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2000
Volume 25, Issue 3
  • ISSN: 1871-529X
  • E-ISSN: 2212-4063

Abstract

Introduction

Myocardial ischemia/reperfusion injuries (MI/RI) are responsible for fatal cardiovascular diseases. Myocardial infarction may lead to ischemic cardiomyopathy (ICM). Thereby, illustrating the MI/RI molecular basis could lead to the emergence of novel therapeutic options. pathway is well-known in renal ischemia/ reperfusion. protein can promote autophagy after hypoxia.

Materials and Methods

We selected the dataset GSE46224 from the National Center of Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database for evaluation. This dataset was analyzed using tools such as the Kyoto Encyclopedia of Genes and Genomes, GeneCodis, and BioGRID. Three groups of patients were selected from the dataset. ICM group (n=8), non-failing (NF) group (n=8), and non-ischemic cardiomyopathy (NICM) group (n=8) evaluated for 15 genes expression levels. P-value <0.05 is statistically significant.

Results

showed significantly lower gene expression in the ICM group compared to the NF group (-value = 0.012, difference = -6.24). was also significantly down-regulated in the ICM group compared to the NF group (-value =0.0159, difference = -1.478). In contrast, and NF-κB were significantly up-regulated in the ICM group (STAT5B: -value = 0.0238, difference = 2.388; NF-κB: -value = 0.0158, difference = 1.11). The analysis of differences and the volcano plot confirmed these findings, highlighting key dysregulated genes in ICM.

Conclusion

In conclusion, ICM patients have altered expression compared to NF individuals. The significant down-regulation of and , along with the up-regulation of and NF-κB, suggests that targeting could be an important strategy to ameliorate ischemia-related cardiomyocyte damage.

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2025-11-16

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Expression of PIM1/ASK1 Molecular Pathway Related Genes in Ischemic Cardiomyopathy
Cardiovasc Hematol Disord Drug Targets 25, 207 (2025); https://doi.org/10.2174/011871529X366280250526131550
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  • Article Type:     Research Article
Keyword(s): apoptosis; cardiomyocyte; gene expression omnibus; gene ontology; Heart failure; ischemia/reperfusion injury; myocardial infarction

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