Skip to content
2000
image of Nanomaterials for Temporomandibular Joint Osteoarthritis Therapy: A Mini-Review

Abstract

Osteoarthritis, particularly temporomandibular joint (TMJ) osteoarthritis (OA), poses significant challenges in diagnosis and treatment. Recent studies suggest that nanomaterials hold considerable promise in treating TMJ-OA, showing validated efficacy in animal models. However, further research is required to ensure their long-term safety within the TMJ-OA environment. Nanomaterials can facilitate drug delivery and encapsulate functional cells and extracellular vesicles, offering new avenues for exploration. This paper reviews the current research status of nanomaterials in TMJ-OA treatment, including drug delivery, anti-inflammatory, lubricating and buffering, antioxidant, tissue regeneration, scaffold, and stimuli-responsive nanomaterials. Additionally, the paper explores the development and future prospects of nanomaterials in TMJ-OA treatment, highlighting their unique contributions and aiming to provide new perspectives and solutions for unexplored areas.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cchts/10.2174/0113862073339608241214053500
2025-01-02
2025-09-14

  • From This Site

    /content/journals/cchts/10.2174/0113862073339608241214053500
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. Zou Z. Luo X. Chen Z. Zhang Y.S. Wen C. Emerging microfluidics-enabled platforms for osteoarthritis management: From benchtop to bedside. Theranostics 2022 12 2 891 909 10.7150/thno.62685 34976219
    [Google Scholar]
  2. Glyn-Jones S. Palmer A.J.R. Agricola R. Price A.J. Vincent T.L. Weinans H. Carr A.J. Osteoarthritis. Lancet 2015 386 9991 376 387 10.1016/S0140‑6736(14)60802‑3 25748615
    [Google Scholar]
  3. Schminke B. Muhammad H. Bode C. Sadowski B. Gerter R. Gersdorff N. Bürgers R. Monsonego-Ornan E. Rosen V. Miosge N. A discoidin domain receptor 1 knock-out mouse as a novel model for osteoarthritis of the temporomandibular joint. Cell. Mol. Life Sci. 2014 71 6 1081 1096 10.1007/s00018‑013‑1436‑8 23912900
    [Google Scholar]
  4. Wang X.D. Zhang J.N. Gan Y.H. Zhou Y.H. Current understanding of pathogenesis and treatment of TMJ osteoarthritis. J. Dent. Res. 2015 94 5 666 673 10.1177/0022034515574770 25744069
    [Google Scholar]
  5. Wang Z. Wang S. Wang K. Wu X. Tu C. Gao C. Stimuli-sensitive nanotherapies for the treatment of osteoarthritis. Macromol. Biosci. 2021 21 11 2100280 10.1002/mabi.202100280 34396698
    [Google Scholar]
  6. Liang Y. Xu X. Xu L. Prasadam I. Duan L. Xiao Y. Xia J. Non-surgical osteoarthritis therapy, intra-articular drug delivery towards clinical applications. J. Drug Target. 2021 29 6 609 616 10.1080/1061186X.2020.1870231 33356642
    [Google Scholar]
  7. Zerrillo L. Gigliobianco M.R. D’Atri D. Garcia J.P. Baldazzi F. Ridwan Y. Fuentes G. Chan A. Creemers L.B. Censi R. Di Martino P. Cruz L.J. PLGA nanoparticles grafted with hyaluronic acid to improve site-specificity and drug dose delivery in osteoarthritis nanotherapy. Nanomaterials (Basel) 2022 12 13 2248 10.3390/nano12132248 35808084
    [Google Scholar]
  8. Gambaro F.M. Ummarino A. Torres Andón F. Ronzoni F. Di Matteo B. Kon E. Drug delivery systems for the treatment of knee osteoarthritis: A systematic review of in vivo studies. Int. J. Mol. Sci. 2021 22 17 9137 10.3390/ijms22179137 34502046
    [Google Scholar]
  9. Hunter D.J. Chang C.C. Wei J.C.C. Lin H.Y. Brown C. Tai T.T. Wu C.F. Chuang W.C.M. Shih S.F. TLC599 in patients with osteoarthritis of the knee: A phase IIa, randomized, placebo-controlled, dose-finding study. Arthritis Res. Ther. 2022 24 1 52 10.1186/s13075‑022‑02739‑4 35189943
    [Google Scholar]
  10. Kraus V.B. Conaghan P.G. Aazami H.A. Mehra P. Kivitz A.J. Lufkin J. Hauben J. Johnson J.R. Bodick N. Synovial and systemic pharmacokinetics (PK) of triamcinolone acetonide (TA) following intra-articular (IA) injection of an extended-release microsphere-based formulation (FX006) or standard crystalline suspension in patients with knee osteoarthritis (OA). Osteoarthritis Cartilage 2018 26 1 34 42 10.1016/j.joca.2017.10.003 29024802
    [Google Scholar]
  11. Langworthy M.J. Conaghan P.G. Ruane J.J. Kivitz A.J. Lufkin J. Cinar A. Kelley S.D. Efficacy of triamcinolone acetonide extended-release in participants with unilateral knee osteoarthritis: A post hoc analysis. Adv. Ther. 2019 36 6 1398 1411 10.1007/s12325‑019‑00944‑3 30968336
    [Google Scholar]
  12. Dilley J.E. Everhart J.S. Klitzman R.G. Hyaluronic acid as an adjunct to microfracture in the treatment of osteochondral lesions of the talus: A systematic review of randomized controlled trials. BMC Musculoskelet. Disord. 2022 23 1 313 10.1186/s12891‑022‑05236‑6 35366851
    [Google Scholar]
  13. Kim Y.S. Guilak F. Engineering hyaluronic acid for the development of new treatment strategies for osteoarthritis. Int. J. Mol. Sci. 2022 23 15 8662 10.3390/ijms23158662 35955795
    [Google Scholar]
  14. Pereira T.V. Jüni P. Saadat P. Xing D. Yao L. Bobos P. Agarwal A. Hincapié C.A. da Costa B.R. Viscosupplementation for knee osteoarthritis: Systematic review and meta-analysis. BMJ 2022 378 e069722 10.1136/bmj‑2022‑069722 36333100
    [Google Scholar]
  15. Tang A.C.W. Tang S.F.T. Hong W.H. Chen H.C. Kinetics features changes before and after intra-articular hyaluronic acid injections in patients with knee osteoarthritis. Clin. Neurol. Neurosurg. 2015 129 Suppl 1 S21 S26 10.1016/S0303‑8467(15)30007‑X 25683308
    [Google Scholar]
  16. Webner D. Huang Y. Hummer C.D. Intraarticular hyaluronic acid preparations for knee osteoarthritis: Are some better than others? Cartilage 2021 13 Suppl 1 1619S 1636S 10.1177/19476035211017320 34044600
    [Google Scholar]
  17. Liapaki A. Thamm J.R. Ha S. Monteiro J.L.G.C. McCain J.P. Troulis M.J. Guastaldi F.P.S. Is there a difference in treatment effect of different intra-articular drugs for temporomandibular joint osteoarthritis? A systematic review of randomized controlled trials. Int. J. Oral Maxillofac. Surg. 2021 50 9 1233 1243 10.1016/j.ijom.2021.01.019 33642154
    [Google Scholar]
  18. Macedo de Sousa B. López-Valverde A. Caramelo F. Rodrigues M.J. López-Valverde N. Medium-term effect of treatment with intra-articular injection of sodium hyaluronate, betamethasone and platelet-rich plasma in patients with temporomandibular arthralgia: A retrospective cohort study. Life (Basel) 2022 12 11 1739 10.3390/life12111739 36362894
    [Google Scholar]
  19. Cai Z. Zhang H. Wei Y. Cong F. Hyaluronan-inorganic nanohybrid materials for biomedical applications. Biomacromolecules 2017 18 6 1677 1696 10.1021/acs.biomac.7b00424 28485601
    [Google Scholar]
  20. Chang M.C. Chiang P.F. Kuo Y.J. Peng C.L. Chen K.Y. Chiang Y.C. Hyaluronan-loaded liposomal dexamethasone-diclofenac nanoparticles for local osteoarthritis treatment. Int. J. Mol. Sci. 2021 22 2 665 10.3390/ijms22020665 33440880
    [Google Scholar]
  21. Zhang Y.S. Gong J.S. Yao Z.Y. Jiang J.Y. Su C. Li H. Kang C.L. Liu L. Xu Z.H. Shi J.S. Insights into the source, mechanism and biotechnological applications of hyaluronidases. Biotechnol. Adv. 2022 60 108018 10.1016/j.biotechadv.2022.108018 35853550
    [Google Scholar]
  22. Luo Y. Tan J. Zhou Y. Guo Y. Liao X. He L. Li D. Li X. Liu Y. From crosslinking strategies to biomedical applications of hyaluronic acid-based hydrogels: A review. Int. J. Biol. Macromol. 2023 231 123308 10.1016/j.ijbiomac.2023.123308 36669634
    [Google Scholar]
  23. Li H. Guo H. Lei C. Liu L. Xu L. Feng Y. Ke J. Fang W. Song H. Xu C. Yu C. Long X. Nanotherapy in joints: Increasing endogenous hyaluronan production by delivering hyaluronan synthase 2. Adv. Mater. 2019 31 46 1904535 10.1002/adma.201904535 31549776
    [Google Scholar]
  24. Nakka K. Hachmer S. Mokhtari Z. Kovac R. Bandukwala H. Bernard C. Li Y. Xie G. Liu C. Fallahi M. Megeney L.A. Gondin J. Chazaud B. Brand M. Zha X. Ge K. Dilworth F.J. JMJD3 activated hyaluronan synthesis drives muscle regeneration in an inflammatory environment. Science 2022 377 6606 666 669 10.1126/science.abm9735 35926054
    [Google Scholar]
  25. Yu Y. Li S. Yao Y. Shen X. Li L. Huang Y. Increasing stiffness promotes pulmonary retention of ligand-directed dexamethasone-loaded nanoparticle for enhanced acute lung inflammation therapy. Bioact. Mater. 2023 20 539 547 10.1016/j.bioactmat.2022.06.016 35846844
    [Google Scholar]
  26. Quiñones J.P. Peniche H. Peniche C. Chitosan based self-assembled nanoparticles in drug delivery. Polymers (Basel) 2018 10 3 235 10.3390/polym10030235 30966270
    [Google Scholar]
  27. de Sousa F.D. Vasconselos P.D. da Silva A.F.B. Mota E.F. da Rocha Tomé A. Mendes F.R.S. Gomes A.M.M. Abraham D.J. Shiwen X. Owen J.S. Lourenzoni M.R. Campos A.R. Moreira R.A. Monteiro-Moreira A.C.O. RETRACTED: Hydrogel and membrane scaffold formulations of Frutalin (breadfruit lectin) within a polysaccharide galactomannan matrix have potential for wound healing. Int. J. Biol. Macromol. 2019 121 429 442 10.1016/j.ijbiomac.2018.10.050 30326222
    [Google Scholar]
  28. Damasceno M.B.M.V. de Melo Júnior J.M.A. Santos S.A.A.R. Melo L.T.M. Leite L.H.I. Vieira-Neto A.E. Moreira R.A. Monteiro-Moreira A.C.O. Campos A.R. Frutalin reduces acute and neuropathic nociceptive behaviours in rodent models of orofacial pain. Chem. Biol. Interact. 2016 256 9 15 10.1016/j.cbi.2016.06.016 27302204
    [Google Scholar]
  29. Tiyaboonchai W. Chitosan nanoparticles: A promising system for drug delivery. Medicine. Mater. Sci. 2003 11 3 51 56 10.1248/cpb.58.1423
    [Google Scholar]
  30. de Barros Mamede Vidal Damasceno M. Santos S.A.A.R. Araújo J.R.C. Barroso L.K.V. Benevides S.C. Magalhães F.E.A. Tavares K.C.S. de Azevedo Moreira R. de Oliveira Monteiro-Moreira A.C. Silva A.R.A. Campos A.R. Development of a nanoformulation for oral protein administration: Characterization and preclinical orofacial antinociceptive effect. AAPS PharmSciTech 2022 23 7 239 10.1208/s12249‑022‑02396‑5 36002707
    [Google Scholar]
  31. Ribeiro L.N.M. Franz-Montan M. Cristina Breitkreitz M. Rodrigues da Silva G.H. Ramos de Castro S. Aparecida Guilherme V. de Araújo D.R. de Paula E. Nanohybrid hydrogels designed for transbuccal anesthesia. Int. J. Nanomedicine 2018 13 6453 6463 10.2147/IJN.S180080 30410331
    [Google Scholar]
  32. Ribeiro L.N.M. Breitkreitz M.C. Guilherme V.A. da Silva G.H.R. Couto V.M. Castro S.R. de Paula B.O. Machado D. de Paula E. Natural lipids-based NLC containing lidocaine: From pre-formulation to in vivo studies. Eur. J. Pharm. Sci. 2017 106 102 112 10.1016/j.ejps.2017.05.060 28558981
    [Google Scholar]
  33. Ribeiro L.N.M. Franz-Montan M. Breitkreitz M.C. Alcântara A.C.S. Castro S.R. Guilherme V.A. Barbosa R.M. de Paula E. Nanostructured lipid carriers as robust systems for topical lidocaine-prilocaine release in dentistry. Eur. J. Pharm. Sci. 2016 93 192 202 10.1016/j.ejps.2016.08.030 27543066
    [Google Scholar]
  34. Rodrigues da Silva G.H. Ribeiro L.N.M. Mitsutake H. Guilherme V.A. Castro S.R. Poppi R.J. Breitkreitz M.C. de Paula E. Optimised NLC: A nanotechnological approach to improve the anaesthetic effect of bupivacaine. Int. J. Pharm. 2017 529 1-2 253 263 10.1016/j.ijpharm.2017.06.066 28655546
    [Google Scholar]
  35. Shinde C.G. Pramod kumar T.M. Venkatesh M.P. Rajesh K.S. Srivastava A. Osmani R.A.M. Sonawane Y.H. Intra-articular delivery of a methotrexate loaded nanostructured lipid carrier based smart gel for effective treatment of rheumatic diseases. RSC Advances 2016 6 16 12913 12924 10.1039/C5RA22672D
    [Google Scholar]
  36. Dyondi D. Sarkar A. Banerjee R. Joint surface-active phospholipid-mimetic liposomes for intra-articular delivery of paclitaxel. J. Biomed. Nanotechnol. 2015 11 7 1225 1235 10.1166/jbn.2015.2061 26307845
    [Google Scholar]
  37. Pivetta T.P. Simões S. Araújo M.M. Carvalho T. Arruda C. Marcato P.D. Development of nanoparticles from natural lipids for topical delivery of thymol: Investigation of its anti-inflammatory properties. Colloids Surf. B Biointerfaces 2018 164 281 290 10.1016/j.colsurfb.2018.01.053 29413607
    [Google Scholar]
  38. Vieira I.R.S. Conte-Junior C.A. Nano-delivery systems for food bioactive compounds in cancer: prevention, therapy, and clinical applications. Crit. Rev. Food Sci. Nutr. 2024 64 2 381 406 10.1080/10408398.2022.2106471 35938315
    [Google Scholar]
  39. Guilherme V.A. Ribeiro L.N.M. Alcântara A.C.S. Castro S.R. Rodrigues da Silva G.H. da Silva C.G. Breitkreitz M.C. Clemente-Napimoga J. Macedo C.G. Abdalla H.B. Bonfante R. Cereda C.M.S. de Paula E. Improved efficacy of naproxen-loaded NLC for temporomandibular joint administration. Sci. Rep. 2019 9 1 11160 10.1038/s41598‑019‑47486‑w 31371737
    [Google Scholar]
  40. Gao C. Song X.D. Chen F.H. Wei G.L. Guo C.Y. The protective effect of natural medicines in rheumatoid arthritis via inhibit angiogenesis. Front. Pharmacol. 2024 15 1380098 10.3389/fphar.2024.1380098 38881875
    [Google Scholar]
  41. Brown S. Kumar S. Sharma B. Intra-articular targeting of nanomaterials for the treatment of osteoarthritis. Acta Biomater. 2019 93 239 257 10.1016/j.actbio.2019.03.010 30862551
    [Google Scholar]
  42. Hu Q. Ecker M. Overview of MMP-13 as a promising target for the treatment of osteoarthritis. Int. J. Mol. Sci. 2021 22 4 1742 10.3390/ijms22041742 33572320
    [Google Scholar]
  43. Vincent T.L. IL-1 in osteoarthritis: Time for a critical review of the literature. F1000Res 2019 8 F1000 Faculty Rev-934 10.12688/f1000research.18831.1
    [Google Scholar]
  44. Fernandes J.C. Martel-Pelletier J. Pelletier J.P. The role of cytokines in osteoarthritis pathophysiology. Biorheology 2002 39 1-2 237 246 12082286
    [Google Scholar]
  45. Jung J.H. Kim S.E. Kim H.J. Park K. Song G.G. Choi S.J. A comparative pilot study of oral diacerein and locally treated diacerein-loaded nanoparticles in a model of osteoarthritis. Int. J. Pharm. 2020 581 119249 10.1016/j.ijpharm.2020.119249 32217157
    [Google Scholar]
  46. Boyault S. Simonin M.A. Bianchi A. Compe E. Liagre B. Mainard D. Bécuwe P. Dauça M. Netter P. Terlain B. Bordji K. 15‐Deoxy‐Δ 12,14 ‐PGJ 2, but not troglitazone, modulates IL‐1β effects in human chondrocytes by inhibiting NF‐κB and AP‐1 activation pathways. FEBS Lett. 2001 501 1 24 30 10.1016/S0014‑5793(01)02614‑X 11457450
    [Google Scholar]
  47. Huang X. Pan X. Xiong X. Zhao Z. Cen X. Drug delivery systems for treatment of temporomandibular joint osteoarthritis. Front. Pharmacol. 2022 13 1054703 10.3389/fphar.2022.1054703 36419625
    [Google Scholar]
  48. Abdalla H.B. Napimoga M.H. Macedo C.G. Bonfante R. De Araujo D.R. de Mello N.F.S. Carvalho L.B. Fraceto L.F. Clemente-Napimoga J.T. Poloxamer micellar system for intra-articular injection of 15-deoxy-Δ12,14-prostaglandin J2 with improved bioavailability and anti-inflammatory properties in the temporomandibular joint of rats. Int. J. Pharm. 2020 583 119383 10.1016/j.ijpharm.2020.119383 32360545
    [Google Scholar]
  49. Silva Quinteiro M. Henrique Napimoga M. Gomes Macedo C. Furtado Freitas F. Balassini Abdalla H. Bonfante R. Trindade Clemente-Napimoga J. 15-deoxy-Δ12,14-prostaglandin J2 reduces albumin-induced arthritis in temporomandibular joint of rats. Eur. J. Pharmacol. 2014 740 58 65 10.1016/j.ejphar.2014.07.002 25016088
    [Google Scholar]
  50. Macedo C.G. Napimoga M.H. Rocha-Neto L.M. Abdalla H.B. Clemente-Napimoga J.T. The role of endogenous opioid peptides in the antinociceptive effect of 15-deoxyΔ12,14-prostaglandin J2 in the temporomandibular joint. Prostaglandins Leukot. Essent. Fatty Acids 2016 110 27 34 10.1016/j.plefa.2016.05.009 27255640
    [Google Scholar]
  51. Urban I. Turinsky M. Gehrmann S. Morgenstern J. Brune M. Milewski M.R. Wagner A.H. Rumig C. Fleming T. Leuschner F. Gleissner C.A. Hecker M. 15-Deoxy-δ12,14-prostaglandin j2 reinforces the anti-inflammatory capacity of endothelial cells with a genetically determined no deficit. Circ. Res. 2019 125 3 282 294 10.1161/CIRCRESAHA.118.313820 31213138
    [Google Scholar]
  52. Tang Q. Chen L.L. Wei F. Sun W.L. Lei L.H. Ding P.H. Tan J.Y. Chen X.T. Wu Y.M. Effect of 15-Deoxy-δ12,14-prostaglandin j2nanocapsules on inflammation and bone regeneration in a rat bone defect model. Chin. Med. J. (Engl.) 2017 130 3 347 356 10.4103/0366‑6999.198924 28139520
    [Google Scholar]
  53. Martínez A.E. Sánchez-Gómez F.J. Díez-Dacal B. Oeste C.L. Pérez-Sala D. 15-Deoxy-Δ(12,14)-prostaglandin J2 exerts pro- and anti-inflammatory effects in mesangial cells in a concentration-dependent manner. Inflamm. Allergy Drug Targets 2012 11 1 58 65 10.2174/187152812798889349 22309084
    [Google Scholar]
  54. Napimoga M.H. da Silva C.A.T. Carregaro V. Farnesi-de-Assunção T.S. Duarte P.M. de Melo N.F.S. Fraceto L.F. Exogenous administration of 15d-PGJ2-loaded nanocapsules inhibits bone resorption in a mouse periodontitis model. J. Immunol. 2012 189 2 1043 1052 10.4049/jimmunol.1200730 22706081
    [Google Scholar]
  55. Mercadante V. Scarpa E. De Matteis V. Rizzello L. Poma A. Engineering polymeric nanosystems against oral diseases. Molecules 2021 26 8 2229 10.3390/molecules26082229 33924289
    [Google Scholar]
  56. Macedo C.G. Jain A.K. Franz-Montan M. Napimoga M.H. Clemente-Napimoga J.T. Gill H.S. Microneedles enhance topical delivery of 15-deoxy-Δ 12,14 -prostaglandin J 2 and reduce nociception in temporomandibular joint of rats. J. Control. Release 2017 265 22 29 10.1016/j.jconrel.2017.06.031 28673836
    [Google Scholar]
  57. Kajimoto K. Abbasi S. Harashima H. Elimination of the biphasic pharmacodynamics of 15d-PGJ2 by controlling its release from a nanoemulsion. Int. J. Nanomedicine 2016 11 2685 2694 10.2147/IJN.S106297 27354798
    [Google Scholar]
  58. Alves C.F. de Melo N.F.S. Fraceto L.F. de Araújo D.R. Napimoga M.H. Effects of 15d‐PGJ 2 ‐loaded poly(D,L‐lactide‐co‐glycolide) nanocapsules on inflammation. Br. J. Pharmacol. 2011 162 3 623 632 10.1111/j.1476‑5381.2010.01057.x 20883476
    [Google Scholar]
  59. Clemente-Napimoga J.T. Moreira J.A. Grillo R. de Melo N.F.S. Fraceto L.F. Napimoga M.H. 15d-PGJ2-loaded in nanocapsules enhance the antinociceptive properties into rat temporomandibular hypernociception. Life Sci. 2012 90 23-24 944 949 10.1016/j.lfs.2012.04.035 22564409
    [Google Scholar]
  60. Shi T. Zhao J. Long K. Gao M. Chen F. Chen X. Zhang Y. Huang B. Shao D. Yang C. Wang L. Zhang M. Leong K.W. Chen L. He K. Cationic mesoporous silica nanoparticles alleviate osteoarthritis by targeting multiple inflammatory mediators. Biomaterials 2023 303 122366 10.1016/j.biomaterials.2023.122366 37948854
    [Google Scholar]
  61. Klein J. Chemistry. Repair or replacement - A joint perspective. Science 2009 323 5910 47 48 10.1126/science.1166753 19119205
    [Google Scholar]
  62. Ma L. Gaisinskaya-Kipnis A. Kampf N. Klein J. Origins of hydration lubrication. Nat. Commun. 2015 6 1 6060 10.1038/ncomms7060 25585501
    [Google Scholar]
  63. Yang J. Han Y. Lin J. Zhu Y. Wang F. Deng L. Zhang H. Xu X. Cui W. Ball-bearing-inspired polyampholyte-modified microspheres as bio-lubricants attenuate osteoarthritis. Small 2020 16 44 2006356 10.1002/smll.202006356 33151026
    [Google Scholar]
  64. Dong Y. Kampf N. Schilt Y. Cao W. Raviv U. Klein J. Dehydration does not affect lipid-based hydration lubrication. Nanoscale 2022 14 48 18241 18252 10.1039/D2NR04799C 36468753
    [Google Scholar]
  65. Yan Y. Sun T. Zhang H. Ji X. Sun Y. Zhao X. Deng L. Qi J. Cui W. Santos H.A. Zhang H. Euryale ferox seed-inspired superlubricated nanoparticles for treatment of osteoarthritis. Adv. Funct. Mater. 2019 29 4 1807559 10.1002/adfm.201807559
    [Google Scholar]
  66. Yang W. Zhou F. Polymer brushes for antibiofouling and lubrication. Biosurf. Biotribol. 2017 3 3 97 114 10.1016/j.bsbt.2017.10.001
    [Google Scholar]
  67. Liu G. Feng Y. Zhao N. Chen Z. Shi J. Zhou F. Polymer-based lubricating materials for functional hydration lubrication. Chem. Eng. J. 2022 429 132324 10.1016/j.cej.2021.132324
    [Google Scholar]
  68. Zhao W. Wang H. Han Y. Wang H. Sun Y. Zhang H. Dopamine/phosphorylcholine copolymer as an efficient joint lubricant and ros scavenger for the treatment of osteoarthritis. ACS Appl. Mater. Interfaces 2020 12 46 51236 51248 10.1021/acsami.0c14805 33166449
    [Google Scholar]
  69. Zhao W. Yu Y. Zhang Z. He D. Zhang H. Bioinspired nanospheres as anti-inflammation and antisenescence interfacial biolubricant for treating temporomandibular joint osteoarthritis. ACS Appl. Mater. Interfaces 2022 14 31 35409 35422 10.1021/acsami.2c09120 35894784
    [Google Scholar]
  70. Park K.W. Lee K.M. Yoon D.S. Park K.H. Choi W.J. Lee J.W. Kim S.H. Inhibition of microRNA-449a prevents IL-1β-induced cartilage destruction via SIRT1. Osteoarthritis Cartilage 2016 24 12 2153 2161 10.1016/j.joca.2016.07.002 27421775
    [Google Scholar]
  71. Nimse S.B. Pal D. Free radicals, natural antioxidants, and their reaction mechanisms. RSC Advances 2015 5 35 27986 28006 10.1039/C4RA13315C
    [Google Scholar]
  72. Lepetsos P. Papavassiliou A.G. ROS/oxidative stress signaling in osteoarthritis. Biochim. Biophys. Acta Mol. Basis Dis. 2016 1862 4 576 591 10.1016/j.bbadis.2016.01.003 26769361
    [Google Scholar]
  73. C Juneja S. Ventura M. Jay G.D. Veillette C. A less invasive approach of medial meniscectomy in rat: A model to target early or less severe human osteoarthritis. J. Arthritis 2016 5 2 10.4172/2167‑7921.1000193
    [Google Scholar]
  74. Ansari M.Y. Ahmad N. Haqqi T.M. Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols. Biomed. Pharmacother. 2020 129 110452 10.1016/j.biopha.2020.110452 32768946
    [Google Scholar]
  75. Kim S.E. Choi S.J. Park K. Kim H.J. Song G.G. Jung J.H. Intra-articular injection of rebamipide-loaded nanoparticles attenuate disease progression and joint destruction in osteoarthritis rat model: A pilot study. Cartilage 2022 13 1 19476035211069250 10.1177/19476035211069250 35118894
    [Google Scholar]
  76. Tang Q. Zheng G. Feng Z. Chen Y. Lou Y. Wang C. Zhang X. Zhang Y. Xu H. Shang P. Liu H. Trehalose ameliorates oxidative stress-mediated mitochondrial dysfunction and ER stress via selective autophagy stimulation and autophagic flux restoration in osteoarthritis development. Cell Death Dis. 2017 8 10 e3081 10.1038/cddis.2017.453
    [Google Scholar]
  77. Tangtrongsup S. Kisiday J.D. Modulating the oxidative environment during mesenchymal stem cells chondrogenesis with serum increases collagen accumulation in agarose culture. J. Orthop. Res. 2018 36 1 506 514 10.1002/jor.23618 28548680
    [Google Scholar]
  78. Gui T. Luo L. Chhay B. Zhong L. Wei Y. Yao L. Yu W. Li J. Nelson C.L. Tsourkas A. Superoxide dismutase-loaded porous polymersomes as highly efficient antioxidant nanoparticles targeting synovium for osteoarthritis therapy. Biomaterials 2022 283 121437 10.1016/j.biomaterials.2022.121437
    [Google Scholar]
  79. Ogboo B.C. Grabovyy U.V. Maini A. Scouten S. van der Vliet A. Mattevi A. Heppner D.E. Architecture of the NADPH oxidase family of enzymes. Redox Biol. 2022 52 102298 10.1016/j.redox.2022.102298 35334249
    [Google Scholar]
  80. Brandes R.P. Weissmann N. Schröder K. Nox family NADPH oxidases: Molecular mechanisms of activation. Free Radic. Biol. Med. 2014 76 208 226 10.1016/j.freeradbiomed.2014.07.046 25157786
    [Google Scholar]
  81. Arra M. Swarnkar G. Ke K. Otero J.E. Ying J. Duan X. Maruyama T. Rai M.F. O’Keefe R.J. Mbalaviele G. Shen J. Abu-Amer Y. LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis. Nat. Commun. 2020 11 1 3427 10.1038/s41467‑020‑17242‑0 32647171
    [Google Scholar]
  82. Xiong L. Bao H. Li S. Gu D. Li Y. Yin Q. Li W. Miao L. Liu C. Cerium oxide nanoparticles protect against chondrocytes and cartilage explants from oxidative stress via Nrf2/HO-1 pathway in temporomandibular joint osteoarthritis. Front. Bioeng. Biotechnol. 2023 11 1076240 10.3389/fbioe.2023.1076240 36815898
    [Google Scholar]
  83. Liu Y. Cheng Y. Zhang H. Zhou M. Yu Y. Lin S. Jiang B. Zhao X. Miao L. Wei C.W. Liu Q. Lin Y.W. Du Y. Butch C.J. Wei H. Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy. Sci. Adv. 2020 6 29 eabb2695 10.1126/sciadv.abb2695 32832640
    [Google Scholar]
  84. Zhang Z. Yuan L. Liu Y. Wang R. Zhang Y. Yang Y. Wei H. Ma J. Integrated cascade nanozyme remodels chondrocyte inflammatory microenvironment in temporomandibular joint osteoarthritis via inhibiting ROS-NF-κB and MAPK pathways. Adv. Healthc. Mater. 2023 12 10 2203195 10.1002/adhm.202203195 36738173
    [Google Scholar]
  85. Al-Moraissi E.A. Wolford L.M. Ellis E. Neff A. The hierarchy of different treatments for arthrogenous temporomandibular disorders: A network meta-analysis of randomized clinical trials. J. Craniomaxillofac. Surg. 2020 48 1 9 23 10.1016/j.jcms.2019.10.004 31870713
    [Google Scholar]
  86. Trindade D. Cordeiro R. José H.C. Ângelo D.F. Alves N. Moura C. Biological treatments for temporomandibular joint disc disorders: strategies in tissue engineering. Biomolecules 2021 11 7 933 10.3390/biom11070933 34201698
    [Google Scholar]
  87. Singh A.K. Khanal N. Chaulagain R. Advances in tissue engineering of the temporomandibular joint disc: An overview of current status and future directions. Int. J. Dent. 2022 2022 1 8 10.1155/2022/9696378 35910087
    [Google Scholar]
  88. Wu L. Gu Y. Liu L. Tang J. Mao J. Xi K. Jiang Z. Zhou Y. Xu Y. Deng L. Chen L. Cui W. Hierarchical micro/nanofibrous membranes of sustained releasing VEGF for periosteal regeneration. Biomaterials 2020 227 119555 10.1016/j.biomaterials.2019.119555 31655445
    [Google Scholar]
  89. Xue J. Wu T. Dai Y. Xia Y. Electrospinning and electrospun nanofibers: Methods, materials, and applications. Chem. Rev. 2019 119 8 5298 5415 10.1021/acs.chemrev.8b00593 30916938
    [Google Scholar]
  90. Gan Z. Zhao Y. Wu Y. Yang W. Zhao Z. Zhao L. Three-dimensional, biomimetic electrospun scaffolds reinforced with carbon nanotubes for temporomandibular joint disc regeneration. Acta Biomater. 2022 147 221 234 10.1016/j.actbio.2022.05.008 35562008
    [Google Scholar]
  91. Moarrefzadeh A. Morovvati M.R. Angili S.N. Smaisim G.F. Khandan A. Toghraie D. Fabrication and finite element simulation of 3D printed poly L-lactic acid scaffolds coated with alginate/carbon nanotubes for bone engineering applications. Int. J. Biol. Macromol. 2023 224 1496 1508 10.1016/j.ijbiomac.2022.10.238 36550791
    [Google Scholar]
  92. Chi N. Wang R. Electrospun protein-CNT composite fibers and the application in fibroblast stimulation. Biochem. Biophys. Res. Commun. 2018 504 1 211 217 10.1016/j.bbrc.2018.08.157 30172370
    [Google Scholar]
  93. Zhao Y. Wei C. Chen X. Liu J. Yu Q. Liu Y. Liu J. Drug delivery system based on near-infrared light-responsive molybdenum disulfide nanosheets controls the high-efficiency release of dexamethasone to inhibit inflammation and treat osteoarthritis. ACS Appl. Mater. Interfaces 2019 11 12 11587 11601 10.1021/acsami.8b20372 30844228
    [Google Scholar]
  94. Liu Y. Ai K. Lu L. Polydopamine and its derivative materials: Synthesis and promising applications in energy, environmental, and biomedical fields. Chem. Rev. 2014 114 9 5057 5115 10.1021/cr400407a 24517847
    [Google Scholar]
  95. Lin K. Gan Y. Zhu P. Li S. Lin C. Yu S. Zhao S. Shi J. Li R. Yuan J. Hollow mesoporous polydopamine nanospheres: Synthesis, biocompatibility and drug delivery. Nanotechnology 2021 32 28 10.1088/1361‑6528/abf4a9
    [Google Scholar]
  96. Li Q. Hou Y. Cao P. Bi R. Zhu S. Near-infrared light-activated mesoporous polydopamine for temporomandibular joint osteoarthritis combined photothermal-chemo therapy. Int. J. Mol. Sci. 2023 24 10 9055 10.3390/ijms24109055 37240401
    [Google Scholar]
  97. Roy H.S. Singh R. Ghosh D. Recent advances in nanotherapeutic strategies that target nitric oxide pathway for preventing cartilage degeneration. Nitric Oxide 2021 109-110 1 11 10.1016/j.niox.2021.01.002 33571602
    [Google Scholar]
/content/journals/cchts/10.2174/0113862073339608241214053500
Loading

  • Article Type:     Review Article
Keywords: intra-articular injection ; nanotechnology ; temporomandibular joint ; osteoarthritis ; nanotherapy ; Nanomaterials

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test