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2000
Volume 10, Issue 1
  • ISSN: 2667-3371
  • E-ISSN: 2667-338X

Abstract

Background

Early in December 2019, Wuhan City, Hubei Province, China, had an epidemic of the Coronavirus illness 2019 (COVID-19), which was brought on by a brand-new severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2). The epidemic was deemed a Public Health Emergency of International Concern by the World Health Organization on January 30, 2020. Many governments have implemented a range of control measures as a result of perceived illness risk.

Objectives

The pandemic revealed that COVID-19 affects a variety of organs in addition to the lungs, including the heart and brain, raising the risk of long-term health consequences. The illness can affect someone's health even after recovery in a variety of ways. The long-term effects of COVID-19 on locals are still being researched. The objective is to compile knowledge regarding the virus and the present Post pandemic complications in Long Haulers.

Methods

We reviewed the body of publicly available literature. To discover publications published between December 2019 and October 2020, we conducted a systematic search utilizing the keywords in online databases such as Pub Med, Scopus, Science Direct, Up to Date, and Web of Science. The review includes peer-reviewed original publications published that matched the qualifying requirements.

Results

Although the majority of patients recovered quickly after receiving COVID-19, the possibility of long-term issues induced by COVID-19 necessitates the search for and research of its late consequences. This article aims to provide a comprehensive assessment of COVID-19 late complications in order to determine how prevalent these symptoms are and who is most likely to be impacted.

Conclusion

There are a number of difficulties with the COVID-19 pandemic that has yet to be resolved. Review of the literature reported several long-lasting clinical problems that affect different phases of health, including chronic fatigue, reduced physical capacity, muscle weakness, increased depression, anxiety, post-traumatic stress disorder and sleep problems. A complete turndown in quality of life has been observed even one year after major Coronavirus outbreaks.

The pandemic revealed that COVID-19 affects a variety of organs in addition to the lungs, including the heart and brain, raising the risk of long-term health consequences even after years making them to be “Long Haulers”.

The causal agent, pathogenesis, immunological responses, epidemiology, diagnosis, therapy, and management of the disease, as well as control and preventive efforts, are all included in this review of the literature.

© 2024 Bentham Science Publishers
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2024-03-21
2026-02-27

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References

  1. BoldriniM. CanollP.D. KleinR.S. How COVID-19 affects the brain.JAMA Psychiatry202178668268310.1001/jamapsychiatry.2021.0500 33769431
     [Google Scholar]
  2. ButowtR. von BartheldC.S. Anosmia in COVID-19: Underlying mechanisms and assessment of an olfactory route to brain infection.Neuroscientist202127658260310.1177/1073858420956905 32914699
     [Google Scholar]
  3. MerchantS.N. AdamsJ.C. NadolJ.B.Jr Pathology and pathophysiology of idiopathic sudden sensorineural hearing loss.Otol. Neurotol.200526215116010.1097/00129492‑200503000‑00004 15793397
     [Google Scholar]
  4. OliveiraT.L. MeloI.S. Cardoso-SousaL. Pathophysiology of SARS-CoV-2 in lung of diabetic patients.Front. Physiol.20201158701310.3389/fphys.2020.587013 33362575
     [Google Scholar]
  5. YeQ. WangB. ZhangT. XuJ. ShangS. The mechanism and treatment of gastrointestinal symptoms in patients with COVID-19.Am. J. Physiol. Gastrointest. Liver Physiol.20203192G245G25210.1152/ajpgi.00148.2020 32639848
     [Google Scholar]
  6. Basu-RayI AlmaddahNK AdeboyeA SoosMP Cardiac manifestations of Coronavirus (COVID-19). Treasure Island [FL]: StatPearls Publishing20212235
     [Google Scholar]
  7. WoodsJ.A. HutchinsonN.T. PowersS.K. The COVID-19 pandemic and physical activity.Sports Med. Health Sci.202022556410.1016/j.smhs.2020.05.006 34189484
     [Google Scholar]
  8. Eurosurveillance editorial team. Note from the editors: World Health Organization declares novel coronavirus (2019-nCoV) sixth public health emergency of international concern. Euro Surveill2020255200131e
     [Google Scholar]
  9. CipollaroL. GiordanoL. PaduloJ. OlivaF. Maffulli Musculoskeletal symptoms in SARS-CoV-2 [COVID-19] patients.J. Orthop. Surg. Res.2020151178184
     [Google Scholar]
  10. WuY. XuX. ChenZ. Nervous system involvement after infection with COVID-19 and other coronaviruses.Brain Behav. Immun.202087182210.1016/j.bbi.2020.03.031 32240762
     [Google Scholar]
  11. EllulM.A. BenjaminL. SinghB. LantS. MichaelB.D. EastonA. Neurological associations of COVID-19.Lancet Neurol.20202302210
     [Google Scholar]
  12. WostynP. COVID-19 and chronic fatigue syndrome: Is the worst yet to come?Med. Hypotheses202114611046910.1016/j.mehy.2020.110469 33401106
     [Google Scholar]
  13. KomaroffA.L. BatemanL. Will COVID-19 lead to myalgic Encephalomyelitis/chronic fatigue syndrome?Front. Med.2021760682410.3389/fmed.2020.606824 33537329
     [Google Scholar]
  14. DisserN.P. De MicheliA.J. SchonkM.M. Musculoskeletal consequences of COVID-19.J. Bone Joint Surg. Am.2020102141197120410.2106/JBJS.20.00847 32675661
     [Google Scholar]
  15. AhmedH. PatelK. GreenwoodD. Long-term clinical outcomes in survivors of severe acute respiratory syndrome and Middle East respiratory syndrome coronavirus outbreaks after hospitalisation or ICU admission: A systematic review and meta-analysis.J. Rehabil. Med.202052511110.2340/16501977‑2694 32449782
     [Google Scholar]
  16. SteinerW.A. RyserL. HuberE. UebelhartD. AeschlimannA. StuckiG. Use of the ICF model as a clinical problem-solving tool in physical therapy and rehabilitation medicine.Phys. Ther.200282111098110710.1093/ptj/82.11.1098 12405874
     [Google Scholar]
  17. OrlandiM. LepriG. BruniC. The systemic sclerosis patient in the COVID-19 era: the challenging crossroad between immunosuppression, differential diagnosis and long-term psychological distress.Clin. Rheumatol.20203972043204710.1007/s10067‑020‑05193‑2 32514674
     [Google Scholar]
  18. HenekaM.T. GolenbockD. LatzE. MorganD. BrownR. Immediate and long-term consequences of COVID-19 infections for the development of neurological disease.Alzheimers Res. Ther.20201216910.1186/s13195‑020‑00640‑3 32498691
     [Google Scholar]
  19. MehraeenE. BehnezhadF. SalehiM.A. NooriT. HarandiH. SeyedA.S. Olfactory and gustatory dysfunctions due to the coronavirus disease [COVID-19]: A review of current evidence.Eur. Arch. Otorhinolaryngol.2020316
     [Google Scholar]
  20. MehraeenE HayatiB SaeidiS HeydariM SeyedalinaghiS Selfcare instructions for people not requiring hospitalization for coronavirus disease 2019 (COVID-19). Arch Clin Infect Dis202015(COVID-19)276810.5812/archcid.102978
     [Google Scholar]
  21. SeyedAlinaghi AGhadimi M, Hajiabdolbaghi M, Rasoolinejad M, Abbasian L, Nezhad MH. Prevalence of COVID-19-like symptoms among people living with HIV, and using antiretroviral therapy for prevention and treatment.Curr. HIV Res.202022326
     [Google Scholar]
  22. WangX FangX CaiZ Comorbid chronic diseases and acute organ injuries are strongly correlated with disease severity and mortality among COVID-19 patients: A systemic review and meta-analysis. Research 2020;20202020/240296110.34133/2020/2402961 32377638
     [Google Scholar]
  23. ConsoliL. BendottiV. CicchinelliS. GaioniF. PrandoliniP. BettonagliM. 2019 novel coronavirus [COVID-19] pneumonia complications: The importance of lung ultrasound.J. Ultrasound2020114 32562109
     [Google Scholar]
  24. Asadollahi-AminA. HasibiM. GhadimiF. RezaeiH. SeyedAlinaghi S. Lung involvement found on chest CT scan in a pre-symptomatic person with SARS-CoV-2 infection: A case report.Trop. Med. Infect. Dis.2020525610.3390/tropicalmed5020056 32272630
     [Google Scholar]
  25. GhiasvandF. MiandoabS.Z. HarandiH. GolestanF.S. AlinaghiS.A.S. A patient with COVID-19 disease in a referral hospital in Iran: A typical case.Infect. Disord. Drug Targets202020455956210.2174/22123989MTA2CMjMox 32348232
     [Google Scholar]
  26. WagenerF. PickkersP. PetersonS.J. ImmenschuhS. AbrahamN.G. Targeting the heme-heme oxygenase system to prevent severe complications following COVID-19 infections.Antioxidants202096221
     [Google Scholar]
  27. MontalvanV. LeeJ. BuesoT. De ToledoJ. RivasK. Neurological manifestations of COVID-19 and other coronavirus infections: A systematic review.Clin. Neurol. Neurosurg.202019410592110.1016/j.clineuro.2020.105921 32422545
     [Google Scholar]
  28. BeghiE. FeiginV. CasoV. SantaluciaP. LogroscinoG. COVID-19 infection and neurological complications: present findings and future predictions.Neuroepidemiology202054536436910.1159/000508991 32610334
     [Google Scholar]
  29. AghagoliG. Gallo MarinB. SolimanL.B. SellkeF.W. Cardiac involvement in COVID‐19 patients: Risk factors, predictors, and complications: A review.J. Card. Surg.20203561302130510.1111/jocs.14538 32306491
     [Google Scholar]
  30. InciardiR.M. LupiL. ZacconeG. Cardiac involvement in a patient with coronavirus disease 2019.JAMA Cardiol.20205781982410.1001/jamacardio.2020.1096 32219357
     [Google Scholar]
  31. BandyopadhyayD. AkhtarT. HajraA. COVID-19 pandemic: Cardiovascular complications and future implications.Am. J. Cardiovasc. Drugs202020431132410.1007/s40256‑020‑00420‑2 32578167
     [Google Scholar]
  32. BellastellaG. MaiorinoM.I. EspositoK. Endocrine complications of COVID-19: what happens to the thyroid and adrenal glands?J. Endocrinol. Invest.20204381169117010.1007/s40618‑020‑01311‑8 32488724
     [Google Scholar]
  33. DochertyA.B. HarrisonE.M. GreenC.A. HardwickH.E. PiusR. NormanL. Features of 16,749 hospitalized UK patients with COVID-19 using the ISARIC WHO Clinical Characterization Protocol.BMJ2020369m1985
     [Google Scholar]
  34. SinghY. GuptaG. KazmiI. SARS CoV‐2 aggravates cellular metabolism mediated complications in COVID ‐19 infection.Dermatol. Ther.2020336e1387110.1111/dth.13871 32558055
     [Google Scholar]
  35. CoperchiniF. ChiovatoL. CroceL. MagriF. RotondiM. The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system.Cytokine Growth Factor Rev.202053253210.1016/j.cytogfr.2020.05.003 32446778
     [Google Scholar]
  36. HeissR. GrodzkiD.M. HorgerW. UderM. NagelA.M. BickelhauptS. High-performance low field MRI enables visualization of persistent pulmonary damage after COVID-19.Magn. Reson. Imaging202176495110.1016/j.mri.2020.11.004 33220447
     [Google Scholar]
  37. HuQ. GuanH. SunZ. Early CT features and temporal lung changes in COVID-19 pneumonia in Wuhan, China.Eur. J. Radiol.202012810901710.1016/j.ejrad.2020.109017 32387924
     [Google Scholar]
  38. LatronicoN PeliE RodellaF NovelliMP RasuloFA PivaS Six-month outcome in survivors of COVID-19 associated acute respiratory distress syndrome.2020
     [Google Scholar]
  39. LiangL. YangB. JiangN. FuW. HeX. ZhouY. Three-month follow-up study of survivors of coronavirus disease 2019 after discharge.J. Korean Med. Sci.201935471146256
     [Google Scholar]
  40. LiaoB. LiuZ. TangL. Longitudinal clinical and radiographic evaluation reveals interleukin-6 as an indicator of persistent pulmonary injury in COVID-19.Int. J. Med. Sci.2021181294110.7150/ijms.49728 33390771
     [Google Scholar]
  41. ManckoundiaP. FranonF. Is persistent thick copious mucus a long-term symptom of COVID-19?Eur. J. Case Rep. Intern. Med.2020700214510.12890/2020_002145 33457378
     [Google Scholar]
  42. MoX. JianW. SuZ. Abnormal pulmonary function in COVID-19 patients at time of hospital discharge.Eur. Respir. J.2020556200121710.1183/13993003.01217‑2020 32381497
     [Google Scholar]
  43. Moreno-PérezO. MerinoE. Leon-RamirezJ.M. Post-acute COVID-19 syndrome. Incidence and risk factors: A Mediterranean cohort study.J. Infect.202182337838310.1016/j.jinf.2021.01.004 33450302
     [Google Scholar]
  44. RamakrishnanA. ZreloffJ. MooreM.A. Prolonged symptoms after COVID-19 infection in outpatients.Open Forum Infect. Dis.202183ofab06010.1093/ofid/ofab060 33732751
     [Google Scholar]
  45. ShahA.S. WongA.W. HagueC.J. MurphyD.T. JohnstonJ.C. RyersonC.J. Prospective studies of 12-weeks respiratory outcomes in COVID-19-related hospitalizations.Thorax20203667669 33273023
     [Google Scholar]
  46. SonnweberT. BoehmA. SahanicS. Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients’ performance: a prospective observational cohort study.Respir. Res.202021127610.1186/s12931‑020‑01546‑2 33087116
     [Google Scholar]
  47. TabatabaeiS.M.H. RajebiH. MoghaddasF. GhasemiadlM. TalariH. Chest CT in COVID-19 pneumonia: What are the findings in mid-term follow-up?Emerg. Radiol.202027671171910.1007/s10140‑020‑01869‑z 33165674
     [Google Scholar]
  48. TrinkmannF. MüllerM. ReifA. Residual symptoms and lower lung function in patients recovering from SARS-CoV-2 infection.Eur. Respir. J.2021572200300210.1183/13993003.03002‑2020 33479105
     [Google Scholar]
  49. TruffautL. DemeyL. BruyneelA.V. Post-discharge critical COVID-19 lung function related to severity of radiologic lung involvement at admission.Respir. Res.20212212910.1186/s12931‑021‑01625‑y 33478527
     [Google Scholar]
  50. van den BorstB. PetersJ.B. BrinkM. SchoonY. Bleeker-RoversC.P. SchersH. Comprehensive health assessment three months after recovery from acute COVID-19.Clin. Infect. Dis.2020211750
     [Google Scholar]
  51. van GasselR.J.J. BelsJ.L.M. RaafsA. High prevalence of pulmonary sequelae at 3 months after hospital discharge in mechanically ventilated survivors of COVID-19.Am. J. Respir. Crit. Care Med.2021203337137410.1164/rccm.202010‑3823LE 33326353
     [Google Scholar]
  52. WeerahandiH. HochmanK.A. SimonE. Post-discharge health status and symptoms in patients with severe COVID-19.J. Gen. Intern. Med.202136373874510.1007/s11606‑020‑06338‑4 33443703
     [Google Scholar]
  53. YaoX.H. HeZ.C. LiT.Y. Pathological evidence for residual SARS-CoV-2 in pulmonary tissues of a ready-for-discharge patient.Cell Res.202030654154310.1038/s41422‑020‑0318‑5 32346074
     [Google Scholar]
  54. ZhaoY.M. ShangY.M. SongW.B. LiQ.Q. XieH. XuQ.F. Pulmonary functions and related physiological characteristics of COVID-19 survivors.EClinicalMedicine20202510046310.1016/j.eclinm.2020.100463
     [Google Scholar]
  55. ZhuM. ChenD. ZhuY. Long-term sero-positivity for IgG, sequelae of respiratory symptoms, and abundance of malformed sperms in a patient recovered from severe COVID-19.Eur. J. Clin. Microbiol. Infect. Dis.20214071559156710.1007/s10096‑021‑04178‑6 33555444
     [Google Scholar]
  56. Boscolo-RizzoP. PoleselJ. SpinatoG. Predominance of an altered sense of smell or taste among long-lasting symptoms in patients with mildly symptomatic COVID-19.Rhinology202058552452510.4193/Rhin20.263 32683438
     [Google Scholar]
  57. CaronnaE. BallvéA. LlauradóA. Headache: A striking prodromal and persistent symptom, predictive of COVID-19 clinical evolution.Cephalalgia202040131410142110.1177/0333102420965157 33146036
     [Google Scholar]
  58. D’AscanioL. PandolfiniM. CingolaniC. Olfactory dysfunction in COVID-19 patients: Prevalence and prognosis for recovering sense of smell.Otolaryngol. Head Neck Surg.20211641828610.1177/0194599820943530 32662745
     [Google Scholar]
  59. DaniM. DirksenA. TaraborrelliP. TorocastroM. PanagopoulosD. SuttonR. Autonomic dysfunction in ‘long COVID’: Rationale, physiology and management strategies.Clin. Med.202021e63e67
     [Google Scholar]
  60. FjaeldstadA.W. Prolonged complaints of chemosensory loss after COVID-19.Dan. Med. J.2020678A05200340 32741438
     [Google Scholar]
  61. GalalS. HusseinA.A.R. AminM.T. SaadM.M. ZayanH.E.E. AbdelsayedM.Z. Determinants of persistent post COVID-19 symptoms: Value of a novel COVID-19 symptoms score.Egypt. J. Bronchol.2021151010.1186/s43168‑020‑00049‑4
     [Google Scholar]
  62. GallusR. MelisA. RizzoD. Audiovestibular symptoms and sequelae in COVID-19 patients.J. Vestib. Res.202131538138710.3233/VES‑201505 33579886
     [Google Scholar]
  63. GuedjE. MillionM. DudouetP. Tissot-DupontH. BregeonF. CammilleriS. F-FDG brain PET hypometabolism in post-SARS-CoV-2 infection: Substrate for persistent/delayed disorders?Eur. J. Nucl. Med. Mol. Imaging20203014 32728799
     [Google Scholar]
  64. HellmuthJ. BarnettT.A. AskenB.M. Persistent COVID-19-associated neurocognitive symptoms in non-hospitalized patients.J. Neurovirol.202127119119510.1007/s13365‑021‑00954‑4 33528824
     [Google Scholar]
  65. LimS.T. JanawayB. CostelloH. TripA. PriceG. Persistent psychotic symptoms following COVID-19 infection.BJPsych Open202065e10510.1192/bjo.2020.76 32696735
     [Google Scholar]
  66. LuY. LiX. GengD. Cerebral micro-structural changes in COVID-19 patients-an MRI-based 3-month follow-up study E.EClinicalMedicine20202510048410.1016/j.eclinm.2020.100484 32838240
     [Google Scholar]
  67. MéndezR. Balanzá-MartínezV. LuperdiS.C. Short‐term neuropsychiatric outcomes and quality of life in COVID‐19 survivors.J. Intern. Med.2021290362163110.1111/joim.13262 33533521
     [Google Scholar]
  68. MoeinS.T. HashemianS.M. TabarsiP. DotyR.L. Prevalence and reversibility of smell dysfunction measured psychophysically in a cohort of COVID‐19 patients.Int. Forum Allergy Rhinol.202010101127113510.1002/alr.22680 32761796
     [Google Scholar]
  69. NegriniF. FerrarioI. MazziottiD. Neuropsychological features of severe hospitalized coronavirus disease 2019 Patients at clinical stability and clues for postacute rehabilitation.Arch. Phys. Med. Rehabil.2021102115515810.1016/j.apmr.2020.09.376 32991870
     [Google Scholar]
  70. NovakP. Post COVID-19 syndrome associated with orthostatic cerebral hypoperfusion syndrome, small fiber neuropathy and benefit of immunotherapy: a case report.eNeurologicalSci20202110027610028210.1016/j.ensci.2020.100276 32984564
     [Google Scholar]
  71. PandaS. MohamedA. SikkaK. KanodiaA. SakthivelP. ThakarA. Otolaryngologic manifestation and long-term outcome in mild COVID-19: experience from a Tertiary Care Centre in India.Indian J. Otolaryngol. Head Neck Surg.20201416 33078125
     [Google Scholar]
  72. PilottoA. CristilloV. Cotti PiccinelliS. ZoppiN. BonziG. SattinD. COVID-19 severity impacts on long-term neurological manifestation after hospitalisation.Neurol. Sci.20214249034907
     [Google Scholar]
  73. PrintzaA. KatotomichelakisM. MetallidisS. The clinical course of smell and taste loss in COVID-19 hospitalized patients.Hippokratia20202426671 33488054
     [Google Scholar]
  74. RaahimiM.M. KaneA. MooreC.E.G. AlareedA.W. Late onset of Guillain-Barré syndrome following SARS-CoV-2 infection: part of ‘long COVID-19 syndrome’?BMJ Case Rep.2021141e24017810.1136/bcr‑2020‑240178 33462068
     [Google Scholar]
  75. Sampaio Rocha-FilhoP.A. VossL. Persistent headache and persistent anosmia associated with COVID-19.Headache20206081797179910.1111/head.13941 32790179
     [Google Scholar]
  76. CloudenT.A. Persistent hallucinations in a 46-year-old woman after COVID-19 infection: A case report.Cureus20201212e1199310.7759/cureus.11993 33437548
     [Google Scholar]
  77. UgurluB.N. AkdoganO. YilmazY.A. Quantitative evaluation and progress of olfactory dysfunction in COVID-19.Eur. Arch. Otorhinolaryngol.202127872363236910.1007/s00405‑020‑06516‑4 33385250
     [Google Scholar]
  78. VairaL.A. HopkinsC. PetrocelliM. Smell and taste recovery in coronavirus disease 2019 patients: A 60-day objective and prospective study.J. Laryngol. Otol.2020134870370910.1017/S0022215120001826 32782030
     [Google Scholar]
  79. YanC.H. PrajapatiD.P. RitterM.L. DeCondeA.S. Persistent smell loss following undetectable SARS-CoV-2.Otolaryngol. Head Neck Surg.2020163592392510.1177/0194599820934769 32513065
     [Google Scholar]
  80. AbdallahH. PorterfieldF. FajgenbaumD. Symptomatic relapse and long-term sequelae of COVID-19 in a previously healthy 30-year-old man.BMJ Case Rep.20201312e23982510.1136/bcr‑2020‑239825 33318288
     [Google Scholar]
  81. ArnoldD.T. HamiltonF.W. MilneA. Patient outcomes after hospitalisation with COVID-19 and implications for follow-up: Results from a prospective UK cohort.Thorax202011889898 33273026
     [Google Scholar]
  82. BuonsensoD. MunblitD. De RoseC. SinattiD. RicchiutoA. CarfiA. Preliminary evidence on long COVID in children.Acta Pecliator202111072208221110.1101/2021.01.23.21250375
     [Google Scholar]
  83. BuselliR. CorsiM. NecciariG. Sudden and persistent dysphonia within the framework of COVID-19: The case report of a nurse.Brain Behav. Immun. Health2020910016010016510.1016/j.bbih.2020.100160 33078141
     [Google Scholar]
  84. CarfìA. BernabeiR. LandiF. Gemelli against COVID-19 post-acute care study group.JAMA2020324603605 32644129
     [Google Scholar]
  85. Carvalho-SchneiderC. LaurentE. LemaignenA. Follow-up of adults with noncritical COVID-19 two months after symptom onset.Clin. Microbiol. Infect.202127225826310.1016/j.cmi.2020.09.052 33031948
     [Google Scholar]
  86. ChenK.Y. LiT. GongF.H. ZhangJ.S. LiX.K. Predictors of health-related quality of life and influencing factors for COVID-19 patients: a follow-up at one month.Front. Psychiatry20201166867510.3389/fpsyt.2020.00668 32733299
     [Google Scholar]
  87. CirulliE. Schiabor BarrettK.M. RiffleS. BolzeA. NeveuxI. DabeS. Long-term COVID-19 symptoms in a large unselected population.medRxiv202010.1101/2020.10.07.20208702
     [Google Scholar]
  88. D’CruzR.F. WallerM.D. PerrinF. Chest radiography is a poor predictor of respiratory symptoms and functional impairment in survivors of severe COVID-19 pneumonia.ERJ Open Res.202171006550202010.1183/23120541.00655‑2020 33575312
     [Google Scholar]
  89. ErçalikT. AyyildizA. Gencer-AtalayK. AkgünC. ÖzdemirH.M. KuranB. Pain symptoms in COVID-19.Am. J. Phys. Med. Rehabil.20211991559166
     [Google Scholar]
  90. Galván-TejadaC.E. Herrera-GarcíaC.F. Godina-GonzálezS. Persistence of COVID-19 symptoms after recovery in Mexican population.Int. J. Environ. Res. Public Health202017249367937310.3390/ijerph17249367 33327641
     [Google Scholar]
  91. HosseiniZ. GhodsiS. HejaziS.F. Persistent complete heart block in a patient with COVID-19 infection: A case report.SN Compr. Clin. Med.20213125926210.1007/s42399‑020‑00712‑3 33432301
     [Google Scholar]
  92. HuangC. HuangL. WangY. 6-month consequences of COVID-19 in patients discharged from hospital: A cohort study.Lancet20213971027022023210.1016/S0140‑6736(20)32656‑8 33428867
     [Google Scholar]
  93. IsoldiS. MallardoS. MarcellinoA. The comprehensive clinic, laboratory, and instrumental evaluation of children with COVID‐19: A 6‐months prospective study.J. Med. Virol.20219353122313210.1002/jmv.26871 33570199
     [Google Scholar]
  94. IqbalA. IqbalK. Arshad AliS. The COVID-19 sequelae: A cross-sectional evaluation of post-recovery symptoms and the need for rehabilitation of COVID-19 survivors.Cureus2021132e1308010.7759/cureus.13080 33680620
     [Google Scholar]
  95. JacobsL.G. Gourna PaleoudisE. Lesky-Di BariD. Persistence of symptoms and quality of life at 35 days after hospitalization for COVID-19 infection.PLoS One20201512e024388210.1371/journal.pone.0243882 33306721
     [Google Scholar]
  96. KhalafM BazeedSE Abdel-GawadM Abu-ElfatthA AbdelhamedW ZaghloulM Prevalence and predictors of persistent symptoms after clearance of SARS-CoV-2 infection: A report from Egypt2020
     [Google Scholar]
  97. LudvigssonJ.F. Case report and systematic review suggest that children may experience similar long‐term effects to adults after clinical COVID‐19.Acta Paediatr.2021110391492110.1111/apa.15673 33205450
     [Google Scholar]
  98. MandalS. BarnettJ. BrillS.E. BrownJ.S. DennenyE.K. HareS.S. ‘Long-COVID’: A cross-sectional study of persisting symptoms, biomarker and imaging abnormalities following hospitalisation for COVID-19.Thorax202010247256 33172844
     [Google Scholar]
  99. MahmudR. RahmanM. RasselM.A. MonayemF.B. SayeedS.J.B. Post COVID syndrome among symptomatic COVID-19 patients: A prospective study in a Tertiary Care Center in Bangladesh.PLoS ONE2021164e024964410.1371/journal.pone.0249644
     [Google Scholar]
  100. MartinJ.T. Akama-GarrenE. PuranikA. LiukasemsarnS. VenkatakrishnanA.J. O’HoroJ.C. Augmented curation of clinical notes of COVID-19 and influenza patients reveals that long-term neuropsychiatric and coagulopathic symptoms are more associated with COVID-19.medRxiv2021
     [Google Scholar]
  101. PellaudC. GrandmaisonG. ThienH.P.P.H. Characteristics, comorbidities, 30-day outcome and in-hospital mortality of patients hospitalised with COVID-19 in a Swiss area-a retrospective cohort study.Swiss Med. Wkly.20201502930w2031410.4414/smw.2020.20314 32662869
     [Google Scholar]
  102. PetersenM.S. KristiansenM.F. HanussonK.D. Long COVID in the Faroe Islands-a longitudinal study among non-hospitalized patients.Clin. Infect. Dis.202015122130
     [Google Scholar]
  103. RamanB. CassarM.P. TunnicliffeE.M. Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge.EClinicalMedicine20213110068310068910.1016/j.eclinm.2020.100683 33490928
     [Google Scholar]
  104. Rosales-CastilloA. García de Los RíosC. Mediavilla GarcíaJ.D. Persistent symptoms after acute COVID-19 infection: Importance of follow-up.Med Clin2021156353610.1016/j.medcli.2020.08.001
     [Google Scholar]
  105. SaeedW. HussainI. AltafF. Telogen effluvium: Long term COVID-19 symptom.J. Pak. Assoc. Dermatol.202030700703
     [Google Scholar]
  106. IslamM.S. FerdousM.Z. IslamU.S. MosaddekA.S.M. PotenzaM.N. PardhanS. Treatment, persistent symptoms, and depression in people infected with COVID-19 in Bangladesh.Int. J. Environ. Res. Public Health20211841453145810.3390/ijerph18041453 33562427
     [Google Scholar]
  107. SmaneL. StarsI. PucukaZ. RogeI. PavareJ. Persistent clinical features in paediatric patients after SARS-CoV-2 virological recovery: A retrospective population-based cohort study from a single centre in Latvia.BMJ Paediatr. Open202041e00090510.1136/bmjpo‑2020‑000905 34192185
     [Google Scholar]
  108. SofianM. VelayatiA.A. BanifazlM. SARS-CoV 2, a virus with many faces: A series of cases with prolonged persistence of COVID-19 symptoms.Wien. Med. Wochenschr.20211711-23610.1007/s10354‑020‑00793‑8 33315163
     [Google Scholar]
  109. StavemK. GhanimaW. OlsenM.K. GilboeH.M. EinvikG. Persistent symptoms 1.5-6 months after COVID-19 in non-hospitalised subjects: A population-based cohort study.Thorax202014655665 33273028
     [Google Scholar]
  110. SykesD.L. HoldsworthL. JawadN. GunasekeraP. MoriceA.H. CrooksM.G. Post-COVID-19 symptom burden: What is long-COVID and how should we manage it?Lung2021199211311910.1007/s00408‑021‑00423‑z 33569660
     [Google Scholar]
  111. TaboadaM. MorenoE. CariñenaA. Quality of life, functional status, and persistent symptoms after intensive care of COVID-19 patients.Br. J. Anaesth.20211263e110e11310.1016/j.bja.2020.12.007 33413976
     [Google Scholar]
  112. TownsendL. DyerA.H. JonesK. Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection.PLoS One20201511e024078410.1371/journal.pone.0240784 33166287
     [Google Scholar]
  113. TownsendL. DowdsJ. O’BrienK. SheillG. DyerA.H. O’KellyB. Persistent poor health post-COVID-19 is not associated with respiratory complications or initial disease severity.Ann. Am. Thorac. Soc.202112340349
     [Google Scholar]
  114. VargheseJ. SandmannS. VollenbergR. Follow up of COVID-19 features in recovered adults without comorbidities- persistent symptoms and lab-abnormalities.Res Square20201566567010.21203/rs.3.rs‑116030/v1
     [Google Scholar]
  115. AnY.W. SongS. LiW.X. Liver function recovery of COVID-19 patients after discharge, a follow-up study.Int. J. Med. Sci.202118117618610.7150/ijms.50691 33390786
     [Google Scholar]
  116. GuanW. NiZ. HuY. Clinical characteristics of coronavirus disease 2019 in China.N. Engl. J. Med.2020382181708172010.1056/NEJMoa2002032 32109013
     [Google Scholar]
  117. YangX. YuY. XuJ. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: A single-centered, retrospective, observational study.Lancet Respir. Med.20208547548110.1016/S2213‑2600(20)30079‑5 32105632
     [Google Scholar]
  118. XuZ. ShiL. WangY. Pathological findings of COVID-19 associated with acute respiratory distress syndrome.Lancet Respir. Med.20208442042210.1016/S2213‑2600(20)30076‑X 32085846
     [Google Scholar]
  119. FraserE. Long term respiratory complications of COVID-19.BMJ2020370m300110.1136/bmj.m3001 32747332
     [Google Scholar]
  120. MarshallM. The lasting misery of coronavirus long-haulers.Nature2020585782533934110.1038/d41586‑020‑02598‑6 32929257
     [Google Scholar]
  121. ShawB. DaskarehM. GholamrezanezhadA. The lingering manifestations of COVID-19 during and after convalescence: Update on long-term pulmonary consequences of coronavirus disease 2019.Radiol. Med.2020117 33006087
     [Google Scholar]
  122. AhmadI. RathoreF.A. Neurological manifestations and complications of COVID-19: A literature review.J. Clin. Neurosci.20207781210.1016/j.jocn.2020.05.017 32409215
     [Google Scholar]
  123. BougakovD. PodellK. GoldbergE. Multiple neuroinvasive pathways in COVID-19.Mol. Neurobiol.202029112 32990925
     [Google Scholar]
  124. CandanS.A. ElibolN. AbdullahiA. Consideration of prevention and management of long-term consequences of post-acute respiratory distress syndrome in patients with COVID-19.Physiother. Theory Pract.202036666366810.1080/09593985.2020.1766181 32419564
     [Google Scholar]
  125. WijeratneT. Gillard CrewtherS. SalesC. KarimiL. COVID-19 pathophysiology predicts that ischemic stroke occurrence is an expectation, not an exception-a systematic review.Front. Neurol.20211160722110.3389/fneur.2020.607221 33584506
     [Google Scholar]
  126. FischerP.R. RenemaneL. Mental disorders following COVID-19 infection: A systematic review of acute and long-term psychiatric manifestations and associated brain changes. Proc. Latvian Acad.Proceedings of the Latvian Academy of Sciences Section B Natural, Exact, and Applied Sciences202074634735710.2478/prolas‑2020‑0053
     [Google Scholar]
  127. Hundreds of ‘Long Haulers’ Present with Neurologic Complaints at Post-COVID-19 Clinics. Available from: https://journals.lww. com/neurotodayonline/Fulltext/2020/11050/Hundreds_of__Long_Haulers__Present_with_Neurologic.3.aspx
  128. NathA. Long-Haul COVID.Neurology2020951355956010.1212/WNL.0000000000010640 32788251
     [Google Scholar]
  129. OtteM.S. EckelH.N.C. PoluschkinL. KlussmannJ.P. LuersJ.C. Olfactory dysfunction in patients after recovering from COVID-19.Acta Otolaryngol.2020140121032103510.1080/00016489.2020.1811999 32852240
     [Google Scholar]
  130. KonstantinidisI. DelidesA. TsakiropoulouE. MaragoudakisP. SapounasS. TsiodrasS. Short-term follow-up of self-isolated COVID-19 patients with smell and taste dysfunction in Greece: Two phenotypes of recovery.ORL J. Otorhinolaryngol. Relat. Spec.202082629530310.1159/000511436 33049753
     [Google Scholar]
  131. PaoloG. Does COVID-19 cause permanent damage to olfactory and gustatory function?Med. Hypotheses202014311008611009410.1016/j.mehy.2020.110086 32721795
     [Google Scholar]
  132. HopkinsC. Burges WatsonD.L. KellyC. DearyV. SmithB.C. Managing long COVID: Don’t overlook olfactory dysfunction.BMJ2020370m373610.1136/bmj.m3736 32978178
     [Google Scholar]
  133. HopkinsC. SurdaP. VairaL.A. Six month follow-up of self-reported loss of smell during the COVID-19 pandemic.Rhinology20215912631 33320115
     [Google Scholar]
  134. KamalM. Abo OmirahM. HusseinA. SaeedH. Assessment and characterisation of post-COVID-19 manifestations.Int. J. Clin. Pract.202012250259 32991035
     [Google Scholar]
  135. AmentaE.M. SpalloneA. Rodriguez-BarradasM.C. El SahlyH.M. AtmarR.L. KulkarniP.A. Postacute COVID-19: An overview and approach to classification.Open Forum Infect. Dis.2020712ofaa50910.1093/ofid/ofaa509 33403218
     [Google Scholar]
/content/journals/adctra/10.2174/2667337109666230301145233
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Misery of Long Haulers of COVID-19 - A Review
Appl. Drug Resea., Clin. Trials and Regu. Affa. 10, E010323214229 (2024); https://doi.org/10.2174/2667337109666230301145233
/content/journals/adctra/10.2174/2667337109666230301145233
/content/journals/adctra/10.2174/2667337109666230301145233
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  • Article Type:     Review Article
Keyword(s): COVID-19; dysfunctions; long haulers; post pandemic complications; SARS-CoV-2; sequelae

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