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In the traditional system of medicine, medicinal herbs play an important role in human health and have a variety of therapeutic characteristics. F. benjamina is a popular ornamental and household plant, belonging to the family Moraceae, which usually grows under mild to moderate temperature conditions. This review highlights the morphological studies, cultivation, collection, traditional uses, chemical constituents, phytochemistry of major constituents, and pharmacological properties of F. benjamina. To identify all the related published studies, PubMed, Scopus, Embase, Web of Science, MEDLINE, Google Scholar, and ScienceDirect databases were searched using all available terms for F. benjamina. This article systematically reviews the various pharmacological activities of this plant, such as antibacterial, antifungal, antiviral, antioxidant, hepatoprotective, antidiabetic, anticancer, anticonvulsant, and hemolytic activities. This plant has been used in herbal medicine for the treatment of various diseases, such as skin disorders, inflammation, wounds, lesions and ulcers, malaria, constipation, leprosy, and cancer. This plant has also been used as an insect repellent and air purifier. Chemically, it contains several phytoconstituents, for e.g., triterpenes, cinnamic acid, lactose, quercetin, caffeic acid, stigmasterol, lutein, sitosterol, chlorophyll-A, phytol, fatty alcohols, triglycerides, fatty acids, essential oils, flavone glycosides, isoflavonoids, and chlorogenic, p-coumaric, and ferulic acids. F. benjamina has been suggested to play a vital role in the prevention and treatment of chronic diseases, like cancer, diabetes, and epilepsy. This updated review may help many researchers carry out further investigations on this medicinal plant.