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2000
Volume 24, Issue 4
  • ISSN: 1871-5230
  • E-ISSN: 1875-614X

Abstract

Introduction

The low solubility and permeability of tetrahydrocurcumin act as a barrier in its therapeutic effectiveness, particularly in the topical treatment of skin diseases like psoriasis.

Methods

Niosomes were prepared using thin-film hydration method using span 60, cholesterol as independent variables in Box Behnken design. Particle size, entrapment efficiency and drug loading were taken as dependent variables. In Box Behnken design the levels are -1, 0, and +1. The values for span 60 are 50, 75, and 100mg and for cholesterol 10, 20, and 30mg.

Results

The optimized formulation has a particle size of 116.9 nm, entrapment efficiency of 94.7% and, drug loading of 85.23%. The niosomes showed first-order release kinetics property and maintained stability at 4°C and 25°C for three months. The desirability score obtained was 0.896.

Discussion

The optimized niosomal formulation enhanced THC’s solubility, permeability, and stability, supporting its potential for effective topical psoriasis treatment. Future studies will focus on gel incorporation and validation.

Conclusion

The developed formulation significantly improves the solubility and permeability of tetrahydrocurcumin which leads to improved therapeutic effectiveness in the formulation for the treatment of psoriasis. Further studies will incorporate these niosomes in gels for the application.

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Optimization and In-Vitro Characterization of Tetrahydrocurcumin Loaded Niosome for Psoriasis Management
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 24, 278 (2025); https://doi.org/10.2174/0118715230385381250807024537
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  • Article Type:     Research Article
Keyword(s): cholesterol; kinetics; nanotechnology; Niosomes; optimization; particle size

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