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Background: Microwave irradiation usage has reduced the time of reactions in organic synthesis. Nano-Fe2O3 proved to be a highly efficient and recyclable catalyst for the synthesis of organic molecules. Objective: One pot synthesis of substituted oxadiazoles using ultrasonic irradiation and nano- Fe2O3 as catalyst at ambient conditions. Method: Probe sonicator was used for ultrasonication synthesis along with nano- Fe2O3 as catalyst. Results: The synthesised substituted oxadiazoles were obtained in high yields and shorter reaction time. Conclusion: Eco-friendly protocols, easy recovery of catalyst, efficient recyclability, high stability of catalyst, high yields and lesser reaction time render the protocol sustainable and economic.