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Long-Term Sleep Deprivation

Abstract

Introduction

This study aims to identify key genes by analyzing gene expression changes induced by prolonged sleep deprivation (SD) and to explore their potential relationship with immune regulation and neurobehavioral disorders.

Methods

Microarray data of SD at different time points were obtained to screen differentially expressed genes (DEGs). The functions of DEGs and the biological pathways involved were explored. Additionally, significant DEGs were screened as key genes for SD. Finally, immune scores and immune cell scores were calculated. The relationships between key genes, immune scores, and immune-related pathways were explored.

Results

The relevant DEGs were identified, including , , , , , and . Among these, , , , and were upregulated in SD samples, while and were downregulated. These key genes were involved in the biological processes, including DNA repair, KRAS signaling, and the PI3K-AKT signaling pathway. Furthermore, , , , and exhibited a significant negative correlation with immune scores and were closely associated with various immune regulatory pathways, like antigen processing and presentation, B cell receptor signaling, and T cell receptor signaling pathways.

Discussion

This study, based on microarray data, investigated the dynamic changes in gene expression induced by SD and their underlying mechanisms. Six key genes with differential expression levels and distinct enriched biological processes were identified.

Conclusion

The altered expression of 6 identified genes induced by SD and their underlying molecular mechanisms may provide a foundation for the early diagnosis and personalized treatment of SD-related diseases.

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2025-04-18
2025-09-06

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Identifying Key Genes for Neurobehavioral Disorders Caused by 
Long-Term Sleep Deprivation
Bentham Science Publishers ; https://doi.org/10.2174/0115734110374719250411094921
/content/journals/cac/10.2174/0115734110374719250411094921
/content/journals/cac/10.2174/0115734110374719250411094921
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  • Article Type:     Research Article
Keywords: biomarkers ; therapeutic targets ; immune ; Sleep deprivation ; differentially expressed genes ; time series

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