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image of Patent Landscape Analysis of Antioxidants from Lamiaceae Plants: Innovations and Applications

Abstract

Introduction

plants are a rich source of natural antioxidants, widely applied in cosmetics, pharmaceuticals, and functional foods due to their therapeutic potential against oxidative stress-related disorders. As natural product innovation accelerates, understanding patent trends can provide strategic insights into technological advances, key stakeholders, and emerging applications.

Methods

A systematic patent landscape analysis was performed using the Espacenet database. The search strategy was based on the intersection of Cooperative Patent Classification (CPC) codes related to therapeutic applications (, A61P39/06 for oxidative stress, A61P17/18 for dermatological use), medicinal preparations (A61K36), and botanical classifications (A01H6/50 for ). All patent documents up to 2024 were included, with no language restrictions. Patent families, publication trends, jurisdictions, assignees, CPC classifications, and technological applications were analyzed to map the innovation landscape.

Results

Between 2001 and 2021, there was a steady rise in patent activity related to antioxidants from species. China led in both the volume and diversity of innovations, followed by the United States and Europe. Technological applications are predominantly concerned with cosmetics, dermatological treatments, pharmaceuticals, and functional food products. Leading assignees included multinational and regional companies, indicating strong commercial interest in these bioactive compounds.

Discussion

The patent trends reveal increasing global interest in sustainable, plant-derived antioxidant solutions. The strong presence of industry players highlights the translational potential of -derived compounds in high-value sectors such as anti-aging, anti-inflammatory therapeutics, and wellness. Jurisdictional variations reflect strategic patenting behavior and regional innovation capacities.

Conclusion

This study highlights the growing strategic importance of -derived antioxidants in innovation ecosystems. The patent landscape identifies key technologies, markets, and actors driving development in natural antioxidant applications. These findings support future interdisciplinary research and industry partnerships aimed at advancing sustainable, bioactive product innovation.

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2025-09-29
2025-10-25
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References

  1. Zafar F. Asif H.M. Shaheen G. Ghauri A.O. Rajpoot S.R. Tasleem M.W. Shamim T. Hadi F. Noor R. Ali T. Gulzar M.N. Nazar H. A comprehensive review on medicinal plants possessing antioxidant potential. Clin Exp Pharmacol Physiol 2023 50 3 205 217 10.1111/1440‑1681.13743 36479862
    [Google Scholar]
  2. Duque-Soto C. Borrás-Linares I. Quirantes-Piné R. Falcó I. Sánchez G. Segura-Carretero A. Lozano-Sánchez J. Potential antioxidant and antiviral activities of hydroethanolic extracts of selected Lamiaceae species. Foods 2022 11 13 1862 10.3390/foods11131862 35804677
    [Google Scholar]
  3. Moshari-Nasirkandi A. Alirezalu A. Alipour H. Amato J. Screening of 20 species from Lamiaceae family based on phytochemical analysis, antioxidant activity and HPLC profiling. Sci Rep 2023 13 1 16987 10.1038/s41598‑023‑44337‑7 37813985
    [Google Scholar]
  4. Xin Z. Wang W. Yang W. Li Y. Niu L. Zhang Y. Investigation of volatile components and assessment of antioxidant potential in seven Lamiaceae plant hydrosols. Molecules 2023 29 1 145 10.3390/molecules29010145 38202728
    [Google Scholar]
  5. Paulus D. Luchesi L.A. Ramos C.E.P. León L.D.V.T. Bioactivity of essential oils of species of the Lamiaceae family. Curr Innov Med Med Sci 2022 4 1 19 10.9734/bpi/cimms/v4/3226C
    [Google Scholar]
  6. Tsitsigianni E. Tomou E.M. Almpani C. Rallis M.C. Skaltsa H. Biological activities of Lamiaceae species: Bio-guided isolation of active metabolites from Salvia officinalis L. Agronomy 2023 13 5 1224 10.3390/agronomy13051224
    [Google Scholar]
  7. El Boukhari R. Fatimi A. Extraction methods applied to natural Lamiaceae-derived compounds: An overview based on patents. Eng Proc 2023 56 79 10.3390/ASEC2023‑15362
    [Google Scholar]
  8. El Boukhari R. Fatimi A. Extract of rosemary as food additive: The landmark patents. Biol Life Sci Forum 2023 26 1 37 10.3390/Foods2023‑15062
    [Google Scholar]
  9. Campinho A. Alves J. Martins R. Vieira M. Grosso C. Delerue- Matos C. Exploring the antiradical potential of species from Lamiaceae family: Implications for functional food development in the context of neurodegenerative and neuropsychiatric diseases. Biol Life Sci Forum 2023 26 33 10.3390/Foods2023‑15493
    [Google Scholar]
  10. El Boukhari R. Fatimi A. Advancing functional food innovation: A patent landscape analysis of Lamiaceae bioactives through Cooperative Patent Classification systems. Biol Life Sci Forum 2024 38 1 10.3390/blsf2024038001
    [Google Scholar]
  11. El Boukhari R. Fatimi A. Lamiaceae plants and cardiovascular health: A patent-driven path to functional foods. Biol Life Sci Forum 2024 40 2 10.3390/blsf2024040002
    [Google Scholar]
  12. El Boukhari R. Matin M. Atanasov A.G. Fatimi A. Recent advances in pest-repellents based on the Lamiaceae family’s plants: A patent analysis overview. Anim Sci Pap Rep 2024 42 4 383 400 10.2478/aspr‑2023‑0044
    [Google Scholar]
  13. El Boukhari R. Fatimi A. Patent analysis of four Lamiaceae-derived plants: A medicinally active resource against new health challenges. Med Sci Forum 2023 21 1 10.3390/ECB2023‑14093
    [Google Scholar]
  14. Kowalczyk T. Merecz-Sadowska A. Ghorbanpour M. Szemraj J. Piekarski J. Bijak M. Śliwiński T. Zajdel R. Sitarek P. Enhanced natural strength: Lamiaceae essential oils and nanotechnology in in vitro and in vivo medical research. Int J Mol Sci 2023 24 20 15279 10.3390/ijms242015279 37894959
    [Google Scholar]
  15. Aebisher D. Cichonski J. Szpyrka E. Masjonis S. Chrzanowski G. Essential oils of seven Lamiaceae plants and their antioxidant capacity. Molecules 2021 26 13 3793 10.3390/molecules26133793 34206525
    [Google Scholar]
  16. Espacenet: Free access to over 150 million patent documents. Available from:https://worldwide.espacenet.com
  17. Espacenet glossary. Available from:https://worldwide.espacenet.com/patent/help/espacenet-glossary
  18. Ghosh N. Chatterjee S. Sil P.C. Nabavi S.M. Silva A.S. Evolution of antioxidants over times (including current global market and trend). Antioxidants Effects in Health Amsterdam Elsevier 2022 3 32 10.1016/B978‑0‑12‑819096‑8.00011‑2
    [Google Scholar]
  19. Antioxidant market size and forecast. Available from:https://www.verifiedmarketresearch.com/product/antioxidant-market 2024
  20. Antioxidants Market Size, Share & Industry Analysis. 2025. Available from: http://www.fortunebusinessinsights.com/industry-reports/food-antioxidants-market-100789
  21. Amarachukwu Uzombah T. Prieto M.Á. Otero P. Carpena Rodriguez M. The implications of replacing synthetic antioxidants with natural ones in the food systems. Natural Food Additives Rijeka IntechOpen 2022 10.5772/intechopen.103810
    [Google Scholar]
  22. Antioxidants market research report information. Available from: https://www.marketresearchfuture.com/reports/antioxidants- market-10309 2025
  23. Song K.S. Moon B.K. Back S.O. A composition for skin-care comprising coenzyme Q10. 2007 K.R. Patent 20070103173A
  24. Gianeti M.D. Mercurio D.G. Maia Campos P.M.B.G. The use of green tea extract in cosmetic formulations: Not only an antioxidant active ingredient. Dermatol Ther 2013 26 3 267 271 10.1111/j.1529‑8019.2013.01552.x 23742288
    [Google Scholar]
  25. Cao C. Pathak S. Patil K. Cao C. Pathak S. Patil K. Antioxidant Nutraceuticals: Preventive and Healthcare Applications CRC Press 2017 1st ed 10.1201/9781315121024
    [Google Scholar]
  26. Marttin E. Derrien A.C. How to apply examiner search strategies in Espacenet. A case study. World Pat Inf 2018 54 S33 S43 10.1016/j.wpi.2017.06.001
    [Google Scholar]
  27. Fatimi A. Exploring the patent landscape and innovation of hydrogel-based bioinks used for 3D bioprinting. Recent Adv Drug Deliv Formul 2022 16 2 145 163 10.2174/2667387816666220429095834 35507801
    [Google Scholar]
  28. Nishimura E. Skin composition. 2024 J.P. Patent 2024175085A
  29. Yang X. An Z. Ma J. Liu X. Xu Z. Gao P. Zhang Y. Liu D. Yang Q. Miao H. Wang Z. Zhang C. Oil-in-water type lavender essential oil emulsion and preparation method thereof. 2024 C.N. Patent 118634261A
  30. Wang M. External medicament for maintaining and cleaning mucosa cell tissues of female reproductive system. 2022 C.N. Patent 115192699A
  31. Sun Y. Xiong S. Zhao H. Chen W. Nie Y. Guo C. Sun H. Hu L. Pharmaceutical composition as well as preparation method and application thereof. 2022 C.N. Patent 112656838B
  32. Whan C.Y. Young P.S. Guo L. Ha P.J. Mi K.H. Nam P.J. Hee Y.K. A composition for antioxidant or whitening comprising rosemary ionic liquid extract. 2021 K.R. Patent 20210108911A
  33. Bian M. Xiao X. Luo S. Yang Y. Zou Y. Xu Q. Bath medicine bag and preparation method thereof. 2021 C.N. Patent 112402526A
  34. Ki C.C. Hyun B. Kook J.B. Geun L.J. Ung Y.J. Byoung B.H. Su K.H. Ju A.Y. A composition for antioxidation anti-inflammation antiaging or skin soothing comprising herb complex extracts. 2020 K.R. Patent 102127771B1
  35. Dal Monte R. Dal Toso R. Minghetti A. Crespi Perellino N. Pressi G. Extracts from Ajuga reptans cell lines, their preparation and use. 2017 U.S. Patent 9623063B2
  36. Golz-Berner K. Zastrow L. Use of free radical scavengers for protecting and treating skin and hair damages caused by chemotherapy. 2016 U.S. Patent 9446084B2
  37. Cioca G. Ionita-Manzatu V. George L. Giacomoni P. Mammone T. Collins D.F. Maes D.H. Bevacqua A.J. Gedeon H. Fthenakis C. Tadlock C.C. Method of enhancing biological activity of plant extracts. 2011 E.P. Patent 1503776B1
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