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2000
Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Introduction:

It has been reported in the literature that Vitamin D can inhibit the growth of uterine fibroids, but the evaluation index is only the size of the uterine fibroids. The purpose of this study was to evaluate the effect of vitamin D on the size, hardness, and blood flow of uterine fibroids in pre-menopausal women by multimodal ultrasound.

Methods:

A total of 64 pre-menopausal women with uterine fibroids complicated vitamin D deficiency were enrolled in this study and randomly divided into two groups: the vitamin D group (n=32) which received oral vitamin D (1600 IU/ day) and the control group (n=32) without vitamin D supplementation. After three months of intervention, the mean diameter of uterine fibroids, elastic strain ratio, and blood flow grade were evaluated by multimodal ultrasound, and the clinical symptoms of the two groups were evaluated by questionnaire.

Results:

The vitamin D group reported a significant increment in the serum 25-hydroxyvitamin D ( < 0.001). In addition, there were significant reductions in the mean diameter, and elastic strain ratio of uterine fibroids ( =.043 and =.038, respectively), but no significant difference in the blood flow grade of uterine fibroids was observed ( =.272). Compared with the control group, the vitamin D group achieved significant relief in dysmenorrhea and frequent urination, as well as improvement in heavy menstrual bleeding.

Conclusion:

The application of multimodal ultrasound provides a more comprehensive theoretical basis for vitamin on uterine fibroids. Vitamin D can effectively reduce the size of uterine fibroids in pre-menopausal women and relieve their symptoms. It is highly likely to be a promising, safe, effective, and inexpensive drug for uterine fibroids, which has good application value and promotion prospects.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2024-01-01
2025-09-04

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References

  1. GambadauroP. GudmundssonJ. TorrejónR. Intrauterine Adhesions following Conservative Treatment of Uterine Fibroids.Obstet. Gynecol. Int.201220121610.1155/2012/85326922190959
     [Google Scholar]
  2. StewartE.A. Laughlin-TommasoS.K. CatherinoW.H. LalitkumarS. GuptaD. VollenhovenB. Uterine fibroids.Nat. Rev. Dis. Primers2016211604310.1038/nrdp.2016.4327335259
     [Google Scholar]
  3. WuB.J. WeiW. HuC.Y. ZhangX.J. ZhongF. Investigation on factors related to uterine fibroids in rural women of northern Anhui province.J. Obstet. Gynaecol. Res.20214793279328710.1111/jog.1489934212456
     [Google Scholar]
  4. OsugaY. NakanoY. YamauchiY. MurakawaH. Phase III long‐term study to evaluate the efficacy and safety of ulipristal acetate in Japanese patients with uterine fibroids.J. Obstet. Gynaecol. Res.20214793269327810.1111/jog.1480234109697
     [Google Scholar]
  5. ShahN. EgbaseE. SiderisM. OdejinmiF. What happens after randomised controlled trials? Uterine fibroids and ulipristal acetate: systematic review and meta-analysis of “real-world” data.Arch. Gynecol. Obstet.202130351121113010.1007/s00404‑020‑05918‑333389100
     [Google Scholar]
  6. BairdD.D. PatchelS.A. SaldanaT.M. UmbachD.M. CooperT. WegienkaG. HarmonQ.E. Uterine fibroid incidence and growth in an ultrasound-based, prospective study of young African Americans.Am. J. Obstet. Gynecol.20202233402.e1402.e1810.1016/j.ajog.2020.02.01632105679
     [Google Scholar]
  7. De La CruzM.S. BuchananE.M. Uterine fibroids: Diagnosis and treatment.Am. Fam. Physician201795210010728084714
     [Google Scholar]
  8. CappelliA. MosconiC. CocozzaM.A. BrandiN. BartalenaL. ModestinoF. GalaverniM.C. VaraG. PaccapeloA. PizzoliG. VillaG. SeracchioliR. RenzulliM. Uterine artery embolization for the treatment of symptomatic uterine fibroids of different sizes: A single center experience.J. Pers. Med.202313690610.3390/jpm1306090637373895
     [Google Scholar]
  9. ShiL. ZhangR. TaoS. YuanX. ZhangJ. WangB. XiangM. RenZ. CaiH. FuC. Efficacy and safety of ultrasound-guided high-intensity focused ultrasound ablation in women with multiple uterine fibroids: An exploratory study.Ultrasound Med. Biol.202349112378238710.1016/j.ultrasmedbio.2023.08.00137596155
     [Google Scholar]
  10. LipsP. Vitamin D physiology.Prog. Biophys. Mol. Biol.20069214810.1016/j.pbiomolbio.2006.02.01616563471
     [Google Scholar]
  11. QiuY. YuanS. WangH. Vitamin D status in endometriosis: A systematic review and meta-analysis.Arch. Gynecol. Obstet.2020302114115210.1007/s00404‑020‑05576‑532430755
     [Google Scholar]
  12. HolickM.F. BinkleyN.C. Bischoff-FerrariH.A. GordonC.M. HanleyD.A. HeaneyR.P. MuradM.H. WeaverC.M. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline.J. Clin. Endocrinol. Metab.20119671911193010.1210/jc.2011‑038521646368
     [Google Scholar]
  13. van SchoorN. LipsP. Global overview of vitamin D status.Endocrinol. Metab. Clin. North Am.201746484587010.1016/j.ecl.2017.07.00229080639
     [Google Scholar]
  14. PludowskiP. HolickM.F. PilzS. WagnerC.L. HollisB.W. GrantW.B. ShoenfeldY. LerchbaumE. LlewellynD.J. KienreichK. SoniM. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality—A review of recent evidence.Autoimmun. Rev.2013121097698910.1016/j.autrev.2013.02.00423542507
     [Google Scholar]
  15. PludowskiP. GrantW.B. KonstantynowiczJ. HolickM.F. Editorial: Classic and pleiotropic actions of vitamin D.Front. Endocrinol.20191034110.3389/fendo.2019.0034131191460
     [Google Scholar]
  16. ArslanS. AkdevelioğluY. The relationship between female reproductive functions and vitamin D.J. Am. Coll. Nutr.201837654655110.1080/07315724.2018.143116029533153
     [Google Scholar]
  17. MenichiniD. FacchinettiF. Effects of vitamin D supplementation in women with polycystic ovary syndrome: A review.Gynecol. Endocrinol.20203611510.1080/09513590.2019.162588131187648
     [Google Scholar]
  18. KumariR. NathB. Kashika GaikwadH.S. SharmaM. Association between serum vitamin D level and uterine fibroid in premenopausal women in Indian population.Drug Discov. Ther.202216181310.5582/ddt.2021.0101935264477
     [Google Scholar]
  19. KumariS. SwethaP. Krishnan RS. NayakS. SinghS. The association between ferritin and vitamin D levels in premenopausal fibroid uterus cases with anemia.Cureus2021132e1339210.7759/cureus.1339233758693
     [Google Scholar]
  20. XiaW ZhangZ LinH Consensus on clinical application of vitamin D and its analogues.CSOBMR2018111119
     [Google Scholar]
  21. FuY. FengQ. ZhangS. LiY. Application of oxytocin in ultrasound-guided percutaneous microwave ablation for treatment of hypervascular uterine fibroids: A preliminary report.Int. J. Hyperthermia201936176076610.1080/02656736.2019.163983231431080
     [Google Scholar]
  22. HalderS.K. SharanC. HarirahH. Lower serum levels of vitamin D3 is a risk factor for uterine fibroids in African Americans.Abstracts of the 57th Annual Scientific Meeting of the Society for Gynecologic InvestigationMarch 24–27, 2010Orlando, Florida, USA67A363A10.1177/193371912010173s003
     [Google Scholar]
  23. BairdD.D. HillM.C. SchectmanJ.M. HollisB.W. Vitamin d and the risk of uterine fibroids.Epidemiology201324344745310.1097/EDE.0b013e31828acca023493030
     [Google Scholar]
  24. Oskovi KaplanZ.A. TaşçiY. TopçuH.O. ErkayaS. 25-Hydroxy vitamin D levels in premenopausal Turkish women with uterine leiomyoma.Gynecol. Endocrinol.201834326126410.1080/09513590.2017.139177429067857
     [Google Scholar]
  25. XuF. LiF. LiL. LinD. HuH. ShiQ. Vitamin D as a risk factor for the presence of asymptomatic uterine fibroids in premenopausal Han Chinese women.Fertil. Steril.202111551288129310.1016/j.fertnstert.2020.12.00133589134
     [Google Scholar]
  26. BudaniM.C. FensoreS. Di MarzioM. TiboniG.M. Effect of vitamin D supplementation on uterine fibroids: A meta-analysis of the literature.Minerva Obstet. Gynecol.202274219820010.23736/S2724‑606X.21.04988‑534694097
     [Google Scholar]
  27. SharanC. HalderS.K. ThotaC. JaleelT. NairS. Al-HendyA. Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase.Fertil. Steril.201195124725310.1016/j.fertnstert.2010.07.104120736132
     [Google Scholar]
  28. HalderS.K. GoodwinJ.S. Al-HendyA. 1,25-Dihydroxyvitamin D3 reduces TGF-beta3-induced fibrosis-related gene expression in human uterine leiomyoma cells.J. Clin. Endocrinol. Metab.2011964E754E76210.1210/jc.2010‑213121289245
     [Google Scholar]
  29. HalderS.K. SharanC. Al-HendyA. 1,25-dihydroxyvitamin D3 treatment shrinks uterine leiomyoma tumors in the Eker rat model.Biol. Reprod.201286411610.1095/biolreprod.111.09814522302692
     [Google Scholar]
  30. CorachánA. FerreroH. AguilarA. GarciaN. MonleonJ. FausA. CervellóI. PellicerA. Inhibition of tumor cell proliferation in human uterine leiomyomas by vitamin D via Wnt/β-catenin pathway.Fertil. Steril.2019111239740710.1016/j.fertnstert.2018.10.00830458994
     [Google Scholar]
  31. HajhashemiM. AnsariM. HaghollahiF. EslamiB. The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency.Caspian J. Intern. Med.201910212513131363390
     [Google Scholar]
  32. BajboujK. Al-AliA. ShafarinJ. SahnoonL. SawanA. ShehadaA. ElkhalifaW. Saber-AyadM. MuhammadJ.S. ElmoselhiA.B. GurayaS.Y. HamadM. Vitamin D exerts significant antitumor effects by suppressing vasculogenic mimicry in breast cancer cells.Front. Oncol.20221291834010.3389/fonc.2022.91834035747793
     [Google Scholar]
  33. CorachánA. FerreroH. EscrigJ. MonleonJ. FausA. CervellóI. PellicerA. Long-term vitamin D treatment decreases human uterine leiomyoma size in a xenograft animal model.Fertil. Steril.20201131205216.e410.1016/j.fertnstert.2019.09.01831739978
     [Google Scholar]
  34. NajafiN. KhalkhaliH. Moghaddam TabriziF. ZarrinR. Major dietary patterns in relation to menstrual pain: A nested case control study.BMC Womens Health20181816910.1186/s12905‑018‑0558‑429783972
     [Google Scholar]
  35. AmzajerdiA. KeshavarzM. GhorbaliE. PezaroS. SarviF. The effect of vitamin D on the severity of dysmenorrhea and menstrual blood loss: A randomized clinical trial.BMC Womens Health202323113810.1186/s12905‑023‑02284‑536973702
     [Google Scholar]
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A Multimodal Ultrasound Observation Study on the Effect of Vitamin D on Uterine Fibroids in Non-menopausal Women
Curr. Med. Imaging 20, e15734056281479 (2024); https://doi.org/10.2174/0115734056281479231030053817
/content/journals/cmir/10.2174/0115734056281479231030053817
/content/journals/cmir/10.2174/0115734056281479231030053817
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  • Article Type:     Research Article
Keyword(s): Blood flow grade; Elastic strain ratio; Multimodal ultrasound; Pre-menopausal women; Uterine fibroids; Vitamin D

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