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2000
Volume 22, Issue 11
  • ISSN: 1567-2050
  • E-ISSN: 1875-5828

Abstract

Introduction

Neuropsychiatric symptoms frequently occur in patients with Alzheimer´s disease (AD); apathy, depression, delusions, optical hallucinations, anxiety, and agitation often appear as first symptoms of AD, while auditory hallucinations have never been described as the first symptom. In this case report, we describe a case of a woman who had auditory hallucinations as the first symptom of AD.

Case Presentation

An 85-year-old woman was admitted to our hospital suffering from imperative auditory hallucinations without subjective and minimal objective memory complaints. Further diagnostics with an MRI scan, neuropsychological tests, and an analysis of cerebral spinal fluid were accomplished. AD was confirmed during the hospital stay, suggesting auditory hallucinations as the first symptom of AD. She was temporarily treated with risperidone, which improved the hallucinations.

Conclusion

Auditory hallucinations in older age could be the first symptom of AD and even occur before cognitive decline.

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2025-10-21
2026-01-08
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References

  1. SafiriS. Ghaffari JolfayiA. FazlollahiA. MorsaliS. SarkeshA. Daei SorkhabiA. GolabiB. AletahaR. Motlagh AsghariK. HamidiS. MousaviS.E. JamalkhaniS. KaramzadN. ShamekhA. MohammadinasabR. SullmanM.J.M. ŞahinF. KolahiA.A. Alzheimer’s disease: a comprehensive review of epidemiology, risk factors, symptoms diagnosis, management, caregiving, advanced treatments and associated challenges.Front. Med. (Lausanne)202411147404310.3389/fmed.2024.147404339736972
    [Google Scholar]
  2. ZabihiS. BestwickJ.P. JitlalM. BothongoP.L.K. ZhangQ. CarterC. RocheM. Morgan-TrimmerS. BirksY. WilberforceM. DobsonR. NoyceA.J. RobsonJ. WalterF.M. CooperC. MarshallC.R. Early presentations of dementia in a diverse population.Alzheimers Dement.2025212e1457810.1002/alz.1457840008622
    [Google Scholar]
  3. PeriniG. CottaR.M. VerganiM. GattiA. ImbimboC. LeoneS. BallanteE. AllegriN. D’AntonioF. ZuffiM. PomatiS. FarinaE. TremolizzoL. CostaA. SINdem BPSD Study Group Biomarkers in Neuropsychiatric Symptoms (BIONESY): A multicenter nation survey and a systematic review.J. Alzheimers Dis.2025106249051110.1177/1387287725134463140443135
    [Google Scholar]
  4. JackC.R.Jr AndrewsJ.S. BeachT.G. BuracchioT. DunnB. GrafA. HanssonO. HoC. JagustW. McDadeE. MolinuevoJ.L. OkonkwoO.C. PaniL. RafiiM.S. ScheltensP. SiemersE. SnyderH.M. SperlingR. TeunissenC.E. CarrilloM.C. Revised criteria for diagnosis and staging of Alzheimer’s disease: Alzheimer’s Association Workgroup.Alzheimers Dement.20242085143516910.1002/alz.1385938934362
    [Google Scholar]
  5. DevanandD.P. JesteD.V. StroupT.S. GoldbergT.E. Overview of late-onset psychoses.Int. Psychogeriatr.2024361284210.1017/S104161022300015736866576
    [Google Scholar]
  6. TampiR.R. YoungJ. HoqR. ResnickK. TampiD.J. Psychotic disorders in late life: A narrative review.Ther. Adv. Psychopharmacol.20199204512531988279810.1177/204512531988279831662846
    [Google Scholar]
  7. NaasanG. ShdoS.M. RodriguezE.M. SpinaS. GrinbergL. LopezL. KarydasA. SeeleyW.W. MillerB.L. RankinK.P. Psychosis in neurodegenerative disease: Differential patterns of hallucination and delusion symptoms.Brain20211443999101210.1093/brain/awaa41333501939
    [Google Scholar]
  8. World Health Organization. International Classification of Diseases Eleventh Revision (ICD-11).GenevaWorld Health Organization2022
    [Google Scholar]
  9. SchneiderK. Clinical Psychopathology.Grune & Stratton1959
    [Google Scholar]
  10. ChenL. SelvendraA. StewartA. CastleD. Risk factors in early and late onset schizophrenia.Compr. Psychiatry20188015516210.1016/j.comppsych.2017.09.00929096206
    [Google Scholar]
  11. Diagnostic and statistical manual of mental disorders : DSM-5. 5th edAmerican Psychiatric Association2013
    [Google Scholar]
  12. ReevesS. MahdiJ. ApplebyM. ZubkoO. LeeT. BarberJ.A. LiuK.Y. TaylorJ.P. HendersonE.J. SchragA. HowardR. WeilR.S. Hallucinations Working Group Minimal clinically important differences for treatment of hallucinations in Parkinson’s disease and dementia with Lewy bodies.Psychol. Med.202555e9310.1017/S003329172500053440125723
    [Google Scholar]
  13. Wyman-ChickK.A. FermanT.J. WeintraubD. ArmstrongM.J. BoeveB.F. BayramE. ChrenkaE. BarrettM.J. Distinguishing Prodromal dementia with lewy bodies from prodromal alzheimer disease.Neurol. Clin. Pract.2025151e20038010.1212/CPJ.000000000020038039399551
    [Google Scholar]
  14. Canessa-MuñozS. Yelmo-CruzS. Hamilton-LopezA. Baez-MarreroC. Corticosteroid-induced psychosis: A report of two cases and review of the literature.Cureus2025173e8151510.7759/cureus.8151540308413
    [Google Scholar]
  15. LeskoA. KalafatN. AfreenM. Four case reports of acute psychosis secondary to low doses of prednisone/prednisolone.Cureus20211312e2085310.7759/cureus.2085335141097
    [Google Scholar]
/content/journals/car/10.2174/0115672050421769250929051818
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