular calcifications are diagnostic. However, Magnetic Resonance Enterography (MRE) findings of phlebosclerotic colitis have not yet been reported, and its diagnosis might be overlooked without awareness of this disease.

Case Report

A 70-year-old female patient without prior systemic disease presented with a 3-month history of nausea, vomiting, abdominal pain, and diarrhea. Personal history was unremarkable except for long-term use of herbal medicine. She was initially investigated at a regional hospital with a colonoscopy and biopsy. Due to the presence of stenosis at the transverse colon and biopsy results suggestive of Inflammatory Bowel Disease (IBD), she was referred to our hospital for further investigation and treatment. MRE was performed as part of the IBD workup, which showed a thickened ascending and transverse colonic wall that was fibrotic, non-edematous, and with triangular projections on the mesenteric aspect. Owing to findings that were inconsistent with IBD, subsequent abdominal plain-film radiography confirmed characteristic linear dendritic serpiginous radiopaque opacities alongside the ascending and transverse colon. Re-biopsy of the affected colon confirmed the diagnosis of phlebosclerotic colitis. The patient’s symptoms improved after conservative treatment.

Conclusion

MRE of phlebosclerotic colitis appears as symmetrical non-edematous bowel wall thickening with triangular signal voids indicative of venous calcifications.

© 2025 The Author(s).
© 2025 The Author(s). Published by Bentham Science Publishers. This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
Loading

Article metrics loading...

/content/journals/cmir/10.2174/0115734056382571250509114555
2025-01-01
2025-09-02

  • From This Site

    /content/journals/cmir/10.2174/0115734056382571250509114555
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

/deliver/fulltext/cmir/21/1/CMIR-21-E15734056382571.html?itemId=/content/journals/cmir/10.2174/0115734056382571250509114555&mimeType=html&fmt=ahah

References

  1. KusanagiM. MatsuiO. KawashimaH. GabataT. IdaM. AboH. IsseK. Phlebosclerotic colitis: Imaging-pathologic correlation.AJR Am. J. Roentgenol.2005185244144710.2214/ajr.185.2.0185044116037518
     [Google Scholar]
  2. MaruyamaY. WatanabeF. KanaokaS. KanamaruH. YoshinoG. KodaK. HanaiH. KanekoE. KinouI. A case of phlebosclerotic ischemic colitis: A distinct entity.Endoscopy199729433410.1055/s‑2007‑10042079255548
     [Google Scholar]
  3. WangM.H. Chronic ischemic colitis mimicking Crohn’s disease: A case report.J. Intern. Med. Taiwan.2017285298303
     [Google Scholar]
  4. WillekeP. DomagkD. FloerM. BrüwerM. KreuterM. GaubitzM. DomschkeW. KucharzikT. Ischaemic colitis mimicking inflammatory bowel disease in a young adult receiving oral anticoagulation.Scand. J. Gastroenterol.200540787888010.1080/0036552051001564716109668
     [Google Scholar]
  5. BruiningD.H. ZimmermannE.M. LoftusE.V.Jr SandbornW.J. SauerC.G. StrongS.A. Al-HawaryM. AnupindiS. BakerM.E. BruiningD. DargeK. DillmanJ. EinsteinD. FidlerJ.L. FletcherJ.G. GeeM.S. GrandD. GuglielmoF. HaraA.K. JaffeT.A. MaglinteD. MegibowA. ParkS.H. PlattJ. PodbereskyD. RimolaJ. SahaniD.V. SotoJ. TaylorS.A. Society of Abdominal Radiology Crohn’s Disease-Focused Panel Consensus recommendations for evaluation, interpretation, and utilization of computed tomography and magnetic resonance enterography in patients with small bowel crohn’s disease.Gastroenterology201815441172119410.1053/j.gastro.2017.11.27429329905
     [Google Scholar]
  6. GoreR. ThakrarK. MehtaU. BerlinJ. YaghmaiV. NewmarkG. Imaging in intestinal ischemic disorders.Clin. Gastroenterol. Hepatol.20086884985810.1016/j.cgh.2008.05.00718674733
     [Google Scholar]
  7. SugiM.D. MeniasC.O. LubnerM.G. BhallaS. MellnickV.M. KwonM.H. KatzD.S. CT findings of acute small-bowel entities.Radiographics20183851352136910.1148/rg.201817014830207931
     [Google Scholar]
  8. IwashitaA. YaoT. SchlemperR.J. KuwanoY. YaoT. IidaM. MatsumotoT. KikuchiM. Mesenteric phlebosclerosis.Dis. Colon Rectum200346220922010.1007/s10350‑004‑6526‑012576895
     [Google Scholar]
  9. MeyersM.A. McGuireP.V. Spiral CT demonstration of hypervascularity in Crohn disease: “Vascular jejunization of the ileum” or the “comb sign”.Abdom. Imaging199520432733210.1007/BF002033657549737
     [Google Scholar]
  10. GhaiS. PattisonJ. GhaiS. O’MalleyM.E. KhaliliK. StephensM. Primary gastrointestinal lymphoma: Spectrum of imaging findings with pathologic correlation.Radiographics20072751371138810.1148/rg.27506515117848697
     [Google Scholar]
  11. MukewarS. MukewarS. RaviR. PrasadA. DuaK.S. Colon tuberculosis: Endoscopic features and prospective endoscopic follow-up after anti-tuberculosis treatment.Clin. Transl. Gastroenterol.2012310e2410.1038/ctg.2012.1923238066
     [Google Scholar]
  12. MaulahelaH. SimadibrataM. NelwanE.J. RahadianiN. RenesteenE. SuwartiS.W.T. AnggrainiY.W. Recent advances in the diagnosis of intestinal tuberculosis.BMC Gastroenterol.20222218910.1186/s12876‑022‑02171‑735227196
     [Google Scholar]
  13. TzogiasL. LabropoulosN. AmaralS.I. AntoniouG.A. GiannoukasA.D. Distribution and clinical impact of phlebosclerosis.Int. Angiol.201130321222021617604
     [Google Scholar]
  14. RoseA.G. Diseases of peripheral arteries.2nd edChurchill LivingstoneNew York1991
     [Google Scholar]
  15. MohigeferJ. Gómez-MillánP. BorreroJ.J. Phlebosclerotic colitis in a non-Asian patient: A case report.J. Med. Case Rep.202115134910.1186/s13256‑021‑02930‑234274012
     [Google Scholar]
  16. YenT.S. LiuC.A. ChiuN.C. ChiouY.Y. ChouY.H. ChangC.Y. Relationship between severity of venous calcifications and symptoms of phlebosclerotic colitis.World J. Gastroenterol.201521268148815510.3748/wjg.v21.i26.814826185388
     [Google Scholar]
  17. WenY. ChenY.W. MengA.H. ZhaoM. FangS.H. MaY.Q. Idiopathic mesenteric phlebosclerosis associated with long-term oral intake of geniposide.World J. Gastroenterol.202127223097310810.3748/wjg.v27.i22.309734168411
     [Google Scholar]
  18. MiyazakiM. NakamuraS. MatsumotoT. Idiopathic mesenteric phlebosclerosis occurring in a wife and her husband.Clin. Gastroenterol. Hepatol.200976e32e3310.1016/j.cgh.2009.01.02419514111
     [Google Scholar]
  19. ChangK.M. New histologic findings in idiopathic mesenteric phlebosclerosis: Clues to its pathogenesis and etiology--probably ingested toxic agent-related.J. Chin. Med. Assoc.200770622723510.1016/S1726‑4901(09)70364‑817591581
     [Google Scholar]
  20. XuJ. JinM. JiangZ. KeQ. LiA. ZhuT. LaiM. Clinicopathological features of phlebosclerotic colitis.Pathol. Res. Pract.20202161115319310.1016/j.prp.2020.15319332927306
     [Google Scholar]
  21. Mohd HisamN.S. WongK.H. Oxidative stress in spinocerebellar ataxia type 3 and its attenuation by herbal remedies in traditional chinese medicine: A systematic review.Antioxidants202413337510.3390/antiox1303037538539908
     [Google Scholar]
  22. ShimizuS. KobayashiT. TomiokaH. OhtsuK. MatsuiT. HibiT. Involvement of herbal medicine as a cause of mesenteric phlebosclerosis: Results from a large-scale nationwide survey.J. Gastroenterol.201752330831410.1007/s00535‑016‑1218‑927220772
     [Google Scholar]
  23. HiramatsuK. SakataH. HoritaY. OritaN. KidaA. MizukamiA. MiyazawaM. HiraiS. ShimataniA. MatsudaK. MatsudaM. OginoH. FujinagaH. TeradaI. ShimizuK. UchiyamaA. IshizawaS. AboH. DemachiH. NodaY. Mesenteric phlebosclerosis associated with long‐term oral intake of geniposide, an ingredient of herbal medicine.Aliment. Pharmacol. Ther.201236657558610.1111/j.1365‑2036.2012.05221.x22817400
     [Google Scholar]
  24. GongG. ZhengZ. LiuH. WangL. DiaoJ. WangP. ZhaoG. Purification and characterization of a β-glucosidase from aspergillus niger and its application in the hydrolysis of geniposide to genipin.J. Microbiol. Biotechnol.201424678879410.4014/jmb.1401.0105324608563
     [Google Scholar]
  25. KangM.J. KhanalT. KimH.G. LeeD.H. YeoH.K. LeeY.S. AhnY.T. KimD.H. JeongH.G. JeongT.C. Role of metabolism by human intestinal microflora in geniposide-induced toxicity in HepG2 cells.Arch. Pharm. Res.201235473373810.1007/s12272‑012‑0418‑y22553067
     [Google Scholar]
  26. ShibataH. NishikawaJ. SakaidaI. Dark purple‐colored colon: Sign of idiopathic mesenteric phlebosclerosis.Dig. Endosc.201426460460510.1111/den.1229924720619
     [Google Scholar]
  27. YinF. LiuJ. Research and application progress of Gardenia jasminoides.Chin. Herb. Med.201810436237010.1016/j.chmed.2018.09.001
     [Google Scholar]
  28. KoS.F. ChenH.H. HuangC.C. LinL.H. NgS.H. LeeY.W. Phlebosclerotic colitis: An analysis of clinical and CT findings in 29 patients with long-term follow-up.Insights Imaging20221311910.1186/s13244‑022‑01159‑x35092508
     [Google Scholar]
  29. WangP.Y. WengK.H. LiouJ.Y. KuoH.T. HoC.H. SheuM.J. Clinical significance of abdominal computed tomography and colonoscopy in the evaluation of phlebosclerotic colitis.Kaohsiung J. Med. Sci.202440329630310.1002/kjm2.1276137732706
     [Google Scholar]
  30. DingJ. ZhangW. WangL. ZhuZ. WangJ. MaJ. Idiopathic mesenteric phlebosclerosis: Clinical and CT imaging characteristics.Quant. Imaging Med. Surg.202111276377110.21037/qims‑20‑30133532275
     [Google Scholar]
  31. AnneseV. DapernoM. RutterM.D. AmiotA. BossuytP. EastJ. FerranteM. GötzM. KatsanosK.H. KießlichR. OrdásI. RepiciA. RosaB. SebastianS. KucharzikT. EliakimR. European Crohn’s and Colitis Organisation European evidence based consensus for endoscopy in inflammatory bowel disease.J. Crohn’s Colitis2013712982101810.1016/j.crohns.2013.09.01624184171
     [Google Scholar]
  32. VetroC. RomanoA. AmicoI. ConticelloC. MottaG. FigueraA. ChiarenzaA. Di RaimondoC. GiuliettiG. BonannoG. PalumboG.A. Di RaimondoF. Endoscopic features of gastro-intestinal lymphomas: From diagnosis to follow-up.World J. Gastroenterol.20142036129931300510.3748/wjg.v20.i36.1299325278693
     [Google Scholar]
/content/journals/cmir/10.2174/0115734056382571250509114555
Loading
Magnetic Resonance Enterography of Phlebosclerotic Colitis: A Case Report
Curr. Med. Imaging 21, E15734056382571 (2025); https://doi.org/10.2174/0115734056382571250509114555
/content/journals/cmir/10.2174/0115734056382571250509114555
/content/journals/cmir/10.2174/0115734056382571250509114555
Loading

Data & Media loading...


  • Article Type:     Case Report
Keyword(s): Biopsy; Case report; Gardenia fruit; Inflammatory bowel disease; Ischemic colitis; Magnetic resonance enterography; Phlebosclerotic colitis

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test