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2000
Volume 19, Issue 3
  • ISSN: 2212-7968
  • E-ISSN: 1872-3136

Abstract

Insulin resistance (IR) is a pathological condition of type-2 diabetes mellitus, a complex metabolic disorder with numerous mechanisms. Insulin is a nutrient-responsive hormone released into the blood from the pancreatic β cells and binds to the receptor kinase at the targeted sites . skeletal muscle, adipose tissue, and liver cells. Insulin acts through the phosphoinositide 3-kinase/Ak strain transforming (PI3/Akt) pathway to translocate Glut4 into the plasma membrane thus mediating the intake of glucose in the tissue from the blood. Insulin resistance is when either insulin binding to the receptor is inefficient or the activated insulin receptor cannot transmit the signal downstream effectively. Numerous molecular mechanisms lead to hampered downstream signalling and reduced response to insulin binding. This review gives a complete overview of the current knowledge and understanding of the mechanism of insulin signalling, factors affecting insulin resistance, and the role of bioactive compounds like curcumin, resveratrol, withaferin in managing insulin resistance.

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2025-04-04
2025-12-16

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/content/journals/ccb/10.2174/0122127968376217250324190715
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Insulin Sensitization as a Mechanistic Approach in the Management of Diabetes; Bio-actives from Plants as Possible Insulin-sensitizing Agents; A Review
Curr Chem Biol 19, 173 (2025); https://doi.org/10.2174/0122127968376217250324190715
/content/journals/ccb/10.2174/0122127968376217250324190715
/content/journals/ccb/10.2174/0122127968376217250324190715
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  • Article Type:     Review Article
Keyword(s): bioactive compounds; Glut4 translocation; insulin resistance; Insulin signaling; insulin-sensitizing agents; natural insulin sensitizers; PI3/Akt pathway

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