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2000
Volume 22, Issue 1
  • ISSN: 1573-3998
  • E-ISSN: 1875-6417
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Abstract

Introduction

(), commonly known as Alfalfa, is a herb from the Fabaceae family that has a long history of being used to treat digestive, diabetic, and blood disorders, as well as to support liver health. The objective was to evaluate the effects of ethanolic extract of (EEMS) on wounds in normal rats or alloxan hydrate-induced diabetic rats.

Methods

The wounds were created by excision (n=30) and incision (n=30) in rats. The Group II-V were diabetic rats treated with simple ointment BP, 10% weight-based povidone-iodine (10% PI), ointment of 5% w/w EEMS (5% w/w OEEMS), and 10% w/w EEMS (10% w/w OEEMS). Group 1 acted as a control and was treated with simple ointment BP. The wound area in the diabetic control groups was 292.33 ± 0.8 mm2 on the 18th day.

Results

Rats treated with 10% PI, 5% OEEMS, and 10% OEEMS showed a significant reduction in wound area of 68.33 ± 1.29, 248.33 ± 1.30, and 61 ± 1.91 mm2, respectively, on the 18th day as compared to the control group. Rats treated with 10% PI, 5% w/w OEEMS, and 10% w/w OEEMS showed a significant increment in wound-breaking strength, respectively, as compared to diabetic rats on day 10 in the incision wound model.

Conclusion

The results demonstrated that the OEEMS has potent wound-healing properties in diabetic rats.

© 2026 The Author(s). Published by Bentham Science Publishers.
This is an open access article published under CC BY 4.0 https://creativecommons.org/licenses/by/4.0/legalcode
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2026-02-19

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Protective Effect of Medicago sativa L. (Fabaceae) against Excision and Incision Wound Models in Diabetic Rats
Curr. Diabetes Rev. 22, E15733998345972 (2026); https://doi.org/10.2174/0115733998345972250117103918
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  • Article Type:     Research Article
Keyword(s): alfalfa; diabetic rats; excision wound; incision wound; Medicago sativa; wound healing

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