Skip to content
2000
Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
file format pdf download PDF
side by side viewer icon HTML

Abstract

Background:

Dissection of the lymph nodes posterior to the right recurrent laryngeal nerve (LN-prRLNs) in papillary thyroid cancer (PTC) remains controversial.

Objective:

This study aimed to determine the capability of ultrasonography (US)-based radiomics for presurgical prediction of metastasis in LN-prRLNs in PTC.

Methods:

Patients were retrospectively enrolled and pathologically confirmed as LN-prRLN metastasis with PTC after surgery. Radiomic analysis based on preoperative US images with manual segmentation of targets was used to develop a radiomics model. US features described in ACR TI-RADS were collected to construct a clinical model. The Radiomics model, a combined model integrating radiomics and clinical model, were also developed for the presurgical prediction of metastasis in LN-prRLNs.

Results:

A total of 570 patients, including 488 patients with non-LN-prRLN metastasis and 82 with LN-prRLN metastasis, were assessed. The 15 top-performing features finally remained significant for constructing the radiomics model. The combined model showed that US measured tumor size (OR: 1.036, = 0.044), US suspected lateral lymph node metastasis (OR: 2.247, = 0.009), multifocality (OR: 1.920, = 0.021), Delphian lymph node metastasis (DLNM) (OR: 2.300, = 0.039), VIa compartment metastasis (OR: 5.357, = 0.000), the radiomics score (OR: 1.003, = 0.001) were significant risk factors for predicting LN-prRLN metastasis. The combined model achieved a higher AUC of 0.849 than that of the clinical model (AUC: 0.826) and radiomics model (AUC: 0.759).

Conclusion:

The US-based radiomics combined model can more effectively predict LN-prRLN metastasis in PTCs patients preoperatively. This approach had the potential to assist surgeons in decision-making regarding LN-prRLN dissection.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Loading

Article metrics loading...

/content/journals/cmir/10.2174/0115734056257332231024112410
2023-10-31
2025-10-14

  • From This Site

    /content/journals/cmir/10.2174/0115734056257332231024112410
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

/deliver/fulltext/cmir/20/1/e15734056257332.html?itemId=/content/journals/cmir/10.2174/0115734056257332231024112410&mimeType=html&fmt=ahah

References

  1. KaplanE.L. SaltiG.I. RoncellaM. FultonN. KadowakiM. History of the recurrent laryngeal nerve: From Galen to Lahey.World J. Surg.200933338639310.1007/s00268‑008‑9798‑z19023621
     [Google Scholar]
  2. YuanJ. LiJ. ChenX. ZhongZ. ChenZ. YinY. DuJ. CongS. WuZ. Predictors of lymph nodes posterior to the right recurrent laryngeal nerve metastasis in patients with papillary thyroid carcinoma.Medicine20179635e790810.1097/MD.000000000000790828858110
     [Google Scholar]
  3. ChangH. YooR.N. KimS.M. KimB.W. LeeY.S. LeeS.C. ChangH.S. ParkC.S. The clinical significance of the right para-oesophageal lymph nodes in papillary thyroid cancer.Yonsei Med. J.20155661632163710.3349/ymj.2015.56.6.163226446647
     [Google Scholar]
  4. DuW. FangQ. ZhangX. DaiL. Metastasis of cN0 papillary thyroid carcinoma of the isthmus to the lymph node posterior to the right recurrent laryngeal nerve.Front. Endocrinol.20211267798610.3389/fendo.2021.67798634040587
     [Google Scholar]
  5. ClaymanG.L. AgarwalG. EdeikenB.S. WaguespackS.G. RobertsD.B. ShermanS.I. Long-term outcome of comprehensive central compartment dissection in patients with recurrent/persistent papillary thyroid carcinoma.Thyroid201121121309131610.1089/thy.2011.017022136266
     [Google Scholar]
  6. WangY. GuanQ. XiangJ. Nomogram for predicting central lymph node metastasis in papillary thyroid microcarcinoma: A retrospective cohort study of 8668 patients.Int. J. Surg.2018559810210.1016/j.ijsu.2018.05.02329803769
     [Google Scholar]
  7. LiuY. HuangJ. ZhangZ. HuangY. DuJ. WangS. WuZ. Ultrasonic characteristics improve prediction of central lymph node metastasis in cN0 unifocal papillary thyroid cancer.Front. Endocrinol.20221387081310.3389/fendo.2022.87081335795144
     [Google Scholar]
  8. HwangH.S. OrloffL.A. Efficacy of preoperative neck ultrasound in the detection of cervical lymph node metastasis from thyroid cancer.Laryngoscope2011121348749110.1002/lary.2122721344423
     [Google Scholar]
  9. HaugenB.R. AlexanderE.K. BibleK.C. DohertyG.M. MandelS.J. NikiforovY.E. PaciniF. RandolphG.W. SawkaA.M. SchlumbergerM. SchuffK.G. ShermanS.I. SosaJ.A. StewardD.L. TuttleR.M. WartofskyL. 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer.Thyroid2016261113310.1089/thy.2015.002026462967
     [Google Scholar]
  10. YehMW BauerAJ BernetVA FerrisRL LoevnerLA MandelSJ OrloffLA RandolphGW StewardDL American thyroid association surgical affairs committee writing task F. American thyroid association statement on preoperative imaging for thyroid cancer surgery.Thyroid201525131410.1089/thy.2014.009625188202
     [Google Scholar]
  11. SolorzanoC.C. CarneiroD.M. RamirezM. LeeT.M. IrvinG.L.III Surgeon-performed ultrasound in the management of thyroid malignancy.Am. Surg.200470757658210.1177/00031348040700070315279178
     [Google Scholar]
  12. StulakJ.M. GrantC.S. FarleyD.R. ThompsonG.B. van HeerdenJ.A. HayI.D. ReadingC.C. CharboneauJ.W. Value of preoperative ultrasonography in the surgical management of initial and reoperative papillary thyroid cancer.Arch. Surg.2006141548949410.1001/archsurg.141.5.48916702521
     [Google Scholar]
  13. O’ConnellK. YenT.W. QuirozF. EvansD.B. WangT.S. The utility of routine preoperative cervical ultrasonography in patients undergoing thyroidectomy for differentiated thyroid cancer.Surgery2013154469770310.1016/j.surg.2013.06.04024011674
     [Google Scholar]
  14. ZhaoH. LiH. Meta-analysis of ultrasound for cervical lymph nodes in papillary thyroid cancer: Diagnosis of central and lateral compartment nodal metastases.Eur. J. Radiol.2019112142110.1016/j.ejrad.2019.01.00630777203
     [Google Scholar]
  15. YuJ. DengY. LiuT. ZhouJ. JiaX. XiaoT. ZhouS. LiJ. GuoY. WangY. ZhouJ. ChangC. Lymph node metastasis prediction of papillary thyroid carcinoma based on transfer learning radiomics.Nat. Commun.2020111480710.1038/s41467‑020‑18497‑332968067
     [Google Scholar]
  16. LiuT. ZhouS. YuJ. GuoY. WangY. ZhouJ. ChangC. Prediction of lymph node metastasis in patients with papillary thyroid carcinoma: A radiomics method based on preoperative ultrasound images.Technol. Cancer Res. Treat.201918:10.1177/153303381983171330890092
     [Google Scholar]
  17. LiuT. GeX. YuJ. GuoY. WangY. WangW. CuiL. Comparison of the application of B-mode and strain elastography ultrasound in the estimation of lymph node metastasis of papillary thyroid carcinoma based on a radiomics approach.Int. J. CARS201813101617162710.1007/s11548‑018‑1796‑529931410
     [Google Scholar]
  18. ZhouS.C. LiuT.T. ZhouJ. HuangY.X. GuoY. YuJ.H. WangY.Y. ChangC. An ultrasound radiomics nomogram for preoperative prediction of central neck lymph node metastasis in papillary thyroid carcinoma.Front. Oncol.202010159110.3389/fonc.2020.0159133014810
     [Google Scholar]
  19. TongY. LiJ. HuangY. ZhouJ. LiuT. GuoY. YuJ. ZhouS. WangY. ChangC. Ultrasound-based radiomic nomogram for predicting lateral cervical lymph node metastasis in papillary thyroid carcinoma.Acad. Radiol.202128121675168410.1016/j.acra.2020.07.01732782219
     [Google Scholar]
  20. LuK.N. ZhangY. DaJ.Y. ZhouT. ZhaoL.Q. PengY. PanG. ShiJ.J. ZhouL. NiY.Q. LuoD.C. A novel scoring system for predicting the metastases of posterior right recurrent laryngeal nerve lymph node involvement in patients with papillary thyroid carcinoma by preoperative ultrasound.Front. Endocrinol.20211273813810.3389/fendo.2021.73813834531829
     [Google Scholar]
  21. ChéreauN. BuffetC. TrésalletC. TissierF. GolmardJ.L. LeenhardtL. MenegauxF. Does extracapsular extension impact the prognosis of papillary thyroid microcarcinoma?Ann. Surg. Oncol.20142151659166410.1245/s10434‑013‑3447‑y24394985
     [Google Scholar]
  22. SauerbreiW. RoystonP. BinderH. Selection of important variables and determination of functional form for continuous predictors in multivariable model building.Stat. Med.200726305512552810.1002/sim.314818058845
     [Google Scholar]
  23. LiC. XiangJ. WangY. Risk factors for predicting lymph nodes posterior to right recurrent laryngeal nerve (LN-prRLN) metastasis in thyroid papillary carcinoma: A meta-analysis.Int. J. Endocrinol.2019201911110.1155/2019/706432831049063
     [Google Scholar]
  24. YuF.H. WangJ.X. YeX.H. DengJ. HangJ. YangB. Ultrasound-based radiomics nomogram: A potential biomarker to predict axillary lymph node metastasis in early-stage invasive breast cancer.Eur. J. Radiol.201911910865810.1016/j.ejrad.2019.10865831521878
     [Google Scholar]
  25. TengY. AiY. LiangT. YuB. JinJ. XieC. JinX. The effects of automatic segmentations on preoperative lymph node status prediction models with ultrasound radiomics for patients with early stage cervical cancer.Technol. Cancer Res. Treat.202221:10.1177/1533033822109939635522305
     [Google Scholar]
  26. LinM. TangX. CaoL. LiaoY. ZhangY. ZhouJ. Using ultrasound radiomics analysis to diagnose cervical lymph node metastasis in patients with nasopharyngeal carcinoma.Eur. Radiol.202233277478310.1007/s00330‑022‑09122‑636070091
     [Google Scholar]
  27. YanL. LanY. XiaoJ. LinL. JiangB. LuoY. Long-term outcomes of radiofrequency ablation for unifocal low-risk papillary thyroid microcarcinoma: A large cohort study of 414 patients.Eur. Radiol.202131268569410.1007/s00330‑020‑07128‑632813103
     [Google Scholar]
  28. ZhangH. HungC.L. MinG. GuoJ.P. LiuM. HuX. GPU-accelerated GLRLM algorithm for feature extraction of MRI.Sci. Rep.2019911088310.1038/s41598‑019‑46622‑w31350428
     [Google Scholar]
  29. HwangY.N. LeeJ.H. KimG.Y. ShinE.S. KimS.M. Characterization of coronary plaque regions in intravascular ultrasound images using a hybrid ensemble classifier.Comput. Methods Programs Biomed.2018153839210.1016/j.cmpb.2017.10.00929157464
     [Google Scholar]
  30. ZhaoL. MaB. Radiomics features of different sizes of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) tumors: A comparative study.Clin. Med. Insights Oncol.202216:10.1177/1179554922109767535603093
     [Google Scholar]
  31. CaoX.J. WangS.R. CheY. LiuJ. CongZ.B. HeJ.F. WangH.L. LiuG. GuoJ.Q. HaoY. WangZ.H. ZhouY. JianM. ShiL.L. QiL. ZhuY.L. WangX. YanG.Z. ShataerA. LiuX.F. WeiY. ZhaoZ.L. PengL.L. LiY. YuM.A. Efficacy and safety of thermal ablation for treatment of solitary T1N0M0 papillary thyroid carcinoma: A multicenter retrospective study.Radiology2021300120921610.1148/radiol.202120273533904775
     [Google Scholar]
  32. LuW.W. ZhangD. NiX.J. A review of the role of ultrasound radiomics and its application and limitations in the investigation of thyroid disease.Med. Sci. Monit.202228e93773810.12659/MSM.93773836258648
     [Google Scholar]
  33. HouJ. ShanH. ZhangY. FanY. WuB. Risk factors of metastasis to the lymph nodes posterior to the right recurrent laryngeal nerve in papillary thyroid carcinoma.Eur. Arch. Otorhinolaryngol.2020277388188610.1007/s00405‑019‑05748‑331792653
     [Google Scholar]
  34. BaeS.Y. YangJ.H. ChoiM.Y. ChoeJ.H. KimJ.H. KimJ.S. Right paraesophageal lymph node dissection in papillary thyroid carcinoma.Ann. Surg. Oncol.2012193996100010.1245/s10434‑011‑2144‑y22094496
     [Google Scholar]
  35. LiJ. HeG. TongY. TaoL. XieL. GaoL. ZhangD. A novel scoring system for the risk of papillary thyroid cancer metastases in lymph nodes posterior to the right of the recurrent laryngeal nerve.Endocr. Pract.2021271152010.4158/EP‑2020‑012933471728
     [Google Scholar]
  36. LiuZ. SunM. XiaoY. YangJ. ZhangT. ZhaoY. Predictors of metastasis to lymph nodes posterior to the right recurrent laryngeal nerve in differentiated thyroid carcinoma: A prospective study.Asian J. Surg.201740427027710.1016/j.asjsur.2015.12.00326948300
     [Google Scholar]
  37. KimD. KwonH.K. ShinS.C. SungE.S. JeonY.K. KimB.H. KimI.J. LeeJ.C. LeeB.J. Right posterior paratracheal lymph nodes metastasis is one of the predictive factors in right-sided papillary thyroid carcinoma.Surgery201916661154115910.1016/j.surg.2019.06.02431444006
     [Google Scholar]
  38. WatkinsonJ.C. FranklynJ.A. OlliffJ.F.C. Detection and surgical treatment of cervical lymph nodes in differentiated thyroid cancer.Thyroid200616218719410.1089/thy.2006.16.18716676409
     [Google Scholar]
  39. MolteniG. BonaliM. MattioliF. GhirelliM. FermiM. FerriG. AndreaM. PresuttiL. Central compartment revision surgery for persistent or recurrent thyroid carcinoma: Analysis of survival and complication rate.Eur. Arch. Otorhinolaryngol.2019276255155710.1007/s00405‑018‑5239‑230535975
     [Google Scholar]
/content/journals/cmir/10.2174/0115734056257332231024112410
Loading
Ultrasound-based Radiomics for Predicting Metastasis in the Lymph Nodes Posterior to the Right Recurrent Laryngeal Nerve in Patients with Papillary Thyroid Cancer
Curr. Med. Imaging 20, e15734056257332 (2024); https://doi.org/10.2174/0115734056257332231024112410
/content/journals/cmir/10.2174/0115734056257332231024112410
/content/journals/cmir/10.2174/0115734056257332231024112410
Loading

Data & Media loading...

Supplements

Supplementary material is available on the Publisher’s website.

file format download Download

  • Article Type:     Research Article
Keyword(s): LN-prRLNs; Lymph nodes posterior to the right recurrent laryngeal nerve; Papillary thyroid carcinoma; PTC; Radiomics; Ultrasound

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test