Buccoadhesive Dosage Form Containing Antifungal Agent for Treating Oropharyngeal Candidiasis: A Review

Oral candidiasis is a common fungal infection in patients with an impaired immune system, such as those undergoing chemotherapy for cancer and patients with AIDS (Acquired immune deficiency syndrome). The majority of infections are due to Candida albicans although other species such as Candida glabrata, Candida tropicalis, Candida krusei and Candida parapsilosis are increasingly isolated. The objective of this article is to review candidiasis, types of candidiasis, discussing the structure and environment and permeability of the oral mucosa. Buccoadhesive drug delivery will also be reviewed with an emphasis on Bioadhesion, theories of Bioadhesion, investigated mucoadhesive polymer's and Buccoadhesive tablet/film containing antifungal agent for treating oropharyngeal candidiasis.