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- ISSN: 1386-2073
- E-ISSN: 1875-5402
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Novel Synthesis of N4-Substituted 1,4-Benzodiazepine-2,5-diones Using Poly(Ethylene Glycol) as Soluble Polymer Support
- Source: Combinatorial Chemistry & High Throughput Screening, Volume 9, Issue 10, Dec 2006, p. 743 - 746
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- 01 Dec 2006
Abstract
An efficient method for the liquid-phase combinatorial synthesis of N4-substituted 1,4-benzodiazepine-2,5- diones has been developed. Poly(ethylene glycol) (PEG) stepwise reacted with bromoacetyl bromide, a primary amine and 2-azidobenzoic acid to give a potential PEG-bound dipeptide, which was reduced by NaI / acetic acid, along with concurrent cyclization and cleavage of the seven-membered heterocycle from the PEG support.
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