Skip to content
2000
Volume 18, Issue 2
  • ISSN: 1874-6098
  • E-ISSN: 1874-6128

Abstract

Background

Burning Mouth Syndrome (BMS) is defined as an idiopathic orofacial pain with recurrent intraoral burning. It mainly affects middle-aged women in peri- or post-menopause and the elderly, without any identifiable causative lesions and with or without somatosensory alterations. BMS has a complex pathogenesis involving psychogenic factors and deregulated peripheral and central pain, and there is no standard treatment protocol, making its diagnosis and management challenges.

Objective

This study was to carry out a review literature on BMS, addressing its identification and therapeutic possibilities.

Methods

Review articles and randomized controlled clinical studies whose full text was available, published between 2017 and 2022 in national and international journals, from PubMed and SCIELO databases, WHO manuals and books, were collected. As a search strategy, the keywords “burning mouth syndrome”, “treatment” and “diagnosis” were used, totaling 42 papers. Of these, after applying the exclusion criteria, 34 articles were selected.

Results

Studies indicate that a comprehensive and thorough anamnesis is essential to exclude secondary factors leading to the correct diagnosis of BMS. In addition, a comprehensive anamnesis directs the best management considering a combination of neuropathic and palliative therapies, which aim to control, eliminate and/or minimize painful symptoms, treating the patient in an individualized way and not the disease itself, since this pathology has no cure.

Conclusion

Considering the impact of BMS on quality of life, further studies are needed to expand diagnostic and treatment strategies, aiming to complement existing pharmacological and non-pharmacological treatments, observing the influence that biopsychosocial and neurophysiological mechanisms have on this syndrome.

Loading

Article metrics loading...

/content/journals/cas/10.2174/0118746098279205240812113353
2024-08-28
2025-10-24
Loading full text...

Full text loading...

References

  1. KimM-J. KhoH-S. Understanding of burning mouth syndrome based on psychological aspects.Chin. J. Dent. Res.201821191929507908
    [Google Scholar]
  2. International Classification of Orofacial Pain1st edCephalalgia202040129221
    [Google Scholar]
  3. López-JornetP. Camacho-AlonsoF. Andujar-MateosP. Sánchez-SilesM. Gómez-GarciaF. Burning mouth syndrome: An update.Med. Oral Patol. Oral Cir. Bucal2010154e562e56810.4317/medoral.15.e56220038880
    [Google Scholar]
  4. ForssellH. JääskeläinenS. TenovuoO. HinkkaS. Sensory dysfunction in burning mouth syndrome.Pain2002991414710.1016/S0304‑3959(02)00052‑012237182
    [Google Scholar]
  5. ZakrzewskaJ.M. The burning mouth syndrome remains an enigma.Pain199562325325710.1016/0304‑3959(95)00089‑B8657425
    [Google Scholar]
  6. GuoY. WangB. GaoH. HeC. HuaR. GaoL. DuY. XuJ. Insight into the role of psychological factors in oral mucosa diseases.Int. J. Mol. Sci.20222394760Epub ahead of print10.3390/ijms2309476035563151
    [Google Scholar]
  7. BenderS.D. Burning mouth syndrome.Dent. Clin. North Am.201862458559610.1016/j.cden.2018.05.00630189984
    [Google Scholar]
  8. RussoM. CrafaP. GuglielmettiS. FranzoniL. FioreW. Di MarioF. Burning mouth syndrome etiology: A narrative review.J. Gastrointestin. Liver Dis.202231222322810.15403/jgld‑424535574619
    [Google Scholar]
  9. WrightS.L. Limited utility for benzodiazepines in chronic pain management: A narrative review.Adv. Ther.20203762604261910.1007/s12325‑020‑01354‑632378069
    [Google Scholar]
  10. VerhulstM.J.L. LoosB.G. GerdesV.E.A. TeeuwW.J. Evaluating all potential oral complications of diabetes mellitus.Front. Endocrinol2019105610.3389/fendo.2019.0005630962800
    [Google Scholar]
  11. JääskeläinenS.K. WodaA. Burning mouth syndrome.Cephalalgia201737762764710.1177/033310241769488328569120
    [Google Scholar]
  12. (a AlnazzawiA. Effect of Fixed Metallic Oral Appliances on Oral Health.J Int Soc Prev Community Dent2018849398
    [Google Scholar]
  13. (b AlrashdanM.S. AlkhaderM. Psychological factors in oral mucosal and orofacial pain conditions.Eur J Dent20171145485210.4103/ejd.ejd_11_1729279685
    [Google Scholar]
  14. NomaN. WatanabeY. ShimadaA. UsudaS. IidaT. ShimadaA. TanakaY. OonoY. SasakiK. Effects of cognitive behavioral therapy on orofacial pain conditions.J. Oral Sci.20216314710.2334/josnusd.20‑043733298629
    [Google Scholar]
  15. BraudA. TouréB. Agbo-GodeauS. DescroixV. BoucherY. Characteristics of pain assessed with visual analog scale and questionnaire in burning mouth syndrome patients: A pilot study.J. Orofac. Pain201327323524210.11607/jop.103823882456
    [Google Scholar]
  16. AbetzL.M. SavageN.W. Burning mouth syndrome and psychological disorders.Aust. Dent. J.2009542849310.1111/j.1834‑7819.2009.01099.x19473148
    [Google Scholar]
  17. SardellaA. LodiG. DemarosiF. BezC. CassanoS. CarrassiA. Burning mouth syndrome: A retrospective study investigating spontaneous remission and response to treatments.Oral Dis.200612215215510.1111/j.1601‑0825.2005.01174.x16476036
    [Google Scholar]
  18. BorgesGH AraujoMS Diagnóstico e tratamento da síndrome da ardência bucal.Rev Família, Ciclos Vida e Saúde no Context Soc2016426
    [Google Scholar]
  19. CherubiniK MaidanaJD WeigertKL Síndrome da ardência bucal: revisão de cem casos.Rev Odonto Ciência – Fac Odonto/PUCRS2005109113
    [Google Scholar]
  20. HirschA.R. ZiadA. KimA.Y. LailN.S. SharmaS. Pilot study: Alleviation of pain in burning mouth syndrome with topical sucralose.Headache201151344444610.1111/j.1526‑4610.2010.01821.x21352218
    [Google Scholar]
  21. Rodríguez-de Rivera-CampilloE. López-LópezJ. Evaluation of the response to treatment and clinical evolution in patients with burning mouth syndrome.Med. Oral Patol. Oral Cir. Bucal2013183e403e41010.4317/medoral.1814223229252
    [Google Scholar]
  22. Minguez-SanzM.P. Salort-LlorcaC. Silvestre-DonatF.J. Etiology of burning mouth syndrome: A review and update.Med. Oral Patol. Oral Cir. Bucal2011162e144e14810.4317/medoral.16.e14421217613
    [Google Scholar]
  23. SteeleJ.C. BruceA.J. DrageL.A. RogersR.S.III α-Lipoic acid treatment of 31 patients with sore, burning mouth.Oral Dis.200814652953210.1111/j.1601‑0825.2007.01414.x18266840
    [Google Scholar]
  24. CerchiariD.P. MoriczR.D. SanjarF.A. RapoportP.B. MorettiG. GuerraM.M. Síndrome da boca ardente: etiologia.Rev. Bras. Otorrinolaringol.200672341942410.1590/S0034‑72992006000300021
    [Google Scholar]
  25. CoculescuE.C. TovaruS. CoculescuB.I. Epidemiological and etiological aspects of burning mouth syndrome.J. Med. Life20147330530925408745
    [Google Scholar]
  26. TanH.L. SmithJ.G. HoffmannJ. RentonT. A systematic review of treatment for patients with burning mouth syndrome.Cephalalgia202242212816110.1177/0333102421103615234404247
    [Google Scholar]
  27. CiesielskaA. KusiakA. OssowskaA. GrzybowskaM.E. Changes in the oral cavity in menopausal women—a narrative review.Int. J. Environ. Res. Public Health2021191253Epub ahead of print10.3390/ijerph1901025335010513
    [Google Scholar]
  28. KohorstJ.J. BruceA.J. TorgersonR.R. SchenckL.A. DavisM.D.P. The prevalence of burning mouth syndrome: A population-based study.Br. J. Dermatol.201517261654165610.1111/bjd.1361325495557
    [Google Scholar]
  29. TuT.T.H. TakenoshitaM. MatsuokaH. WatanabeT. SugaT. AotaY. AbikoY. ToyofukuA. Current management strategies for the pain of elderly patients with burning mouth syndrome: A critical review.Biopsychosoc. Med.2019131110.1186/s13030‑019‑0142‑730733824
    [Google Scholar]
  30. TakenoshitaM. SatoT. KatoY. KatagiriA. YoshikawaT. SatoY. MatsushimaE. SasakiY. ToyofukuA. Psychiatric diagnoses in patients with burning mouth syndrome and atypical odontalgia referred from psychiatric to dental facilities.Neuropsychiatr. Dis. Treat.2010669970521127687
    [Google Scholar]
  31. (a TuT.T.H. MiuraA. ShinoharaY. MikuzukiL. KawasakiK. SugawaraS. SugaT. WatanabeT. WatanabeM. UmezakiY. YoshikawaT. MotomuraH. TakenoshitaM. ToyofukuA. Evaluating burning mouth syndrome as a comorbidity of atypical odontalgia: The impact on pain experiences.Pain Pract.201818558058610.1111/papr.1264728972293
    [Google Scholar]
  32. (b ThoppayJ. DesaiB. Oral burning: local and systemic connection for a patient-centric approach.EPMA J201910111
    [Google Scholar]
  33. BergdahlM BergdahlJ. Burning mouth syndrome: prevalence and associated factors. J oral Pathol Med Off Publ Int Assoc Oral Pathol Am Acad Oral Pathol199928350354
    [Google Scholar]
  34. WodaA. NavezM.L. PicardP. GremeauC. Pichard-LeandriE. A possible therapeutic solution for stomatodynia (burning mouth syndrome).J. Orofac. Pain199812427227810425973
    [Google Scholar]
  35. GaitondeP. RostronJ. LongmanL. FieldE.A. Burning mouth syndrome and vulvodynia coexisting in the same patient: A case report.Dent. Update2002292757610.12968/denu.2002.29.2.7511928344
    [Google Scholar]
  36. GrinspanD. Fernández BlancoG. Angel AllevatoM. StengelF.M. Burning mouth syndrome.Int. J. Dermatol.199534748348710.1111/j.1365‑4362.1995.tb00617.x7591412
    [Google Scholar]
  37. GurvitsG.E. TanA. Burning mouth syndrome.World J. Gastroenterol.201319566567210.3748/wjg.v19.i5.66523429751
    [Google Scholar]
  38. TatulloM. MarrelliM. ScaccoS. LorussoM. DoriaS. SabatiniR. AuteriP. CagianoR. InchingoloF. Relationship between oxidative stress and “burning mouth syndrome” in female patients: A scientific hypothesis.Eur. Rev. Med. Pharmacol. Sci.20121691218122123047505
    [Google Scholar]
  39. PattonLL SiegelMA BenolielR Management of burning mouth syndrome: Systematic review and management recommendations.Oral Surg Oral Med Oral Pathol Oral Radiol Endod2007103S39e11310.1016/j.tripleo.2006.11.009
    [Google Scholar]
  40. PoonR. SuN. ChingV. DarlingM. GrushkaM. Reduction in unstimulated salivary flow rate in burning mouth syndrome.Br. Dent. J.20142177E1410.1038/sj.bdj.2014.88425303607
    [Google Scholar]
  41. SpadariF VenesiaP AzziL Low basal salivary flow and burning mouth syndrome: New evidence in this enigmatic pathology.J oral Pathol Med Off Publ Int Assoc Oral Pathol Am Acad Oral Pathol201544229233
    [Google Scholar]
  42. ThomasD.C. ChablaniD. ParekhS. PichammalR.C. ShanmugasundaramK. PitchumaniP.K. Dysgeusia.J. Am. Dent. Assoc.2022153325126410.1016/j.adaj.2021.08.00934799014
    [Google Scholar]
  43. López-JornetP. Camacho-AlonsoF. Leon-EspinosaS. Burning mouth syndrome, oral parafunctions, and psychological profile in a longitudinal case study.J. Eur. Acad. Dermatol. Venereol.200923336336510.1111/j.1468‑3083.2008.02873.x18624879
    [Google Scholar]
  44. XieS.F. LiC.C. HeH. Current advances in research of burning mouth syndrome: biological nerve and social psychology patterns. Zhonghua kou qiang yi xue za zhi Zhonghua kouqiang yixue zazhi = Chinese.J. Stomatol202055123128
    [Google Scholar]
  45. CarvalhoV.J.G. GalloC.B. SugayaN.N. DomaneschiC. Clinical characteristics and therapeutic response in patients with Burning Mouth Syndrome: accompanying 2 years.Rev. Odontol. UNESP2017461455010.1590/1807‑2577.00416
    [Google Scholar]
  46. The international classification of headache disorders.Cephalalgia(3rd ed,.) 2013629808
    [Google Scholar]
  47. RabieiM. LeiliE. AlizadehL. Burning mouth syndrome: A comparative cross-sectional study.Contemp. Clin. Dent.201896Suppl. 225610.4103/ccd.ccd_175_1830294154
    [Google Scholar]
  48. ŚlebiodaZ SzponarE. Burning mouth syndrome - a common dental problem in perimenopausal women.Prz menopauzalny = Menopause Rev2014133198202
    [Google Scholar]
  49. Antoun ReyadA. MishrikyR. GirgisE. Pharmacological and non-pharmacological management of burning mouth syndrome: A systematic review.Dent. Med. Probl.202057329530410.17219/dmp/12099133113291
    [Google Scholar]
  50. OrliaguetM. MiseryL. Neuropathic and psychogenic components of burning mouth syndrome: A systematic review.Biomolecules2021118123710.3390/biom1108123734439903
    [Google Scholar]
  51. JääskeläinenS.K. Differential diagnosis of chronic neuropathic orofacial pain: Role of clinical neurophysiology.J. Clin. Neurophysiol.201936642242910.1097/WNP.000000000000058331688325
    [Google Scholar]
  52. KolkkaM. ForssellH. VirtanenA. PuhakkaA. PesonenU. JääskeläinenS.K. Neurophysiology and genetics of burning mouth syndrome.Eur. J. Pain20192361153116110.1002/ejp.138230793423
    [Google Scholar]
  53. CahanaA. ForsterA. Mécanismes de la chronicisation de la douleur oro-faciale aiguë.Rev. Stomatol. Chir. Maxillofac.2006107315616010.1016/S0035‑1768(06)77011‑516804482
    [Google Scholar]
  54. ChungM.K. WangS. OhS.L. KimY.S. Acute and chronic pain from facial skin and oral mucosa: unique neurobiology and challenging treatment.Int. J. Mol. Sci.202122115810Epub ahead of print10.3390/ijms2211581034071720
    [Google Scholar]
  55. EliavE. KamranB. SchahamR. CzerninskiR. GracelyR.H. BenolielR. Evidence of chorda tympani dysfunction in patients with burning mouth syndrome.J. Am. Dent. Assoc.2007138562863310.14219/jada.archive.2007.023417473041
    [Google Scholar]
  56. JustT SteinerS PauHW Oral pain perception and taste in burning mouth syndrome.J oral Pathol Med Off Publ Int Assoc Oral Pathol Am Acad Oral Pathol2010392227
    [Google Scholar]
  57. MaedaE. KatsuraH. NinT. Sakaguchi-FukunagaA. MishiroY. SakagamiM. Change of somatosensory function of the tongue caused by chorda tympani nerve disorder after stapes surgery.Laryngoscope2018128370170610.1002/lary.2659828397279
    [Google Scholar]
  58. SchöbelN. KyeremeJ. MinoviA. DazertS. BartoshukL. HattH. Sweet taste and chorda tympani transection alter capsaicin-induced lingual pain perception in adult human subjects.Physiol. Behav.2012107336837310.1016/j.physbeh.2012.09.00422995977
    [Google Scholar]
  59. BartoshukL.M. SnyderD.J. GrushkaM. BergerA.M. DuffyV.B. KvetonJ.F. Taste damage: Previously unsuspected consequences.Chem. Senses200530Suppl. 1i218i21910.1093/chemse/bjh19215738123
    [Google Scholar]
  60. Nasri-HeirC. ZaguryJ. ThomasD. AnanthanS. Burning mouth syndrome: Current concepts.J. Indian Prosthodont. Soc.201515430030710.4103/0972‑4052.17182326929531
    [Google Scholar]
  61. ImuraH ShimadaM YamazakiY Characteristic changes of saliva and taste in burning mouth syndrome patients.J oral Pathol Med Off Publ Int Assoc Oral Pathol Am Acad Oral Pathol201645231236
    [Google Scholar]
  62. KlasserG.D. GrushkaM. SuN. Burning Mouth Syndrome.Oral Maxillofac. Surg. Clin. North Am.201628338139610.1016/j.coms.2016.03.00527475513
    [Google Scholar]
  63. KhanJ. AnwerM. NoboruN. ThomasD. KalladkaM. Topical application in burning mouth syndrome.J. Dent. Sci.201914435235710.1016/j.jds.2019.04.00731890121
    [Google Scholar]
  64. Nasri-HeirC. ShigdarD. AlnaasD. KorczeniewskaO.A. EliavR. HeirG.M. Primary burning mouth syndrome: Literature review and preliminary findings suggesting possible association with pain modulation.Quintessence Int.2017491496029192294
    [Google Scholar]
  65. BergdahlM. JB. Perceived taste disturbance in adults: Prevalence and association with oral and psychological factors and medication.Clin. Oral Investig.20026314514910.1007/s00784‑002‑0169‑012271346
    [Google Scholar]
  66. KimM.J. KimJ. KhoH.S. Comparison of clinical characteristics between burning mouth syndrome patients with bilateral and unilateral symptoms.Int. J. Oral Maxillofac. Surg.2020491384310.1016/j.ijom.2019.06.01331235389
    [Google Scholar]
  67. SinjariB. D’ArdesD. SantilliM. RexhepiI. D’AddazioG. Di CarloP. ChiacchiarettaP. CaputiS. CipolloneF. SARS-CoV-2 and oral manifestation: An observational, human study.J. Clin. Med.2020910321810.3390/jcm910321833036482
    [Google Scholar]
  68. KusiakA CichońskaD TubajaM COVID-19 manifestation in the oral cavity - a narrative literature review.Acta Otorhinolaryngol Ital organo Uff della Soc Ital di Otorinolaringol e Chir Cerv-facc202141395400
    [Google Scholar]
  69. FakhruddinK.S. SamaranayakeL.P. BuranawatB. NgoH. Oro-facial mucocutaneous manifestations of Coronavirus Disease-2019 (COVID-19): A systematic review.PLoS One2022176e026553110.1371/journal.pone.026553135648785
    [Google Scholar]
  70. RenY.F. RasubalaL. MalmstromH. EliavE. Dental care and oral health under the clouds of COVID-19.JDR Clin. Trans. Res.20205320221010.1177/238008442092438532330078
    [Google Scholar]
  71. XuH. ZhongL. DengJ. PengJ. DanH. ZengX. LiT. ChenQ. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa.Int. J. Oral Sci.2020121810.1038/s41368‑020‑0074‑x32094336
    [Google Scholar]
  72. CanoI.P. DionisioT.J. CestariT.M. CalvoA.M. Colombini-IshikiriamaB.L. FariaF.A.C. SiqueiraW.L. SantosC.F. Losartan and isoproterenol promote alterations in the local renin-angiotensin system of rat salivary glands.PLoS One2019145e021703010.1371/journal.pone.021703031116771
    [Google Scholar]
  73. LiuL. WeiQ. AlvarezX. WangH. DuY. ZhuH. JiangH. ZhouJ. LamP. ZhangL. LacknerA. QinC. ChenZ. Epithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of rhesus macaques.J. Virol.20118584025403010.1128/JVI.02292‑1021289121
    [Google Scholar]
  74. FellerL. FourieJ. BouckaertM. KhammissaR.A.G. BallyramR. LemmerJ. Burning mouth syndrome: Aetiopathogenesis and principles of management.Pain Res. Manag.201720171610.1155/2017/192626929180911
    [Google Scholar]
  75. TaitRC FergusonM HerndonCM Chronic orofacial pain: Burning mouth syndrome and other neuropathic disorders.J pain Manag Med3
    [Google Scholar]
  76. MignognaM.D. FedeleS. Lo RussoL. LeuciS. Lo MuzioL. The diagnosis of burning mouth syndrome represents a challenge for clinicians.J. Orofac. Pain200519216817315895840
    [Google Scholar]
  77. SuriV. SuriV. Menopause and oral health.J Midlife Health20145311512010.4103/0976‑7800.14118725316996
    [Google Scholar]
  78. MinicucciE.M. PiresR.B.C. VieiraR.A. MiotH.A. SpostoM.R. Assessing the impact of menopause on salivary flow and xerostomia.Aust. Dent. J.201358223023410.1111/adj.1205723713645
    [Google Scholar]
  79. Srebrzyńska-WitekA. KoszowskiR. Effect of menopause on salivary glands and oral mucosa.Przegl. Menopauz.2013541842210.5114/pm.2013.38598
    [Google Scholar]
  80. PetkowiczB. PiotrkowiczJ. SzeszkoŁ. BanakiewiczK. ZielińskiP. Selected aspects of oral cavity diseases in menopausal women.Przegl. Menopauz.2013435235710.5114/pm.2013.37855
    [Google Scholar]
  81. SoaresC.N. Depression and Menopause.Psychiatr. Clin. North Am.201740223925410.1016/j.psc.2017.01.00728477650
    [Google Scholar]
  82. SteinbergB.J. Women’s oral health issues.J. Calif. Dent. Assoc.200028966366710.1080/19424396.2000.1222311611324047
    [Google Scholar]
  83. KangJ.H. KimY.Y. ChangJ.Y. KhoH.S. Relationships between oral MUC1 expression and salivary hormones in burning mouth syndrome.Arch. Oral Biol.201778586410.1016/j.archoralbio.2017.01.02228199919
    [Google Scholar]
  84. TagaT. ItoK. TakamatsuK. OgawaM. FunayamaS. InoueM. Menopausal symptoms are associated with oral sensory complaints in perimenopausal women: An observational study.BMC Womens Health202121126210.1186/s12905‑021‑01401‑634193118
    [Google Scholar]
  85. MeneguetteA.F. MoraesP de C. GuimarãesA.S. Pain perception and quality of life in burning mouth syndrome.Br. J. Pain20203153157
    [Google Scholar]
  86. de TommasoM. LavolpeV. Di VenereD. CorsaliniM. VecchioE. FaviaG. SardaroM. LivreaP. NolanoM. A case of unilateral burning mouth syndrome of neuropathic origin.Headache201151344144310.1111/j.1526‑4610.2010.01754.x20807251
    [Google Scholar]
  87. LauriaG. MajoranaA. BorgnaM. LombardiR. PenzaP. PadovaniA. SapelliP. Trigeminal small-fiber sensory neuropathy causes burning mouth syndrome.Pain2005115333233710.1016/j.pain.2005.03.02815911160
    [Google Scholar]
  88. PenzaP. MajoranaA. LombardiR. CamozziF. BonadeoS. SapelliP. LauriaG. “Burning tongue” and “burning tip”: The diagnostic challenge of the burning mouth syndrome.Clin. J. Pain201026652853210.1097/AJP.0b013e3181e15b8320551728
    [Google Scholar]
  89. YilmazZ. RentonT. YiangouY. ZakrzewskaJ. ChessellI.P. BountraC. AnandP. Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score.J. Clin. Neurosci.200714986487110.1016/j.jocn.2006.09.00217582772
    [Google Scholar]
  90. SeolS.H. ChungG. Estrogen-dependent regulation of transient receptor potential vanilloid 1 (TRPV1) and P2X purinoceptor 3 (P2X3): Implication in burning mouth syndrome.J. Dent. Sci.202217181310.1016/j.jds.2021.06.00735028015
    [Google Scholar]
  91. ImamuraY. ShinozakiT. Okada-OgawaA. NomaN. ShinodaM. IwataK. WadaA. AbeO. WangK. SvenssonP. An updated review on pathophysiology and management of burning mouth syndrome with endocrinological, psychological and neuropathic perspectives.J. Oral Rehabil.201946657458710.1111/joor.1279530892737
    [Google Scholar]
  92. YilmazZ. EgbuniweO. RentonT. The detection of small-fiber neuropathies in burning mouth syndrome and iatrogenic lingual nerve injuries: Use of quantitative sensory testing.J. Oral Facial Pain Headache2016302879810.11607/ofph.153127128472
    [Google Scholar]
  93. ChanC.L.H. FacerP. DavisJ.B. SmithG.D. EgertonJ. BountraC. WilliamsN.S. AnandP. Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency.Lancet2003361935538539110.1016/S0140‑6736(03)12392‑612573376
    [Google Scholar]
  94. TympanidisP. CasulaM.A. YiangouY. TerenghiG. DowdP. AnandP. Increased vanilloid receptor VR1 innervation in vulvodynia.Eur. J. Pain20048212913310.1016/S1090‑3801(03)00085‑514987622
    [Google Scholar]
  95. BenengK. YilmazZ. YiangouY. McParlandH. AnandP. RentonT. Sensory purinergic receptor P2X3 is elevated in burning mouth syndrome.Int. J. Oral Maxillofac. Surg.201039881581910.1016/j.ijom.2010.03.01320418063
    [Google Scholar]
  96. MoissetX. CalbachoV. TorresP. Gremeau-RichardC. DallelR. Co-occurrence of Pain Symptoms and Somatosensory Sensitivity in Burning Mouth Syndrome: A Systematic Review.PLoS One2016119e016344910.1371/journal.pone.016344927657531
    [Google Scholar]
  97. MadariagaV.I. TanakaH. ErnbergM. Psychophysical characterisation of burning mouth syndrome-A systematic review and meta-analysis.J. Oral Rehabil.202047121590160510.1111/joor.1302832500929
    [Google Scholar]
  98. Stuginski-BarbosaJ. RodriguesG.G.R. BigalM.E. SpecialiJ.G. Burning mouth syndrome responsive to pramipexol.J. Headache Pain200891434510.1007/s10194‑008‑0003‑418219443
    [Google Scholar]
  99. JääskeläinenS.K. LindholmP. ValmunenT. PesonenU. TaiminenT. VirtanenA. LamusuoS. ForssellH. HagelbergN. HietalaJ. PertovaaraA. Variation in the dopamine D2 receptor gene plays a key role in human pain and its modulation by transcranial magnetic stimulation.Pain2014155102180218710.1016/j.pain.2014.08.02925180011
    [Google Scholar]
  100. AmenábarJ.M. PawlowskiJ. HilgertJ.B. HugoF.N. BandeiraD. LhüllerF. Lopes de SouzaM.A. Anxiety and salivary cortisol levels in patients with burning mouth syndrome: case-control study.Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.2008105446046510.1016/j.tripleo.2007.10.00218329582
    [Google Scholar]
  101. HeuserI. LammersC.H. Stress and the brain.Neurobiol. Aging200324Suppl. 1S69S7610.1016/S0197‑4580(03)00048‑412829112
    [Google Scholar]
  102. KauferD. OgleW.O. PincusZ.S. ClarkK.L. NicholasA.C. DinkelK.M. DumasT.C. FergusonD. LeeA.L. WintersM.A. SapolskyR.M. Restructuring the neuronal stress response with anti-glucocorticoid gene delivery.Nat. Neurosci.20047994795310.1038/nn129615300253
    [Google Scholar]
  103. AriyawardanaA. ChmieliauskaiteM. FaragA.M. AlbuquerqueR. ForssellH. Nasri-HeirC. KlasserG.D. SardellaA. MignognaM.D. IngramM. CarlsonC.R. MillerC.S. World Workshop on Oral Medicine VII: Burning mouth syndrome: A systematic review of disease definitions and diagnostic criteria utilized in randomized clinical trials.Oral Dis.201925S1Suppl. 114115610.1111/odi.1306730785661
    [Google Scholar]
  104. Siqueira SRDT de, Teixeira MJ, Siqueira JTT de. The orofacial pain clinic questionnaire (EDOF-HC) in the evaluation and diagnosis of orofacial pain.Arquivos de Neuro-Psiquiatria78
    [Google Scholar]
  105. ZborowskiJ. KonopkaT. Comparison of Clonazepam and Tongue Protector in the Treatment of Burning Mouth Syndrome.Int. J. Environ. Res. Public Health20221915899910.3390/ijerph1915899935897370
    [Google Scholar]
  106. WhiteT.L. KentP.F. KurtzD.B. EmkoP. Effectiveness of gabapentin for treatment of burning mouth syndrome.Arch. Otolaryngol. Head Neck Surg.2004130678678810.1001/archotol.130.6.78615210564
    [Google Scholar]
  107. López-D alessandroE. EscovichL. Combination of alpha lipoic acid and gabapentin, its efficacy in the treatment of Burning Mouth Syndrome: A randomized, double-blind, placebo controlled trial.Med. Oral Patol. Oral Cir. Bucal2011165e635e64010.4317/medoral.1694220711135
    [Google Scholar]
  108. ChristyJ. NooraniS. SyF. Al-EryaniK. EncisoR. Efficacy of alpha-lipoic acid in patients with burning mouth syndrome compared to that of placebo or other interventions: A systematic review with meta-analyses.J. Dent. Anesth. Pain Med.202222532333810.17245/jdapm.2022.22.5.32336246031
    [Google Scholar]
  109. PakfetratA. TalebiM. DalirsaniZ. MohajeriA. ZamaniR. GhaziA. Evaluation of the effectiveness of crocin isolated from saffron in treatment of burning mouth syndrome: A randomized controlled trial.Avicenna J. Phytomed.20199650551631763210
    [Google Scholar]
  110. Palacios-SánchezB. Moreno-LópezL.A. Cerero-LapiedraR. Llamas-MartínezS. Esparza-GómezG. Alpha lipoic acid efficacy in burning mouth syndrome. A controlled clinical trial.Med. Oral Patol. Oral Cir. Bucal2015204e435e44010.4317/medoral.2041026034927
    [Google Scholar]
  111. FemianoF. GombosF. ScullyC. BusciolanoM. LucaP.D. Clinical oral medicine: Burning mouth syndrome (BMS): Controlled open trial of the efficacy of alpha-lipoic acid (thioctic acid) on symptomatology.Oral Dis.20006527427710.1111/j.1601‑0825.2000.tb00138.x11002408
    [Google Scholar]
  112. MiziaraI. VargasC. FreitasL. MahmoudA. ChaguryA. Therapeutic options in idiopathic burning mouth syndrome: Literature review.Int. Arch. Otorhinolaryngol.201419108608910.1055/s‑0034‑137813825992157
    [Google Scholar]
  113. BilskaA. WłodekL. Lipoic acid - the drug of the future?Pharmacol. Rep.200557557057716227639
    [Google Scholar]
  114. LiuY.F. KimY. YooT. HanP. InmanJ.C. Burning mouth syndrome: A systematic review of treatments.Oral Dis.201824332533410.1111/odi.1266028247977
    [Google Scholar]
  115. AlqahtaniS.S. The efficiency of alpha-lipoic acid in the treatment of burning mouth syndrome: A systematic review.Eur. Rev. Med. Pharmacol. Sci.202125216585659134787861
    [Google Scholar]
  116. CavalcantiDR da SilveiraFRX Alpha lipoic acid in burning mouth syndrome--a randomized double-blind placebo-controlled trial.J oral Pathol Med Off Publ Int Assoc Oral Pathol Am Acad Oral Pathol200938254261
    [Google Scholar]
  117. KiselyS. ForbesM. SawyerE. BlackE. LallooR. A systematic review of randomized trials for the treatment of burning mouth syndrome.J. Psychosom. Res.201686394610.1016/j.jpsychores.2016.05.00127302545
    [Google Scholar]
  118. CarboneM. PenteneroM. CarrozzoM. IppolitoA. GandolfoS. Lack of efficacy of alpha-lipoic acid in burning mouth syndrome: A double-blind, randomized, placebo-controlled study.Eur. J. Pain200913549249610.1016/j.ejpain.2008.06.00418675569
    [Google Scholar]
  119. VaroniE. Lo FaroA. LodiG. CarrassiA. IritiM. SardellaA. Melatonin treatment in patients with burning mouth syndrome: A triple-blind, placebo-controlled, crossover randomized clinical trial.J. Oral Facial Pain Headache201832217818810.11607/ofph.191329694465
    [Google Scholar]
  120. AdamoD. SardellaA. VaroniE. LajoloC. BiasottoM. OttavianiG. VescoviP. SimonazziT. PenteneroM. ArdoreM. SpadariF. BombeccariG. MontebugnoliL. GissiD.B. CampisiG. PanzarellaV. CarboneM. ValpredaL. GiulianiM. AriaM. Lo MuzioL. MignognaM.D. The association between burning mouth syndrome and sleep disturbance: A case–control multicentre study.Oral Dis.201824463864910.1111/odi.1280729156085
    [Google Scholar]
  121. Lopez-JornetP. Lucero-BerdugoM. Castillo-FelipeC. Zamora LavellaC. Ferrandez-PujanteA. Pons-FusterA. Assessment of self-reported sleep disturbance and psychological status in patients with burning mouth syndrome.J. Eur. Acad. Dermatol. Venereol.20152971285129010.1111/jdv.1279525351854
    [Google Scholar]
  122. LoweH. ToyangN. SteeleB. BryantJ. NgwaW. NedamatK. The current and potential application of medicinal cannabis products in dentistry.Dent. J.20219910610.3390/dj909010634562980
    [Google Scholar]
  123. Conselho Federal de Odontologia. Resolução no 82 de 25 de setembro deReconhece e regulamenta o uso pelo cirurgião-dentista de práticas integrativas e complementares à saúde bucalRio de Janeiro2008Available at: https://sistemas.cfo.org.br/visualizar/atos/RESOLU
    [Google Scholar]
  124. GambinoA. CabrasM. PanagiotakosE. CalvoF. MacciottaA. CafaroA. SuriaM. HaddadG.E. BroccolettiR. ArduinoP.G. Evaluating the Suitability and Potential Efficiency of Cannabis sativa Oil for Patients with Primary Burning Mouth Syndrome: A Prospective, Open-Label, Single-Arm Pilot Study.Pain Med.202122114215110.1093/pm/pnaa31833123730
    [Google Scholar]
  125. BorsaniE. MajoranaA. CocchiM.A. ContiG. BonadeoS. PadovaniA. LauriaG. BardelliniE. RezzaniR. RodellaL.F. Epithelial expression of vanilloid and cannabinoid receptors: A potential role in burning mouth syndrome pathogenesis.Histol. Histopathol.201429452353324190005
    [Google Scholar]
  126. SunarianiJ. WijaksanaI.K.E. SetiawatieE.M. The Role of Vanilloid and Cannabinoid Receptors in Taste and Pain Perception in Burning Mouth Syndrome.Proceedings of the 7th International Meeting and the 4th Joint Scientific Meeting in Dentistry9910210.5220/0007292900990102
    [Google Scholar]
  127. de SouzaI.F. MármoraB.C. RadosP.V. VisioliF. Treatment modalities for burning mouth syndrome: A systematic review.Clin. Oral Investig.20182251893190510.1007/s00784‑018‑2454‑629696421
    [Google Scholar]
  128. SilvestreF.J. Silvestre-RangilJ. Tamarit-SantaféC. BautistaD. Application of a capsaicin rinse in the treatment of burning mouth syndrome.Med. Oral Patol. Oral Cir. Bucal2012171e1e410.4317/medoral.1721921743415
    [Google Scholar]
  129. JørgensenM.R. PedersenA.M.L. Analgesic effect of topical oral capsaicin gel in burning mouth syndrome.Acta Odontol. Scand.201775213013610.1080/00016357.2016.126919128007005
    [Google Scholar]
  130. MarinoR TorrettaS CapaccioP Different therapeutic strategies for burning mouth syndrome: preliminary data.J oral Pathol Med Off Publ Int Assoc Oral Pathol Am Acad Oral Pathol201039611616
    [Google Scholar]
  131. SpanembergJ.C. CherubiniK. de FigueiredoM.A.Z. GomesA.P.N. CamposM.M. SalumF.G. Effect of an herbal compound for treatment of burning mouth syndrome: Randomized, controlled, double-blind clinical trial.Oral Surg. Oral Med. Oral Pathol. Oral Radiol.2012113337337710.1016/j.oooo.2011.09.00522669143
    [Google Scholar]
  132. Cano-CarrilloP. Pons-FusterA. López-JornetP. Efficacy of lycopene-enriched virgin olive oil for treating burning mouth syndrome: A double-blind randomised.J. Oral Rehabil.201441429630510.1111/joor.1214724612248
    [Google Scholar]
  133. AmadoriF. BardelliniE. ContiG. PedriniN. SchumacherR.F. MajoranaA. Low-level laser therapy for treatment of chemotherapy-induced oral mucositis in childhood: A randomized double-blind controlled study.Lasers Med. Sci.20163161231123610.1007/s10103‑016‑1975‑y27272517
    [Google Scholar]
  134. YangH.W. HuangY.F. Treatment of burning mouth syndrome with a low-level energy diode laser.Photomed. Laser Surg.201129212312510.1089/pho.2010.278720969436
    [Google Scholar]
  135. HuangY.Y. ChenA.C.H. CarrollJ.D. HamblinM.R. Biphasic dose response in low level light therapy.Dose Response200974dose-response.010.2203/dose‑response.09‑027.Hamblin20011653
    [Google Scholar]
  136. PandeshwarP. RoaM.D. DasR. ShastryS.P. KaulR. SrinivasreddyM.B. Photobiomodulation in oral medicine: A review.J. Investig. Clin. Dent.20167211412610.1111/jicd.1214825720555
    [Google Scholar]
  137. MoskvinS.V. Low-level laser therapy in russia: History, science and practice.J. Lasers Med. Sci.201782566510.15171/jlms.2017.1128652897
    [Google Scholar]
  138. MizutaniK. MusyaY. WakaeK. KobayashiT. TobeM. TairaK. HaradaT. A clinical study on serum prostaglandin E2 with low-level laser therapy.Photomed. Laser Surg.200422653753910.1089/pho.2004.22.53715684758
    [Google Scholar]
  139. HagiwaraS. IwasakaH. OkudaK. NoguchiT. GaAlAs (830 nm) low-level laser enhances peripheral endogenous opioid analgesia in rats.Lasers Surg. Med.2007391079780210.1002/lsm.2058318081143
    [Google Scholar]
  140. MussttafR.A. JenkinsD.F.L. JhaA.N. Assessing the impact of low level laser therapy (LLLT) on biological systems: A review.Int. J. Radiat. Biol.201995212014310.1080/09553002.2019.152494430614743
    [Google Scholar]
  141. HoureldN.N. MashaR.T. AbrahamseH. Low-intensity laser irradiation at 660 nm stimulates cytochrome c oxidase in stressed fibroblast cells.Lasers Surg. Med.201244542943410.1002/lsm.2202722488690
    [Google Scholar]
  142. Pezelj-RibarićS. KqikuL. BruminiG. UrekM.M. AntonićR. KuišD. GlažarI. StädtlerP. Proinflammatory cytokine levels in saliva in patients with burning mouth syndrome before and after treatment with low-level laser therapy.Lasers Med. Sci.201328129730110.1007/s10103‑012‑1149‑522773117
    [Google Scholar]
  143. SimcićD. Pezelj-RibarićS. GržicR. HorvatJ. BruminiG. Muhvić-UrekM. Detection of salivary interleukin 2 and interleukin 6 in patients with burning mouth syndrome.Mediators Inflamm.20062006105463210.1155/MI/2006/5463216864905
    [Google Scholar]
  144. MatosA.L. SilvaP.U. ParanhosL.R. SantanaI.T. MatosF.R. Efficacy of the laser at low intensity on primary burning oral syndrome: A systematic review.Med. Oral Patol. Oral Cir. Bucal2021262e216e22510.4317/medoral.2414433609024
    [Google Scholar]
  145. CamolesiG.C.V. Marichalar-MendíaX. Padín-IruegasM.E. SpanembergJ.C. López-LópezJ. Blanco-CarriónA. Gándara-VilaP. Gallas-TorreiraM. Pérez-SayánsM. Efficacy of photobiomodulation in reducing pain and improving the quality of life in patients with idiopathic burning mouth syndrome. A systematic review and meta-analysis.Lasers Med. Sci.20223742123213310.1007/s10103‑022‑03518‑y35122543
    [Google Scholar]
  146. HannaR. DalviS. BensadounR.J. Raber-DurlacherJ.E. BenedicentiS. Role of photobiomodulation therapy in neurological primary burning mouth syndrome. A systematic review and meta-analysis of human randomised controlled clinical trials.Pharmaceutics202113111838Epub ahead of print10.3390/pharmaceutics1311183834834253
    [Google Scholar]
  147. RestivoD.A. LauriaG. Marchese-RagonaR. VigneriR. Botulinum toxin for burning mouth syndrome.Ann. Intern. Med.20171661076276310.7326/L16‑045128395302
    [Google Scholar]
  148. DiepC.P. GoddardG. MauroG. Acupuncture improves pain and rest in Burning Mouth Syndrome patients: A clinical cases.Dent. Cadmos201987316010.19256/d.cadmos.03.2019.06
    [Google Scholar]
  149. ZavoreoI. SikoraM. Vučićević-BorasV. Efficacy of acupuncture and vitamin C in burning mouth syndrome a pilot study.Epub ahead of print2017Available at: https://worldcat.org/title/ 974831105
    [Google Scholar]
  150. Jurisic KvesicA. ZavoreoI. Basic KesV. Vucicevic BorasV. CiligaD. GabricD. VrdoljakD.V. The effectiveness of acupuncture versus clonazepam in patients with burning mouth syndrome.Acupunct. Med.201533428929210.1136/acupmed‑2015‑01075925987645
    [Google Scholar]
  151. SardellaA. LodiG. TarozziM. VaroniE. FranchiniR. CarrassiA. Acupuncture and burning mouth syndrome: A pilot study.Pain Pract.201313862763210.1111/papr.1203123336607
    [Google Scholar]
  152. FrancoF.R.V. CastroL.A. BorsattoM.C. SilveiraE.A. Ribeiro-RottaR.F. Combined acupuncture and auriculotherapy in burning mouth syndrome treatment: A preliminary single-arm clinical trial.J. Altern. Complement. Med.201723212613410.1089/acm.2016.017927585312
    [Google Scholar]
  153. ScardinaG.A. RuggieriA. ProvenzanoF. MessinaP. Burning mouth syndrome: Is acupuncture a therapeutic possibility?Br. Dent. J.20102091E210.1038/sj.bdj.2010.58220596066
    [Google Scholar]
  154. SilvaL.A. SiqueiraJ.T.T. TeixeiraM.J. SiqueiraS.R.D.T. The role of xerostomia in burning mouth syndrome: A case-control study.Arq. Neuropsiquiatr.2014722919810.1590/0004‑282X2013021824604360
    [Google Scholar]
  155. ShuebS.S. NixdorfD.R. JohnM.T. AlonsoB.F. DurhamJ. What is the impact of acute and chronic orofacial pain on quality of life?J. Dent.201543101203121010.1016/j.jdent.2015.06.00126073033
    [Google Scholar]
  156. Herrero BabiloniA. GuayS. NixdorfD. De BeaumontL. LavigneG. Non-invasive brain stimulation in chronic orofacial pain: A systematic review.J. Pain Res.2018111445145710.2147/JPR.S16870530122975
    [Google Scholar]
  157. UmezakiY. BadranB.W. DeVriesW.H. MossJ. GonzalesT. GeorgeM.S. The efficacy of daily prefrontal repetitive transcranial magnetic stimulation (rTMS) for burning mouth syndrome (BMS): A randomized controlled single-blind study.Brain Stimul.20169223424210.1016/j.brs.2015.10.00526597930
    [Google Scholar]
  158. López-JornetP. Camacho-AlonsoF. Andujar-MateosP. A prospective, randomized study on the efficacy of tongue protector in patients with burning mouth syndrome.Oral Dis.201117327728210.1111/j.1601‑0825.2010.01737.x20860765
    [Google Scholar]
  159. KaurD. BehlA. IsherP.S. Oral manifestations of stress-related disorders in the general population of Ludhiana.J. Indian Acad. Oral Med. Radiol.201628326210.4103/0972‑1363.195671
    [Google Scholar]
  160. NezamS. NishatR. BhuyanL. SinghS. JaiswalM. SinghR. The precedence and viability of yoga in the lives of D3-dental students, dental practitioners, and dental patients.J. Family Med. Prim. Care20198123808381310.4103/jfmpc.jfmpc_784_1931879617
    [Google Scholar]
  161. ShankardassK. Place-Based Stress and Chronic Disease: A Systems View of Environmental Determinants BT - Rethinking Social Epidemiology: Towards a Science of Change. O’CampoP. DunnJ.R. DordrechtSpringer Netherlands113136
    [Google Scholar]
  162. BergdahlJ AnnerothG PerrisH Cognitive therapy in the treatment of patients with resistant burning mouth syndrome: A controlled study.J oral Pathol Med Off Publ Int Assoc Oral Pathol Am Acad Oral Pathol199524213215
    [Google Scholar]
/content/journals/cas/10.2174/0118746098279205240812113353
Loading
/content/journals/cas/10.2174/0118746098279205240812113353
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test