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2000
Volume 23, Issue 5
  • ISSN: 2211-3525
  • E-ISSN: 2211-3533

Abstract

Introduction

The incidence of Extended-spectrum Beta-lactamase (ESBL)- and carbapenemase-producing enterobacteriaceae in enterobacterales is increasing globally, posing a threat to health. Schoolchildren under adolescence show a gradual increase in immunity, and respiratory infections like pneumonia and others are more prevalent in children under five-years of age. However, gastrointestinal disorders primarily affect children under one-year of age.

Aims

The study aimed to analyze the ESBL and carbapenemase-producing cephalosporin-resistant strain of and , isolated from various specimens of hospitalized children below ten years of age.

Methods

A cross-sectional study on laboratory reports of positive culture specimens from children below ten years of age was conducted to analyze the cephalosporin-resistant strains of and between July, 2023 and July, 2024 in the Microbiology Department of a tertiary care hospital central Kerala, South India. The cephalosporin-resistant strain was analyzed for carbapenemase or ESBL presence using a double disc synergy test. The data were subjected to statistical analysis.

Results and Discussion

A total of 1636 culture reports were analyzed, and growth was found in 672 (41%) specimens. Among the cephalosporin-resistant 187 strains (66%), and were 106 (57%) and 81 (43%), respectively. A significant difference ( <0.05) was noted between cephalosporin-resistant and sensitive among the various age groups. The difference between cephalosporin-resistant and susceptible across different age groups, however, was negligible (>0.05). Carbapenemase and ESBL-producing and were 39%, 29%, and 48%, respectively. The carbapenemase and ESBL-producing strains were more in children below one year. An insignificant difference (>0.05) between ESBL (+) and ESBL (-) or was found among various age groups. A similar observation was found between carbapenemase [+] and carbapenemase (-) or . According to the effect value (Cramer's V) determined for each comparison, the association was either very weak or negligible.

Conclusion

The cephalosporin-resistant strains (66%) of and were 57% and 43%, respectively. Specimens of children below one year of age showed more incidence of ESBL-producing (67%) and carbapenemase-producing (68%).

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2025-02-13
2025-10-13

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Analysis of Carbapenemase and Extended-spectrum Beta-lactamases-producing Cephalosporin-resistant Strain of Escherichia coli and Klebsiella pneumoniae among Children in a Tertiary Care Centre, South India
Anti Infect. Agents 23, E22113525363630 (2025); https://doi.org/10.2174/0122113525363630250203053527
/content/journals/aia/10.2174/0122113525363630250203053527
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  • Article Type:     Research Article
Keyword(s): Carbapenemase; enterobacteriaceae; Escherichia coli; extended-spectrum beta-lactamase; Klebsiella pneumoniae; statistical analysis

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