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- ISSN: 1386-2073
- E-ISSN: 1875-5402
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Qualitative and Quantitative Analyses of Resin-Bound Organic Compounds
- Source: Combinatorial Chemistry & High Throughput Screening, Volume 4, Issue 4, Jun 2001, p. 353 - 362
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- 01 Jun 2001
Abstract
Methods for qualitative and quantitative analyses of resin-bound organic compounds are essential tools for chemistry development in solid-phase combinatorial and parallel syntheses. Here we discuss the use of gel-phase 19F NMR, the fluoride ion-selective electrode method, and spectrophotometry for monitoring solid-phase reactions. Our results indicate that the application of these diverse methods for analyzing the outcome of solid-phase combinatorial synthesis are sensitive and conclusive.
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