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2000
Volume 24, Issue 2
  • ISSN: 2211-3525
  • E-ISSN: 2211-3533

Abstract

Introduction

BGR-34, a polyherbal formulation, has garnered attention for its antimicrobial properties, attributed to its diverse composition of primary and secondary metabolites.

Objective

The objective of the study was to generate good scientific data regarding BGR-34.

Methods

This study was carried out to investigate the phytochemical screening, High Performance Liquid Chromatography (HPLC) analysis used Quercetin as a standard, and antimicrobial efficacy of BGR-34 against significant human pathogens, including and .

Results and Discussion

The findings revealed a dose-dependent antimicrobial effect, with optimal activity observed at 100 mg/mL, highlighting its potential as a therapeutic agent. The phytochemical screening confirmed the presence of various primary and secondary metabolites, such as flavonoids, alkaloids, saponins, carbohydrates, alkaloids, tannins, proteins, terpenoids, . HPLC analysis demonstrated the presence of quercetin (2.2974 ug/mL), which is responsible for various pharmacological activities. Antimicrobial potential showed activity of BGR-34 against various microbes that are responsible for various diseases. The bioactive compounds in BGR-34, such as phenolics, flavonoids, and terpenoids, exhibit mechanisms like biofilm disruption and microbial membrane interference, underscoring its broad-spectrum efficacy. Furthermore, its potential role in addressing infections related to biofilm-forming pathogens and resistant strains establishes its clinical significance.

Conclusion

These results support the continued exploration of BGR-34 as a viable option in combating microbial infections, with implications for managing resistant pathogens, and reducing the burden of infectious diseases.

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Antimicrobial Potential and HPLC Analysis of BGR-34: An Antidiabetic Ayurvedic Formulation
Anti Infect. Agents 24, E22113525393510 (2026); https://doi.org/10.2174/0122113525393510250513061353
/content/journals/aia/10.2174/0122113525393510250513061353
/content/journals/aia/10.2174/0122113525393510250513061353
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  • Article Type:     Research Article
Keyword(s): antimicrobial; antioxidant; BGR-34; flavonoids; HPLC; Klebsiella pneumoniae

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