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image of Synthesis, Antioxidant Evaluation, and Electrochemical Behavior of Novel Schiff Base-Metal Complexes

Abstract

Introduction

This study presents the synthesis and evaluation of five novel Schiff base–metal complexes containing Cu2+, Cr3+, Co2+, Fe3+, and Hg2+ ions coordinated to a bis(indole)-based Schiff base ligand. The aim was to investigate their antioxidant and electrochemical properties in a comparative framework.

Methods

The complexes were synthesized from indole-3-carbaldehyde and trans-cyclohexane-1,2-diamine and characterized using FT-IR spectroscopy. Antioxidant activities were assessed by DPPH, ABTS, and CUPRAC assays. Electrochemical behavior was analyzed by cyclic voltammetry using a glassy carbon electrode in TBAP/DMSO electrolyte medium.

Results

The Cu(II) complex exhibited the highest DPPH radical scavenging activity, while the Cr(III), Co(II), and the free Schiff base showed superior ABTS activity compared to the standard antioxidant BHA. The free ligand also demonstrated CUPRAC activity comparable to BHA. Cyclic voltammetry revealed that all metal complexes exhibited anodic shifts in oxidation peaks relative to the free ligand. Additionally, the Cu(II) and Co(II) complexes showed extra redox waves, indicating unique redox-active behavior.

Discussion

These findings suggest that metal coordination alters the electron-donating capacity of the Schiff base ligand and enables tunable redox behavior. The observed differences across metal ions underscore their role in defining both antioxidant potential and electrochemical reactivity.

Conclusion

The synthesized Schiff base-metal complexes possess significant antioxidant activity and diverse redox properties, particularly the Cu(II) and Co(II) derivatives. These characteristics make them promising candidates for applications in redox-sensitive medicinal and analytical technologies.

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2025-10-27
2026-02-01

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Synthesis, Antioxidant Evaluation, and Electrochemical Behavior of Novel Schiff Base-Metal Complexes
Bentham Science Publishers ; https://doi.org/10.2174/0115734110408174251006160757
/content/journals/cac/10.2174/0115734110408174251006160757
/content/journals/cac/10.2174/0115734110408174251006160757
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  • Article Type:     Research Article
Keywords: transition metal complexes ; antioxidant activity ; redox-active compounds ; electrochemical characterization ; Schiff base ; redox mechanism ; schiff base-metal complexes ; cyclic voltammetry

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