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2000
Volume 21, Issue 5
  • ISSN: 1573-403X
  • E-ISSN: 1875-6557

Abstract

Introduction

Thoracic aortic aneurysms (TAAs) are worrisome for their propensity to dissect. Previous studies have demonstrated the potential benefits of statin use, particularly with slowing aortic aneurysm growth. The aim of this meta-analysis was to consolidate existing research to ascertain if statins effectively reduce TAA growth.

Methods

Multiple databases were searched to identify studies assessing TAA growth in patients on statins (cases) and those not on statins (controls). The primary outcome was TAA (ascending/aortic arch) growth rate per year. Standard mean difference (SMD) and 95% confidence intervals (95% CI) were estimated with a random-effects model using the inverse-variance technique. We assigned I2>50% as an indicator of statistical heterogeneity. value <0.05 was considered significant. Data analysis was performed using SPSS v.25.0.

Results

Four studies comprising 757 cases (male 64%, mean age 65±14 years) and 1,696 controls (male 62%, mean age 61±18 years) were included. The baseline diameters of TAA for cases and controls were 40.35±8.75 mm and 42.39±12.60 mm, respectively. Pooled results suggested statins to be associated with slower growth of TAAs with pooled SMD -0.70 mm/year [95% CI (-1.23 – -0.16); 0.01]. Heterogeneity statistics among 4 studies was 95%.

Conclusion

This pooled meta-analysis showed statins as associated with slower growth of TAAs. However, given the heterogeneity of the included studies in this meta-analysis, results should be interpreted with caution.

© 2025 Bentham Science Publishers
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References

  1. IsselbacherE.M. PreventzaO. Hamilton BlackJ.III AugoustidesJ.G. BeckA.W. BolenM.A. BravermanA.C. BrayB.E. Brown-ZimmermanM.M. ChenE.P. CollinsT.J. DeAndaA.Jr FanolaC.L. GirardiL.N. HicksC.W. HuiD.S. Schuyler JonesW. KalahastiV. KimK.M. MilewiczD.M. OderichG.S. OgbechieL. PromesS.B. Gyang RossE. SchermerhornM.L. Singleton TimesS. TsengE.E. WangG.J. WooY.J. FaxonD.P. UpchurchG.R.Jr AdayA.W. AzizzadehA. BoisenM. HawkinsB. KramerC.M. LucJ.G.Y. MacGillivrayT.E. MalaisrieS.C. OsteenK. PatelH.J. PatelP.J. PopescuW.M. RodriguezE. SorberR. TsaoP.S. Santos VolgmanA. Peer Review Committee Members 2022 ACC/AHA guideline for the diagnosis and management of aortic disease: A report of the American Heart Association/American College of cardiology joint committee on clinical practice guidelines.Circulation202214624e334e48210.1161/CIR.000000000000110636322642
     [Google Scholar]
  2. KuzmikG.A. SangA.X. ElefteriadesJ.A. Natural history of thoracic aortic aneurysms.J. Vasc. Surg.201256256557110.1016/j.jvs.2012.04.05322840907
     [Google Scholar]
  3. BooherA.M. EagleK.A. Diagnosis and management issues in thoracic aortic aneurysm.Am. Heart J.201116213846.e110.1016/j.ahj.2011.04.01021742088
     [Google Scholar]
  4. ErbelR. EggebrechtH. Aortic dimensions and the risk of dissection.Heart200692113714210.1136/hrt.2004.05511116365370
     [Google Scholar]
  5. AronowW.S. Treatment of thoracic aortic aneurysm.Ann. Transl. Med.2018636610.21037/atm.2018.01.0729610755
     [Google Scholar]
  6. NatafP. LansacE. Dilation of the thoracic aorta: Medical and surgical management.Heart20069291345135210.1136/hrt.2005.07478116908722
     [Google Scholar]
  7. DaviesR.R. GoldsteinL.J. CoadyM.A. TittleS.L. RizzoJ.A. KopfG.S. ElefteriadesJ.A. Yearly rupture or dissection rates for thoracic aortic aneurysms: Simple prediction based on size.Ann. Thorac. Surg.2002731172810.1016/S0003‑4975(01)03236‑211834007
     [Google Scholar]
  8. LandenhedM. EngströmG. GottsäterA. CaulfieldM.P. HedbladB. Newton-ChehC. MelanderO. SmithJ.G. Risk profiles for aortic dissection and ruptured or surgically treated aneurysms: A prospective cohort study.J. Am. Heart Assoc.201541e00151310.1161/JAHA.114.00151325609416
     [Google Scholar]
  9. SalibaE. SiaY. DoreA. El HamamsyI. The ascending aortic aneurysm: When to intervene?Int. J. Cardiol. Heart Vasc.201569110010.1016/j.ijcha.2015.01.00938598654
     [Google Scholar]
  10. NewmanJ. MattiaA. ManettaF. Indications for thoracic endovascular aortic repair (TEVAR): A brief review.Int. J. Angiol.201827417718410.1055/s‑0038‑166697230410287
     [Google Scholar]
  11. UpchurchG.R.Jr EscobarG.A. AzizzadehA. BeckA.W. ConradM.F. MatsumuraJ.S. MuradM.H. PerryR.J. SinghM.J. VeeraswamyR.K. WangG.J. Society for vascular surgery clinical practice guidelines of thoracic endovascular aortic repair for descending thoracic aortic aneurysms.J. Vasc. Surg.202173155S83S10.1016/j.jvs.2020.05.07632628988
     [Google Scholar]
  12. BonsL.R. Rueda-OchoaO.L. El GhoulK. RohdeS. BuddeR.P.J. LeeningM.J.G. VernooijM.W. FrancoO.H. van der LugtA. Roos-HesselinkJ.W. KavousiM. BosD. Sex-specific distributions and determinants of thoracic aortic diameters in the elderly.Heart2020106213313910.1136/heartjnl‑2019‑31532031551294
     [Google Scholar]
  13. KimE.K. ChoiS.H. SungK. KimW.S. ChoeY.H. OhJ.K. KimD.K. Aortic diameter predicts acute type A aortic dissection in patients with Marfan syndrome but not in patients without Marfan syndrome.J. Thorac. Cardiovasc. Surg.201414751505151010.1016/j.jtcvs.2013.05.02523879932
     [Google Scholar]
  14. OesterleA. LaufsU. LiaoJ.K. Pleiotropic effects of statins on the cardiovascular system.Circ. Res.2017120122924310.1161/CIRCRESAHA.116.30853728057795
     [Google Scholar]
  15. JovinI.S. DuggalM. EbisuK. PaekH. OpreaA.D. TranquilliM. RizzoJ. MemetR. FeldmanM. DziuraJ. BrandtC.A. ElefteriadesJ.A. Comparison of the effect on long-term outcomes in patients with thoracic aortic aneurysms of taking versus not taking a statin drug.Am. J. Cardiol.201210971050105410.1016/j.amjcard.2011.11.03822221941
     [Google Scholar]
  16. KhatiwadaN. HongZ. Potential benefits and risks associated with the use of statins.Pharmaceutics202416221410.3390/pharmaceutics1602021438399268
     [Google Scholar]
  17. MoherD. LiberatiA. TetzlaffJ. AltmanD.G. PRISMA Group Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement.PLoS Med.200967e100009710.1371/journal.pmed.100009719621072
     [Google Scholar]
  18. SteinL.H. BergerJ. TranquilliM. ElefteraidesJ.A. Effect of statin drugs on thoracic aortic aneurysms.Am. J. Cardiol.201311281240124510.1016/j.amjcard.2013.05.08124079445
     [Google Scholar]
  19. AngeloniE. VitaternaA. PirelliM. ReficeS. Effects of statin therapy on ascending aorta aneurysms growth: A propensity-matched analysis.Int. J. Cardiol.2015191525510.1016/j.ijcard.2015.05.00125965598
     [Google Scholar]
  20. MasakiN. KumagaiK. SasakiK. MatsuoS. MotoyoshiN. AdachiO. AkiyamaM. KawamotoS. TabayashiK. SaikiY. STANP trial investigators Suppressive effect of pitavastatin on aortic arch dilatation in acute stanford type B aortic dissection: analysis of STANP trial.Gen. Thorac. Cardiovasc. Surg.201866633434310.1007/s11748‑018‑0916‑z29626287
     [Google Scholar]
  21. RegeerM.V. van RosendaelP.J. KamperidisV. SchalijM.J. BaxJ.J. MarsanN.A. DelgadoV. Effect of statins on aortic root growth rate in patients with bicuspid aortic valve anatomy.Int. J. Cardiovasc. Imaging20153181583159010.1007/s10554‑015‑0749‑026319215
     [Google Scholar]
  22. YoshimuraK. NagasawaA. KudoJ. OnodaM. MorikageN. FurutaniA. AokiH. HamanoK. Inhibitory effect of statins on inflammation-related pathways in human abdominal aortic aneurysm tissue.Int. J. Mol. Sci.2015165112131122810.3390/ijms16051121325993292
     [Google Scholar]
  23. PanZ. CuiH. WuN. ZhangH. Effect of statin therapy on abdominal aortic aneurysm growth rate and mortality: A systematic review and meta-analysis.Ann. Vasc. Surg.20206750351010.1016/j.avsg.2020.03.03632234575
     [Google Scholar]
  24. SalataK. SyedM. HussainM.A. de MestralC. GrecoE. MamdaniM. TuJ.V. ForbesT.L. BhattD.L. VermaS. Al-OmranM. Statins reduce abdominal aortic aneurysm growth, rupture, and perioperative mortality: A systematic review and meta‐analysis.J. Am. Heart Assoc.2018719e00865710.1161/JAHA.118.00865730371297
     [Google Scholar]
  25. LiaoK.M. WangS.W. LuC.H. ChenC.Y. HuangY.B. The influence of statins on aortic aneurysm after operation.Medicine (Baltimore)20199817e1536810.1097/MD.000000000001536831027125
     [Google Scholar]
  26. MuehlingB. OberhuberA. SchelzigH. BischoffG. MarxN. Sunder-PlassmannL. OrendK.H. Effect of statin therapy on serum activity of proteinases and cytokines in patients with abdominal aortic aneurysm.Vasc. Health Risk Manag.2008461433143710.2147/VHRM.S385519337556
     [Google Scholar]
  27. KuivaniemiH. RyerE.J. ElmoreJ.R. TrompG. Understanding the pathogenesis of abdominal aortic aneurysms.Expert Rev. Cardiovasc. Ther.201513997598710.1586/14779072.2015.107486126308600
     [Google Scholar]
  28. LuH. DuW. RenL. HamblinM.H. BeckerR.C. ChenY.E. FanY. Vascular smooth muscle cells in Aortic Aneurysm: From genetics to mechanisms.J. Am. Heart Assoc.20211024e02360110.1161/JAHA.121.02360134796717
     [Google Scholar]
  29. RomboutsK.B. van MerrienboerT.A.R. KetJ.C.F. BogunovicN. van der VeldenJ. YeungK.K. The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections.Eur. J. Clin. Invest.2022524e1369710.1111/eci.1369734698377
     [Google Scholar]
  30. GaoJ. CaoH. HuG. WuY. XuY. CuiH. LuH.S. ZhengL. The mechanism and therapy of aortic aneurysms.Signal Transduct. Target. Ther.2023815510.1038/s41392‑023‑01325‑736737432
     [Google Scholar]
  31. PramanaK.A.A.P. PintaningrumY. RahmatB. The effects of statin therapy on aneurysm size, growth rate, and matrix metalloproteinases-9 levels in patients with aortic aneurysm: A systematic review and meta-analysis.Egypt. Heart J.20237518810.1186/s43044‑023‑00407‑937831310
     [Google Scholar]
  32. KarrowniW. DughmanS. HajjG.P. MillerF.J.Jr Statin therapy reduces growth of abdominal aortic aneurysms.J. Investig. Med.20115981239124310.2310/JIM.0b013e31823548e821997311
     [Google Scholar]
  33. HosseiniA. SahranavardT. ReinerŽ. JamialahmadiT. DhaheriY.A. EidA.H. SahebkarA. Effect of statins on abdominal aortic aneurysm.Eur. J. Pharm. Sci.202217810628410.1016/j.ejps.2022.10628436038100
     [Google Scholar]
  34. WassmannS. LaufsU. MüllerK. KonkolC. AhlboryK. BäumerA.T. LinzW. BöhmM. NickenigG. Cellular antioxidant effects of atorvastatin in vitro and in vivo.Arterioscler. Thromb. Vasc. Biol.200222230030510.1161/hq0202.10408111834532
     [Google Scholar]
  35. MansouriA. ReinerŽ. RuscicaM. Tedeschi-ReinerE. RadbakhshS. Bagheri EktaM. SahebkarA. Antioxidant effects of statins by modulating Nrf2 and Nrf2/HO-1 signaling in different diseases.J. Clin. Med.2022115131310.3390/jcm1105131335268403
     [Google Scholar]
  36. SørensenA.L. HasselbalchH.C. NielsenC.H. PoulsenH.E. EllervikC. Statin treatment, oxidative stress and inflammation in a Danish population.Redox Biol.20192110108810.1016/j.redox.2018.10108830594900
     [Google Scholar]
  37. ZivkovicS. MaricG. CvetinovicN. Lepojevic-StefanovicD. Bozic CvijanB. Anti-inflammatory effects of lipid-lowering drugs and supplements: A narrative review.Nutrients2023156151710.3390/nu1506151736986246
     [Google Scholar]
  38. KalyanasundaramA. ElmoreJ.R. ManazerJ.R. GoldenA. FranklinD.P. GaltS.W. ZakharyE.M.A. CareyD.J. Simvastatin suppresses experimental aortic aneurysm expansion.J. Vasc. Surg.2006431117117.e3910.1016/j.jvs.2005.08.00716414398
     [Google Scholar]
  39. KohK. Effects of statins on vascular wall: Vasomotor function, inflammation, and plaque stability.Cardiovasc. Res.200047464865710.1016/S0008‑6363(00)00146‑210974215
     [Google Scholar]
  40. LiB. BaiW.W. GuoT. TangZ.Y. JingX.J. ShanT.C. YinS. LiY. WangF. ZhuM.L. LuJ.X. BaiY.P. DongB. LiP. WangS.X. Statins improve cardiac endothelial function to prevent heart failure with preserved ejection fraction through upregulating circRNA-RBCK1.Nat. Commun.2024151295310.1038/s41467‑024‑47327‑z38580662
     [Google Scholar]
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Slowing Thoracic Aortic Aneurysm Growth with Statins: A Meta-Analysis
Curr. Cardiol. Rev. 21, E1573403X343512 (2025); https://doi.org/10.2174/011573403X343512250127075044
/content/journals/ccr/10.2174/011573403X343512250127075044
/content/journals/ccr/10.2174/011573403X343512250127075044
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  • Article Type:     Research Article
Keyword(s): aneurysm; data analysis; heterogeneity; metalloproteases; statins; Thoracic aorta; thoracic aortic aneurysms

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