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(Q-Marker) Based on Chemical Composition, Activity and Network Pharmacology
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Abstract

L. is a long-honored medicinal and edible aromatic plant extensively employed in the food, pharmaceutical, and spice industries. It is rich in various bioactive compounds, including flavonoids, terpenes, phenylpropanoic acids, quinones, and steroids, which exhibit a range of effects such as antimicrobial, anti-inflammatory, antioxidant, antitumor, hypoglycemic, hypolipidemic, hepatoprotective, and nephroprotective properties. To further explore the application potential of , we predicted the quality marker (Q-Marker) based on the measurability of chemical constituents, traditional medicinal properties, and effectiveness. This approach was informed by research on the components, biological activities, and mechanisms of action, followed by network pharmacology analysis. Ultimately, 17 practical components were selected as potential biomarkers, including carnosic acid, carnosol, rosmanol, isorosmanol, epirosmanol, 7-methoxyrosmanol, 7-ethoxyrosmanol, rosmaridiphenol, rosmadial, rosmarinic acid, 1,8-cineole, rosmarinine, royleanone, horminone, homovanillic acid, ferruginol, and cryptotanshinone. Most of these compounds belong to the categories of terpenoids and organic acids. Through enrichment analysis, we identified the targets and pathways of these components in various diseases, such as microbial infection, cancer, apoptosis, oxidative stress, and abnormal glycolipid metabolism. This integrated approach that combines plant components, big data, and pharmacology for marker screening is more rational. The results provide a reference for the development, research, and quality evaluation of rosemary resources.

2025 © 2025 The Author(s). Published by Bentham Science Publisher.
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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2025-09-04

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/content/journals/cac/10.2174/0115734110367575250418100500
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Predictive Analysis of Rosmarinus officinalis L. Quality Marker 
(Q-Marker) Based on Chemical Composition, Activity and Network Pharmacology
Bentham Science Publishers ; https://doi.org/10.2174/0115734110367575250418100500
/content/journals/cac/10.2174/0115734110367575250418100500
/content/journals/cac/10.2174/0115734110367575250418100500
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  • Article Type:     Review Article
Keywords: flavonoids ; Rosmarinus officinalis L. ; terpenes ; phenylpropanoic acids ; quality control ; quality marker

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