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image of GC-MS Profiling and In vitro Assessment of the Antimicrobial and Anticancer Potential of the Methanolic Extract of Strychnos chromatoxylon L. Leaves

Abstract

Introduction

Medicinal plants have long served as a foundation for therapeutic development, offering a vast repository of bioactive compounds. This study examines the phytochemical composition and potential pharmacological properties of L. leaves, aiming to identify natural compounds that may contribute to sustainable and effective healthcare solutions.

Methods

Methanolic extraction was performed using maceration followed by evaporation to optimize the yield of phytochemicals. The extract was then subjected to qualitative phytochemical screening, Thin-Layer Chromatography (TLC), Gas Chromatography-Mass Spectrometry (GC-MS) analysis, and assays, including the MTT assay, to evaluate its antioxidant, antimicrobial, and anticancer activities.

Results

The methanolic extract of revealed a diverse array of phytochemicals, including alkaloids, carbohydrates, glycosides, phenolics, flavonoids, and phytosterols. GC-MS profiling identified several bioactive compounds. The extract exhibited promising antimicrobial activity and demonstrated cytotoxic effects in MTT assays, indicating its potential anticancer properties.

Discussion

The presence of a broad spectrum of phytochemicals supports the traditional use of in herbal medicine. The observed bioactivities, particularly antimicrobial and anticancer effects, are likely attributed to the synergistic actions of its constituents. While the findings are promising, further investigation, including studies and compound isolation, is needed to validate therapeutic potential and ensure safety.

Conclusion

This study highlights as a promising source of natural bioactive agents with antimicrobial and anticancer potential. By integrating traditional medicinal knowledge with contemporary scientific approaches, we can advance the search for novel and sustainable therapeutic agents.

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2025-07-28
2025-10-29

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GC-MS Profiling and In vitro Assessment of the Antimicrobial and Anticancer Potential of the Methanolic Extract of Strychnos chromatoxylon L. Leaves
Bentham Science Publishers ; https://doi.org/10.2174/0115734110352570250718053235
/content/journals/cac/10.2174/0115734110352570250718053235
/content/journals/cac/10.2174/0115734110352570250718053235
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  • Article Type:     Research Article
Keywords: GC-MS analysis ; phytochemicals ; antimicrobial activity ; in vitro cytotoxicity ; Strychnos spp. ; traditional herbal knowledge ; Bioactive compounds ; metabolite profiling

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