oa Network Pharmacology and Experimental Validation of the Anti-Inflammatory Effect of Modified Qianzheng Powder in Atherosclerosis

References

1. Vos T. Lim S.S. Abbafati C. Abbas K.M. Abbasi M. Abbasifard M. Abbasi-Kangevari M. Abbastabar H. Abd-Allah F. Abdelalim A. Abdollahi M. Abdollahpour I. Abolhassani H. Aboyans V. Abrams E.M. Abreu L.G. Abrigo M.R.M. Abu-Raddad L.J. Abushouk A.I. Acebedo A. Ackerman I.N. Adabi M. Adamu A.A. Adebayo O.M. Adekanmbi V. Adelson J.D. Adetokunboh O.O. Adham D. Afshari M. Afshin A. Agardh E.E. Agarwal G. Agesa K.M. Aghaali M. Aghamir S.M.K. Agrawal A. Ahmad T. Ahmadi A. Ahmadi M. Ahmadieh H. Ahmadpour E. Akalu T.Y. Akinyemi R.O. Akinyemiju T. Akombi B. Al-Aly Z. Alam K. Alam N. Alam S. Alam T. Alanzi T.M. Albertson S.B. Alcalde-Rabanal J.E. Alema N.M. Ali M. Ali S. Alicandro G. Alijanzadeh M. Alinia C. Alipour V. Aljunid S.M. Alla F. Allebeck P. Almasi-Hashiani A. Alonso J. Al-Raddadi R.M. Altirkawi K.A. Alvis-Guzman N. Alvis-Zakzuk N.J. Amini S. Amini-Rarani M. Aminorroaya A. Amiri F. Amit A.M.L. Amugsi D.A. Amul G.G.H. Anderlini D. Andrei C.L. Andrei T. Anjomshoa M. Ansari F. Ansari I. Ansari-Moghaddam A. Antonio C.A.T. Antony C.M. Antriyandarti E. Anvari D. Anwer R. Arabloo J. Arab-Zozani M. Aravkin A.Y. Ariani F. Ärnlöv J. Aryal K.K. Arzani A. Asadi-Aliabadi M. Asadi-Pooya A.A. Asghari B. Ashbaugh C. Atnafu D.D. Atre S.R. Ausloos F. Ausloos M. Ayala Quintanilla B.P. Ayano G. Ayanore M.A. Aynalem Y.A. Azari S. Azarian G. Azene Z.N. Babaee E. Badawi A. Bagherzadeh M. Bakhshaei M.H. Bakhtiari A. Balakrishnan S. Balalla S. Balassyano S. Banach M. Banik P.C. Bannick M.S. Bante A.B. Baraki A.G. Barboza M.A. Barker-Collo S.L. Barthelemy C.M. Barua L. Barzegar A. Basu S. Baune B.T. Bayati M. Bazmandegan G. Bedi N. Beghi E. Béjot Y. Bello A.K. Bender R.G. Bennett D.A. Bennitt F.B. Bensenor I.M. Benziger C.P. Berhe K. Bernabe E. Bertolacci G.J. Bhageerathy R. Bhala N. Bhandari D. Bhardwaj P. Bhattacharyya K. Bhutta Z.A. Bibi S. Biehl M.H. Bikbov B. Bin Sayeed M.S. Biondi A. Birihane B.M. Bisanzio D. Bisignano C. Biswas R.K. Bohlouli S. Bohluli M. Bolla S.R.R. Boloor A. Boon-Dooley A.S. Borges G. Borzì A.M. Bourne R. Brady O.J. Brauer M. Brayne C. Breitborde N.J.K. Brenner H. Briant P.S. Briggs A.M. Briko N.I. Britton G.B. Bryazka D. Buchbinder R. Bumgarner B.R. Busse R. Butt Z.A. Caetano dos Santos F.L. Cámera L.L.A.A. Campos-Nonato I.R. Car J. Cárdenas R. Carreras G. Carrero J.J. Carvalho F. Castaldelli-Maia J.M. Castañeda-Orjuela C.A. Castelpietra G. Castle C.D. Castro F. Catalá-López F. Causey K. Cederroth C.R. Cercy K.M. Cerin E. Chandan J.S. Chang A.R. Charlson F.J. Chattu V.K. Chaturvedi S. Chimed-Ochir O. Chin K.L. Cho D.Y. Christensen H. Chu D.T. Chung M.T. Cicuttini F.M. Ciobanu L.G. Cirillo M. Collins E.L. Compton K. Conti S. Cortesi P.A. Costa V.M. Cousin E. Cowden R.G. Cowie B.C. Cromwell E.A. Cross D.H. Crowe C.S. Cruz J.A. Cunningham M. Dahlawi S.M.A. Damiani G. Dandona L. Dandona R. Darwesh A.M. Daryani A. Das J.K. Das Gupta R. das Neves J. Dávila-Cervantes C.A. Davletov K. De Leo D. Dean F.E. DeCleene N.K. Deen A. Degenhardt L. Dellavalle R.P. Demeke F.M. Demsie D.G. Denova-Gutiérrez E. Dereje N.D. Dervenis N. Desai R. Desalew A. Dessie G.A. Dharmaratne S.D. Dhungana G.P. Dianatinasab M. Diaz D. Dibaji Forooshani Z.S. Dingels Z.V. Dirac M.A. Djalalinia S. Do H.T. Dokova K. Dorostkar F. Doshi C.P. Doshmangir L. Douiri A. Doxey M.C. Driscoll T.R. Dunachie S.J. Duncan B.B. Duraes A.R. Eagan A.W. Ebrahimi Kalan M. Edvardsson D. Ehrlich J.R. El Nahas N. El Sayed I. El Tantawi M. Elbarazi I. Elgendy I.Y. Elhabashy H.R. El-Jaafary S.I. Elyazar I.R.F. Emamian M.H. Emmons-Bell S. Erskine H.E. Eshrati B. Eskandarieh S. Esmaeilnejad S. Esmaeilzadeh F. Esteghamati A. Estep K. Etemadi A. Etisso A.E. Farahmand M. Faraj A. Fareed M. Faridnia R. Farinha C.S.S. Farioli A. Faro A. Faruque M. Farzadfar F. Fattahi N. Fazlzadeh M. Feigin V.L. Feldman R. Fereshtehnejad S-M. Fernandes E. Ferrari A.J. Ferreira M.L. Filip I. Fischer F. Fisher J.L. Fitzgerald R. Flohr C. Flor L.S. Foigt N.A. Folayan M.O. Force L.M. Fornari C. Foroutan M. Fox J.T. Freitas M. Fu W. Fukumoto T. Furtado J.M. Gad M.M. Gakidou E. Galles N.C. Gallus S. Gamkrelidze A. Garcia-Basteiro A.L. Gardner W.M. Geberemariyam B.S. Gebrehiwot A.M. Gebremedhin K.B. Gebreslassie A.A.A.A. Gershberg Hayoon A. Gething P.W. Ghadimi M. Ghadiri K. Ghafourifard M. Ghajar A. Ghamari F. Ghashghaee A. Ghiasvand H. Ghith N. Gholamian A. Gilani S.A. Gill P.S. Gitimoghaddam M. Giussani G. Goli S. Gomez R.S. Gopalani S.V. Gorini G. Gorman T.M. Gottlich H.C. Goudarzi H. Goulart A.C. Goulart B.N.G. Grada A. Grivna M. Grosso G. Gubari M.I.M. Gugnani H.C. Guimaraes A.L.S. Guimarães R.A. Guled R.A. Guo G. Guo Y. Gupta R. Haagsma J.A. Haddock B. Hafezi-Nejad N. Hafiz A. Hagins H. Haile L.M. Hall B.J. Halvaei I. Hamadeh R.R. Hamagharib Abdullah K. Hamilton E.B. Han C. Han H. Hankey G.J. Haro J.M. Harvey J.D. Hasaballah A.I. Hasanzadeh A. Hashemian M. Hassanipour S. Hassankhani H. Havmoeller R.J. Hay R.J. Hay S.I. Hayat K. Heidari B. Heidari G. Heidari-Soureshjani R. Hendrie D. Henrikson H.J. Henry N.J. Herteliu C. Heydarpour F. Hird T.R. Hoek H.W. Hole M.K. Holla R. Hoogar P. Hosgood H.D. Hosseinzadeh M. Hostiuc M. Hostiuc S. Househ M. Hoy D.G. Hsairi M. Hsieh V.C. Hu G. Huda T.M. Hugo F.N. Huynh C.K. Hwang B-F. Iannucci V.C. Ibitoye S.E. Ikuta K.S. Ilesanmi O.S. Ilic I.M. Ilic M.D. Inbaraj L.R. Ippolito H. Irvani S.S.N. Islam M.M. Islam M.M. Islam S.M.S. Islami F. Iso H. Ivers R.Q. Iwu C.C.D. Iyamu I.O. Jaafari J. Jacobsen K.H. Jadidi-Niaragh F. Jafari H. Jafarinia M. Jahagirdar D. Jahani M.A. Jahanmehr N. Jakovljevic M. Jalali A. Jalilian F. James S.L. Janjani H. Janodia M.D. Jayatilleke A.U. Jeemon P. Jenabi E. Jha R.P. Jha V. Ji J.S. Jia P. John O. John-Akinola Y.O. Johnson C.O. Johnson S.C. Jonas J.B. Joo T. Joshi A. Jozwiak J.J. Jürisson M. Kabir A. Kabir Z. Kalani H. Kalani R. Kalankesh L.R. Kalhor R. Kamiab Z. Kanchan T. Karami Matin B. Karch A. Karim M.A. Karimi S.E. Kassa G.M. Kassebaum N.J. Katikireddi S.V. Kawakami N. Kayode G.A. Keddie S.H. Keller C. Kereselidze M. Khafaie M.A. Khalid N. Khan M. Khatab K. Khater M.M. Khatib M.N. Khayamzadeh M. Khodayari M.T. Khundkar R. Kianipour N. Kieling C. Kim D. Kim Y-E. Kim Y.J. Kimokoti R.W. Kisa A. Kisa S. Kissimova-Skarbek K. Kivimäki M. Kneib C.J. Knudsen A.K.S. Kocarnik J.M. Kolola T. Kopec J.A. Kosen S. Koul P.A. Koyanagi A. Kravchenko M.A. Krishan K. Krohn K.J. Kuate Defo B. Kucuk Bicer B. Kumar G.A. Kumar M. Kumar P. Kumar V. Kumaresh G. Kurmi O.P. Kusuma D. Kyu H.H. La Vecchia C. Lacey B. Lal D.K. Lalloo R. Lam J.O. Lami F.H. Landires I. Lang J.J. Lansingh V.C. Larson S.L. Larsson A.O. Lasrado S. Lassi Z.S. Lau K.M-M. Lavados P.M. Lazarus J.V. Ledesma J.R. Lee P.H. Lee S.W.H. LeGrand K.E. Leigh J. Leonardi M. Lescinsky H. Leung J. Levi M. Lewington S. Li S. Lim L-L. Lin C. Lin R-T. Linehan C. Linn S. Liu H-C. Liu S. Liu Z. Looker K.J. Lopez A.D. Lopukhov P.D. Lorkowski S. Lotufo P.A. Lucas T.C.D. Lugo A. Lunevicius R. Lyons R.A. Ma J. MacLachlan J.H. Maddison E.R. Maddison R. Madotto F. Mahasha P.W. Mai H.T. Majeed A. Maled V. Maleki S. Malekzadeh R. Malta D.C. Mamun A.A. Manafi A. Manafi N. Manguerra H. Mansouri B. Mansournia M.A. Mantilla Herrera A.M. Maravilla J.C. Marks A. Martins-Melo F.R. Martopullo I. Masoumi S.Z. Massano J. Massenburg B.B. Mathur M.R. Maulik P.K. McAlinden C. McGrath J.J. McKee M. Mehndiratta M.M. Mehri F. Mehta K.M. Meitei W.B. Memiah P.T.N. Mendoza W. Menezes R.G. Mengesha E.W. Mengesha M.B. Mereke A. Meretoja A. Meretoja T.J. Mestrovic T. Miazgowski B. Miazgowski T. Michalek I.M. Mihretie K.M. Miller T.R. Mills E.J. Mirica A. Mirrakhimov E.M. Mirzaei H. Mirzaei M. Mirzaei-Alavijeh M. Misganaw A.T. Mithra P. Moazen B. Moghadaszadeh M. Mohamadi E. Mohammad D.K. Mohammad Y. Mohammad Gholi Mezerji N. Mohammadian-Hafshejani A. Mohammadifard N. Mohammadpourhodki R. Mohammed S. Mokdad A.H. Molokhia M. Momen N.C. Monasta L. Mondello S. Mooney M.D. Moosazadeh M. Moradi G. Moradi M. Moradi-Lakeh M. Moradzadeh R. Moraga P. Morales L. Morawska L. Moreno Velásquez I. Morgado-da-Costa J. Morrison S.D. Mosser J.F. Mouodi S. Mousavi S.M. Mousavi Khaneghah A. Mueller U.O. Munro S.B. Muriithi M.K. Musa K.I. Muthupandian S. Naderi M. Nagarajan A.J. Nagel G. Naghshtabrizi B. Nair S. Nandi A.K. Nangia V. Nansseu J.R. Nayak V.C. Nazari J. Negoi I. Negoi R.I. Netsere H.B.N. Ngunjiri J.W. Nguyen C.T. Nguyen J. Nguyen M. Nguyen M. Nichols E. Nigatu D. Nigatu Y.T. Nikbakhsh R. Nixon M.R. Nnaji C.A. Nomura S. Norrving B. Noubiap J.J. Nowak C. Nunez-Samudio V. Oţoiu A. Oancea B. Odell C.M. Ogbo F.A. Oh I-H. Okunga E.W. Oladnabi M. Olagunju A.T. Olusanya B.O. Olusanya J.O. Oluwasanu M.M. Omar Bali A. Omer M.O. Ong K.L. Onwujekwe O.E. Orji A.U. Orpana H.M. Ortiz A. Ostroff S.M. Otstavnov N. Otstavnov S.S. Øverland S. Owolabi M.O. P A M. Padubidri J.R. Pakhare A.P. Palladino R. Pana A. Panda-Jonas S. Pandey A. Park E-K. Parmar P.G.K. Pasupula D.K. Patel S.K. Paternina-Caicedo A.J. Pathak A. Pathak M. Patten S.B. Patton G.C. Paudel D. Pazoki Toroudi H. Peden A.E. Pennini A. Pepito V.C.F. Peprah E.K. Pereira A. Pereira D.M. Perico N. Pham H.Q. Phillips M.R. Pigott D.M. Pilgrim T. Pilz T.M. Pirsaheb M. Plana-Ripoll O. Plass D. Pokhrel K.N. Polibin R.V. Polinder S. Polkinghorne K.R. Postma M.J. Pourjafar H. Pourmalek F. Pourmirza Kalhori R. Pourshams A. Poznańska A. Prada S.I. Prakash V. Pribadi D.R.A. Pupillo E. Quazi Syed Z. Rabiee M. Rabiee N. Radfar A. Rafiee A. Rafiei A. Raggi A. Rahimi-Movaghar A. Rahman M.A. Rajabpour-Sanati A. Rajati F. Ramezanzadeh K. Ranabhat C.L. Rao P.C. Rao S.J. Rasella D. Rastogi P. Rathi P. Rawaf D.L. Rawaf S. Rawal L. Razo C. Redford S.B. Reiner R.C. Reinig N. Reitsma M.B. Remuzzi G. Renjith V. Renzaho A.M.N. Resnikoff S. Rezaei N. Rezai M. Rezapour A. Rhinehart P-A. Riahi S.M. Ribeiro A.L.P. Ribeiro D.C. Ribeiro D. Rickard J. Roberts N.L.S. Roberts S. Robinson S.R. Roever L. Rolfe S. Ronfani L. Roshandel G. Roth G.A. Rubagotti E. Rumisha S.F. Sabour S. Sachdev P.S. Saddik B. Sadeghi E. Sadeghi M. Saeidi S. Safi S. Safiri S. Sagar R. Sahebkar A. Sahraian M.A. Sajadi S.M. Salahshoor M.R. Salamati P. Salehi Zahabi S. Salem H. Salem M.R.R. Salimzadeh H. Salomon J.A. Salz I. Samad Z. Samy A.M. Sanabria J. Santomauro D.F. Santos I.S. Santos J.V. Santric-Milicevic M.M. Saraswathy S.Y.I. Sarmiento-Suárez R. Sarrafzadegan N. Sartorius B. Sarveazad A. Sathian B. Sathish T. Sattin D. Sbarra A.N. Schaeffer L.E. Schiavolin S. Schmidt M.I. Schutte A.E. Schwebel D.C. Schwendicke F. Senbeta A.M. Senthilkumaran S. Sepanlou S.G. Shackelford K.A. Shadid J. Shahabi S. Shaheen A.A. Shaikh M.A. Shalash A.S. Shams-Beyranvand M. Shamsizadeh M. Shannawaz M. Sharafi K. Sharara F. Sheena B.S. Sheikhtaheri A. Shetty R.S. Shibuya K. Shiferaw W.S. Shigematsu M. Shin J.I. Shiri R. Shirkoohi R. Shrime M.G. Shuval K. Siabani S. Sigfusdottir I.D. Sigurvinsdottir R. Silva J.P. Simpson K.E. Singh A. Singh J.A. Skiadaresi E. Skou S.T. Skryabin V.Y. Sobngwi E. Sokhan A. Soltani S. Sorensen R.J.D. Soriano J.B. Sorrie M.B. Soyiri I.N. Sreeramareddy C.T. Stanaway J.D. Stark B.A. Ştefan S.C. Stein C. Steiner C. Steiner T.J. Stokes M.A. Stovner L.J. Stubbs J.L. Sudaryanto A. Sufiyan M.B. Sulo G. Sultan I. Sykes B.L. Sylte D.O. Szócska M. Tabarés-Seisdedos R. Tabb K.M. Tadakamadla S.K. Taherkhani A. Tajdini M. Takahashi K. Taveira N. Teagle W.L. Teame H. Tehrani-Banihashemi A. Teklehaimanot B.F. Terrason S. Tessema Z.T. Thankappan K.R. Thomson A.M. Tohidinik H.R. Tonelli M. Topor-Madry R. Torre A.E. Touvier M. Tovani-Palone M.R.R. Tran B.X. Travillian R. Troeger C.E. Truelsen T.C. Tsai A.C. Tsatsakis A. Tudor Car L. Tyrovolas S. Uddin R. Ullah S. Undurraga E.A. Unnikrishnan B. Vacante M. Vakilian A. Valdez P.R. Varughese S. Vasankari T.J. Vasseghian Y. Venketasubramanian N. Violante F.S. Vlassov V. Vollset S.E. Vongpradith A. Vukovic A. Vukovic R. Waheed Y. Walters M.K. Wang J. Wang Y. Wang Y-P. Ward J.L. Watson A. Wei J. Weintraub R.G. Weiss D.J. Weiss J. Westerman R. Whisnant J.L. Whiteford H.A. Wiangkham T. Wiens K.E. Wijeratne T. Wilner L.B. Wilson S. Wojtyniak B. Wolfe C.D.A. Wool E.E. Wu A-M. Wulf Hanson S. Wunrow H.Y. Xu G. Xu R. Yadgir S. Yahyazadeh Jabbari S.H. Yamagishi K. Yaminfirooz M. Yano Y. Yaya S. Yazdi-Feyzabadi V. Yearwood J.A. Yeheyis T.Y. Yeshitila Y.G. Yip P. Yonemoto N. Yoon S-J. Yoosefi Lebni J. Younis M.Z. Younker T.P. Yousefi Z. Yousefifard M. Yousefinezhadi T. Yousuf A.Y. Yu C. Yusefzadeh H. Zahirian Moghadam T. Zaki L. Zaman S.B. Zamani M. Zamanian M. Zandian H. Zangeneh A. Zastrozhin M.S. Zewdie K.A. Zhang Y. Zhang Z-J. Zhao J.T. Zhao Y. Zheng P. Zhou M. Ziapour A. Zimsen S.R.M. Naghavi M. Murray C.J.L. Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: A systematic analysis for the global burden of disease study 2019. Lancet 2020 396 10258 1204 1222 10.1016/S0140‑6736(20)30925‑9 33069326
   [Google Scholar]
2. Mensah G.A. Fuster V. Roth G.A. A heart-healthy and stroke-free world. J. Am. Coll. Cardiol. 2023 82 25 2343 2349 10.1016/j.jacc.2023.11.003 38092508
   [Google Scholar]
3. Kobiyama K. Ley K. Atherosclerosis. Circ. Res. 2018 123 10 1118 1120 10.1161/CIRCRESAHA.118.313816 30359201
   [Google Scholar]
4. Tedgui A. Mallat Z. Cytokines in atherosclerosis: Pathogenic and regulatory pathways. Physiol. Rev. 2006 86 2 515 581 10.1152/physrev.00024.2005 16601268
   [Google Scholar]
5. Herrington W. Lacey B. Sherliker P. Armitage J. Lewington S. Epidemiology of atherosclerosis and the potential to reduce the global burden of atherothrombotic disease. Circ. Res. 2016 118 4 535 546 10.1161/CIRCRESAHA.115.307611 26892956
   [Google Scholar]
6. Lechner K. von Schacky C. McKenzie A.L. Worm N. Nixdorff U. Lechner B. Kränkel N. Halle M. Krauss R.M. Scherr J. Lifestyle factors and high-risk atherosclerosis: Pathways and mechanisms beyond traditional risk factors. Eur. J. Prev. Cardiol. 2020 27 4 394 406 10.1177/2047487319869400 31408370
   [Google Scholar]
7. Gimbrone M.A. García-Cardeña G. Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circ. Res. 2016 118 4 620 636 10.1161/CIRCRESAHA.115.306301 26892962
   [Google Scholar]
8. Bäck M. Yurdagul A. Tabas I. Öörni K. Kovanen P.T. Inflammation and its resolution in atherosclerosis: Mediators and therapeutic opportunities. Nat. Rev. Cardiol. 2019 16 7 389 406 10.1038/s41569‑019‑0169‑2 30846875
   [Google Scholar]
9. Attardo S. Musumeci O. Velardo D. Toscano A. Statins neuromuscular adverse effects. Int. J. Mol. Sci. 2022 23 15 8364 10.3390/ijms23158364 35955495
   [Google Scholar]
10. Chen W.H. Cheng X. Lee P.Y. Ng W. Kwok J.Y.Y. Tse H.F. Lau C.P. Aspirin resistance and adverse clinical events in patients with coronary artery disease. Am. J. Med. 2007 120 7 631 635 10.1016/j.amjmed.2006.10.021 17602938
    [Google Scholar]
11. Leung E.L.H. Xu S. Traditional Chinese medicine in cardiovascular drug discovery. Pharmacol. Res. 2020 160 105168 10.1016/j.phrs.2020.105168 32853746
    [Google Scholar]
12. Huang X. Meng L. Zhao L. Yang S. Lai D. Zhang J. Wu X. Jiang Y. Zhou J. Zhou P. Fu W. Efficacy of acupuncture in patients with carotid atherosclerosis: A randomized controlled clinical trial. BMC Complement Med. Ther. 2024 24 1 313 10.1186/s12906‑024‑04601‑3 39174985
    [Google Scholar]
13. Liu H. Zhu L. Chen L. Li L. Therapeutic potential of traditional Chinese medicine in atherosclerosis: A review. Phytother. Res. 2022 36 11 4080 4100 10.1002/ptr.7590 36029188
    [Google Scholar]
14. Zhi W. Liu Y. Wang X. Zhang H. Recent advances of traditional Chinese medicine for the prevention and treatment of atherosclerosis. J. Ethnopharmacol. 2023 301 115749 10.1016/j.jep.2022.115749 36181983
    [Google Scholar]
15. Jiang X. Ma C. Gao Y. Cui H. Zheng Y. Li J. Zong W. Zhang Q. Tongxinluo attenuates atherosclerosis by inhibiting ROS/NLRP3/caspase-1-mediated endothelial cell pyroptosis. J. Ethnopharmacol. 2023 304 116011 10.1016/j.jep.2022.116011 36529253
    [Google Scholar]
16. Yuan J. Yan F. Li W. Yuan G. Network pharmacological analysis of Xuefu Zhuyu decoction in the treatment of atherosclerosis. Front. Pharmacol. 2022 13 1069704 10.3389/fphar.2022.1069704 36532728
    [Google Scholar]
17. Zhao F. Peng C. Li H. Chen H. Yang Y. Ai Q. Chen N. Liu F. Paeoniae Radix Rubra extract attenuates cerebral ischemia injury by inhibiting ferroptosis and activating autophagy through the PI3K/Akt signalling pathway. J. Ethnopharmacol. 2023 315 116567 10.1016/j.jep.2023.116567 37172921
    [Google Scholar]
18. Li Z. Xu S. Liu P. Salvia miltiorrhizaBurge (Danshen): A golden herbal medicine in cardiovascular therapeutics. Acta Pharmacol. Sin. 2018 39 5 802 824 10.1038/aps.2017.193 29698387
    [Google Scholar]
19. Ma X. Zhang L. Gao F. Jia W. Li C. Salvia miltiorrhiza and Tanshinone IIA reduce endothelial inflammation and atherosclerotic plaque formation through inhibiting COX-2. Biomed. Pharmacother. 2023 167 115501 10.1016/j.biopha.2023.115501 37713995
    [Google Scholar]
20. Cheung D.W.S. Koon C.M. Wong P.H. Yau K.C. Wat E. Hung A.S.M. Wang Y.P. Lau K.M. Ko C.H. Chan J.Y.W. Waye M.M.Y. Fung K.P. Evaluating efficacy and safety of combination medication of atorvastatin and a herbal formula containing Salvia miltiorrhiza and Pueraria lobata on Hyperlipidemia. Phytother. Res. 2017 31 10 1579 1589 10.1002/ptr.5888 28840970
    [Google Scholar]
21. Zhou L. Jia R. Zeng W. Cai Q. Qu Y. Study on the difference of protective efficacy and mechanism of radix aconiti coreani and rhizoma typhonii in gerbils with ischemic stroke. ACS Chem. Neurosci. 2023 14 19 3686 3693 10.1021/acschemneuro.3c00299 37698590
    [Google Scholar]
22. Chi S. Cai W. Liu P. Zhang Z. Chen X. Gao L. Qi J. Bi L. Chen L. Qi Z. Baifuzi reduces transient ischemic brain damage through an interaction with the STREX domain of BKCa channels. Cell. Death Dis. 2010 1 1 e13 10.1038/cddis.2009.10 21364615
    [Google Scholar]
23. Kong Y. Xu C. He Z.L. Zhou Q.M. Wang J.B. Li Z.Y. Ming X. A novel peptide inhibitor of platelet aggregation from stiff silkworm, Bombyx batryticatus. Peptides 2014 53 70 78 10.1016/j.peptides.2013.12.004 24361453
    [Google Scholar]
24. Wang S. Xu H. Ge A. Yang K. He Q. Ge J. Bombyx batryticatus extract activates coagulation factor Ⅻ to promote angiogenesis in rats with cerebral ischemia/reperfusion injury. J. Ethnopharmacol. 2024 319 Pt 1 117081 10.1016/j.jep.2023.117081 37633622
    [Google Scholar]
25. Srairi-Abid N. Othman H. Aissaoui D. BenAissa R. Anti-tumoral effect of scorpion peptides: Emerging new cellular targets and signaling pathways. Cell. Calcium 2019 80 160 174 10.1016/j.ceca.2019.05.003 31108338
    [Google Scholar]
26. Guo R. Liu J. Chai J. Gao Y. Abdel-Rahman M.A. Xu X. Scorpion peptide Smp24 exhibits a potent antitumor effect on human lung cancer cells by damaging the membrane and cytoskeleton in vivo and in vitro. Toxins 2022 14 7 438 10.3390/toxins14070438 35878176
    [Google Scholar]
27. Wali A. Wubulikasimu A. Mirzaakhmedov S. Gao Y. Omar A. Arken A. Yili A. Aisa H.A. Optimization of scorpion protein extraction and characterization of the proteins’ functional properties. Molecules 2019 24 22 4103 10.3390/molecules24224103 31766309
    [Google Scholar]
28. Wang Z. Sang M. Zhang Y. Chen S. Li S. Chen Y. Xu E. Zhou Q. Xu W. Zhao C. Wang D. Lu W. Cao P. BmKK2, a thermostable Kv1.3 blocker from Buthus martensii Karsch (BmK) scorpion, inhibits the activation of macrophages via Kv1.3-NF-κB- NLRP3 axis. J. Ethnopharmacol. 2023 314 116624 10.1016/j.jep.2023.116624 37182676
    [Google Scholar]
29. Luo P. Shi W. Wang Y. Ma H. Liu T. Yan D. Huo S. Guo J. Wang M. Li C. Lin J. Zhang C. Li S. Lv J. Lin L. Raloxifene inhibits IL-6/STAT3 signaling pathway and protects against high-fat-induced atherosclerosis in ApoE−/− mice. Life Sci. 2020 261 118304 10.1016/j.lfs.2020.118304 32828944
    [Google Scholar]
30. Chen Q. Lv J. Yang W. Xu B. Wang Z. Yu Z. Wu J. Yang Y. Han Y. Targeted inhibition of STAT3 as a potential treatment strategy for atherosclerosis. Theranostics 2019 9 22 6424 6442 10.7150/thno.35528 31588227
    [Google Scholar]
31. Hong M. Wu Y. Zhang H. Gu J. Chen J. Guan Y. Qin X. Li Y. Cao J. Network pharmacology and experimental analysis to reveal the mechanism of Dan-Shen-Yin against endothelial to mesenchymal transition in atherosclerosis. Front. Pharmacol. 2022 13 946193 10.3389/fphar.2022.946193 36091823
    [Google Scholar]
32. Ji L. Song T. Ge C. Wu Q. Ma L. Chen X. Chen T. Chen Q. Chen Z. Chen W. Identification of bioactive compounds and potential mechanisms of scutellariae radix-coptidis rhizoma in the treatment of atherosclerosis by integrating network pharmacology and experimental validation. Biomed. Pharmacother. 2023 165 115210 10.1016/j.biopha.2023.115210 37499457
    [Google Scholar]
33. Sun T. Quan W. Peng S. Yang D. Liu J. He C. Chen Y. Hu B. Tuo Q. Network pharmacology-based strategy combined with molecular docking and in vitro validation study to explore the underlying mechanism of huo luo xiao ling dan in treating atherosclerosis. Drug Des. Devel. Ther. 2022 16 1621 1645 10.2147/DDDT.S357483 35669282
    [Google Scholar]
34. Tan Y. Zhang F. Fan X. Lu S. Liu Y. Wu Z. Huang Z. Wu C. Cheng G. Li B. Huang J. Stalin A. Zhou W. Wu J. Exploring the effect of Yinzhihuang granules on alcoholic liver disease based on pharmacodynamics, network pharmacology and molecular docking. Chin. Med. 2023 18 1 52 10.1186/s13020‑023‑00759‑z 37165407
    [Google Scholar]
35. Jiang H. Li M. Du K. Ma C. Cheng Y. Wang S. Nie X. Fu C. He Y. Traditional Chinese Medicine for adjuvant treatment of breast cancer: Taohong Siwu Decoction. Chin. Med. 2021 16 1 129 10.1186/s13020‑021‑00539‑7 34857023
    [Google Scholar]
36. Shang L. Wang Y. Li J. Zhou F. Xiao K. Liu Y. Zhang M. Wang S. Yang S. Mechanism of Sijunzi Decoction in the treatment of colorectal cancer based on network pharmacology and experimental validation. J. Ethnopharmacol. 2023 302 P1 115876 10.1016/j.jep.2022.115876 36343798
    [Google Scholar]
37. Seeliger D. de Groot B.L. Ligand docking and binding site analysis with PyMOL and Autodock/Vina. J. Comput. Aided Mol. Des. 2010 24 5 417 422 10.1007/s10822‑010‑9352‑6 20401516
    [Google Scholar]
38. Ling M. Hongmei S. Xiaogang G. Xin H. Yushan G. Yi Z. Protective effect of qianzheng san plus dabuyin wan on mitochondria in SH-SY5Y cells in Parkinson’s disease model induced by MPP +. WJITWM 2015 10 4 487 492
    [Google Scholar]
39. Li C. Jia W. Yang J. Cheng C. Olaleye O.E. Multi-compound and drug-combination pharmacokinetic research on Chinese herbal medicines. Acta Pharmacol. Sin. 2022 43 12 3080 3095 10.1038/s41401‑022‑00983‑7 36114271
    [Google Scholar]
40. Zhao L. Zhang H. Li N. Chen J. Xu H. Wang Y. Liang Q. Network pharmacology, a promising approach to reveal the pharmacology mechanism of Chinese medicine formula. J. Ethnopharmacol. 2023 309 116306 10.1016/j.jep.2023.116306 36858276
    [Google Scholar]
41. Bai Y.M. Liang S. Zhou B. Yangyinghuoxue decoction exerts a treatment effect on hepatic fibrosis by PI3K/AKT pathway in rat model: Based on the network pharmacology and molecular docking. Aging 2024 16 4 3773 3789 10.18632/aging.205559 38364259
    [Google Scholar]
42. Gao W. Tian M. Li M. Gao S. Wei X. Gao C. Zhou Y. Li T. Wang H. Bian B. Si N. Zhao W. Zhao H. Study on the potential mechanism of Qingxin Lianzi Yin Decoction on renoprotection in db/db mice via network pharmacology and metabolomics. Phytomedicine 2024 126 155222 10.1016/j.phymed.2023.155222 38382279
    [Google Scholar]
43. Wang Z. Li M. Li W. Ouyang J. Gou X. Huang Y. Mechanism of action of Daqinjiao decoction in treating cerebral small vessel disease explored using network pharmacology and molecular docking technology. Phytomedicine 2023 108 154538 10.1016/j.phymed.2022.154538 36370638
    [Google Scholar]
44. Gong G. Xie F. Zheng Y. Hu W. Qi B. He H. Dong T.T.X. Tsim K.W.K. The effect of methanol extract from Saussurea involucrata in the lipopolysaccharide-stimulated inflammation in cultured RAW 264.7 cells. J. Ethnopharmacol. 2020 251 112532 10.1016/j.jep.2019.112532 31884036
    [Google Scholar]
45. Wen Y. Wang Y. Zhao C. Zhao B. Wang J. The pharmacological efficacy of baicalin in inflammatory diseases. Int. J. Mol. Sci. 2023 24 11 9317 10.3390/ijms24119317 37298268
    [Google Scholar]
46. Zhao L. Chen X. Shao X. Wang Z. Du Y. Zhu C. Du W. Tang D. Ji S. Prenylated phenolic compounds from licorice (Glycyrrhiza uralensis) and their anti-inflammatory activity against osteoarthritis. Food Funct. 2022 13 2 795 805 10.1039/D1FO03659A 34984422
    [Google Scholar]
47. Lin H.C.H. Paul C.R. Kuo C.H. Chang Y.H. Chen W.S.T. Ho T.J. Day C.H. Velmurugan B.K. Tsai Y. Huang C.Y. Glycyrrhiza uralensis root extract ameliorates high glucose‐induced renal proximal tubular fibrosis by attenuating tubular epithelial‐myofibroblast transdifferentiation by targeting TGF‐β1/Smad/Stat3 pathway. J. Food Biochem. 2022 46 5 e14041 10.1111/jfbc.14041 35064587
    [Google Scholar]
48. Gong G. Qin Y. Huang W. Anti-thrombosis effect of diosgenin extract from Dioscorea zingiberensis C.H. Wright in vitro and in vivo. Phytomedicine 2011 18 6 458 463 10.1016/j.phymed.2010.08.015 21036572
    [Google Scholar]
49. Chen M.Y.C. Tsai B.C.K. Kuo W.W. Kuo C.H. Lin Y.M. Hsieh D.J.Y. Pai P.Y. Liao S.C. Huang S.E. Lee S.D. Huang C.Y. Diosgenin attenuates myocardial cell apoptosis triggered by oxidative stress through estrogen receptor to activate the PI3K/Akt and ERK axes. Am. J. Chin. Med. 2023 51 5 1211 1232 10.1142/S0192415X23500556 37335210
    [Google Scholar]
50. Zhao D. Zhang X. Jin W. Huang P. Wan H. He Y. Efficacy of Astragalus membranaceus–Carthamus tinctorius in cerebral ischemia/reperfusion injury: Insights from metabolomics and mass spectrometry imaging. Phytomedicine 2024 133 155881 10.1016/j.phymed.2024.155881 39059267
    [Google Scholar]
51. Gai C. Feng W.D. Qiang T.Y. Ma H.J. Chai Y. Zhang S.J. Guo Z.Y. Hu J.H. Sun H.M. Da-Bu-Yin-Wan and Qian-Zheng-San ameliorate mitochondrial dynamics in the Parkinson’s disease cell model induced by MPP+. Front. Pharmacol. 2019 10 372 10.3389/fphar.2019.00372 31068806
    [Google Scholar]
52. Chen B. A R. Yue R. Zhang G. Qianzheng powder for the treatment of primary Hemifacial spasm. Medicine 2021 100 14 e25436 10.1097/MD.0000000000025436 33832147
    [Google Scholar]
53. Jin L. Liuyan Z. Fang L. Tingting D. Effects of“Qianzheng San”with warm acupuncture at Zusanli on endothelial progenitor cells from peripheral blood in patients with acute idiopathic facial palsy. SJTCM 2016 50 4 50 52
    [Google Scholar]
54. Lang Z. Observation on the effect of ditan decoction combined with qianzheng powder in treating acute ischemic stroke. Guide of China Medicine 2021 19 1 128 129
    [Google Scholar]
55. Fdhila F. Vázquez V. Sánchez J.L. Riguera R. dd-diketopiperazines: Antibiotics active against Vibrio anguillarum isolated from marine bacteria associated with cultures of Pecten maximus. J. Nat. Prod. 2003 66 10 1299 1301 10.1021/np030233e 14575426
    [Google Scholar]
56. de Carvalho M.P. Abraham W.R. Antimicrobial and biofilm inhibiting diketopiperazines. Curr. Med. Chem. 2012 19 21 3564 3577 10.2174/092986712801323243 22709011
    [Google Scholar]
57. André A. Touré A.K. Stien D. Eparvier V. 2,5‐diketopiperazines mitigate the amount of advanced glycation end products accumulated with age in human dermal fibroblasts. Int. J. Cosmet. Sci. 2020 42 6 596 604 10.1111/ics.12655 32767373
    [Google Scholar]
58. Cornacchia C. Cacciatore I. Baldassarre L. Mollica A. Feliciani F. Pinnen F. 2,5-diketopiperazines as neuroprotective agents. Mini Rev. Med. Chem. 2012 12 1 2 12 10.2174/138955712798868959 22070690
    [Google Scholar]
59. Yoon C.S. Kim D.C. Lee D.S. Kim K.S. Ko W. Sohn J.H. Yim J.H. Kim Y.C. Oh H. Anti-neuroinflammatory effect of aurantiamide acetate from the marine fungus Aspergillus sp. SF-5921: Inhibition of NF-κB and MAPK pathways in lipopolysaccharide-induced mouse BV2 microglial cells. Int. Immunopharmacol. 2014 23 2 568 574 10.1016/j.intimp.2014.10.006 25448500
    [Google Scholar]
60. Zweers M.C. de Boer T.N. van Roon J. Bijlsma J.W.J. Lafeber F.P.J.G. Mastbergen S.C. Celecoxib: Considerations regarding its potential disease-modifying properties in osteoarthritis. Arthritis Res. Ther. 2011 13 5 239 10.1186/ar3437 21955617
    [Google Scholar]
61. Tomoda H. Doi T. Discovery and combinatorial synthesis of fungal metabolites beauveriolides, novel antiatherosclerotic agents. Acc. Chem. Res. 2008 41 1 32 39 10.1021/ar700117b 17803269
    [Google Scholar]
62. Namatame I. Tomoda H. Ishibashi S. Ōmura S. Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophages. Proc. Natl. Acad. Sci. USA 2004 101 3 737 742 10.1073/pnas.0307757100 14718664
    [Google Scholar]
63. Guevara N.V. Kim H.S. Antonova E.I. Chan L. The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo. Nat. Med. 1999 5 3 335 339 10.1038/6585 10086392
    [Google Scholar]
64. Wu G. Cai J. Han Y. Chen J. Huang Z.P. Chen C. Cai Y. Huang H. Yang Y. Liu Y. Xu Z. He D. Zhang X. Hu X. Pinello L. Zhong D. He F. Yuan G.C. Wang D.Z. Zeng C. LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity. Circulation 2014 130 17 1452 1465 10.1161/CIRCULATIONAHA.114.011675 25156994
    [Google Scholar]
65. Harrison M.J. Chimen M. Hussain M. Iqbal A.J. Senis Y.A. Nash G.B. Watson S.P. Rainger G.E. Signalling through Src family kinase isoforms is not redundant in models of thrombo‐inflammatory vascular disease. J. Cell. Mol. Med. 2018 22 9 4317 4327 10.1111/jcmm.13721 29974666
    [Google Scholar]
66. Tucka J. Yu H. Gray K. Figg N. Maguire J. Lam B. Bennett M. Littlewood T. Akt1 regulates vascular smooth muscle cell apoptosis through FoxO3a and Apaf1 and protects against arterial remodeling and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2014 34 11 2421 2428 10.1161/ATVBAHA.114.304284 25234814
    [Google Scholar]
67. Wei Y. Lan B. Zheng T. Yang L. Zhang X. Cheng L. Tuerhongjiang G. Yuan Z. Wu Y. GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis. Nat. Commun. 2023 14 1 929 10.1038/s41467‑023‑36614‑w 36807553
    [Google Scholar]
68. Dong G. Yu J. Shan G. Su L. Yu N. Yang S. N6-Methyladenosine methyltransferase METTL3 promotes angiogenesis and atherosclerosis by upregulating the JAK2/STAT3 pathway via m6A reader IGF2BP1. Front. Cell Dev. Biol. 2021 9 731810 10.3389/fcell.2021.731810 34950654
    [Google Scholar]
69. Li H. Zhang H.M. Fan L.J. Li H.H. Peng Z.T. Li J.P. Zhang X.Y. Xiang Y. Gu C.J. Liao X.H. Wang L. Zhang T.C. STAT3/miR-15a-5p/CX3CL1 loop regulates proliferation and migration of vascular endothelial cells in atherosclerosis. Int. J. Med. Sci. 2021 18 4 964 974 10.7150/ijms.49460 33456354
    [Google Scholar]
70. Akita K. Isoda K. Sato-Okabayashi Y. Kadoguchi T. Kitamura K. Ohtomo F. Shimada K. Daida H. An Interleukin-6 receptor antibody suppresses atherosclerosis in atherogenic mice. Front. Cardiovasc. Med. 2017 4 84 10.3389/fcvm.2017.00084 29312959
    [Google Scholar]
71. Fu X. Sun Z. Long Q. Tan W. Ding H. Liu X. Wu L. Wang Y. Zhang W. Glycosides from Buyang Huanwu Decoction inhibit atherosclerotic inflammation via JAK/STAT signaling pathway. Phytomedicine 2022 105 154385 10.1016/j.phymed.2022.154385 35987015
    [Google Scholar]
72. Liu F. Shan S. Li H. Li Z. Treatment of peroxidase derived from foxtail millet bran attenuates atherosclerosis by inhibition of CD36 and STAT3 in vitro and in vivo. J. Agric. Food Chem. 2020 68 5 1276 1285 10.1021/acs.jafc.9b06963 31965794
    [Google Scholar]