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image of Synthesis and Antimicrobial Activity of Silver/Copper Oxide/Clay Hybrid Nanocomposites Against Gram-Positive and Gram-Negative Bacteria

Abstract

Background

The rapid surge in bacterial resistance to classical antibiotics and antimicrobial agents has driven researchers to identify new classes of antimicrobial agents. At the nanoscale, nanotechnological progress has strongly underscored the application of silver and copper since they present high antimicrobial activities toward gram-positive and gram-negative bacteria. Nanostructures containing these two elements-all the more so for hybrid nanocomposites—have been scantily the subject of investigated. The present work aims to develop and study a silver/copper oxide/clay hybrid nanocomposite.

Methods

Nanocomposites of silver, copper oxide, and their hybrid with clay were synthesized chemical precipitation under controlled pH (9-11) and temperature (60–90°C) conditions. The antibacterial activity was assessed using standard 0.5 McFarland-adjusted bacterial inocula. Characterization was performed using FTIR, XRD, FESEM, and TEM techniques. MIC and MBC were determined through serial dilution, and data were analyzed using one-way ANOVA and Tukey’s test (SPSS v26).

Results

The results indicated that the fabricated nanocomposite was impure, with nanosilver particles measuring 30–40 nm and copper oxide particles measuring 200–250 nm. The morphological properties of synthesized Ag/CuO/clay nanocomposites were evaluated using X-ray diffractometer analysis. The minimum inhibitory concentration (MIC) of the hybrid nanocomposite against and was 1024 μg/ml, and for and 2048 μg/ml. The minimum bactericidal concentration (MBC) against and was 4096 μg/ml, and for 4096 μg/ml, and 8192 μg/ml.

Conclusion

These results showed that the antimicrobial property of silver/copper/clay hybrid nanocomposite was better than copper/silver and clay nanocomposite against gram-positive bacteria, while showing a similar effect against gram-negative bacteria.

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2025-06-24
2025-09-15

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Synthesis and Antimicrobial Activity of Silver/Copper Oxide/Clay Hybrid Nanocomposites Against Gram-Positive and Gram-Negative Bacteria
Bentham Science Publishers ; https://doi.org/10.2174/0113892002392051250612052515
/content/journals/cdm/10.2174/0113892002392051250612052515
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  • Article Type:     Research Article
Keywords: Staphylococcus aureus ; copper ; Escherichia coli ; Pseudomonas aeruginosa ; antimicrobial activity ; nanoclay ; Hybrid nanocomposite ; Bacillus subtilis ; silver

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