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2000
Volume 5, Issue 1
  • ISSN: 1872-2083
  • E-ISSN: 2212-4012

Abstract

Baculovirus has been widely utilized as a protein production tool in insect cells for nearly 3 decades and has captured growing interests as a vector for gene delivery into mammalian cells and animals over the past decade. This review summarizes important patents pertaining to the use of baculovirus for insect cell infection and mammalian cell transduction, with special emphasis on the vector development, new applications and downstream processing.

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/content/journals/biot/10.2174/187220811795655904
2011-04-01
2025-12-10

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  • Article Type:     Research Article
Keyword(s): Baculovirus; cytomegalovirus (CMV); delivery of vaccine immunogens; DNA cloning capacity; downstream processing; eucaryotic proteins; expression system; human interferon; insect cell; long terminal repeat (LTR) promoter; mammalian cell; mammalian cell transduction; nucleopolyhedrovirus; polyadenylation sequence; replication; Rous Sarcoma Virus (RSV); vaccine

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