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2000
Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
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Abstract

Background

Lung cancer patients with post-chemotherapy may have disconnected or weakened function connections within brain networks.

Objective

This study aimed to explore the abnormality of brain functional networks in lung cancer patients with post-chemotherapy by modular edge analysis.

Methods

Resting-state functional magnetic resonance imaging (rs-fMRI) scans were performed on 40 patients after chemotherapy, 40 patients before chemotherapy and 40 normal controls. Patients in all three groups were age and sex well-matched. Then, modular edge analysis was applied to assess brain functional network alterations.

Results

Post-chemotherapy patients had the worst MoCA scores among the three groups ( < 0.001). In intra-modular connections, compared with normal controls, the patients after chemotherapy had decreased connection strengths in the occipital lobe module ( < 0.05). Compared with the non-chemotherapy group, the patients after chemotherapy had decreased connection strengths in the subcortical module ( < 0.05). In inter-modular connections, compared with normal controls, the patients after chemotherapy had decreased connection strength in the frontal-temporal lobe modules ( < 0.05). Compared with the non-chemotherapy group, the patients after chemotherapy had decreased connection strength in the subcortical-temporal lobe modules ( < 0.05).

Conclusion

The results reveal that chemotherapy can disrupt connections in brain functional networks. As far as we know, the use of modular edge analysis to report changes in brain functional brain networks associated with chemotherapy was rarely reported. Modular edge analysis may play a crucial part in predicting the clinical outcome for the patients after chemotherapy.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2024-01-01
2025-09-12

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Modular Edge Analysis Reveals Chemotherapy-induced Brain Network Changes in Lung Cancer Patients
Curr. Med. Imaging 20, e15734056277364 (2024); https://doi.org/10.2174/0115734056277364231226081249
/content/journals/cmir/10.2174/0115734056277364231226081249
/content/journals/cmir/10.2174/0115734056277364231226081249
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  • Article Type:     Research Article
Keyword(s): Brain network; Chemotherapy; Lung cancer; Modular edge analysis; s-fMRI; Smoking

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