Skip to content
2000
Volume 20, Issue 1
  • ISSN: 1573-4056
  • E-ISSN: 1875-6603
file format pdf download PDF
side by side viewer icon HTML

Abstract

Objective

This study aimed to characterize and assess the diagnostic value of prenatal magnetic resonance (MR) imaging in detecting fetal cerebellar hypoplasia/dysplasia and developmental malformations.

Methods

Reports of suspected intracranial abnormalities were retrospectively collected on ultrasound screening (US), and MR images of fetuses were reviewed at our institution over a 5-year period on picture archiving and communication system (PACS) servers. Two experienced radiologists recorded major abnormalities and coexisting abnormalities at the reading of the census. The results of the MRI were compared against the US in each case.

Results

For prenatal MR imaging, we enlisted a total of 121 patients (mean gestational week, 24.5 ± 4.7 weeks). This included 28 cases with normal findings of MR imaging, 62 cases with findings of cerebellar hypoplasia or dysplasia, and the remaining 31 cases with other abnormities findings. Cerebral malformations cases included agenesis of the corpus callosum, cerebral hemorrhage, hydrocephalus, holoprosencephaly, ventriculomegaly, and brainstem/gyri malformation. Cerebellar abnormalities included vermis absence, cerebellar tonsil hernia, Dandy-Walker malformation, Blake’s pouch cysts, arachnoid cysts, and intracranial hemorrhage. Other systemic malformation cases included tethered cord syndromes (9 cases), cleft lip and palate (1 case), club foot (1 case), and cardiac malformation (1 case). In 12 cases (24.5%), compared to the US, MR imaging proved the value of confirming the diagnosis and/or even yielded more findings on abnormalities.

Conclusion

Prenatal MR imaging can better visualize systemic malformations coexisting with cerebellar abnormalities. MR imaging, a complementary means to the US, can aid in prenatal counseling and treatment selection for term delivery.

© 2024 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Loading

Article metrics loading...

/content/journals/cmir/10.2174/0115734056256514231020103822
2024-01-01
2025-11-01

  • From This Site

    /content/journals/cmir/10.2174/0115734056256514231020103822
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

/deliver/fulltext/cmir/20/1/CMIR-20-E15734056256514.html?itemId=/content/journals/cmir/10.2174/0115734056256514231020103822&mimeType=html&fmt=ahah

References

  1. PaladiniD. QuarantelliM. SglavoG. PastoreG. CavallaroA. D’ArmientoM.R. SalvatoreM. NappiC. Accuracy of neurosonography and MRI in clinical management of fetuses referred with central nervous system abnormalities.Ultrasound Obstet. Gynecol.201444218819610.1002/uog.1324324186262
     [Google Scholar]
  2. van der KnoopB.J. ZonnenbergI.A. VerbekeJ.I.M.L. de VriesL.S. PistoriusL.R. van WeissenbruchM.M. VermeulenR.J. de VriesJ.I.P. Additional value of advanced neurosonography and magnetic resonance imaging in fetuses at risk for brain damage.Ultrasound Obstet. Gynecol.202056334835810.1002/uog.2194331828836
     [Google Scholar]
  3. TrigoL. EixarchE. BotturaI. Prevalence of supratentorial anomalies assessed by fetal magnetic resonance in fetuses with open spina bifida.Ultrasound Obstet. Gynecol.2022596804812
     [Google Scholar]
  4. MantoM. HuismanT.A.G.M. The cerebellum from the fetus to the elderly: history, advances, and future challenges.Handbook of Clinical Neurology. MantoM. HuismanT.A.G.M. Elsevier2018407413
     [Google Scholar]
  5. ManganaroL. BernardoS. AntonelliA. VinciV. SaldariM. CatalanoC. Fetal MRI of the central nervous system: State-of-the-art.Eur. J. Radiol.20179327328310.1016/j.ejrad.2017.06.00428668426
     [Google Scholar]
  6. GoergenS.K. AlibrahimE. GovenderN. StanislavskyA. AbelC. PrystupaS. CollettJ. ShelmerdineS.C. ArthursO.J. Diagnostic assessment of foetal brain malformations with intra-uterine MRI versus perinatal post-mortem MRI.Neuroradiology201961892193410.1007/s00234‑019‑02218‑931076826
     [Google Scholar]
  7. MoltoniG. TalentiG. RighiniA. Brain fetal neuroradiology: A beginner’s guide.Transl. Pediatr.20211041065107710.21037/tp‑20‑29334012856
     [Google Scholar]
  8. MillerE. OrmanG. HuismanT.A.G.M. Fetal MRI assessment of posterior fossa anomalies: A review.J. Neuroimaging202131462064010.1111/jon.1287133964092
     [Google Scholar]
  9. KauT. BirnbacherR. SchwärzlerP. HabernigS. DeutschmannH. BoltshauserE. Delayed fenestration of Blake’s pouch with or without vermian hypoplasia: fetal MRI at 3 tesla versus 1.5 tesla.Cerebellum Ataxias201961410.1186/s40673‑019‑0098‑130873288
     [Google Scholar]
  10. Lerman-SagieT. PrayerD. StöckleinS. MalingerG. Fetal cerebellar disorders.Handb. Clin. Neurol.201815532310.1016/B978‑0‑444‑64189‑2.00001‑929891067
     [Google Scholar]
  11. GhaiS. FongK.W. ToiA. ChitayatD. PantaziS. BlaserS. Prenatal US and MR imaging findings of lissencephaly: Review of fetal cerebral sulcal development.Radiographics200626238940510.1148/rg.26205505916549605
     [Google Scholar]
  12. SchneiderM.M. BermanJ.I. BaumerF.M. GlassH.C. JengS. JeremyR.J. EschM. BiranV. BarkovichA.J. StudholmeC. XuD. GlennO.A. Normative apparent diffusion coefficient values in the developing fetal brain.AJNR Am. J. Neuroradiol.20093091799180310.3174/ajnr.A166119556350
     [Google Scholar]
  13. Mignone PhilpottC. ShannonP. ChitayatD. RyanG. RaybaudC.A. BlaserS.I. Diffusion-weighted imaging of the cerebellum in the fetus with Chiari II malformation.AJNR Am. J. Neuroradiol.20133481656166010.3174/ajnr.A346823721901
     [Google Scholar]
  14. BerR. Bar-YosefO. HoffmannC. ShasharD. AchironR. KatorzaE. Normal fetal posterior fossa in MR imaging: New biometric data and possible clinical significance.AJNR Am. J. Neuroradiol.201536479580210.3174/ajnr.A425825655869
     [Google Scholar]
  15. XiY. BrownE. BaileyA. TwicklerD.M. MR imaging of the fetal cerebellar vermis: Biometric predictors of adverse neurologic outcome.J. Magn. Reson. Imaging20164451284129210.1002/jmri.2527027086739
     [Google Scholar]
  16. WoitekR. DvorakA. WeberM. SeidlR. BettelheimD. SchöpfV. AmannG. BruggerP.C. FurtnerJ. AsenbaumU. PrayerD. KasprianG. MR-based morphometry of the posterior fossa in fetuses with neural tube defects of the spine.PLoS One2014911e11258510.1371/journal.pone.011258525393279
     [Google Scholar]
  17. DuczkowskaA. Bekiesinska-FigatowskaM. Herman-SucharskaI. DuczkowskiM. Romaniuk-DoroszewskaA. JurkiewiczE. DubisA. UrbanikA. FurmanekM. WaleckiJ. Magnetic resonance imaging in the evaluation of the fetal spinal canal contents.Brain Dev.2011331102010.1016/j.braindev.2010.01.00320188501
     [Google Scholar]
  18. WangJ. ZhouQ. FuZ. XiaoX. LuY. ZhangG. ZhangH. MRI evaluation of fetal tethered-cord syndrome: Correlation with ultrasound findings and clinical follow-up after birth.Clin. Radiol.2021764314.e1314.e810.1016/j.crad.2020.12.01033485624
     [Google Scholar]
  19. WangT. WangJ. CaiS. Magnetic resonance imaging evaluation of foetal intracranial haemorrhage and the correlation with ultrasound findings and postnatal outcomes.Arch. Gynecol. Obstet.2021305487788434459969
     [Google Scholar]
  20. SchönbergN. WeisstannerC. WiestR. BonélH.M. PiechowiakE.I. CullmannJ.L. RaioL. Pastore-WappM. SlavovaN. The influence of various cerebral and extracerebral pathologies on apparent diffusion coefficient values in the fetal brain.J. Neuroimaging202030447748510.1111/jon.1272732557916
     [Google Scholar]
  21. LetissierC. CrombéA. ChérierL. DelmasJ. ChateilJ.F. Brain fetal magnetic resonance imaging to evaluate maturation of normal white matter during the third trimester of pregnancy.Pediatr. Radiol.202151101826183810.1007/s00247‑021‑05064‑134019102
     [Google Scholar]
  22. TanacanA. OzgenB. FadilogluE. UnalC. OguzK.K. BeksacM.S. Prenatal diagnosis of central nervous system abnormalities: Neurosonography versus fetal magnetic resonance imaging.Eur. J. Obstet. Gynecol. Reprod. Biol.202025019520210.1016/j.ejogrb.2020.05.01332460228
     [Google Scholar]
/content/journals/cmir/10.2174/0115734056256514231020103822
Loading
Prenatal Magnetic Resonance Imaging helps Discover Cerebellar Dysplasia or Malformations in Foetuses
Curr. Med. Imaging 20, e15734056256514 (2024); https://doi.org/10.2174/0115734056256514231020103822
/content/journals/cmir/10.2174/0115734056256514231020103822
/content/journals/cmir/10.2174/0115734056256514231020103822
Loading

Data & Media loading...

Supplements

The following figures are from the file: supplementary-file.docx

file format download Download

  • Article Type:     Research Article
Keyword(s): Cerebellum; Foetal brain; Foetal malformation; Foetus; Magnetic resonance imaging; Parental diagnosis

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test