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2000
Volume 28, Issue 17
  • ISSN: 1386-2073
  • E-ISSN: 1875-5402

Abstract

Cardiovascular diseases (CVDs) remain a key contributor to global morbidity and mortality. Being a vital regulator of hypoxia, hypoxia-inducible factor-1α (HIF-1α) is a crucial player in CVD treatment. Recently, increasing attention has been paid to the effect of natural drugs on CVDs. According to some studies, HIF-1α is a potential target for CVD treatment in traditional Chinese medicine. In this study, we describe the mechanism underlying the regulatory role of HIF-1α in CVDs and summarize 30 natural drugs and 3 formulations for CVD treatment through HIF-1α and its signaling pathway. The study provides new ideas for CVD prevention and treatment.

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2024-11-05
2025-12-20

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/content/journals/cchts/10.2174/0113862073331615241018081811
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Potential Cardiovascular Disease Treatment by Natural Drugs Targeting the HIF-1α Factor and its Pathway
Comb Chem High Throughput Screen 28, 2971 (2025); https://doi.org/10.2174/0113862073331615241018081811
/content/journals/cchts/10.2174/0113862073331615241018081811
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  • Article Type:     Review Article
Keyword(s): angiogenesis; autophagy; Cardiovascular disease; flavonoids; HIF-1α; inflammation; natural drugs; oxidative stress

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