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- ISSN: 1386-2073
- E-ISSN: 1875-5402
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Green Synthesis of Phosphoryl-2-Oxo-2H-Pyran via Three Component Reaction of Trialkyl Phosphites
- Source: Combinatorial Chemistry & High Throughput Screening, Volume 17, Issue 9, Nov 2014, p. 804 - 807
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- 01 Nov 2014
Abstract
An effective one-pot synthesis of dialkoxyphosphoryl-2-oxo-2H-pyran derivatives by three-component reaction of alky bromides and dialkyl acetylenedicarboxylates in the presence of trialkyl phosphite is described. The reactions were performed under solvent-free conditions at 50°C and neutral conditions and provided good yields of products.
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