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Abstract

Coronavirus disease 2019 (COVID-19), which led to a global pandemic causing millions of deaths, is caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). While previous research on COVID-19 has primarily utilized nasal swabs and blood samples, these do not provide comprehensive insights into all the organ systems affected by the infection. A recent study by Topper addressed this gap by analyzing both nasal samples and autopsy tissues from SARS-CoV-2-infected individuals. Their findings highlight a significant role of mitochondrial damage pathways and RAAS overactivation in contributing to the severity of SARS- CoV-2 infections. Importantly, targeting mitochondrial dysfunction and RAAS overactivation pathways may offer promising and specific druggable targets for treating COVID-19 patients.

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2025-05-27
2025-09-14

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RAAS Overactivation and Mitochondrial Damage Signaling as Key Players in Lethal COVID-19
Bentham Science Publishers ; https://doi.org/10.2174/0113894501387212250525161808
/content/journals/cdt/10.2174/0113894501387212250525161808
/content/journals/cdt/10.2174/0113894501387212250525161808
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  • Article Type:     Review Article
Keywords: mitochondrial dysfunction ; mitochondrial damage ; SARS-CoV-2 ; RAAS overactivation ; Aldosterone, COVID-19

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