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image of A Review of Research on the Utilization of Ligularia Plants Based on their Functional Compositions

Abstract

The genus belongs to the family Asteraceae, with approximately 150 species worldwide. It is primarily distributed from Europe and the Himalayas to Japan, and it is rich in resources, with many species possessing medicinal value. According to the research reports on the functional compositions, the research progress and resource utilization of this genus were summarized from 2016 to the present. This paper aims to provide some references for the basic research results of the genus to industrialization. In general, after 2016, combined with the work of chemical and active investigation, some varieties have been applied and explored in drugs, cosmetics, food, daily necessities, pesticides, and feed, reflecting great development and value.

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/content/journals/cchts/10.2174/0113862073367895250324054212
2025-04-29
2025-09-02
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References

  1. Editorial committee of chinese botany, chinese academy of sciences. Flora Chin. 1984 77 2 55
    [Google Scholar]
  2. Cui S.N. Sun J.F. Piao J.Z. Chao Yao Zhi. Jilin Province Yanbian People's Press 1995 20
    [Google Scholar]
  3. Institute of Materia Medica, Chinese Academy of Medical Sciences Chinese medicinal herbal. Beijing People’s Medical Publishing House 1959 1 485 489
    [Google Scholar]
  4. Liu S.W. Deng D.S. Liu J.Q. The origin, evolution and distribution of Ligularia Cass. (Compositam). J. Syst. Evol. 1994 32 6 514 524
    [Google Scholar]
  5. Li Y.M. Jiao L. Jiang S.J. Zhou Y.Q. Featured wild vegetables -- Ligularia fischeri (Ledeb.) Turcz. facility cultivation technology. For. Investig. Des. 2021 50 3 66 69
    [Google Scholar]
  6. Qi W. Lei G.J. Zhou Y.Q. Technology and utilization value of pure natural wild vegetables Ligularia fischeri. For. Investig. Des. 2018 2 71 72
    [Google Scholar]
  7. Liao J.H. Zhang X.Y. Luo R.C. Li Z.M. Dai J.Y. Wang X.Y. Wang H.L. Progress on chemical composition and pharmacological activity of Ligularia. Zhong Yao Cai 2023 46 5 1310 1317 10.13863/j.issn1001‑4454.2023.05.042
    [Google Scholar]
  8. Nurlybekova A.K. Yang Y. Dyusebaeva M.A. Jenis J. Chemical constituents of ligularia narynensis. izvestiya natsional’noi akademii nauk respubliki kazakhstan. Ser. Chem. Tech. 2019 3 435 13 18 10.32014/2019.2518‑1491.23
    [Google Scholar]
  9. Silang Y.Z. Ban D. Laba C.D. Wujin C.M. Gesang Z.G. Zhao B.Y. Preliminary test of chemical constituents of the aerial parts of Ligularia rumicifolia. Chin. J. Trad. Veter. Sci. 2019 38 3 9 11 10.13823/j.cnki.jtcvm.2019.03.002
    [Google Scholar]
  10. Tonahashi Y. Ishizoki Y. Takahashi T. Tori K. Ligularenolide. A new sesquiterpene lactone of eremophilane type. Tetrahedron Lett. 1968 9 34 3739 3742 10.1016/S0040‑4039(00)75530‑4
    [Google Scholar]
  11. Zhai B. Li H. Hu Y. Wu D. Li J. Zhang X. Gao Q. Xie C. Yang C. Anti-inflammatory sesquiterpenoids from Ligularia fischeriTurcz. Fitoterapia 2024 177 106088 10.1016/j.fitote.2024.106088 38897245
    [Google Scholar]
  12. Shen T. Zha X.T. Yu M. Li G.L. He Y.L. A pair epimers of eremophilane sesquiterpene from Ligularia macrophylla. J. Chem. Res. 2024 48 3 17475198241255788 10.1177/17475198241255788
    [Google Scholar]
  13. Ma S. Zhou J.M. Gao Q.S. Liu F.X. A new eremophilane sesquiterpenoid from Ligularia przewalskii. Chem. Nat. Compd. 2021 57 2 309 311 10.1007/s10600‑021‑03354‑6
    [Google Scholar]
  14. Muhammad I. Shams ul Hassan S. Cheung S. Li X. Wang R. Zhang W.D. Yan S.K. Zhang Y. Jin H.Z. Phytochemical study of Ligularia subspicata and valuation of its anti-inflammatory activity. Fitoterapia 2021 148 104800 10.1016/j.fitote.2020.104800 33307175
    [Google Scholar]
  15. Hu Y. Yang H. Ding X. Tao L. Liu M. Zhang C. A sesquiterpenoid from Ligularia pleurocaulis modulated macrophages polarisation through TLR4 pathway. Nat. Prod. Res. 2021 35 22 4853 4856 10.1080/14786419.2020.1736068 32233670
    [Google Scholar]
  16. Xu D. Liu D. Zhang C.H. Zhang R.F. Wang Q.L. Zou K. Wang H. Antitumor constituents from roots of Ligularia veitchiana. Huazhong Shifan Daxue Xuebao Ziran Kexue Ban 2021 55 1 78 81 10.19603/j.cnki.1000‑1190.2021.01.011
    [Google Scholar]
  17. Wang W. Zhan R. Chen Y. Two new eremophilane Sesquiterpenoides from Ligularia dictyoneura. Nat. Prod. Res. 2020 34 9 1297 1302 10.1080/14786419.2018.1556652 30760044
    [Google Scholar]
  18. Lu C. Dai W. Zhou W. Zhang L. Wang Q. A new eremophilanolide sesquiterpene from Ligularia macrophylla and diversity of the species. Nat. Prod. Commun. 2019 14 9 1934578X19878942 10.1177/1934578X19878942
    [Google Scholar]
  19. Wu H. Liu T. Deng W. Zhang J. Yang L. A new eremophilane sesquiterpene with nematocidal activity from Ligularia veitchiana. Chem. Nat. Compd. 2019 55 4 671 673 10.1007/s10600‑019‑02775‑8
    [Google Scholar]
  20. Saito Y. Iga S. Hoshiyama K. Nakashima K. Okamoto Y. Kuroda C. Gong X. Tori M. Eremophilane, bakkane, secoeremophilane, and secobakkane sesquiterpenoids from Ligularia virgaurea collected in China. Tetrahedron 2019 75 14 2239 2245 10.1016/j.tet.2019.02.043
    [Google Scholar]
  21. Gong Y. Meng X.H. Zhu Y. Phytochemical and chemotaxonomic study on the whole plants of Ligularia sagitta. Biochem. Syst. Ecol. 2018 80 122 127 10.1016/j.bse.2018.07.006
    [Google Scholar]
  22. Nakashima K. Hoshiyama K. Hayami C. Sakaoku M. Okamoto Y. Kuroda C. Gong X. Tori M. Eremophilane sesquiterpenoids and nor- and dinorsesquiterpenoids from Ligularia virgaurea collected in China. Nat. Prod. Commun. 2018 13 7 1934578X1801300702 10.1177/1934578X1801300702
    [Google Scholar]
  23. Saito Y. Ichihara M. Takashima Y. Okamoto Y. Gong X. Hanai R. Kuroda C. Tori M. Chemical constituents of hybrids of Ligularia cyathiceps and L. lamarum/L. subspicata collected in China: Structures of subspicatins M, N, O1, and O2, and related compounds. Phytochemistry 2017 140 69 76 10.1016/j.phytochem.2017.04.015 28460262
    [Google Scholar]
  24. Kato T. Hirota H. Kuroda C. Gong X. Ohsaki A. New eremophilane-type sesquiterpenes from Ligularia cymbulifera. Nat. Prod. Commun. 2017 12 8 1934578X1701200804 10.1177/1934578X1701200804
    [Google Scholar]
  25. Wang Y.M. Zhao J.Q. Yang J.L. Tao Y.D. Mei L.J. Shi Y.P. Chemical constituents from Ligularia purdomii (Turrill). Biochem. Syst. Ecol. 2017 72 8 11 10.1016/j.bse.2017.03.007
    [Google Scholar]
  26. Saito Y. Hidaka M. Fukuda A. Okamoto Y. Nakashima K. Tori M. Hanai R. Gong X. Watanabe E. Kuroda C. Intra-specific diversity of the chemical composition of Ligularia lamarum in the Hengduan Mountains, China: The structures of four new eremophilanes and a new seco-eremophilane. Phytochem. Lett. 2017 20 139 145 10.1016/j.phytol.2017.04.026
    [Google Scholar]
  27. Qi F.M. Dong L.L. Li Z.Y. Hu Q.L. Liu Y.H. Wu P.Q. Zhang Z.X. Fei D.Q. Eremophilane-type sesquiterpenes from the leaves of Ligularia Virgaurea. Nat. Prod. Commun. 2017 12 3 1934578X1701200302 10.1177/1934578X1701200302 30549875
    [Google Scholar]
  28. Chen J. Zheng G. Zhang Y. Aisa H.A. Hao X.J. Phytotoxic terpenoids from Ligularia cymbulifera roots. Front. Plant Sci. 2017 7 2033 10.3389/fpls.2016.02033 28119715
    [Google Scholar]
  29. Saito Y. Takashima Y. Okamoto Y. Gong X. Hanai R. Kuroda C. Tori M. Three new eremophilanes from a Ligularia hybrid collected in China. Nat. Prod. Commun. 2016 11 7 1934578X1601100709 10.1177/1934578X1601100709 30452158
    [Google Scholar]
  30. Liu X. Li J. Luo J. Li D. Zhang H. Guo Z. A new sesquiterpene from Ligularia fischeri. Chem. Nat. Compd. 2016 52 4 642 646 10.1007/s10600‑016‑1729‑x
    [Google Scholar]
  31. Xie G.B. Xie Y. Hu Y.Z. Zhu Z.X. Cytotoxic sesquiterpenoids from Ligularia pleurocaulis. Phytochemistry 2016 125 99 105 10.1016/j.phytochem.2016.02.010 26920718
    [Google Scholar]
  32. Ponomarenko L.P. Kalinovsky A.I. Berdyshev D.V. Kuzmich A.S. Menchinskaya E.S. Pislyagin E.A. Kim N.Y. Glazunov V.P. Dmitrenok P.S. Silchenko A.S. Avilov S.A. Gorovoy P.G. Stonik V.A. Chemical constituents of Ligularia alticola Worosch. leaves and their biological activities. Phytochem. Lett. 2016 15 46 52 10.1016/j.phytol.2015.11.014
    [Google Scholar]
  33. Okamoto Y. Taniguchi M. Nakashima K. Gong X. Hanai R. Kuroda C. Tori M. Chemical constituents of Ligularia wilsoniana collected in Chongqing, China. Nat. Prod. Commun. 2016 11 2 1934578X1601100204 10.1177/1934578X1601100204 27032188
    [Google Scholar]
  34. Yu Y.Z. Zheng C.Y. Study of chemical components of Ligularia intermedia. Anhui Nongye Kexue 2016 44 19 121 123
    [Google Scholar]
  35. Dai W. Li H. Cong W. Zhao W. Wang Q. Two new eremophilane sesquiterpenes and one new resorcinol from Ligularia knorringiana. Nat. Prod. Commun. 2016 11 2 1934578X1601100201 10.1177/1934578X1601100201 27032185
    [Google Scholar]
  36. Chen W.H. Yang H.Y. Wang Y.X. Wen M.L. Yang Z.D. Chen J.J. Two new eremophilane-type sesquiterpenoids from Ligularia sagitta. Chem. Biodivers. 2022 19 11 e202200762 10.1002/cbdv.202200762 36177989
    [Google Scholar]
  37. Okamoto Y. Taniguchi M. Terada K. Nakashima K. Gong X. Hanai R. Tori M. Kuroda C. Diversity in chemical constituents of Ligularia longihastata collected in China. Nat. Prod. Commun. 2016 11 2 1934578X1601100203 10.1177/1934578X1601100203 27032187
    [Google Scholar]
  38. Ye Y. Dawa D. Liu G.H. Zhao M. Tseden D. Gu Y.C. Ding L.S. Cao Z.X. Zhou Y. Antiproliferative sesquiterpenoids from Ligularia rumicifolia with diverse skeletons. J. Nat. Prod. 2018 81 9 1992 2003 10.1021/acs.jnatprod.8b00197 30212198
    [Google Scholar]
  39. Hanai R. Tanabe S. Aoyama N. Okamoto Y. Tori M. Zhang N. Gong X. Kuroda C. Chemical and genetic study of two Ligularia hybrids in shangrila county, yunnan province, china. Nat. Prod. Commun. 2016 11 8 1934578X1601100804 10.1177/1934578X1601100804 30725554
    [Google Scholar]
  40. Dai W. Lu C.Q. Wang Y. Lu Y. Chen D.F. Wang Q. Oplopane sesquiterpenes from Ligularia knorringiana and their anti-complementary activity. Chem. Biodivers. 2018 15 3 e1700515 10.1002/cbdv.201700515 29325215
    [Google Scholar]
  41. Hanai R. Watanabe S. Matsushima M. Nagano H. Kuroda C. Gong X. Diversity in eremophilane components of Ligularia dictyoneura in Yunnan and Sichuan Provinces of China. Nat. Prod. Commun. 2019 14 11 1934578X19878935 10.1177/1934578X19878935
    [Google Scholar]
  42. Kuroda C. Kobayashi R. Nagata A. Nakadozono Y. Itoh T. Okamoto Y. Tori M. Hanai R. Gong X. Terpenoids and Phenylpropanoids in Ligularia duciformis, L. kongkalingensis, L. nelumbifolia, and L. limprichtii. Molecules 2017 22 12 2062 10.3390/molecules22122062
    [Google Scholar]
  43. Shimizu A. Hanai R. Okamoto Y. Tori M. Yu J.J. Gong X. Kuroda C. Chemical constituents in hybrids of Ligularia tongolensis and L. cymbulifera: Chemical introgression in L. tongolensis. Chem. Biodivers. 2016 13 7 837 844 10.1002/cbdv.201500227 27233768
    [Google Scholar]
  44. Okamoto Y. Nakadozono Y. Shiojiri K. Suehiro S. Saito Y. Matsuo Y. Tanaka T. Kuroda C. Tori M. Gong X. Hanai R. Diversity of furanoeremophilane composition in Ligularia tongolensis. Nat. Prod. Commun. 2019 14 10 1934578X19878937 10.1177/1934578X19878937
    [Google Scholar]
  45. Saito Y. Shiosaki Y. Fujiwara M. Mihara K. Nakamizo H. Otose K. Okamoto Y. Nakashima K. Hanai R. Kuroda C. Gong X. Matsuo Y. Tanaka T. Tori M. Eremophilanes from Ligularia hookeri Collected in China and Structural Revision of 3β-Acyloxyfuranoeremophilan-15,6-olide. Chem. Pharm. Bull. 2018 66 6 668 673 10.1248/cpb.c18‑00191 29863069
    [Google Scholar]
  46. Kuroda C. Inagaki K. Okamoto Y. Tori M. Hanai R. Chemical dversity in Ligularia oligonema. Nat. Prod. Commun. 2017 12 8 1161 1164 10.1177/1934578X1701200803
    [Google Scholar]
  47. Wang H. Wang S.Y. Zhou K. A sesquiterpene glycoside compound and its preparation method and application. Chian. Patent CN202310600666 2023
  48. Ponomarenko L.P. Ermolaeva S.D. Doudkin R.V. Dyshlovoy S.A. Gorovoy P.G. Eremophilane-type glucosides from the leaves of Ligularia calthifolia Maxim. Phytochem. Lett. 2017 21 264 268 10.1016/j.phytol.2017.07.013
    [Google Scholar]
  49. Silchenko A.S. Ponomarenko L.P. Kalinovsky A.I. Berdyshev D.V. Avilov S.A. Andryjaschenko P.V. Lyakhova E.G. Kuzmich A.S. Terentieva N.A. Gorovoy P.G. Structures of minor glucosides from the Far Eastern high-mountain endemic plant Ligularia alticola Worosch. Screening of bioactivity for some glycosides from L. alticola. Phytochem. Lett. 2017 20 234 238 10.1016/j.phytol.2017.05.011
    [Google Scholar]
  50. Wang Q. Dai W. Yuan S.W. Application of bisabolane-type sesquiterpenoid compound in preparation of anticomplement drug. Patent CN110013473A 2019
  51. Li H.Y. Zheng Z.Q. Wei W.J. Chen J.J. Gao K. Ligusaginoids A–D, four eremophilane-type sesquiterpenoid dimers and trimers from Ligularia sagitta. Tetrahedron Lett. 2018 59 38 3461 3466 10.1016/j.tetlet.2018.08.009
    [Google Scholar]
  52. Defendi F. Thielens N.M. Clavarino G. Cesbron J.Y. Dumestre-Pérard C. The immunopathology of complement proteins and innate immunity in autoimmune disease. Clin. Rev. Allergy Immunol. 2020 58 2 229 251 10.1007/s12016‑019‑08774‑5 31834594
    [Google Scholar]
  53. Zhong D.Y. Analysis of the value of serum immunoglobulin and complement levels tested in rheumatoid arthritis. Mod Diagn Treat 2023 34 2 264 265
    [Google Scholar]
  54. Zhang S.Z. Jiang H.B. Lu Y.Q. Ma H.H. Chen L.Y. Zhao X.Q. Su C. Clinical application and development of anti-complement agents: A review. Wei Sheng Wu Xue Tong Bao 2022 49 6 2347 2361 10.13344/j.microbiol.china.210961
    [Google Scholar]
  55. Si X.L. Xin E.D. Bian T.T. Zhang A.X. Li Y.F. Research progress in TCM anticomplement activity. Chin. J. Infor. TCM 2019 26 6 136 139
    [Google Scholar]
  56. Shi Z.N. Wang Y.D. Gong Y. Li H.F. Zhu Y. New triterpenoid saponins with cytotoxic activities from Ligularia przewalskii. Phytochem. Lett. 2019 30 215 219 10.1016/j.phytol.2019.02.024
    [Google Scholar]
  57. Zhang J. Jiang W. Cao H.J. Qu Y. Liao Z.X. Liu C. Sun J.Y. Two new monoterpene lactones from Ligularia rumicifolia (J.R.Drumm.) S.W.Liu and their anti-proliferative activities. Phytochem. Lett. 2018 28 55 58 10.1016/j.phytol.2018.09.001
    [Google Scholar]
  58. Gobu F.R. Chen J.J. Zeng J. Wei W.J. Wang W.F. Lin C.J. Gao K. Isolation, structure elucidition, and immunosuppressive activity of diterpenoids from Ligularia fischeri. J. Nat. Prod. 2017 80 8 2263 2268 10.1021/acs.jnatprod.7b00198 28783337
    [Google Scholar]
  59. Joshi D. Nailwal M. Mohan L. Melkani A.B. Ligularia amplexicaulis (wall.) DC. Essential oil composition and antibacterial activity. J. Essent. Oil Res. 2018 30 3 189 196 10.1080/10412905.2018.1427636
    [Google Scholar]
  60. Mohadjerani M. Hosseinzadeh R. Hosseini M. Chemical composition and antibacterial properties of essential oil and fatty acids of different parts of Ligularia persica Boiss. Avicenna J. Phytomed. 2016 6 3 357 365 10.22038/AJP.2016.5722 27462560
    [Google Scholar]
  61. Makubayeva A. Romanenko E.P. Adekenov S.M. Tkachev A.V. Component composition and biological activity of essential oil of Ligularia heterophylla. chem. plant Raw Mat. 2020 3 239 244 10.14258/jcprm.2020038243
    [Google Scholar]
  62. Ferreira O.O. Cruz J.N. Moraes d.Â.A.B. Jesus Pereira Franco d.C. Lima R.R. Anjos T.O. Siqueira G.M. Nascimento L.D. Cascaes M.M. Oliveira d.M.S. Andrade E.H.A. Essential oil of the plants growing in the brazilian amazon: Chemical composition, antioxidants, and biological applications. Molecules 2022 27 14 4373 10.3390/molecules27144373 35889245
    [Google Scholar]
  63. Oliveira d.M.S. Silva S.G. Cruz d.J.N. Ortiz E. Costa d.W.A. Bezerra F.W.F. Cunha B. Cordeiro R.M. Jesus Chaves Neto d.A.M. Supercritical CO2 application in essential oil extraction. Mat. Res. Found. 2019 54 1 28 10.21741/9781644900314‑1
    [Google Scholar]
  64. Alves F.S. Cruz J.N. Ramos F.d.I.N. do Nascimento Brandão D.L. Queiroz R.N. Silva d.G.V. Silva d.G.V. Dolabela M.F. Costa d.M.L. Khayat A.S. Rego d.A.R.d.J. Brasil d.S.B.D. Evaluation of antimicrobial activity and cytotoxicity effects of extracts of Piper nigrum L. and piperine. Separations 2022 10 1 21 10.3390/separations10010021
    [Google Scholar]
  65. Han Y.K. Vinh L.B. Nam M. Lee K.Y. Identification of compounds using HPLC-QTOF-MS online antioxidant activity mapping from aerial parts of Ligularia stenocephala. Applied Biological Chemistry 2023 66 1 53 10.1186/s13765‑023‑00814‑1
    [Google Scholar]
  66. Chen J. Zheng G.W. Hao X.J. Study on the chemical constituents of the root of Tibetan medicine Ligularia cymbulifera. Yunnan Minzu Daxue Xuebao. Ziran Kexueban 2020 29 1 5 9
    [Google Scholar]
  67. Liu X. Li J. Li J. Liu Q. Xun M. A new flavonoid glycoside from Ligularia fischeri. Chem. Nat. Compd. 2019 55 4 638 641 10.1007/s10600‑019‑02767‑8
    [Google Scholar]
  68. Shao F.X. Study on antibacterial activity and mechanism of flavonoids from Ligularia sibirica (L.) Cass. China Jilin Agricultural University 2022
    [Google Scholar]
  69. Silang Y.Z. Zhou Q. Fu G.W. Laba C.D. Yang D. Wujin C.M. Gesang Z.G. Ban D. Fan Y.Y. Study on the antibacterial, anti-inflammatory and antiviral effects of the extract of Ligularia rumicifolia (Drumm.) S. W. Liu. Prog. Veter. Med. 2020 41 8 82 86 10.16437/j.cnki.1007‑5038.2020.08.015
    [Google Scholar]
  70. Park S.Y. Kim G.Y. Jhoo J.W. Protective effect of 3,5-dicaffeoylquinic acid isolated from Ligularia fischeri against oxidative damage in HepG2 cells. J. Kor. Soc. Food Sci. Nutr. 2017 46 11 1286 1292 10.3746/jkfn.2017.46.11.1286
    [Google Scholar]
  71. Xu D. Song H.Z. Xu J.L. Hu W.M. Fan X.Y. Wang H. Zou K. Ligulaveitnoid A, a new phenylpropanoid from rhizomes and roots of Ligularia veitchiana. Nat. Prod. Res. 2022 36 3 701 706 10.1080/14786419.2020.1798663 32720521
    [Google Scholar]
  72. Miyazaki T. Shirakami Y. Mizutani T. Maruta A. Ideta T. Kubota M. Sakai H. Ibuka T. Genovese S. Fiorito S. Taddeo V.A. Epifano F. Tanaka T. Shimizu M. Novel FXR agonist nelumal A suppresses colitis and inflammation-related colorectal carcinogenesis. Sci. Rep. 2021 11 1 492 10.1038/s41598‑020‑79916‑5 33436792
    [Google Scholar]
  73. Park C.H. Ahn M.J. Hwang G.S. An S.E. Whang W.K. Cosmeceutical bioactivities of isolated compounds from Ligularia fischeri Turcz leaves. App. Biol. Chem. 2016 59 3 485 494 10.1007/s13765‑016‑0189‑0
    [Google Scholar]
  74. Wu D.S. Fu D.H. Zhao D.Q. Chai X.Y. Jiang C.P. Zhou P.J. Zhu Z.Y. Study on the effects of alcohol extract from Ligularia dictyoneura (Franch.) Hand.-Mazz. on experimental gastric ulcer in rats. CNDR 2020 29 7 66 71
    [Google Scholar]
  75. Kim H.J. Choi H.K. Chung M.Y. Park J.H. Chung S. Lee S.H. Hwang J.T. Ethanol extract of Ligularia fischeri inhibits the lipopolysaccharide-induced inflammatory response by exerting anti-histone acetyltransferase activity to negatively regulate p65. J. Med. Food 2019 22 11 1127 1135 10.1089/jmf.2019.4412 31596631
    [Google Scholar]
  76. Fu Y.P. Yuan H. Xu Y. Liu R.M. Luo Y. Xiao J.H. Protective effects of Ligularia fischeri root extracts against ulcerative colitis in mice through activation of Bcl-2/Bax signalings. Phytomedicine 2022 99 154006 10.1016/j.phymed.2022.154006 35299029
    [Google Scholar]
  77. Park J.H. Ahn E.K. Kim J.K. Oh J.S. Antihyperlipidemic activity of Ligularia fischeri extract in mice fed a high-carbohydrate diet. J. Med. Food 2019 22 4 374 383 10.1089/jmf.2018.4248 30801226
    [Google Scholar]
  78. Baek H.J. Jeong Y.J. Kwon J.E. Ra J.S. Lee S.R. Kang S.C. Antihyperglycemic and antilipidemic effects of the ethanol extract mixture of ligularia fischeri and momordica charantia in type II diabetes-mimicking mice. Evid. Based Complement. Alternat. Med. 2018 2018 3468040 10.1155/2018/3468040
    [Google Scholar]
  79. Joo I.H. Choi J.H. Kim D.H. Chung M.J. Lim M.H. Ligularia fischeri ethanol extract: An inhibitor of alpha‐melanocyte‐stimulating hormone‐stimulated melanogenesis in B16F10 melanoma cells. J. Cosmet. Dermatol. 2023 22 2 637 644 10.1111/jocd.15335 36030197
    [Google Scholar]
  80. Kim T.H. Truong V.L. Jeong W.S. Phytochemical composition and antioxidant and anti-inflammatory activities of Ligularia fischeri Turcz: A comparison between leaf and root extracts. Plants 2022 11 21 3005 10.3390/plants11213005 36365457
    [Google Scholar]
  81. Pyun C.W. Seo T.S. Kim D.J. Kim T.W. Bae J.S. Protective effects of Ligularia fischeri and Aronia melanocarpa extracts on alcoholic liver disease (in vitro and in vivo study). BioMed Res. Int. 2020 2020 1 9720387 10.1155/2020/9720387 32382583
    [Google Scholar]
  82. Jang S. Kim M.S. Park T. Sim J.H. Kim S.Y. Screening and identification of an anti-inflammatory and anti-adipogenic constituent from Ligularia taquetii Nakai. Nat. Prod. Commun. 2020 15 1 1934578X19899503 10.1177/1934578X19899503
    [Google Scholar]
  83. Lee S. Kim I.H. Hong J. Jeon B.J. Kim S.S. Lee J.W. Park J.Y. Choi S.H. Lee T.K. Cha J.K. Won M.H. In vitro and in vivo anti-inflammatory effects of TEES-10®, a mixture of ethanol extracts of Ligularia stenocephala Matsum. & Koidz. and Secale cereale L. Sprout, on Gingivitis and Periodontitis. Dent. J. 2022 10 8 143 10.3390/dj10080143 36005241
    [Google Scholar]
  84. Hong I. Park J.Y. Noh Y.H. Jeon S.H. Paik J.W. Lee J.S. Choi S.H. Cha J.K. Anti-inflammatory potential of complex extracts of Ligularia stenocephala Matsum. & Koidz. and Secale cereale L. sprout in chronic gingivitis: in vitro investigation and randomized clinical trial. Antioxidants 2021 10 10 1586 10.3390/antiox10101586 34679720
    [Google Scholar]
  85. Li H.L. Zhao S.S. Composition for treating cervical cancer and application thereof. Patent KR2022087295 2024
  86. Chung M.J. Ligularia fischeri extract-containing composition for relieving itching. Patent WO2022154602 2022
  87. Kim H.D. Kang M.H. Seo G.H. Kim D.H. Choi S.J. Ji Y.J. Gomchi extract having inhibitory activity on alpha-glucosidase and uses thereof. Patent KR2022087295 2022
  88. Kang S.C. Jung J. Y. Kim H.H. Kwon J.E. Jung Y.J. Pharmaceutical composition comprising Ligularia fischeri and Momordica charantia extract for preventing and treating diabetes and complications. Patent KR2018132571A. 2018
  89. Liu Q. Wang Y.N. Li X.B. Ligularia virgaurea extract, its preparation method and application to blood glucose reduction. Patent CN105250342. 2016
  90. Song X.P. Tang J. Extraction optimization, preliminary characterization and bioactivities in vitro of Ligularia hodgsonii polysaccharides. Int. J. Mol. Sci. 2016 17 5 788/1 788/18 10.3390/ijms17050788
    [Google Scholar]
  91. Kim Y.J. Composition for improving antibacterial, anti-inflammatory, antiviral, and immune functions,. comprising extract of Ligularia stenocephala as active ingredient: Patent KR2021115381. 2021
  92. Kim H.A. Yoo M.G. Ki M.S. Kim H.J. Yoo S.J. Composition for treating or preventing obesity comprising Ligularia stenocephala extract. Patent KR2019082437. 2019
  93. Hwang S.G. Kim H.G. Anti-obesity composition comprising leek and gondree extract as active ingredients and method for manufacturing the same. Patent KR2024047864A. 2024
  94. Zhao Z.H. Wang X.Y. Zhan H.Q. Application of euparin in preparation of drug for treating depression. Patent CN105919991. 2016
  95. Tang J. Wen J.X. Cheng M. TApplication of Ligularia hodgsonii Hook polysaccharide in preparation of medicine for treating and/or preventing liver disease using pharmaceutically acceptable excipients. Patent CN112089725. 2020
  96. Hao D.C. Xiao P-G. Lyu H-Y. Wang F. Evaluating potentials of species rich taxonomic groups in cosmetics and dermatology: Clustering and dispersion of skin efficacy of Asteraceae and Ranunculales plants on the species phylogenetic tree. Curr. Pharm. Biotechnol. 2023 24 2 279 298 10.2174/1389201023666220324123926 35331107
    [Google Scholar]
  97. Kim S.U. Cosmetic or food composition containing ligularia stenocephala extract as active ingredient and method for producing hangover-free beverage using thereof. Patent KR2019035139. 2019
  98. Ha N.M. Hwang H. Alam S.T. Nguyen U.T.T. Lee S.K. Park J.S. Kim J.C. Kwon H.C. Kwon J. Kang K. Antimicrobial photodynamic therapy with Ligularia fischeri against methicillin-resistant Staphylococcus aureus infection in Caenorhabditis elegans model. Applied Biological Chemistry 2023 66 1 19 10.1186/s13765‑023‑00778‑2
    [Google Scholar]
  99. Lee T.B. Yoo B.W. Kim J.H. So Y.G. Hwang J.Y. Kim S.Y. Antioxidant and moisturizing cosmetic composition containing plant extracts. Patent KR2021041680 2021
  100. Han G.H. Lee J.H. Oh D.S. Kim J.H. Kang J.R. Cosmetic composition contains leaf extract of Ligularia stenocephala showed antioxidant activity as well as prevented skin inflammation and skin aging due to presence of polyphenols and flavonoids. Patent KR2020098799A. 2020
  101. Zhao Y. Peng L. Lu L. Gao Y.G. Cai E.B. Zhang L.X. Determination of contents of 21 kinds of ammo acids in Ligularia jaluensis by using PITC pre-column derivation RP-HPLC method. Zhonghua Zhongyiyao Zazhi 2016 31 12 5049 5052
    [Google Scholar]
  102. Hwang K.H. Shin J.A. Lee K.T. True retention and β-carotene contents in 22 blanched vegetables. J. Korean Soc. Food Sci. Nutr. 2016 45 7 990 995 10.3746/jkfn.2016.45.7.990
    [Google Scholar]
  103. Wang S. Zhang J.Y. Wang B. Zhao G.Y. Zhu M. Determination and analysis of mineral elements on two kinds of Ligularia in Changbai Mountain. J. Beihua University 2021 22 6 30 35
    [Google Scholar]
  104. Yao Y.H. Nan J.X. Li C.F. Analysis of the nutritional composition of wild and cultural Ligularia fischeri changbai mountain region. FST 2009 34 10 45 47
    [Google Scholar]
  105. Zhang M. Zhang B. Li B.C. Dai W.F. Zhang Y.H. Zhang L.L. Song J. Ligularia cymbulifera health-care tea and preparation method thereof. Patent CN109287808A. 2019
  106. Liu F.Z. Yu R.M. Jiang Y. Yu J.Y. You T.T. Preparation and intelligent sensory analysis of hoof leaf Ligularia functional beverages. Xiandai Shipin Keji 2018 34 6 180 187 10.13982/j.mfst.1673‑9078.2018.6.024
    [Google Scholar]
  107. Kim D.Y. Candy composition comprising Manihot esculenta starch, canthaxanthin, and Apium graveolens powder. Patent KR2549827 2023
  108. Yang G.S. Kim W.S. Bread and confectionery manufacturing method using Ligularia stenocephala. Patent KR2022094463 2022
  109. Shin D.S. Lee Y.E. Kim W.S. Preparation method of Ligularia stenocephala namul bap with nutrition and aroma of Ligularia stenocephala. Patent KR2021059897 2021
  110. Kim B. Production method of tofu using Ligularia fischeri extract. Patent KR2019014767 2019
  111. Seo H.G. Kim S.H. Kim I.H. Jang Y.S. Composition for Ligularia fischeri dumpling and manufacturing method of Ligularia fischeri dumpling containing same. Patent KR2020095015 2020
  112. Jung M.J. Cosmetics and hair care composition containing caffeoylquinic acid derived from Ligularia fischeri extract. Patent KR2023047316 2023
  113. Zhang N. Antibacterial disinfection hand sanitizer containing nano silver and preparation method thereof. Patent CN115429706 2022
  114. Liu J.X. Li J. Ding P. Li N. Fu L.Y. Zhang J.J. Wu J.R. Coating agent containing bioactive ingredients for extracting Ligularia virgaurea, preparation method and application thereof. Patent CN114304171 2022
  115. Li J. Li N. Ding P. Fu L.Y. Wang T. Du W.J. Zhang J.J. Wu J.R. Liu J.X. Insecticidal and bacteriostatic activities of extracts from three species of Ligularia. Caoye Kexue 2022 39 5 899 906
    [Google Scholar]
  116. Fu J.J. Guo Y.Z. Wang S. Guo R. Su Y.X. Zhao B.Y. Chemical composition analysis and nutritional value evaluation of Ligularia narynensis. Prog. Veter. Med. 2021 42 3 59 63 10.16437/j.cnki.1007‑5038.2021.03.012
    [Google Scholar]
  117. Cui X. Wang Z. Yan T. Chang S. Hou F. Modulation of feed digestibility, nitrogen metabolism, energy utilisation and serum biochemical indices by dietary Ligularia virgaurea supplementation in Tibetan sheep. Animal 2023 17 8 100910 10.1016/j.animal.2023.100910 37544052
    [Google Scholar]
  118. Cui X. Wang Z. Fan Q. Chang S. Yan T. Hou F. Ligularia virgaurea improved nutrient digestion, ruminal fermentation, and bacterial composition in Tibetan sheep grazing on the Qinghai–Tibetan plateau in winter. Anim. Feed Sci. Technol. 2023 299 115628 10.1016/j.anifeedsci.2023.115628
    [Google Scholar]
  119. Park C.S. Feed composition for production of functional eggs containing sulforaphane and egg production method. Patent KR2552608 2023
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