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2000
Volume 21, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Introduction

This study aimed to detect the performance of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for assessing primary biliary cholangitis (PBC).

Methods

Seventy-five patients with PBC were included in this prospective study. Shear wave elastography (SWE) and Gd-EOB-DTPA-enhanced MRI were conducted, and then the signal intensity ratio (SIR) and contrast enhancement index (CEI) in different phases, including portal venous phase (PVP), equilibrium phase (EP), and hepatobiliary phase (HBP), were calculated. Afterward, the results were compared with Child-Pugh grading and non-invasive liver fibrosis models using the Kruskal-Wallis H test or Chi-squared test. The area under the curve (AUC) was applied to evaluate the diagnostic performance of SIR, CEI, and SWE across different Child-Pugh grades.

Results

SWE (0.001), SIR (0.001), CEI (0.001), APRI (=0.002), and FIB-4(0.001) showed significant differences in different Child-Pugh grades. Statistically significant differences were found in SIR (=0.005), CEI (=0.010), and FIB-4 (=0.001) of different SWE levels. For the diagnosis of Child-Pugh C, the AUC of SWE, SIR and CEI were 0.889, 0.778, and 0.761, respectively. Correspondingly, the sensitivity was 75.0%, 64.4%, and 54.2%, and the specificity was 94.9%, 100%, and 100%, respectively. For the diagnosis of Child-Pugh B+C, the AUC of SWE, SIR and CEI were 0.919, 0.809, and 0.814, respectively.

Discussion

Our study confirmed that Gd-EOB-DTPA-enhanced MRI is an effective and objective method for assessing liver function in patients with PBC.

Conclusion

SIR and CEI could be regarded as a novel imaging biomarker to evaluate liver function. Gd-EOB-DTPA-enhanced MRI and SWE outperformed serum-based models in sensitivity and specificity, strengthening the value of imaging in clinical decision-making.

© 2025 The Author(s). Published by Bentham Science Publishers.
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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2025-06-23
2025-09-28

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Gd-EOB-DTPA-Enhanced Magnetic Resonance Imaging for Assessing Liver Function in Primary Biliary Cholangitis
Curr. Med. Imaging 21, E15734056379090 (2025); https://doi.org/10.2174/0115734056379090250611073434
/content/journals/cmir/10.2174/0115734056379090250611073434
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  • Article Type:     Research Article
Keyword(s): Gd-EOB-DTPA; Liver function; Magnetic resonance imaging; Portal venous phase; Primary biliary cholangitis; SWE

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