Chaos and Gene expression:A Theoretical Approach

Intoduction: The aim of the study was to investigate whether chaotic phenomena (chaos theory) affects the process of Gene Expression. Methods: Modeling the genes X, Y and Z-which encode a certain protein P-a set of three first order differential equations has been developed and studied in phase-space (x,y,z). Results: The elementary equilibrium points in three dimensional phase portrait analysis, include attractors, saddles and repellors. Conclusions: Attractors indicate a stable equilibrium point which attenuates the production of the protein P, while the saddles and particularly the repellors correspond to an unstable dynamic system, which promotes either the production of a P-flaw protein or totally inhibits gene expression. Among other mechanisms-e.g. patents for gene treatment (US2007000515344) and modulation(US20040014083A1)-chaotic phenomena also seem to regulate in a particular way the DNA encoding , that calls for further theoretical and experimental research(e.g. cardiovascular disease, oncology).