Microwave Assisted One-Pot Synthesis of Novel Trifluoromethyl Coumarin Thiosemicarbazones and their Antifungal Activities

Some new trifluoromethyl coumarin thiosemicarbazones 3a-3m were synthesized by condensation reaction of thiosemicarbazides and 3-trifluoroacetyl coumarins which was from recyclization of ethyl 2-hydroxy-2-(trifluoromethyl)-2H-chromene-3-carboxylates under microwave assisted and solvent-free conditions. The structure of the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, HRMS and X-ray, and their antifungal activity was evaluated. Most of them exhibited potent antifungal activity by comparison with the standard drugs.