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2000
Volume 26, Issue 4
  • ISSN: 1389-2029
  • E-ISSN: 1875-5488

Abstract

Background

Retinal Vein Occlusion (RVO) is a common and main cause of blindness. Causal, possible risk variables must be identified to develop preventative strategies for RVO. Thus, we decided to evaluate whether smoking, alcohol, obesity, sedentary behaviour, hypertension, and hyperglycemia are associated with increased risk of RVO.

Methods

The data sources of Mendelian Randomization (MR) study included FinnGen consortium and the original GWAS article. A total of 130,604 cases with RVO from FinnGen consortium and 12,136 cases with RVO from the original GWAS article. The exposures of this MR study included smoking, alcoholic consumption, obesity, sedentariness, hypertension, and hyperglycemia. The outcome of this MR study was RVO.

Results

Genetic predispositions to alcohol consumption (OR (odds ratio), 1.124; 95%CI, 1.007-1.254; =0.037) and hyperglycemia (OR, 1.108; 95%CI, 1.023-1.200; =0.012) were associated with increased risks of RVO in FinnGen. There were no significant associations of genetically predicted consumption of smoking (OR, 1.037; 95%CI, 0.341-3.155; =0.949), obesity (OR, 1.045; 95%CI, 0.975-1.119; =0.213), sedentariness (OR, 1.022; 95%CI, 0.753-1.38-; =0.888), or hypertension (OR, 0.944; 95%CI, 0.848-1.051; =0.290) with RVO.

Conclusion

This MR analysis provides genetic evidence that increased alcohol consumption and hyperglycemia may be causal risk factors for RVO. In addition, no genetic evidence in this MR analysis supported that there were causal associations between smoking, sedentariness, obesity and hypertension with RVO.

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/content/journals/cg/10.2174/0113892029320896241218055907
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Causal Associations of Smoking, Alcohol, Obesity, Sedentary Behavior, Hypertension, and Hyperglycemia With Retinal Vein Occlusion: A Mendelian Randomization Study
Curr. Genomics 26, 290 (2025); https://doi.org/10.2174/0113892029320896241218055907
/content/journals/cg/10.2174/0113892029320896241218055907
/content/journals/cg/10.2174/0113892029320896241218055907
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  • Article Type:     Research Article
Keyword(s): alcohol; hyperglycemia; hypertension; mendelian randomization; Retinal vein occlusion; smoking

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