Skip to content
2000
Volume 4, Issue 1
  • ISSN: 2542-579X
  • E-ISSN: 2542-5803

Abstract

This study adopts a comprehensive approach to gathering relevant information. A thorough literature search included research articles, clinical studies, and reviews of the application of chitosan in dentistry. The selected sources were critically analyzed to identify key trends, outcomes, and advancements in the field. Chitosan, derived from chitin, has remarkable versatility in dental applications. It holds promise in multiple areas, including endodontic therapy, periodontal treatment, implant dentistry, oral surgery, and as an ingredient in restorative dental materials. Of note is the potential for dental pulp regeneration, which offers a promising avenue for tissue engineering in dentistry. This review revealed that the multifaceted properties of chitosan contribute to its ability to address a wide array of dental challenges, from root canal treatment to combating periodontal diseases and enhancing implant success rates. This review highlights the significant impact of chitosan on the reshaping of modern dental practices. Furthermore, by highlighting its versatile applications and potential benefits, this study contributes to our understanding of the transformative role of chitosan in dentistry. These findings emphasize the need for further research and exploration to unlock the full potential of chitosan, ultimately paving the way for innovative solutions to longstanding dental issues. As the capabilities of chitosan continue to evolve, it holds the potential to redefine dental care standards and establish itself as a cornerstone for future dental therapies.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cdent/10.2174/012542579X302181240821103605
2024-08-27
2025-09-02

  • From This Site

    /content/journals/cdent/10.2174/012542579X302181240821103605
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. DetschR. WillJ. HumJ. RoetherJ.A. BoccacciniA.R. Biomaterials.Learning Materials in Biosciences20189110510.1007/978‑3‑319‑74854‑2_6
     [Google Scholar]
  2. RahimiM. AhmadiR. Samadi KafilH. Shafiei-IrannejadV. A novel bioactive quaternized chitosan and its silver-containing nanocomposites as a potent antimicrobial wound dressing: Structural and biological properties.Mater. Sci. Eng. C201910136036910.1016/j.msec.2019.03.09231029329
     [Google Scholar]
  3. IacobA.T. LupascuF.G. ApotrosoaeiM. VasincuI.M. TauserR.G. LupascuD. GiuscaS.E. CaruntuI.D. ProfireL. Recent biomedical approaches for chitosan based materials as drug delivery nanocarriers.Pharmaceutics202113458710.3390/pharmaceutics1304058733924046
     [Google Scholar]
  4. SubhapradhaN. RamasamyP. ShanmugamV. MadeswaranP. SrinivasanA. ShanmugamA. Physicochemical characterisation of β-chitosan from Sepioteuthis lessoniana gladius.Food Chem.2013141290791310.1016/j.foodchem.2013.03.09823790866
     [Google Scholar]
  5. RamasamyP. SubhapradhaN. ThineshT. SelvinJ. SelvanK.M. ShanmugamV. ShanmugamA. Characterization of bioactive chitosan and sulfated chitosan from Doryteuthis singhalensis (Ortmann, 1891).Int. J. Biol. Macromol.20179968269110.1016/j.ijbiomac.2017.03.04128284937
     [Google Scholar]
  6. RamasamyP. SubhapradhaN. ShanmugamV. ShanmugamA. Extraction, characterization and antioxidant property of chitosan from cuttlebone Sepia kobiensis (Hoyle 1885).Int. J. Biol. Macromol.20146420221210.1016/j.ijbiomac.2013.12.00824333227
     [Google Scholar]
  7. VairamaniS. SubhapradhaN. RamasamyP. RaveendranS. SrinivasanA. ShanmugamA. Physicochemical characteristics and antioxidant efficacy of chitosan from the internal shell of spineless cuttlefish Sepiella inermis.Prep. Biochem. Biotechnol.201343769671610.1080/10826068.2013.77333923768114
     [Google Scholar]
  8. FakhriE. EslamiH. MaroufiP. PakdelF. TaghizadehS. GanbarovK. YousefiM. TanomandA. YousefiB. MahmoudiS. KafilH.S. Chitosan biomaterials application in dentistry.Int. J. Biol. Macromol.202016295697410.1016/j.ijbiomac.2020.06.21132599234
     [Google Scholar]
  9. Skoskiewicz-MalinowskaK. KaczmarekU. MalickaB. WalczakK. ZietekM. Application of chitosan and propolis in endodontic treatment: A review.Mini Rev. Med. Chem.201717541043410.2174/138955751666616041812251027087464
     [Google Scholar]
  10. del Carpio-PerochenaA. BramanteC.M. DuarteM.A.H. de MouraM.R. AouadaF.A. KishenA. Chelating and antibacterial properties of chitosan nanoparticles on dentin.Restor. Dent. Endod201540319520110.5395/rde.2015.40.3.19526295022
     [Google Scholar]
  11. BallalN.V. ShaviG.V. KumarR. KundabalaM. BhatK.S. In vitro sustained release of calcium ions and pH maintenance from different vehicles containing calcium hydroxide.J. Endod.201036586286610.1016/j.joen.2009.12.02120416434
     [Google Scholar]
  12. DraglandI.S. WellendorfH. KopperudH. StenhagenI. ValenH. Investigation on the antimicrobial activity of chitosan-modified zinc oxide-eugenol cement.Biomaterial Investigations in Dentistry2019619910610.1080/26415275.2019.169762131998877
     [Google Scholar]
  13. DucretM. MontembaultA. JosseJ. PasdeloupM. CelleA. BenchrihR. Mallein-GerinF. Alliot-LichtB. DavidL. FargesJ.C. Design and characterization of a chitosan-enriched fibrin hydrogel for human dental pulp regeneration.Dent. Mater.201935452353310.1016/j.dental.2019.01.01830712823
     [Google Scholar]
  14. AtiaG.A.N. ShalabyH.K. ZehraviM. GhobashyM.M. AttiaH.A.N. AhmadZ. KhanF.S. DeyA. MukerjeeN. AlexiouA. RahmanM.H. KlepackaJ. NajdaA. Drug-loaded chitosan scaffolds for periodontal tissue regeneration.Polymers20221415319210.3390/polym1415319235956708
     [Google Scholar]
  15. JoshiD. GargT. GoyalA.K. RathG. Advanced drug delivery approaches against periodontitis.Drug Deliv.201623236337710.3109/10717544.2014.93553125005586
     [Google Scholar]
  16. SilvaD. ArancibiaR. TapiaC. Acuña-RougierC. Diaz-DosqueM. CáceresM. MartínezJ. SmithP.C. Chitosan and platelet‐derived growth factor synergistically stimulate cell proliferation in gingival fibroblasts.J. Periodontal Res.201348667768610.1111/jre.1205323452122
     [Google Scholar]
  17. ArancibiaR. MaturanaC. SilvaD. TobarN. TapiaC. SalazarJ.C. MartínezJ. SmithP.C. Effects of chitosan particles in periodontal pathogens and gingival fibroblasts.J. Dent. Res.201392874074510.1177/002203451349481623788611
     [Google Scholar]
  18. ThangaveluA. StelinK.S. VannalaV. MahabobN. HayyanF.M.B. SundaramR. An overview of chitosan and its role in periodontics.J. Pharm. Bioallied Sci.202113Suppl. 1S15S1810.4103/jpbs.JPBS_701_2034447035
     [Google Scholar]
  19. MaQ. GaoY. SunW. CaoJ. LiangY. HanS. WangX. SunY. Self-Assembled chitosan/phospholipid nanoparticles: From fundamentals to preparation for advanced drug delivery.Drug Deliv.202027120021510.1080/10717544.2020.171687831983258
     [Google Scholar]
  20. MikušováV. MikušP. Advances in chitosan-based nanoparticles for drug delivery.Int. J. Mol. Sci.20212217965210.3390/ijms2217965234502560
     [Google Scholar]
  21. HaugenH.J. BasuP. SukulM. ManoJ.F. ReselandJ.E. Injectable biomaterials for dental tissue regeneration.Int. J. Mol. Sci.20202110344210.3390/ijms2110344232414077
     [Google Scholar]
  22. ChenY.W. LeeB.S. LeeC.C. WangY.P. ChenH.J. LaiC.H. HsiehW-L. Controlled-release of tetracycline and lovastatin by poly(D,L-lactide-co-glycolide acid)-chitosan nanoparticles enhances periodontal regeneration in dogs.Int. J. Nanomedicine201628528510.2147/IJN.S94270
     [Google Scholar]
  23. SharifianjaziF. KhaksarS. EsmaeilkhanianA. BazliL. EskandarinezhadS. SalahshourP. SadeghiF. RostamniaS. VahdatS.M. Advancements in fabrication and application of chitosan composites in implants and dentistry: A review.Biomolecules202212215510.3390/biom1202015535204654
     [Google Scholar]
  24. HallmannL. GerngroßM.D. Chitosan and its application in dental implantology.J. Stomatol. Oral Maxillofac. Surg.20221236e701e70710.1016/j.jormas.2022.02.00635183801
     [Google Scholar]
  25. HusainS. Al-SamadaniK.H. NajeebS. ZafarM.S. KhurshidZ. ZohaibS. QasimS.B. Chitosan biomaterials for current and potential dental applications.Materials201710660210.3390/ma1006060228772963
     [Google Scholar]
  26. Paradowska-StolarzA. MikulewiczM. LaskowskaJ. KarolewiczB. OwczarekA. The importance of chitosan coatings in dentistry.Mar. Drugs2023211261310.3390/md2112061338132934
     [Google Scholar]
  27. ZhangC. HuiD. DuC. SunH. PengW. PuX. LiZ. SunJ. ZhouC. Preparation and application of chitosan biomaterials in dentistry.Int. J. Biol. Macromol.20211671198121010.1016/j.ijbiomac.2020.11.07333202273
     [Google Scholar]
  28. KalyoncuogluU.T. YilmazB. GungorS. Evaluation of the chitosan-coating effectiveness on a dental titanium alloy in terms of microbial and fibroblastic attachment and the effect of aging.Mater. Tehnol.201549692593110.17222/mit.2014.239
     [Google Scholar]
  29. TakancheJ.S. KimJ.E. KimJ.S. LeeM.H. JeonJ.G. ParkI.S. YiH.K. Chitosan-gold nanoparticles mediated gene delivery of c-myb facilitates osseointegration of dental implants in ovariectomized rat.Artif. Cells Nanomed. Biotechnol.201846sup380781710.1080/21691401.2018.151394030307328
     [Google Scholar]
  30. AguilarA. ZeinN. HarmouchE. HafdiB. BornertF. OffnerD. ClaussF. FiorettiF. HuckO. Benkirane-JesselN. HuaG. Application of chitosan in bone and dental engineering.Molecules20192416300910.3390/molecules2416300931431001
     [Google Scholar]
  31. LiuH. WangC. LiC. QinY. WangZ. YangF. LiZ. WangJ. A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing.RSC Advances20188147533754910.1039/C7RA13510F35539132
     [Google Scholar]
  32. ChunB.D. KimS.W. LeeS.T. KimT.H. LeeJ.H. KimG.C. KimY-D. KimU-K. Interaction between odontoblast and bio-calcium phosphate cement reinforced with chitosan.J. Korean Assoc. Oral Maxillofac. Surg.201137541510.5125/jkaoms.2011.37.5.415
     [Google Scholar]
  33. de JesusG. MarquesL. ValeN. MendesR.A. The effects of chitosan on the healing process of oral mucosa: An observational cohort feasibility split-mouth study.Nanomaterials202313470610.3390/nano1304070636839074
     [Google Scholar]
  34. KmiecM. PighinelliL. TedescoMF. Chitosan-properties and applications in dentistry.Adv Tissue Eng Regen Med Open Access20172420521110.15406/atroa.2017.02.00035
     [Google Scholar]
  35. Notario-PérezF. Martín-IllanaA. Cazorla-LunaR. Ruiz-CaroR. VeigaM. Applications of chitosan in surgical and post-surgical materials.Mar. Drugs202220639610.3390/md2006039635736199
     [Google Scholar]
  36. SusantoA. SusanahS. PriosoeryantoB. SatariM. KomaraI. The effect of the chitosan-collagen membrane on wound healing process in rat mandibular defect.J. Indian Soc. Periodontol.201923211311810.4103/jisp.jisp_232_1830983781
     [Google Scholar]
  37. KimY. ZharkinbekovZ. RaziyevaK. TabyldiyevaL. BerikovaK. ZhumagulD. TemirkhanovaK. SaparovA. Chitosan-based biomaterials for tissue regeneration.Pharmaceutics202315380710.3390/pharmaceutics1503080736986668
     [Google Scholar]
  38. StewartC.A. FinerY. Biostable, antidegradative and antimicrobial restorative systems based on host-biomaterials and microbial interactions.Dent. Mater.2019351365210.1016/j.dental.2018.09.01330301624
     [Google Scholar]
  39. FORSTENL. Flouride release of glass ionomers.J. Esthet. Restor. Dent.1994621622210.1111/j.1708‑8240.1994.tb00862.x
     [Google Scholar]
  40. KimD.A. LeeJ.H. JunS.K. KimH.W. EltohamyM. LeeH.H. Sol–gel-derived bioactive glass nanoparticle-incorporated glass ionomer cement with or without chitosan for enhanced mechanical and biomineralization properties.Dent. Mater.201733780581710.1016/j.dental.2017.04.01728535954
     [Google Scholar]
  41. EramoS. NataliA. PinnaR. MiliaE. Dental pulp regeneration via cell homing.Int. Endod. J.201851440541910.1111/iej.1286829047120
     [Google Scholar]
/content/journals/cdent/10.2174/012542579X302181240821103605
Loading
Cephalopod Waste Derived Chitosan: A Promising Biomaterial for Revolutionizing Dental Applications - A Mini Review
Curr. Dentistry 4, e2542579X302181 (2024); https://doi.org/10.2174/012542579X302181240821103605
/content/journals/cdent/10.2174/012542579X302181240821103605
/content/journals/cdent/10.2174/012542579X302181240821103605
Loading

Data & Media loading...


  • Article Type:     Review Article
Keyword(s): biomaterial; Chitosan; endodontic; implant; novel; oral surgery; periodontal

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test