Microwave-induced Triazole Synthesis via 1,3-dipolar azide-alkyne cycloaddition: Recent Advances

Background: 1,3-Dipolar azide-alkyne cycloaddition (AAC) reaction, often referred to as click reaction, is an expeditious and robust protocol for the construction of triazole derivatives. In most cases, the reaction is catalyzed by a copper catalyst. Methods: Non-conventional microwave heating has been used for the reaction showing ample advantages over the conventional thermal heating. Conclusion: This article has presented an overview on the recent advances in the area of microwave- induced AAC reactions in the presence of both homogeneous and heterogeneous copper catalysts, besides a few examples of Ru-catalyzed as well as metal-free AAC reactions.