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2000
Volume 4, Issue 1
  • ISSN: 2666-8629
  • E-ISSN: 2666-8637

Abstract

, a perennial plant from the Vitaceae family, is widely recognized for its extensive use in traditional medicine across tropical and subtropical regions. This review explores the phytochemical composition and pharmacological potential of , focusing on its application in herbal formulations. The plant exhibits a diverse array of bioactive compounds, including triterpenoids, steroids, flavonoids, and phenolic glycosides, found in various parts such as the stem, leaves, fruits, and roots. These phytochemicals contribute to its broad pharmacological activities, which include anti-ulcer, anti-inflammatory, analgesic, anti-diabetic, antioxidant, antimicrobial, and bone-healing properties.

Significant attention is paid to the plant's potential in managing bone-related disorders such as osteoporosis and fractures, owing to its anabolic and mineral absorption-enhancing effects. Moreover, demonstrates promising anti-obesity effects, as evidenced by its ability to reduce body weight, waist circumference, and blood cholesterol levels. Its anti-ulcer activity is attributed to the enhancement of mucosal defense mechanisms and the reduction of gastric secretions. The review also highlights the plant's analgesic and anti-inflammatory properties, showing substantial efficacy in various experimental models. Its anti-diabetic potential is confirmed through studies on alloxan and streptozotocin-induced diabetic models. Additionally, the antioxidant capacity of , facilitated by its secondary metabolites, supports its use in combating oxidative stress-related conditions. Furthermore, the plant's central nervous system activities, including anticonvulsant and muscle relaxant effects, are discussed. The antimicrobial and anti-helmintic properties of the plant underline its therapeutic versatility. The review concludes by emphasizing the need for further research to elucidate the molecular mechanisms, structure-activity relationships, and potential synergistic effects of the plant's components, paving the way for its integration into modern pharmacological applications.

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References

  1. SundaranJ. BegumR. VasanthiM. KamalapathyM. BupeshG. SahooU. A short review on pharmacological activity of Cissus quadrangularis.Biomed Inform202016857958510.6026/97320630016579
     [Google Scholar]
  2. MishraG. SrivastavaS. NagoriB.P. Pharmacological and therapeutic activity of Cissus quadrangularis.Int. J. Pharm. Tech. Res.20102212981310
     [Google Scholar]
  3. UnnatiS. Pharmacognostical investigation on Cissus quadrangularis linn.Int. J. Pharm. Biol. Sci.2010115
     [Google Scholar]
  4. SayyedH.H. PatilS. A phytochemical and pharmacological review of an Indian plant: Cissus quadrangularis. Med Sci Forum20232112010.3390/ECB2023‑14557
     [Google Scholar]
  5. SiddiquaA. MittapallyS. A review on Cissus quadrangularis.Pharma Innov.201767 Part E329
     [Google Scholar]
  6. ShahU. Cissus quadrangularis L.: Phytochemicals, traditional uses and pharmacological activities: A review.Int. J. Pharm. Pharm. Sci.2011344144
     [Google Scholar]
  7. FernandesG. BanuJ. Medicinal properties of plants from the genus Cissus: A review.J. Med. Plants Res.201261630803086
     [Google Scholar]
  8. ShuklaR. PathakA. KambujaS. SachanS. MishraA. KumarS. Pharmacognostical, phytochemical and pharmacological overview: Cissus quadrangularis Linn.Indian J Pharm Biol Res201533596510.30750/ijpbr.3.3.10
     [Google Scholar]
  9. YadavP. Phytochemical screening of stem of Cissus quadrangularis-A traditional medicine.Int. J. Pharm. Tech. Res.2016137780
     [Google Scholar]
  10. SinghG. RawatP. MauryaR. Constituents of Cissus quadrangularis.Nat. Prod. Res.200721652252810.1080/14786410601130471
     [Google Scholar]
  11. MehtaM. KaurN. BhutaniK.K. Determination of marker constituents from Cissus quadrangularis Linn. and their quantitation by HPTLC and HPLC.Phytochem. Anal.2001122919510.1002/pca.569 11705245
     [Google Scholar]
  12. JirikasemS. LimsiriwongP. KajsongkarmT. SoontorntanasartT. Phytochemical study of Cissus quadrangularis.Thai J Pharm Sci200024525
     [Google Scholar]
  13. SenS.P. Studies on active constituents of Cissus quadrangularis—II.Curr. Sci.19663512317
     [Google Scholar]
  14. StohsS.J. RayS.D. A review and evaluation of the efficacy and safety of Cissus quadrangularis extracts.Phytother. Res.201327811071114
     [Google Scholar]
  15. KaurR. MalikC.P. Cissus quadrangularis- its botany, chemistry and medicinal importance: A review.Int J Pharm Clin Res2014612735
     [Google Scholar]
  16. ThakurA. JainV. HingoraniL. LaddhaK.S. Phytochemical studies on Cissus quadrangularis Linn.Pharmacognosy Res.2009145257
     [Google Scholar]
  17. KumarT.S. AnandanA. JegadeesanM. Identification of chemical compounds in Cissus quadrangularis L. variant-I of different sample using GC-MS analysis.Arch. Appl. Sci. Res.20124417821787
     [Google Scholar]
  18. AustinA. KannanR. JegadeesanM. Pharmacognostical studies on Cissus quadrangularis L. variant I and II.Anc. Sci. Life20042343347
     [Google Scholar]
  19. SrivastavaA.K. SrivastavaP. BeheraB.R. ShrivastavaA.K. Pharmacognostical phytochemical investigation of Cissus quadrangularis Linn. stem.Int. J. Pharm. Res. Dev.201111207215
     [Google Scholar]
  20. EnechiO.C. OdonwodoI. An assessment of the phytochemical and nutrient composition of the pulverized root of Cissus quadrangularis.Bio-research2003116368
     [Google Scholar]
  21. SaburiA. NiaR. MartinM.T. BoukamchaN. MontagnacA. PaïsM. Stilbene derivatives from Cissus quadrangularis.J. Nat. Prod.199962121694169510.1021/np9902744
     [Google Scholar]
  22. KhanS.S. SinghM.P. ChaghtaiS.A. Ethnomedicobotany of Cissus quadrangularis Linn.Orient. J. Chem.19917170172
     [Google Scholar]
  23. BafnaP.S. PatilP.H. MaruS.K. MuthaR.E. Cissus quadrangularis L: A comprehensive multidisciplinary review.J. Ethnopharmacol.202127911435510.1016/j.jep.2021.114355 34181958
     [Google Scholar]
  24. BanuJ. VarelaE. BahadurA.N. SoomroR. KaziN. FernandesG. Inhibition of bone loss by Cissus quadrangularis in mice: A preliminary report.J. Osteoporos.2012201210120610.1155/2012/101206 22779034
     [Google Scholar]
  25. UdupaK.N. ArinkarH.J. SinghL.M. Experimental studies of the use of Cissus quadrangularis in healing of fractures.Indian J. Med. Res.196115551557 13778943
     [Google Scholar]
  26. UdupaK.N. PrasadG.C. Further studies on the effect of Cissus quadrangularis in accelerating fracture healing.Indian J. Med. Res.1964522635 14112159
     [Google Scholar]
  27. BenjawanS. NimitphongH. TragulpiankitP. MusigavongO. PrathanturarugS. PathomwichaiwatT. The effect of Cissus quadrangularis L. on delaying bone loss in postmenopausal women with osteopenia: A randomized placebo-controlled trial.Phytomedicine202210115411510.1016/j.phymed.2022.154115
     [Google Scholar]
  28. ParisuthimanD. SinghatanadgitW. DechatiwongseT. KoontongkaewS. Cissus quadrangularis extract enhances biomineralization through up-regulation of MAPK-dependent alkaline phosphatase activity in osteoblasts. In Vitro Cell. Dev. Biol. Anim.2009453-419420010.1007/s11626‑008‑9158‑1 19057968
     [Google Scholar]
  29. BhagathK.P. BhatK.M. RaoM.S. Petroleum ether extract of Cissusqua drangularis L. Enhance bone marrow mesenchymal stem cell proliferation and facilitates osteoblastogenesis.J Clin Sci2009641099399810.1590/S1807‑59322009001000010
     [Google Scholar]
  30. NathR. KarB.K. DhadiwalR.K. DaftaryG.V. KhemnarB.M. PatilN.N. Role of Cissus quadrangularis in bone loss pathologies.Int J Orthop Sci202410119620110.22271/ortho.2024.v10.i1c.3521
     [Google Scholar]
  31. KumarM. RawatP. DixitP. Anti-osteoporotic constituents from Indian medicinal plants.Phytomedicine2010171399399910.1016/j.phymed.2010.03.014 20554183
     [Google Scholar]
  32. TiwariM. GuptaP.S. SharmaN. Ethnopharmacological, phytochemical and pharmacological review of plant Cissus quadrangularis L.J. Pharmacogn. Phytochem.2018101819010.5958/0975‑4385.2018.00014.6
     [Google Scholar]
  33. AyyanarM. IgnacimuthuS. Pharmacological actions of Cassia auriculata L. and Cissus quadrangularis: A short review.J Pharmacol Toxicol20083321322110.3923/jpt.2008.213.221
     [Google Scholar]
  34. PandeyS. ParmarS. ShuklaM.S. Phytochemical and pharmacological investigation of Cissus quadrangularis L.Herb Med J2022726167
     [Google Scholar]
  35. ObenJ. KuateD. AgborG. MomoC. TallaX. The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome.Lipids Health Dis.20065124
     [Google Scholar]
  36. RossS.M. Metabolic syndrome: A proprietary extract of Cissus quadrangularis formulation in the management of metabolic syndrome, weight loss, and central obesity.Holist. Nurs. Pract.201226422823010.1097/HNP.0b013e31825b192a 22694868
     [Google Scholar]
  37. ObenJ.E. EnyegueD. FomekongG.I. SoukontouaY.B. AgborG.A. The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity-induced oxidative stress.Lipids Health Dis.200761410.1186/1476‑511X‑6‑4 17274828
     [Google Scholar]
  38. NashR. AzantsaB. KuateD. SinghH. ObenJ. The use of a stem and leaf aqueous extract of Cissus quadrangularis (CQR-300) to reduce body fat and other components of metabolic syndrome in overweight participants.J. Altern. Complement. Med.20192519810610.1089/acm.2018.0016 29912570
     [Google Scholar]
  39. Hasani-RanjbarS. NayebiN. LarijaniB. AbdollahiM.A. A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity.World J. Gastroenterol.200915253073308510.3748/wjg.15.3073
     [Google Scholar]
  40. KuateD. NashR.J. BartholomewB. PenkovaY. The use of Cissus quadrangularis in the management of components of metabolic syndrome in obese participants.Nat. Prod. Commun.201510712811286 26411031
     [Google Scholar]
  41. RexM.C. RaviL. A review on Cissus quadrangularis L. as herbal medicine.Indian J. Nat. Prod. Resour.2020113155164
     [Google Scholar]
  42. JainuM. DeviC.S. Effect of Cissus quadrangularis on gastric mucosal defensive factors in experimentally induced gastric ulcer-a comparative study with sucralfate.J. Med. Food20047337237610.1089/jmf.2004.7.372 15383234
     [Google Scholar]
  43. BorrelliF. IzzoA.A. The plant kingdom as a source of anti-ulcer remedies.Phytother. Res.2000148581591 11113992
     [Google Scholar]
  44. AustinA. JagdeesanM. Gastric and duodenal antiulcer and cytoprotective effects of Cissus quadrangularis L. varian II in rats.Niger. J. Nat. Prod. Med.200261014
     [Google Scholar]
  45. JainuM. DeviC.S. Gastroprotective action of Cissus quadrangularis extract against NSAID induced gastric ulcer: Role of proinflammatory cytokines and oxidative damage.Chem. Biol. Interact.2006161326227010.1016/j.cbi.2006.04.011 16797507
     [Google Scholar]
  46. JainuM. DeviC.S.S. Attenuation of neutrophil infiltration and proinflammatory cytokines by Cissus quadrangularis: A possible prevention against gastric ulcerogenesis.J. Herb. Pharmacother.200953334210.1080/J157v05n03_04 16520296
     [Google Scholar]
  47. SarkarB.K. KumarR. KumarP. MandalP. BhusanV. Formulation and evaluation of anti inflammatory herbal topical formulation of Cissus quadrangularis L.World J. Pharm. Res.201653681689
     [Google Scholar]
  48. SingS.P. MisraN. DixitK.S. An experimental study of analgesic activity of Cissus quadrangularis.Indian J. Pharmacol.1984163162163
     [Google Scholar]
  49. BhujadeA.M. TalmaleS. KumarN. Evaluation of Cissus quadrangularis extracts as an inhibitor of COX, 5-LOX, and proinflammatory mediators.J. Ethnopharmacol.2012141398999610.1016/j.jep.2012.03.044 22484053
     [Google Scholar]
  50. SrisookK. PalachotM. MongkolN. SrisookE. SarapusitS. Anti-Inflammatory effect of ethyl acetate extract from Cissus quadrangularis Linn may be involved with induction of heme oxygenase-1 and suppression of NF-κB activation.J. Ethnopharmacol.201113331008101410.1016/j.jep.2010.11.029
     [Google Scholar]
  51. SrivastavaA.K. SrivastavaP. MishraJ.N. SinghM.P. SharmaA.K. ShrivastavaA.K. Antidiabetic activity of the stem extracts of Cissus quadrangularis Linn.J. Pharm. Res.201141138733874
     [Google Scholar]
  52. ArunagiriS. SrinivasanK.R. Anti-hyperglycemic acitivity of ethonalic extract of stem Cissus quadrangularis in Streptozotocin induced experimental diabetic rats.J Morphol Sci2022396110.51929/jms.39.60.2022
     [Google Scholar]
  53. LekshmiR.K. SreekuttyM.S. MiniS. The regulatory effects of Cissus quadrangularis on some enzymes involved in carbohydrate metabolism in streptozotocin-induced diabetic rats.Pharm. Biol.20155381194120010.3109/13880209.2014.970286
     [Google Scholar]
  54. AbaP.E. Asuzu1 IU. Mechanism of actions of some bioactive anti-diabetic activity principles from phytochemicals of medicinal plants.Indian J. Nat. Prod. Resour.2018928596
     [Google Scholar]
  55. Chidambara MurthyK.N. VanithaA. Mahadeva SwamyM. RavishankarG.A. Antioxidant and antimicrobial activity of Cissus quadrangularis L.J. Med. Food2003629910510.1089/109662003322233495 12935320
     [Google Scholar]
  56. JainuM. DeviC.S. In Vitro and In Vivo. Evaluation of free-radical scavenging potential of Cissus quadrangularis.Pharm. Biol.2013439773779
     [Google Scholar]
  57. KuppuramalingamP.A. RameshB. Antioxidant activity of Cissus quadrabgularis L stem in-vitro.World J. Pharm. Res.2018711759765
     [Google Scholar]
  58. KumarR. SharmaA.K. SarafS.A. GuptaR. CNS activity of aqueous extract of root of Cissus quadrangularis Linn. (Vitaceae).J. Diet. Suppl.2010711810.3109/19390210903534962 22435569
     [Google Scholar]
  59. MotoF.C.O. Arsa’aA. NgoupayeG.T. Anxiolytic and antiepileptic properties of the aqueous extract of Cissus quadrangularis (Vitaceae) in mice pilocarpine model of epilepsy.Front. Pharmacol.2018975110.3389/fphar.2018.00751 30065650
     [Google Scholar]
  60. SwamyA.V. ThippeswamyA.H. ManjulaD.V. KumarC.M. Some neuropharmacological effects of the methanolic root extract of Cissus quadrangularis in mice.Afr. J. Biomed. Res.2006926975
     [Google Scholar]
  61. MundadaS.J. AgrawalA. DewadeD.R. AdeH.R. Central nervous system depressant activity of aqueous extract of Cissus quadrangularis.Int. J. Biomed. Res.20101141145
     [Google Scholar]
  62. ChauhanR. Exploring neuroprotective potential of Cissus quadrangularis plant extract in Parkinson’s disease.Int J Green Pharm2023173205224
     [Google Scholar]
  63. RajA.J. SelvarajA. GopalakrishnanV.K. DorairajS. Antimicrobial profile of Cissus quadrangularis.J Herbal Med Toxicol201042177180
     [Google Scholar]
  64. KashikarN.D. GeorgeI.A. Antibacterial activity of Cissus quadrangularis Linn.Indian J. Pharm. Sci.2006682245247
     [Google Scholar]
  65. MosaibM.G. MarufM.A. IslamR. Antibacterial activity of Cissus quadrangularis stem extract on the pathogenic and industrial waste watered bacteria.Eur J Health Sci202022283810.34104/ejmhs.020.28038
     [Google Scholar]
  66. MerinalS. VijiS.B. In-vitro screening of antimicrobial potentials of Cissus quadrangularis L.Asian J. Plant Sci.201225862
     [Google Scholar]
  67. KonéW.M. AtindehouK.K. TerreauxC. HostettmannK. TraoréD. DossoM. Traditional medicine in North Côte-d’Ivoire: Screening of 50 medicinal plants for antibacterial activity.J. Ethnopharmacol.2004931434910.1016/j.jep.2004.03.006 15182903
     [Google Scholar]
  68. ZenebeS. FeyeraT. AssefaS. In-vitro anthelmintic activity of crude extracts of aerial parts of Cissus quadrangularis L. and leaves of Schinus molle L. against Haemonchus contortus.BioMed Res. Int.201720171190598710.1155/2017/1905987
     [Google Scholar]
  69. MohanambalE. ShobanaK. Sowmya SreeM. KusumaG.M. SatishK. VijayakumarB. Isolation of alcoholic extract of Cissus quadrangularis and evaluation of in vitro anthelmintic activity.Int. J. Novel Trends Pharm. Sci.2011169
     [Google Scholar]
  70. KakadeA. DangeY. PatilP. A review on Cissus quadrangularis and evaluation of its in-vitro anthelmintic activity.J. Pharm. Sci.20143124153
     [Google Scholar]
  71. PathakA.K. KambhojaS. DhruvS. SinghH.P. ChandH. Anthelimintic activity of Cissus quadraangularis Linn stem.Pharmacologyonline201031518
     [Google Scholar]
  72. PatilP. PatelJ.K. KulkarniP.S. PatelM.U. BhavsarC.J. PatelJ.A. In-vitro anthelmintic activity of various herbal plants extracts against Pheritima posthuma.Res J Pharmacogn Phytochem201023234237
     [Google Scholar]
  73. Ahmadi PirshahidP. ThisayakornC. HemthanonT. Anti-hemorrhoid activities from Cissus quadrangularis L.In: XXIX International Horticultural Congress on Horticulture: Sustaining Lives, Livelihoods and Landscapes (IHC2014): V World 11252014161172
     [Google Scholar]
  74. BamrahT.K. AnsariM.H. MahapatraD.K. Perspectives of Nature-oriented pharmacotherapeutics for the effectual management of hemorrhoidal symptoms.Applied Pharmaceutical Practice and Nutraceuticals.Apple Academic Press20211637910.1201/9781003054894‑11
     [Google Scholar]
  75. ChengB. WeiY. GuerraL. Anti-cancer effect of Cissus quadrangularis on human glioblastoma cells.RPS Pharm. Pharmacol. Rep.202322rqad01410.1093/rpsppr/rqad014
     [Google Scholar]
  76. DhanasekaranS. Phytochemical characteristics of aerial part of Cissus quadrangularis (L) and its in-vitro inhibitory activity against leukemic cells and antioxidant properties.Saudi J. Biol. Sci.20202751302130910.1016/j.sjbs.2020.01.005 32346339
     [Google Scholar]
  77. RuskinR.S. Priya KumariV.M. GopukumarS.T. PraseethaP.K. Evaluation of phytochemical, anti-bacterial and anti-cancerous activity of Cissus quadrangularis from South-Western ghats regions of India.Int. J. Pharm. Sci. Rev. Res.20142811215
     [Google Scholar]
  78. VijayalakshmiA. KumarP.R. Sakthi PriyadarsiniS. MeenaxshiC. In-vitro antioxidant and anticancer activity of flavonoid fraction from the aerial parts of Cissus quadrangularis Linn. against human breast carcinoma cell lines.J. Chem.20132013115067510.1155/2013/150675
     [Google Scholar]
  79. NaliniG. Vinoth PrabhuV. ChidambaranathanN. JeyasundariK. Evaluation of anti-tumour activity of Cissus quadrangularis L. against Dalton’s ascitic lymphoma and Erlich ascetic induced carcinoma in mice.Int. J. Pharm. Sci. Rev. Res.2011817590
     [Google Scholar]
  80. SrisookK. PalachotM. MongkolN. SrisookE. SarapusitS. Anti-inflammatory effect of ethyl acetate extract from Cissus quadrangularis Linn may be involved with induction of heme oxygenase-1 and suppression of NF-κB activation.J. Ethnopharmacol.201113331008101410.1016/j.jep.2010.11.029 21094244
     [Google Scholar]
  81. SyedA.A. ShafiqM. RezaM.I. Ethanolic extract of Cissus quadrangularis improves vasoreactivity by modulation of eNOS expression and oxidative stress in spontaneously hypertensive rats.Clin. Exp. Hypertens.2022441637110.1080/10641963.2021.1991942 34648416
     [Google Scholar]
  82. NalavadeS.P. PandhareY.L. SulS.R. ThakurD.S. Research on “Cardiotonic activity of ethanolic extract of Cissus quadrangularis Linn”.World J. Pharm. Res.2022111541178
     [Google Scholar]
  83. LusebaD. ElgorashE.E. NtloedibeD.T. StadenJ.V. Antibacterial, anti-inflammatory and mutagenic effects of some medicinal plants used in South Africa for the treatment of wounds and retained placenta in livestock.S Afr J200773337838310.1016/j.sajb.2007.03.003
     [Google Scholar]
  84. SyedA.A. RezaM.I. KalletiN. Evaluation of mutagenic, cytotoxic, mitochondrial dysfunction, apoptotic activity, and acute toxicity of ethanolic extract of Cissus quadrangularis.Toxicology202348315337310.1016/j.tox.2022.153373 36370889
     [Google Scholar]
  85. MalathiA.N. Nutritive value of mangoravalli (Cissus quadrangularis) powder and its value addition.Curr Trends Tech Sci201433223225
     [Google Scholar]
  86. AgborG.A. KuateD. ObenJ.E. Medicinal plants can be good source of antioxidants: Case study in Cameroon.Pak. J. Biol. Sci.200710453754410.3923/pjbs.2007.537.544
     [Google Scholar]
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Exploring the Phytochemical Composition and Pharmacological Potential of the Plant Cissus quadrangularis in Herbal Formulations
Curr Func Foods 4, e26668629350836 (2026); https://doi.org/10.2174/0126668629350836250213044151
/content/journals/cff/10.2174/0126668629350836250213044151
/content/journals/cff/10.2174/0126668629350836250213044151
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  • Article Type:     Review Article
Keyword(s): antioxidant activity; bone healing; Cissus quadrangularis; herbal formulations; pharmacological potential; phytochemical composition

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