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2000
Volume 24, Issue 3
  • ISSN: 1871-5230
  • E-ISSN: 1875-614X

Abstract

Background

Chronic inflammatory diseases are rising, driving the search for effective natural treatments. L. and L. (anise) exhibit notable anti-inflammatory properties individually, but their combined effects are less studied. This research evaluates the synergistic anti-inflammatory activities of their hydroalcoholic extracts. Phytochemical analysis confirmed the presence of flavonoids, tannins, and polyphenols in both extracts. Individually, they demonstrated significant activity (78.5% and 72.3%, respectively, at 10 g/L) compared to Diclofenac (62.3%). Their combination achieved 88.6% inhibition at the same concentration. These findings highlight their potential as natural anti-inflammatory agents.

Introduction

The rise in chronic inflammatory diseases has increased interest in natural anti-inflammatory treatments. L. and L. are well-known for their anti-inflammatory potential, attributed to their bioactive compounds like flavonoids and polyphenols. While the individual effects of these plants are established, their combined use is underexplored. This study evaluates the synergistic anti-inflammatory activity of hydroalcoholic extracts from these plants, aiming to offer an effective natural therapeutic alternative.

Methods

Hydroalcoholic extracts were prepared by maceration of both plants. Anti-inflammatory activity was assessed using the protein denaturation method with Diclofenac as a standard.

Results

Phytochemical analysis identified flavonoids, alkaloids, tannins, glycosides, and polyphenols in , with an absence of saponins. contained flavonoids, tannins, heterosides, and polyphenols. The extracts exhibited strong anti-inflammatory activity individually (78.5% and 72.3%, respectively, at 10 g/L) and even higher inhibition (88.6%) when combined, surpassing Diclofenac (62.3%).

Conclusion

The combination of and extracts significantly enhanced anti-inflammatory activity compared to individual extracts, underscoring their potential as natural therapeutic alternatives to conventional treatments.

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2025-02-19
2025-09-25

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In Vitro Evaluation of the Synergistic Anti-inflammatory Activities of the Combined Hydroalcoholic Extracts from Mentha pulegium L. and Pimpinella anisum L.
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents) 24, 215 (2025); https://doi.org/10.2174/0118715230363843250122051332
/content/journals/aiaamc/10.2174/0118715230363843250122051332
/content/journals/aiaamc/10.2174/0118715230363843250122051332
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  • Article Type:     Research Article
Keyword(s): anti-inflammatory activity; chronic inflammatory; hydroalcoholic extract; Mentha pulegium L.; phytochemical analysis natural treatment; Pimpinella anisum L.

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