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2000
Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Purpose

Individuals with depression have an increased risk of cardiovascular disease, and more often have a poor prognosis with cardiovascular disease. This study aimed to investigate the impact of depression on Left Ventricular (LV) alterations using Cardiovascular Magnetic Resonance Feature-tracking (CMR-FT).

Methods

Seven anesthetized, healthy Chinese miniature swine were included in the study. Basic data, including CMR scans at baseline and after 14 days of depression modeling, were collected. Behavioral tests, including the Open-field Test (OFT), Sucrose Preference Test (SPT), and measurements of the time taken to consume a specific amount of food and sugar, were conducted to assess the success of the depression models. CMR cine images were acquired and CVI software was employed to analyze Global Longitudinal Strain (GLS), Global Circumferential Strain (GCS), and Global Radial Strain (GRS). Late Gadolinium Enhancement (LGE) imaging was used to detect myocardial infarction and/or scar.

Results

The outcomes demonstrated successful depression modeling, indicated by reduced scores in the OFT and SPT, as well as an extended time to intake food and sugar compared to baseline. However, no significant differences were observed in LV End-diastolic Volume (LVEDV), LV End-systolic Volume (LVESV), LV Ejection Fraction (LVEF), LV End-diastolic Myocardial Mass (LVMASSED), and Cardiac Output (CO) before and after modeling. Regarding LV global strain parameters, there was a downward trend in GRS (25.35% ± 6.9% . 22.86% ± 6.4%, P=0.021), GCS (-16.71% ± 4.2% . -14.78% ± 2.3%, =0.043), and GLS (-17.66% ± 2.9% . -14.53% ± 2.5%, =0.056), respectively, after modeling. GRS and GCS were significantly reduced after modeling compared to baseline.

Conclusion

The study suggests that depression may contribute to early LV systolic dysfunction, particularly affecting LV GCS and GRS.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2024-01-01
2025-08-21

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Impairment of Left Ventricular Function in the Depressed Chinese Miniature Swine Model by Cardiovascular Magnetic Resonance Feature-Tracking: A Preliminary Study
Curr. Med. Imaging 20, e15734056291652 (2024); https://doi.org/10.2174/0115734056291652240417051951
/content/journals/cmir/10.2174/0115734056291652240417051951
/content/journals/cmir/10.2174/0115734056291652240417051951
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  • Article Type:     Research Article
Keyword(s): Arrhythmia; Cardiovascular magnetic resonance; Depression; Feature-tracking; Heart failure; Myocardial infarction; Swine

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