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2000
Volume 21, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Introduction

Primary Squamous Cell Carcinoma of the Liver (PSCCL) is an exceptionally rare clinical entity characterized by diagnostic challenges, aggressive behavior, and poor prognosis. Globally, few studies have investigated PSCCL.

Case Presentation

We report the case of a 76-year-old male patient with PSCCL, detailing his clinical presentation and imaging findings, to offer insights into the preoperative diagnosis of this disease. The patient presented with upper abdominal pain that had lasted for over two weeks without any specific triggers. Laboratory tests revealed abnormal liver function. Ultrasound examination showed a large, solid, hypoechoic mass in the right anterior lobe of the liver with heterogeneous internal echoes. Color Doppler imaging detected limited blood flow signals. Contrast-enhanced Computed Tomography (CT) of the whole abdomen revealed a low-density mass with indistinct margins in the right lobe of the liver, showing uneven and progressive peripheral enhancement. Comprehensive whole-body CT, gastroscopy, and liver biopsy were performed, excluding metastatic disease in other organs. Based on the pathological findings from a percutaneous ultrasound-guided liver biopsy, the patient was diagnosed with PSCCL.

Conclusion

PSCCL is a rare malignancy that presents significant diagnostic difficulties, often evading easy identification through clinical and imaging examinations. This case report aims to contribute to improving the preoperative diagnosis of PSCCL.

© 2025 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2025-03-17
2025-12-21

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Imaging Findings of Primary Squamous Cell Carcinoma of the Liver: Case Presentation and Literature Review
Curr. Med. Imaging 21, E15734056344249 (2025); https://doi.org/10.2174/0115734056344249250108062855
/content/journals/cmir/10.2174/0115734056344249250108062855
/content/journals/cmir/10.2174/0115734056344249250108062855
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  • Article Type:     Case Report
Keyword(s): Alanine aminotransferase; Case report; Computed tomography; Liver; Primary squamous cell carcinoma; Squamous Cell Carcinoma; Ultrasound

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