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2000
Volume 21, Issue 10
  • ISSN: 1573-3998
  • E-ISSN: 1875-6417

Abstract

Background/Introduction

Albuminuria in Diabetes mellitus (DM) patients may lead to nephropathy and end-stage renal disease. Our study aimed to assess the prevalence of albuminuria and its associated predictors among type 2 DM patients in the United Arab Emirates.

Methods

A retrospective cross-sectional study was conducted among type 2 DM patients in the diabetic clinic at Fujairah Hospital from 1st January 2016 to 30th January 2020 after getting the ethical clearance. Data were collected electronically from the health information system and analyzed using SPSS version 26. Regression analysis and ANOVA were used for inferential analysis. A -value of ≤0.05 was considered significant.

Results and Discussion

Among the 200 patients included in the study, the mean age of the study population was 56 years, and the majority of them were females (71%). The prevalence of albuminuria was found to be 44%. By using regression analysis, glycated hemoglobin (HbA1c; 0.038) and systolic blood pressure (SBP; 0.003) were found to be predictors of albuminuria. One way ANOVA revealed that there were significant associations between the albumin levels and HbA1c (0.004), SBP ( 0.002), diastolic blood pressure (DBP; 0.028), serum creatinine (Scr) (0.039), and glomerular filtration rate (GFR; 0.013).

Conclusion

To the best of our knowledge, this is the first study from Fujairah emirate that explored the prevalence and predictors of albuminuria in type 2 DM patients. We found a high prevalence of albuminuria among type 2 DM patients. HbA1c and SBP directly contributed to albuminuria. To improve glycemic control, patients need to improve physical activity, reduce overweight and, adherence to medications that improve overall therapeutic outcomes.

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2025-09-05

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References

  1. International Diabetes Federation.IDF Diabetes Atlas.10th edBrussels, BelgiumAvailable from: https://www.diabetesatlas.org 2021
     [Google Scholar]
  2. KareemI. JaweedS.A. BardapurkarJ.S. PatilV.P. Study of magnesium, glycosylated hemoglobin and lipid profile in diabetic retinopathy.Indian J. Clin. Biochem.200419212412710.1007/BF02894270 23105469
     [Google Scholar]
  3. KikkawaR KoyaD HanedaM Progression of diabetic nephropathy.Am J Kidney Dis2003413)(S1S192110.1053/ajkd.2003.5007712612945
     [Google Scholar]
  4. RitzE. RychlíkI. LocatelliF. HalimiS. End-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions.Am. J. Kidney Dis.199934579580810.1016/S0272‑6386(99)70035‑1 10561134
     [Google Scholar]
  5. National Kidney FoundationKDOQI, clinical practice guidelines and clinical practice recommendations for diabetes and chronic kidney disease.Am. J. Kidney Dis.200749S2S12S15410.1053/j.ajkd.2006.12.005 17276798
     [Google Scholar]
  6. NathanD.M. GenuthS. LachinJ. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus.N. Engl. J. Med.19933291497798610.1056/NEJM199309303291401 8366922
     [Google Scholar]
  7. UK Prospective Diabetes Study (UKPDS) GroupEffect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34).Lancet1998352913185486510.1016/S0140‑6736(98)07037‑8 9742977
     [Google Scholar]
  8. StrattonIM Association of glycemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35).Prospective observational study200032140512
     [Google Scholar]
  9. Al-MaskariF. El-SadigM. ObinecheE. Prevalence and determinants of microalbuminuria among diabetic patients in the United Arab Emirates.BMC Nephrol.2008911810.1186/1471‑2369‑9‑1 18230135
     [Google Scholar]
  10. World Health OrganizationPhysical activity.2020Available from: https://www.who.int/news-room/fact-sheets/detail/physical-activity
  11. National Kidney FoundationAlbuminuria.Available from: https://www.kidney.org/atoz/content/albuminuria
  12. Use of Glycated Haemoglobin (HbA1c) in the diagnosis of diabetes mellitus.Available from: https://apps.who.int/iris/bitstream/handle/10665/70523/WHO_NMH_CHP_CPM_11.1_eng.pdf
  13. National Kidney FoundationK/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification.Am J Kidney Dis2002392)(S1S1S26611904577
     [Google Scholar]
  14. PerkovicV. HeerspinkH.L. ChalmersJ. Intensive glucose control improves kidney outcomes in patients with type 2 diabetes.Kidney Int.201383351752310.1038/ki.2012.401 23302714
     [Google Scholar]
  15. ArmanRS BelagoduSS GMRP Prevalence and associations of moderately increased albuminuria in patients with type 2 diabetes in United Arab Emirates.Diabetes Metab. Syndr.20201461865187010.1016/j.dsx.2020.09.021 32980790
     [Google Scholar]
  16. ShengC.S. LiuM. ZouJ. HuangQ.F. LiY. WangJ.G. Albuminuria in relation to the single and combined effects of systolic and diastolic blood pressure in Chinese.Blood Press.201322315816410.3109/08037051.2012.748998 23244371
     [Google Scholar]
  17. MaQ. LiuH. XiangG. ShanW. XingW. Association between glycated hemoglobin A1c levels with age and gender in Chinese adults with no prior diagnosis of diabetes mellitus.Biomed. Rep.20164673774010.3892/br.2016.643 27284415
     [Google Scholar]
  18. ZhangF.L. XingY.Q. GuoZ.N. WuY.H. LiuH.Y. YangY. Prevalence and risk factors for diabetes and impaired fasting glucose in Northeast China: Results from the 2016 China national stroke screening survey.Diabetes Res. Clin. Pract.2018144302313
     [Google Scholar]
  19. GongQ. GreggE.W. WangJ. Long-term effects of a randomised trial of a 6-year lifestyle intervention in impaired glucose tolerance on diabetes-related microvascular complications: the china da qing diabetes prevention outcome study.Diabetologia201154230030710.1007/s00125‑010‑1948‑9 21046360
     [Google Scholar]
  20. LiG. ZhangP. WangJ. The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study.Lancet200837196261783178910.1016/S0140‑6736(08)60766‑7 18502303
     [Google Scholar]
  21. SahaT.K. BhattaraiA.M. BatraH.S. BanerjeeM. MisraP. AmbadeV. Correlation of microalbuminuria with estimated GFR (eGFR) by Cockcroft–gault and MDRD formula in type 2 diabetics and hypertensives.Indian J. Clin. Biochem.201530327127410.1007/s12291‑014‑0439‑z 26089611
     [Google Scholar]
  22. AbdelsalamK.A. Correlation between urea level and HbA1c level in type 2 diabetic patients.Sub Med Lab2011116
     [Google Scholar]
  23. KoppeL. PelletierC.C. AlixP.M. Insulin resistance in chronic kidney disease: new lessons from experimental models.Nephrol. Dial. Transplant.20142991666167410.1093/ndt/gft435 24286973
     [Google Scholar]
  24. D’ApolitoM. DuX. ZongH. Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure.J. Clin. Invest.2010120120321310.1172/JCI37672 19955654
     [Google Scholar]
  25. XieY. BoweB. LiT. XianH. YanY. Al-AlyZ. Higher blood urea nitrogen is associated with increased risk of incident diabetes mellitus.Kidney Int.201893374175210.1016/j.kint.2017.08.033 29241622
     [Google Scholar]
  26. HaqueN. DebnathB.C. IbrahimM. SirajuddinK. MajumderM. HossainM.S. Association of HbA1c with urinary ACR & eGFR in Type-2 diabetes mellitus.Pulse20145161110.3329/pulse.v5i1.20183
     [Google Scholar]
  27. GallM.A. NielsenF.S. SmidtU.M. ParvingH.H. The course of kidney function in Type 2 (non-insulin-dependent) diabetic patients with diabetic nephropathy.Diabetologia199336101071107810.1007/BF02374501 8243857
     [Google Scholar]
  28. AsifM. The prevention and control the type-2 diabetes by changing lifestyle and dietary pattern.J. Educ. Health Promot.201431110.4103/2277‑9531.127541 24741641
     [Google Scholar]
  29. ControlT.D. GroupC.D. Effect of intensive therapy on the development and progression of diabetic nephropathy in the Diabetes Control and Complications Trial.Kidney Int.19954761703172010.1038/ki.1995.236 7643540
     [Google Scholar]
  30. NelsonR.G. KnowlerW.C. PettittD.J. SaadM.F. CharlesM.A. BennettP.H. Assessment of risk of overt nephropathy in diabetic patients from albumin excretion in untimed urine specimens.Arch. Intern. Med.199115191761176510.1001/archinte.1991.00400090057011 1888242
     [Google Scholar]
  31. ClausenT.D. MathiesenE. EkbomP. HellmuthE. Mandrup-PoulsenT. DammP. American Diabetes Association: Standards of medical care in diabetes (Position Statement).Diabetes Care2005281S4S36
     [Google Scholar]
  32. MogensenC.E. AndersenM.J.F. Increased kidney size and glomerular filtration rate in untreated juvenile diabetes: Normalization by insulin-treatment.Diabetologia197511322122410.1007/BF00422325 1149954
     [Google Scholar]
  33. SchmitzA. Hvid HansenH. ChristensenT. Kidney function in newly diagnosed type 2 (non-insulin-dependent) diabetic patients, before and during treatment.Diabetologia198932743443910.1007/BF00271263 2806767
     [Google Scholar]
  34. VargheseA. DeepaR. RemaM. MohanV. Prevalence of microalbuminuria in type 2 diabetes mellitus at a diabetes centre in southern India.Postgrad. Med. J.20017790839940210.1136/pmj.77.908.399 11375456
     [Google Scholar]
  35. HuraibS. Abu-AishaH. SulimaniR.A. The pattern of diabetic nephropathy among Saudi patients with noninsulin-dependent diabetes mellitus.Ann. Saudi Med.199515212012410.5144/0256‑4947.1995.120 17587920
     [Google Scholar]
  36. MartensR.J.H. van der BergJ.D. StehouwerC.D.A. Amount and pattern of physical activity and sedentary behavior are associated with kidney function and kidney damage: The Maastricht Study.PLoS One2018134e019530610.1371/journal.pone.0195306 29617428
     [Google Scholar]
  37. American Diabetes AssociationStandards of medical care in diabetes.Diabetes Care200528S1S4S3610.2337/diacare.28.suppl_1.S4 15618112
     [Google Scholar]
/content/journals/cdr/10.2174/1573399819666221014093352
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Prevalence and Predictors of Albuminuria in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study from the United Arab Emirates
Curr. Diabetes Rev. 21, E141022209956 (2025); https://doi.org/10.2174/1573399819666221014093352
/content/journals/cdr/10.2174/1573399819666221014093352
/content/journals/cdr/10.2174/1573399819666221014093352
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  • Article Type:     Research Article
Keyword(s): Albuminuria; end-stage renal disease; hemoglobin A1c; nephropathy; systolic blood pressure; type 2 diabetes

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