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- ISSN: 1389-2002
- E-ISSN: 1875-5453
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Indoleamine 2,3-Dioxygenase in Materno-Fetal Interaction
- Source: Current Drug Metabolism, Volume 8, Issue 3, Apr 2007, p. 205 - 208
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- 01 Apr 2007
Abstract
The mechanism of maternal immunotolerance of the semiallogeneic fetus has been a matter of intense investigation. The tryptophan- degrading enzyme indoleamine 2,3-dioxygenase (IDO) is reported to be critically implicated. This article discusses findings pertaining to the role of IDO in pregnancy, its location at the feto-maternal interface, systemic induction of IDO in pregnancy and the association of IDO to spontaneous abortion and preeclampsia. Whereas there is a large body of evidence supporting the relevance of IDO as a key immunoregulatory factor in feto-maternal tolerance, open questions remain concerning as to its role.
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